WO2003000191A3 - Composition comprising glycosaminogycans and hyaluronidase inhibitors for the treatment of arthritic joints - Google Patents

Composition comprising glycosaminogycans and hyaluronidase inhibitors for the treatment of arthritic joints Download PDF

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Publication number
WO2003000191A3
WO2003000191A3 PCT/US2002/019718 US0219718W WO03000191A3 WO 2003000191 A3 WO2003000191 A3 WO 2003000191A3 US 0219718 W US0219718 W US 0219718W WO 03000191 A3 WO03000191 A3 WO 03000191A3
Authority
WO
WIPO (PCT)
Prior art keywords
hyaluronic acid
composition
hyaluronidase inhibitor
preferred
hyaluronidase
Prior art date
Application number
PCT/US2002/019718
Other languages
French (fr)
Other versions
WO2003000191A2 (en
Inventor
Jonathan Thompson
Anna Gosiewska
Susan Niemiec
Sridevi Dhanaraj
Original Assignee
Depuy
Jonathan Thompson
Anna Gosiewska
Susan Niemiec
Sridevi Dhanaraj
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Depuy, Jonathan Thompson, Anna Gosiewska, Susan Niemiec, Sridevi Dhanaraj filed Critical Depuy
Priority to CA002451248A priority Critical patent/CA2451248A1/en
Priority to JP2003506637A priority patent/JP2005521629A/en
Priority to EP02739947A priority patent/EP1423081A4/en
Publication of WO2003000191A2 publication Critical patent/WO2003000191A2/en
Publication of WO2003000191A3 publication Critical patent/WO2003000191A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

A preferred embodiment of the present invention is directed to a composition and method for treating arthritis comprising one or more glycosaminoglycans in combination with one or more hyaluronidase inhibitor. In a more preferred embodiment the present invention is directed to a composition and method for treating arthritis comprising one or more glycosaminoglycans which would include at least hyaluronic acid in combination with one or more hyaluronidase inhibitors selected from the group consisting of heparan sulphate, dextran sulphate and xylose sulphate. In still a more preferred embodiment the present invention relates to a composition and method for treating arthritis comprising hyaluronic acid co-encapsulated with a hyaluronidase inhibitor in liposomes. Hyaluronic acid in the composition would confer the viscosupplement properties to the joint. The function of the hyaluronidase inhibitor would be to act as a preservative, and protect the hyaluronic acid from premature degradation in the joint. The liposomal encapsulation and delivery of the composition would serve as a slow release depot for the hyaluronic acid and the hyaluronidase inhibitor. This invention therefore provides a means of delivering stable and long lasting high molecular weight HA to the joint. The therpeutic effectiveness of the liposome co-encapsulated hyaluronic acid with the hyaluronidase inhibitor would be greater than simple injection of hyaluronic acid. The preferred method of treatment would be by intra-articular injection of an admixture of hyaluronic acid and a hyaluronidase inhibitor, optionally encapsulated in liposomes. The treatment is more effective than currently available treatments based on HA alone.
PCT/US2002/019718 2001-06-25 2002-06-20 Composition comprising glycosaminogycans and hyaluronidase inhibitors for the treatment of arthritic joints WO2003000191A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002451248A CA2451248A1 (en) 2001-06-25 2002-06-20 Composition comprising glycosaminoglycans and hyaluronidase inhibitors for the treatment of arthritic joints
JP2003506637A JP2005521629A (en) 2001-06-25 2002-06-20 Composition comprising glycosaminoglycan and hyaluronidase inhibitor for treating arthritic joints
EP02739947A EP1423081A4 (en) 2001-06-25 2002-06-20 Composition comprising glycosaminogycans and hyaluronidase inhibitors for the treatment of arthritic joints

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US30073401P 2001-06-25 2001-06-25
US60/300,734 2001-06-25
US74102A 2002-06-06 2002-06-06
USDEP-741 2002-06-06

Publications (2)

Publication Number Publication Date
WO2003000191A2 WO2003000191A2 (en) 2003-01-03
WO2003000191A3 true WO2003000191A3 (en) 2004-03-11

Family

ID=26668090

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/019718 WO2003000191A2 (en) 2001-06-25 2002-06-20 Composition comprising glycosaminogycans and hyaluronidase inhibitors for the treatment of arthritic joints

Country Status (4)

Country Link
EP (1) EP1423081A4 (en)
JP (1) JP2005521629A (en)
CA (1) CA2451248A1 (en)
WO (1) WO2003000191A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109758607A (en) * 2019-03-08 2019-05-17 宁夏妙朗生物科技有限公司 Resist the cross-linked hyaluronic acid gel of hyaluronic acid enzyme hydrolysis

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JP4703948B2 (en) * 2003-05-20 2011-06-15 丸善製薬株式会社 Anti-allergic agent, anti-aging agent and anti-aging skin external preparation
AU2005272578A1 (en) * 2004-08-13 2006-02-23 Angiotech International Ag Compositions and methods using hyaluronic acid and hyluronidase inhibitors
AU2013270451B2 (en) * 2005-10-03 2016-05-12 Mark A. Pinsky Compositions and methods for improved skin care
EP2019647A4 (en) * 2006-05-19 2010-04-28 Univ Boston Novel hydrophilic polymers as medical lubricants and gels
WO2008139123A2 (en) * 2007-05-11 2008-11-20 Galderma Research & Development Pharmaceutical or cosmetic preparations for topical and/or parenteral application, preparation methods thereof and use of same
WO2008139122A2 (en) * 2007-05-11 2008-11-20 Galderma Research & Development Pharmaceutical or cosmetic preparations for topical and/or parenteral application, preparation methods thereof and use of same
US8394782B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having increased longevity
ITMI20072348A1 (en) 2007-12-17 2009-06-18 Medichem Srl METHOD FOR CELL RIGENERATION OF HYALURONIC ACID AND ITS COSMETIC COMPOSITION
MX2010012326A (en) * 2008-05-19 2010-12-01 Univ North Carolina Methods and compositions comprising novel cationic lipids.
ITMI20090779A1 (en) * 2009-05-08 2010-11-08 Vitrupharm Srl NUTRITIONAL COMPOSITIONS BASED ON CISTEIN RESVERATROL OR ITS DERIVATIVES OR METABOLITES AND ASTAXANTIN
US9913810B2 (en) 2009-07-23 2018-03-13 U.S. Nutraceuticals, LLC Composition and method to alleviate joint pain using phospholipids and astaxanthin
US8557275B2 (en) 2009-07-23 2013-10-15 U.S. Nutraceuticals, LLC Composition and method to alleviate joint pain using a mixture of fish oil and fish oil derived, choline based, phospholipid bound fatty acid mixture including polyunsaturated EPA and DHA
US9399047B2 (en) 2009-07-23 2016-07-26 U.S. Nutraceuticals, LLC Composition and method to alleviate joint pain using phospholipids and roe extract
US8481072B2 (en) 2009-07-23 2013-07-09 U.S. Nutraceuticals, LLC Composition and method to alleviate joint pain
US9402857B2 (en) 2009-07-23 2016-08-02 U.S. Nutraceuticals, LLC Composition and method to alleviate joint pain using low molecular weight hyaluronic acid and astaxanthin
US9238043B2 (en) 2009-07-23 2016-01-19 U.S. Nutraceuticals, LLC Composition and method to alleviate joint pain using algae based oils
US9216164B2 (en) 2009-07-23 2015-12-22 U.S. Nutraceuticals, LLC Composition and method to alleviate joint pain using a mixture of fish oil and fish oil derived, choline based, phospholipid bound fatty acid mixture including polyunsaturated EPA and DHA
US8637569B2 (en) 2009-10-22 2014-01-28 Api Genesis, Llc Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compounds
EP2490679B8 (en) 2009-10-22 2022-10-26 Tpc-Api Llc Methods of making and using compositions comprising flavonoids
WO2011160146A1 (en) * 2010-06-23 2011-12-29 Croma-Pharma Gesellschaft M.B.H. Pharmaceutical preparation containing dextran and sodium hyaluronate for the treatment of joint disorders
US8716204B2 (en) 2010-07-27 2014-05-06 Zimmer, Inc. Synthetic synovial fluid compositions and methods for making the same
ITRM20100614A1 (en) * 2010-11-24 2012-05-25 D M G Italia S R L PHARMACEUTICAL PREPARATIONS OF ACID 18 GLYCYRRHETIC BETA AND / OR OF ITS DERIVATIVES FOR INTRARTICULAR INFILTRATIONS FOR THE TREATMENT OF INFLAMMATORY ARTROPATHIES
FR2991876B1 (en) * 2012-06-13 2014-11-21 Vivacy Lab COMPOSITION, IN AQUEOUS MEDIUM, COMPRISING AT LEAST ONE HYALURONIC ACID AND AT LEAST ONE WATER-SOLUBLE SALT OF SUCROSE OCTASULFATE
US20190000874A1 (en) * 2015-08-13 2019-01-03 Newven Sprl Composition for the Treatment of Joint Conditions
DE102016208567A1 (en) * 2016-05-19 2017-11-23 Heraeus Medical Gmbh Polymer solution for viscous supplementation
MX2020002041A (en) 2017-08-22 2020-08-13 Moebius Medical Ltd Liposomal formulation for joint lubrication.

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Publication number Priority date Publication date Assignee Title
US4239754A (en) * 1976-10-23 1980-12-16 Choay, S.A. Liposomes containing heparin and a process for obtaining them
US4743596A (en) * 1987-06-16 1988-05-10 Lapin Alfred R Anti-arthritic preparation
US6136795A (en) * 1998-11-18 2000-10-24 Omni Nutraceuticals, Inc Dietary regimen of nutritional supplements for relief of symptoms of arthritis
US6232315B1 (en) * 1998-09-28 2001-05-15 Merck & Co., Inc. Method for treating inflammatory diseases by administering a thrombin inhibitor

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JP2003501381A (en) * 1999-06-07 2003-01-14 ユニバーシティ・オブ・シェフィールド Arthritis treatment

Patent Citations (4)

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US4743596A (en) * 1987-06-16 1988-05-10 Lapin Alfred R Anti-arthritic preparation
US6232315B1 (en) * 1998-09-28 2001-05-15 Merck & Co., Inc. Method for treating inflammatory diseases by administering a thrombin inhibitor
US6136795A (en) * 1998-11-18 2000-10-24 Omni Nutraceuticals, Inc Dietary regimen of nutritional supplements for relief of symptoms of arthritis

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Title
See also references of EP1423081A4 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109758607A (en) * 2019-03-08 2019-05-17 宁夏妙朗生物科技有限公司 Resist the cross-linked hyaluronic acid gel of hyaluronic acid enzyme hydrolysis
CN109758607B (en) * 2019-03-08 2021-07-27 宁夏妙朗生物科技有限公司 Cross-linked hyaluronic acid gels resistant to hydrolysis by hyaluronidase

Also Published As

Publication number Publication date
CA2451248A1 (en) 2003-01-03
JP2005521629A (en) 2005-07-21
WO2003000191A2 (en) 2003-01-03
EP1423081A4 (en) 2005-05-25
EP1423081A2 (en) 2004-06-02

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