WO2003001200A3 - Optical detection in bio-separation device having axial radiation input and output and widened detection zone - Google Patents

Optical detection in bio-separation device having axial radiation input and output and widened detection zone Download PDF

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Publication number
WO2003001200A3
WO2003001200A3 PCT/US2002/020116 US0220116W WO03001200A3 WO 2003001200 A3 WO2003001200 A3 WO 2003001200A3 US 0220116 W US0220116 W US 0220116W WO 03001200 A3 WO03001200 A3 WO 03001200A3
Authority
WO
WIPO (PCT)
Prior art keywords
detection
detection zone
separation
zone
axially along
Prior art date
Application number
PCT/US2002/020116
Other languages
French (fr)
Other versions
WO2003001200A2 (en
Inventor
Varouj Amirkhanian
Ming-Sun Liu
Original Assignee
Biocal Technology Inc
Varouj Amirkhanian
Ming-Sun Liu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/887,871 external-priority patent/US6932940B2/en
Priority claimed from US09/887,953 external-priority patent/US6929779B2/en
Priority claimed from US09/887,872 external-priority patent/US6529275B2/en
Application filed by Biocal Technology Inc, Varouj Amirkhanian, Ming-Sun Liu filed Critical Biocal Technology Inc
Priority to AU2002310510A priority Critical patent/AU2002310510A1/en
Publication of WO2003001200A2 publication Critical patent/WO2003001200A2/en
Publication of WO2003001200A3 publication Critical patent/WO2003001200A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means

Abstract

In bio-separation system, incident radiation (e.g., from a laser or LED source) for detection of separated analytes is directed at the detection zone axially along the separation medium, instead of through the boundary walls of the detection zone. In one embodiment, incident radiation at one or more wavelengths is directed via at least one optic fiber that extends axially along the separation medium to the proximity of the detection zone. Emitted radiation from the detection zone passes through the boundary walls about the detection zone for off-column detection, and/or is directed axially along the separation medium for on-column detection. In another aspect of the present invention, emitted radiation signal representative of sample analytes are collected from the detection zone axially along the separation medium independent of the excitation radiation input configuration. In another aspect of the present invention, the detection zone is located at a widened zone along the separation channel. In a further aspect of the present invention, the optical detection configuration may be scaled up and implemented in a multi-channel CE system that comprises multiple capillary separation channels.
PCT/US2002/020116 2001-06-22 2002-06-24 Optical detection in bio-separation device having axial radiation input and output and widened detection zone WO2003001200A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002310510A AU2002310510A1 (en) 2001-06-22 2002-06-24 Optical detection in bio-separation device having axial radiation input and output and widened detection zone

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US09/887,871 US6932940B2 (en) 2001-06-22 2001-06-22 Optical detection in bio-separation device using axial radiation input
US09/887,953 2001-06-22
US09/887,953 US6929779B2 (en) 2001-06-22 2001-06-22 Optical detection in bio-separation device using axial radiation output
US09/887,871 2001-06-22
US09/887,872 2001-06-22
US09/887,872 US6529275B2 (en) 2001-06-22 2001-06-22 Optical detection in bio-separation device using a widened detection zone

Publications (2)

Publication Number Publication Date
WO2003001200A2 WO2003001200A2 (en) 2003-01-03
WO2003001200A3 true WO2003001200A3 (en) 2003-06-19

Family

ID=27420530

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/020116 WO2003001200A2 (en) 2001-06-22 2002-06-24 Optical detection in bio-separation device having axial radiation input and output and widened detection zone

Country Status (2)

Country Link
AU (1) AU2002310510A1 (en)
WO (1) WO2003001200A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5297447B2 (en) * 2007-03-26 2013-09-25 イージーン インコーポレイテッド Capillary, bioanalytical cartridge, bioanalytical system, and method for bioanalytical
DE102012209593B4 (en) 2012-06-06 2021-08-12 Osram Gmbh Lighting device

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0386925A1 (en) * 1989-03-06 1990-09-12 Hewlett-Packard Company Capillary zone electrophoresis cell system
US5324401A (en) * 1993-02-05 1994-06-28 Iowa State University Research Foundation, Inc. Multiplexed fluorescence detector system for capillary electrophoresis
EP0704699A2 (en) * 1994-09-29 1996-04-03 Hitachi Software Engineering Co., Ltd. Electrophoresis apparatus of capillary type
US5545901A (en) * 1995-08-23 1996-08-13 Beckman Instruments, Inc. Automated optical alignment using a galvometric scanner
US5650846A (en) * 1995-11-21 1997-07-22 Hewlett-Packard Company Microcolumnar analytical system with optical fiber sensor

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0386925A1 (en) * 1989-03-06 1990-09-12 Hewlett-Packard Company Capillary zone electrophoresis cell system
US5324401A (en) * 1993-02-05 1994-06-28 Iowa State University Research Foundation, Inc. Multiplexed fluorescence detector system for capillary electrophoresis
EP0704699A2 (en) * 1994-09-29 1996-04-03 Hitachi Software Engineering Co., Ltd. Electrophoresis apparatus of capillary type
US5545901A (en) * 1995-08-23 1996-08-13 Beckman Instruments, Inc. Automated optical alignment using a galvometric scanner
US5650846A (en) * 1995-11-21 1997-07-22 Hewlett-Packard Company Microcolumnar analytical system with optical fiber sensor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
M. J. SEPANIAK ET AL: "Demontration of an integrated capillary electrophoresis-laser-induced fluorescence fiber-optic sensor", TALANTA, vol. 43, 1996, pages 1889 - 1901, XP002235423 *

Also Published As

Publication number Publication date
WO2003001200A2 (en) 2003-01-03
AU2002310510A1 (en) 2003-01-08

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