WO2003000202A3 - Particles for inhalation having rapid release properties - Google Patents
Particles for inhalation having rapid release properties Download PDFInfo
- Publication number
- WO2003000202A3 WO2003000202A3 PCT/US2002/020280 US0220280W WO03000202A3 WO 2003000202 A3 WO2003000202 A3 WO 2003000202A3 US 0220280 W US0220280 W US 0220280W WO 03000202 A3 WO03000202 A3 WO 03000202A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- particles
- formulations
- bioactive agent
- inhalation
- release properties
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02752100A EP1404299A2 (en) | 2001-06-22 | 2002-06-24 | Particles for inhalation having rapid release properties |
AU2002350606A AU2002350606B2 (en) | 2000-12-29 | 2002-06-24 | Particles for inhalation having rapid release properties |
NZ530123A NZ530123A (en) | 2001-06-22 | 2002-06-24 | Particles comprising DPPC, insulin, sodium citrate and optionally an amino acid in a composition for inhalation that has rapid release properties |
CA002449439A CA2449439A1 (en) | 2001-06-22 | 2002-06-24 | Particles for inhalation having rapid release properties |
IL15898702A IL158987A0 (en) | 2001-06-22 | 2002-06-24 | Particles for inhalation having rapid release properties |
JP2003506648A JP4067047B2 (en) | 2001-06-22 | 2002-06-24 | Inhalable particles with rapid release characteristics |
MXPA03011861A MXPA03011861A (en) | 2001-06-22 | 2002-06-24 | Particles for inhalation having rapid release properties. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/888,126 | 2001-06-22 | ||
US09/888,126 US20020141946A1 (en) | 2000-12-29 | 2001-06-22 | Particles for inhalation having rapid release properties |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003000202A2 WO2003000202A2 (en) | 2003-01-03 |
WO2003000202A3 true WO2003000202A3 (en) | 2003-08-14 |
Family
ID=25392579
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/020280 WO2003000202A2 (en) | 2000-12-29 | 2002-06-24 | Particles for inhalation having rapid release properties |
Country Status (10)
Country | Link |
---|---|
US (3) | US20020141946A1 (en) |
EP (1) | EP1404299A2 (en) |
JP (1) | JP4067047B2 (en) |
CN (1) | CN1518441A (en) |
CA (1) | CA2449439A1 (en) |
IL (1) | IL158987A0 (en) |
MX (1) | MXPA03011861A (en) |
NZ (1) | NZ530123A (en) |
PL (1) | PL367399A1 (en) |
WO (1) | WO2003000202A2 (en) |
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US8936813B2 (en) | 2001-11-01 | 2015-01-20 | Novartis Ag | Spray drying methods and related compositions |
US9192675B2 (en) | 2008-06-13 | 2015-11-24 | Mankind Corporation | Dry powder inhaler and system for drug delivery |
US9220687B2 (en) | 2008-12-29 | 2015-12-29 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
US9233159B2 (en) | 2011-10-24 | 2016-01-12 | Mannkind Corporation | Methods and compositions for treating pain |
US9241903B2 (en) | 2006-02-22 | 2016-01-26 | Mannkind Corporation | Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent |
US9283193B2 (en) | 2005-09-14 | 2016-03-15 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents |
US9346766B2 (en) | 2004-08-20 | 2016-05-24 | Mannkind Corporation | Catalysis of diketopiperazine synthesis |
US9364436B2 (en) | 2011-06-17 | 2016-06-14 | Mannkind Corporation | High capacity diketopiperazine microparticles and methods |
US9364619B2 (en) | 2008-06-20 | 2016-06-14 | Mannkind Corporation | Interactive apparatus and method for real-time profiling of inhalation efforts |
US9662461B2 (en) | 2008-06-13 | 2017-05-30 | Mannkind Corporation | Dry powder drug delivery system and methods |
US9675674B2 (en) | 2004-08-23 | 2017-06-13 | Mannkind Corporation | Diketopiperazine salts for drug delivery and related methods |
US9993555B2 (en) | 2014-12-16 | 2018-06-12 | Eli Lilly And Company | Rapid-acting insulin compositions |
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US20060171899A1 (en) * | 1998-12-10 | 2006-08-03 | Akwete Adjei | Water-stabilized aerosol formulation system and method of making |
US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
US8337816B2 (en) * | 2001-09-17 | 2012-12-25 | Glaxo Group Limited | Dry powder medicament formulations |
US7008644B2 (en) | 2002-03-20 | 2006-03-07 | Advanced Inhalation Research, Inc. | Method and apparatus for producing dry particles |
WO2003080149A2 (en) | 2002-03-20 | 2003-10-02 | Mannkind Corporation | Inhalation apparatus |
US9339459B2 (en) | 2003-04-24 | 2016-05-17 | Nektar Therapeutics | Particulate materials |
US7862834B2 (en) * | 2003-05-28 | 2011-01-04 | Novartis Pharma Ag | Pharmaceutical formulation comprising a water-insoluble active agent |
EP1667633A4 (en) * | 2003-10-01 | 2008-10-08 | Momenta Pharmaceuticals Inc | Polysaccharides for pulmonary delivery of active agents |
WO2005034915A2 (en) * | 2003-10-03 | 2005-04-21 | Alza Corporation | Screening method for evaluation of bilayer-drug interaction in liposomal compositions |
JP2007522149A (en) * | 2004-02-10 | 2007-08-09 | アドバンスト インハレーション リサーチ,インコーポレイテッド | Particles for inhalation with fast release characteristics |
US20070123449A1 (en) * | 2005-11-01 | 2007-05-31 | Advanced Inhalation Research, Inc. | High load particles for inhalation having rapid release properties |
US20070172430A1 (en) * | 2006-01-20 | 2007-07-26 | Nastech Pharmaceutical Company Inc. | Dry powder compositions for rna influenza therapeutics |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
TWI494123B (en) | 2008-08-11 | 2015-08-01 | Mannkind Corp | Use of ultrarapid acting insulin |
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CA2754595C (en) | 2009-03-11 | 2017-06-27 | Mannkind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
EP2410981B2 (en) | 2009-03-26 | 2020-02-26 | Pulmatrix Operating Company, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
US9018190B2 (en) | 2009-03-27 | 2015-04-28 | Adocia | Functionalized oligosaccharides |
FR2943538B1 (en) | 2009-03-27 | 2011-05-20 | Adocia | QUICK ACTION FORMULATION OF RECOMBINANT HUMAN INSULIN |
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US8815258B2 (en) | 2009-05-29 | 2014-08-26 | Pearl Therapeutics, Inc. | Compositions, methods and systems for respiratory delivery of two or more active agents |
WO2010144789A2 (en) | 2009-06-12 | 2010-12-16 | Mannkind Corporation | Diketopiperazine microparticles with defined specific surface areas |
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US20130231281A1 (en) | 2011-11-02 | 2013-09-05 | Adocia | Rapid acting insulin formulation comprising an oligosaccharide |
US20150136130A1 (en) * | 2012-02-29 | 2015-05-21 | Pulmatrix, Inc. | Inhalable dry powders |
US8988037B1 (en) * | 2012-04-06 | 2015-03-24 | The United States Of America As Represented By The Secretary Of The Navy | Solar panel storage and deployment system |
DK2872205T3 (en) | 2012-07-12 | 2017-02-27 | Mannkind Corp | DRY POWDER FORMAL ADMINISTRATION SYSTEM |
WO2014066856A1 (en) | 2012-10-26 | 2014-05-01 | Mannkind Corporation | Inhalable influenza vaccine compositions and methods |
JP6322642B2 (en) | 2012-11-13 | 2018-05-09 | アドシア | Fast-acting insulin preparation containing a substituted anionic compound |
AU2014228414B2 (en) | 2013-03-15 | 2018-09-13 | Pearl Therapeutics, Inc. | Methods and systems for conditioning of particulate crystalline materials |
KR102499439B1 (en) | 2013-03-15 | 2023-02-13 | 맨카인드 코포레이션 | Microcrystalline diketopiperazine compositions and methods |
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JP2016530930A (en) | 2013-08-05 | 2016-10-06 | マンカインド コーポレイション | Ventilation device and method |
WO2015148905A1 (en) | 2014-03-28 | 2015-10-01 | Mannkind Corporation | Use of ultrarapid acting insulin |
US9795678B2 (en) | 2014-05-14 | 2017-10-24 | Adocia | Fast-acting insulin composition comprising a substituted anionic compound and a polyanionic compound |
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US9993555B2 (en) | 2014-12-16 | 2018-06-12 | Eli Lilly And Company | Rapid-acting insulin compositions |
Also Published As
Publication number | Publication date |
---|---|
PL367399A1 (en) | 2005-02-21 |
JP2005500309A (en) | 2005-01-06 |
IL158987A0 (en) | 2004-05-12 |
US20100026235A1 (en) | 2010-02-04 |
WO2003000202A2 (en) | 2003-01-03 |
EP1404299A2 (en) | 2004-04-07 |
NZ530123A (en) | 2007-01-26 |
US20080227690A1 (en) | 2008-09-18 |
CA2449439A1 (en) | 2003-01-03 |
MXPA03011861A (en) | 2004-03-26 |
JP4067047B2 (en) | 2008-03-26 |
CN1518441A (en) | 2004-08-04 |
US20020141946A1 (en) | 2002-10-03 |
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