WO2003006161A3 - Microchannel thermal reactor - Google Patents

Microchannel thermal reactor Download PDF

Info

Publication number
WO2003006161A3
WO2003006161A3 PCT/CA2002/001057 CA0201057W WO03006161A3 WO 2003006161 A3 WO2003006161 A3 WO 2003006161A3 CA 0201057 W CA0201057 W CA 0201057W WO 03006161 A3 WO03006161 A3 WO 03006161A3
Authority
WO
WIPO (PCT)
Prior art keywords
thermal reactor
microchannel
microchannel thermal
biochemical
reaction
Prior art date
Application number
PCT/CA2002/001057
Other languages
French (fr)
Other versions
WO2003006161A2 (en
Inventor
Dongqing Li
David Erickson
Original Assignee
Dongqing Li
David Erickson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dongqing Li, David Erickson filed Critical Dongqing Li
Priority to AU2002319041A priority Critical patent/AU2002319041A1/en
Publication of WO2003006161A2 publication Critical patent/WO2003006161A2/en
Publication of WO2003006161A3 publication Critical patent/WO2003006161A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00824—Ceramic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00824—Ceramic
    • B01J2219/00828—Silicon wafers or plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00831—Glass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00833—Plastic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00853—Employing electrode arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00858—Aspects relating to the size of the reactor
    • B01J2219/0086—Dimensions of the flow channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B01J2219/00954—Measured properties
    • B01J2219/00961—Temperature
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/147—Employing temperature sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0418—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electro-osmotic flow [EOF]

Abstract

A low power microchannel thermal reactor for a biological or biochemical reaction. During the reaction, the biochemical or biological sample is heated by the microchannel with embedded in-channel heating elements and cooled by conduction and passive convection.
PCT/CA2002/001057 2001-07-11 2002-07-11 Microchannel thermal reactor WO2003006161A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002319041A AU2002319041A1 (en) 2001-07-11 2002-07-11 Microchannel thermal reactor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30412001P 2001-07-11 2001-07-11
US60/304,120 2001-07-11

Publications (2)

Publication Number Publication Date
WO2003006161A2 WO2003006161A2 (en) 2003-01-23
WO2003006161A3 true WO2003006161A3 (en) 2003-05-30

Family

ID=23175129

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2002/001057 WO2003006161A2 (en) 2001-07-11 2002-07-11 Microchannel thermal reactor

Country Status (2)

Country Link
AU (1) AU2002319041A1 (en)
WO (1) WO2003006161A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1452225B1 (en) * 2003-02-26 2008-09-10 National Institute of Advanced Industrial Science and Technology Preparation of nanoparticles
JP2010530057A (en) * 2007-03-30 2010-09-02 富士フイルム株式会社 Temperature control method
RU2473382C1 (en) * 2011-07-07 2013-01-27 Общество с ограниченной ответственностью "СинТоп" Micro channel reactor for synthesis of hydrocarbons by fischer-tropsh method
CN104185311B (en) * 2014-08-26 2016-06-08 无锡市华牧机械有限公司 For biomass granulation machine has the heater circuit of sample circuit
CN107246919B (en) * 2017-05-03 2019-08-23 华中光电技术研究所（中国船舶重工集团公司第七一七研究所） A kind of control system and its refrigeration determination method of refrigeration type infrared detector
GB201812192D0 (en) 2018-07-26 2018-09-12 Ttp Plc Variable temperature reactor, heater and control circuit for the same
CN114252477B (en) * 2021-12-30 2023-12-15 中国科学院力学研究所 Carbon dioxide mixed working medium circulation micro-channel heat exchange experimental device

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5498392A (en) * 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
FR2795426A1 (en) * 1999-06-22 2000-12-29 Commissariat Energie Atomique Support for genetic analysis comprising reservoir(s) for a medium to be analyzed connected by passage(s) having temperature control device(s) to a test strip with analysis sites having biological probes
US6180372B1 (en) * 1997-04-23 2001-01-30 Bruker Daltonik Gmbh Method and devices for extremely fast DNA replication by polymerase chain reactions (PCR)
FR2799139A1 (en) * 1999-10-01 2001-04-06 Genset Sa Microfluidics device with continuous flow system, useful e.g. for nucleic acid amplification or sequencing, providing temperature cycling of sample
WO2001031053A1 (en) * 1999-10-22 2001-05-03 Aclara Biosciences, Inc. Microfluidic card thermal control

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5498392A (en) * 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US6180372B1 (en) * 1997-04-23 2001-01-30 Bruker Daltonik Gmbh Method and devices for extremely fast DNA replication by polymerase chain reactions (PCR)
FR2795426A1 (en) * 1999-06-22 2000-12-29 Commissariat Energie Atomique Support for genetic analysis comprising reservoir(s) for a medium to be analyzed connected by passage(s) having temperature control device(s) to a test strip with analysis sites having biological probes
FR2799139A1 (en) * 1999-10-01 2001-04-06 Genset Sa Microfluidics device with continuous flow system, useful e.g. for nucleic acid amplification or sequencing, providing temperature cycling of sample
WO2001031053A1 (en) * 1999-10-22 2001-05-03 Aclara Biosciences, Inc. Microfluidic card thermal control

Also Published As

Publication number Publication date
AU2002319041A1 (en) 2003-01-29
WO2003006161A2 (en) 2003-01-23

Similar Documents

Publication Publication Date Title
EP1749569A4 (en) Chemical reaction apparatus utilizing microwave
EG223313A (en) Heat exchange unit for isothermal chemical reactors.
WO2006127889A3 (en) Support for use in microchannel processing
AU2003202327A1 (en) Chemical reactor with heat pipe cooling
WO2003037514A3 (en) Method and apparatus for temperature gradient microfluidics
AU2003282531A1 (en) Vapor escape microchannel heat exchanger
CN111771125A (en) Molecular manipulation and determination by temperature control (II)
ATE184094T1 (en) CONTACT ELEMENT AND CEILING ELEMENT FOR A HEATED AND COOLING BLANKET
WO2005082043A3 (en) Thermal cycling device
EP1754698A3 (en) Process for gas phase phosgenation
WO2008133079A1 (en) Cooling/heating panel
FR2783314B1 (en) HEAT EXCHANGER TUBE, METHOD FOR MANUFACTURING SAME, AND CRACKING OVEN USING THE HEAT EXCHANGER TUBE
WO2006071517A3 (en) System and method for directing a fluid through a die
WO2006039293A3 (en) Localized control of thermal properties on microdevices and applications thereof
AU2003222780A1 (en) Micro-reactor and micro-channel heat exchanger
UA99893C2 (en) Container and method for manufacturing thereof
WO2003006161A3 (en) Microchannel thermal reactor
AU2003269494A1 (en) Flat hollow body for passing fluid therethrough, heat exchanger comprising the hollow body and process for fabricating the heat exchanger
ATE351899T1 (en) INCUBATION AND STORAGE DEVICE, ESPECIALLY FOR SAMPLES MADE OF ORGANIC MATERIAL
WO2003048308A3 (en) Thermus brockianus nucleic acid polymerases
ATE401126T1 (en) HEATING OF MULTI-CHAMBER CONTAINERS
AU2002315618A1 (en) Reactor for using solar radiant heat
US9399219B2 (en) Thermal Array
WO2003048310A3 (en) Thermus oshimai nucleic acid polymerases
MXPA04003654A (en) Method and reactor for carrying out chemical reactions in pseudo-isothermal conditions.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP