WO2002101474A3 - Flow control systems - Google Patents

Flow control systems Download PDF

Info

Publication number
WO2002101474A3
WO2002101474A3 PCT/US2002/019121 US0219121W WO02101474A3 WO 2002101474 A3 WO2002101474 A3 WO 2002101474A3 US 0219121 W US0219121 W US 0219121W WO 02101474 A3 WO02101474 A3 WO 02101474A3
Authority
WO
WIPO (PCT)
Prior art keywords
flow
fluid
electroosmotic
flow control
control systems
Prior art date
Application number
PCT/US2002/019121
Other languages
French (fr)
Other versions
WO2002101474A2 (en
Inventor
David W Neyer
Phillip H Paul
Don Wesley Arnold
Christopher G Bailey
Original Assignee
Eksigent Technologies Llc
David W Neyer
Phillip H Paul
Don Wesley Arnold
Christopher G Bailey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eksigent Technologies Llc, David W Neyer, Phillip H Paul, Don Wesley Arnold, Christopher G Bailey filed Critical Eksigent Technologies Llc
Priority to EP20020739909 priority Critical patent/EP1407330B1/en
Priority to US10/480,691 priority patent/US7597790B2/en
Priority to JP2003504171A priority patent/JP2004530221A/en
Priority to CA 2450119 priority patent/CA2450119C/en
Priority to AU2002312530A priority patent/AU2002312530A1/en
Publication of WO2002101474A2 publication Critical patent/WO2002101474A2/en
Publication of WO2002101474A3 publication Critical patent/WO2002101474A3/en
Priority to US12/567,482 priority patent/US8795493B2/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/26Conditioning of the fluid carrier; Flow patterns
    • G01N30/28Control of physical parameters of the fluid carrier
    • G01N30/32Control of physical parameters of the fluid carrier of pressure or speed
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/42Electrodialysis; Electro-osmosis ; Electro-ultrafiltration; Membrane capacitive deionization
    • B01D61/56Electro-osmotic dewatering
    • GPHYSICS
    • G05CONTROLLING; REGULATING
    • G05DSYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D11/00Control of flow ratio
    • G05D11/02Controlling ratio of two or more flows of fluid or fluent material
    • G05D11/13Controlling ratio of two or more flows of fluid or fluent material characterised by the use of electric means
    • G05D11/131Controlling ratio of two or more flows of fluid or fluent material characterised by the use of electric means by measuring the values related to the quantity of the individual components
    • G05D11/132Controlling ratio of two or more flows of fluid or fluent material characterised by the use of electric means by measuring the values related to the quantity of the individual components by controlling the flow of the individual components
    • GPHYSICS
    • G05CONTROLLING; REGULATING
    • G05DSYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D7/00Control of flow
    • G05D7/06Control of flow characterised by the use of electric means
    • G05D7/0617Control of flow characterised by the use of electric means specially adapted for fluid materials
    • G05D7/0629Control of flow characterised by the use of electric means specially adapted for fluid materials characterised by the type of regulator means
    • G05D7/0694Control of flow characterised by the use of electric means specially adapted for fluid materials characterised by the type of regulator means by action on throttling means or flow sources of very small size, e.g. microfluidics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/26Conditioning of the fluid carrier; Flow patterns
    • G01N30/28Control of physical parameters of the fluid carrier
    • G01N30/32Control of physical parameters of the fluid carrier of pressure or speed
    • G01N2030/324Control of physical parameters of the fluid carrier of pressure or speed speed, flow rate
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/26Conditioning of the fluid carrier; Flow patterns
    • G01N30/28Control of physical parameters of the fluid carrier
    • G01N30/32Control of physical parameters of the fluid carrier of pressure or speed
    • G01N2030/326Control of physical parameters of the fluid carrier of pressure or speed pumps
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00Fluid handling
    • Y10T137/8593Systems
    • Y10T137/85978With pump
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00Fluid handling
    • Y10T137/8593Systems
    • Y10T137/85978With pump
    • Y10T137/85986Pumped fluid control
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00Fluid handling
    • Y10T137/8593Systems
    • Y10T137/85978With pump
    • Y10T137/85986Pumped fluid control
    • Y10T137/86027Electric

Abstract

A flow controller which uses a combination of hydrostatic pressure and electroosmotic flow to control the flow of a fluid. A driving fluid (1204) whose flow rate is dependent on both hydrostatic pressures and electroosmotic flow can be used (a) directly as a working fluid in an operable device, for example a chromatograph, or (b) to displace a working fluid (1203) from a storage container (625) into an operable device (1301), or both (a) and (b). The driving fluid (1204) can be composed of one or more fluids. Part or all the driving fluid (1204) is passed through an electroosmotic device (100) so as to increase or decrease the flow rate induced by hydrostatic pressure.
PCT/US2002/019121 2001-06-13 2002-06-13 Flow control systems WO2002101474A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP20020739909 EP1407330B1 (en) 2001-06-13 2002-06-13 Flow control systems
US10/480,691 US7597790B2 (en) 2001-06-13 2002-06-13 Flow control systems
JP2003504171A JP2004530221A (en) 2001-06-13 2002-06-13 Flow control system
CA 2450119 CA2450119C (en) 2001-06-13 2002-06-13 Flow control systems
AU2002312530A AU2002312530A1 (en) 2001-06-13 2002-06-13 Flow control systems
US12/567,482 US8795493B2 (en) 2001-06-13 2009-09-25 Flow control systems

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US29814701P 2001-06-13 2001-06-13
US60/298,147 2001-06-13
US09/942,884 2001-08-29
US09/942,884 US20020189947A1 (en) 2001-06-13 2001-08-29 Electroosmotic flow controller
US10/155,474 2002-05-24
US10/155,474 US20020195344A1 (en) 2001-06-13 2002-05-24 Combined electroosmotic and pressure driven flow system

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US10/155,474 Continuation-In-Part US20020195344A1 (en) 2001-06-13 2002-05-24 Combined electroosmotic and pressure driven flow system

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US10480691 A-371-Of-International 2002-06-13
US12/567,482 Division US8795493B2 (en) 2001-06-13 2009-09-25 Flow control systems
US12/567,482 Continuation US8795493B2 (en) 2001-06-13 2009-09-25 Flow control systems

Publications (2)

Publication Number Publication Date
WO2002101474A2 WO2002101474A2 (en) 2002-12-19
WO2002101474A3 true WO2002101474A3 (en) 2003-05-01

Family

ID=26970501

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/019121 WO2002101474A2 (en) 2001-06-13 2002-06-13 Flow control systems

Country Status (6)

Country Link
US (7) US20020189947A1 (en)
EP (1) EP1407330B1 (en)
JP (2) JP2004530221A (en)
AU (1) AU2002312530A1 (en)
CA (1) CA2450119C (en)
WO (1) WO2002101474A2 (en)

Families Citing this family (120)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6418968B1 (en) 2001-04-20 2002-07-16 Nanostream, Inc. Porous microfluidic valves
US20020186263A1 (en) * 2001-06-07 2002-12-12 Nanostream, Inc. Microfluidic fraction collectors
US7465382B2 (en) * 2001-06-13 2008-12-16 Eksigent Technologies Llc Precision flow control system
US20020189947A1 (en) * 2001-06-13 2002-12-19 Eksigent Technologies Llp Electroosmotic flow controller
DE10130070A1 (en) * 2001-06-21 2003-01-02 Philips Corp Intellectual Pty X-ray tube with liquid metal target
US6627465B2 (en) 2001-08-30 2003-09-30 Micron Technology, Inc. System and method for detecting flow in a mass flow controller
US20030098661A1 (en) * 2001-11-29 2003-05-29 Ken Stewart-Smith Control system for vehicle seats
AU2002351291A1 (en) * 2001-12-06 2003-06-23 Nanostream, Inc. Adhesiveless microfluidic device fabrication
US7261812B1 (en) 2002-02-13 2007-08-28 Nanostream, Inc. Multi-column separation devices and methods
US6814859B2 (en) * 2002-02-13 2004-11-09 Nanostream, Inc. Frit material and bonding method for microfluidic separation devices
US20030164297A1 (en) * 2002-03-04 2003-09-04 Corning Incorporated Electrophoretic inorganic porous material
CN100414265C (en) * 2002-07-05 2008-08-27 加斯帕尔多塞米纳特里奇有限公司 A volumetric metering device for the metered delivery of granular and powdery materials, particularly for machines for distributing the said materials
US7364647B2 (en) * 2002-07-17 2008-04-29 Eksigent Technologies Llc Laminated flow device
US7235164B2 (en) 2002-10-18 2007-06-26 Eksigent Technologies, Llc Electrokinetic pump having capacitive electrodes
US7517440B2 (en) * 2002-07-17 2009-04-14 Eksigent Technologies Llc Electrokinetic delivery systems, devices and methods
US6812458B2 (en) * 2002-08-08 2004-11-02 Nanostream, Inc. Systems and methods for high-throughput microfluidic sample analysis
US7214320B1 (en) 2002-08-08 2007-05-08 Nanostream, Inc. Systems and methods for high throughput sample analysis
US20040092033A1 (en) * 2002-10-18 2004-05-13 Nanostream, Inc. Systems and methods for preparing microfluidic devices for operation
US7010964B2 (en) 2002-10-31 2006-03-14 Nanostream, Inc. Pressurized microfluidic devices with optical detection regions
WO2004040295A1 (en) * 2002-10-31 2004-05-13 Nanostream, Inc. Parallel detection chromatography systems
US6936167B2 (en) * 2002-10-31 2005-08-30 Nanostream, Inc. System and method for performing multiple parallel chromatographic separations
JP2004184138A (en) * 2002-11-29 2004-07-02 Nec Corp Separator, separation method, and mass spectrometric analysis system
US20040107996A1 (en) * 2002-12-09 2004-06-10 Crocker Robert W. Variable flow control apparatus
KR101101737B1 (en) * 2002-12-10 2012-01-05 가부시키가이샤 니콘 Exposure apparatus, exposure method and method for manufacturing device
US20060076482A1 (en) * 2002-12-13 2006-04-13 Hobbs Steven E High throughput systems and methods for parallel sample analysis
US6987263B2 (en) * 2002-12-13 2006-01-17 Nanostream, Inc. High throughput systems and methods for parallel sample analysis
US20040179972A1 (en) * 2003-03-14 2004-09-16 Nanostream, Inc. Systems and methods for detecting manufacturing defects in microfluidic devices
US7178386B1 (en) 2003-04-10 2007-02-20 Nanostream, Inc. Parallel fluid processing systems and methods
US6962658B2 (en) * 2003-05-20 2005-11-08 Eksigent Technologies, Llc Variable flow rate injector
US20050032238A1 (en) * 2003-08-07 2005-02-10 Nanostream, Inc. Vented microfluidic separation devices and methods
US7028536B2 (en) * 2004-06-29 2006-04-18 Nanostream, Inc. Sealing interface for microfluidic device
US7217351B2 (en) * 2003-08-29 2007-05-15 Beta Micropump Partners Llc Valve for controlling flow of a fluid
US20050133371A1 (en) * 2003-09-30 2005-06-23 West Virginia University Research Corporation Apparatus and method for Edman degradation on a microfluidic device utilizing an electroosmotic flow pump
US7106938B2 (en) * 2004-03-16 2006-09-12 Regents Of The University Of Minnesota Self assembled three-dimensional photonic crystal
US7559356B2 (en) * 2004-04-19 2009-07-14 Eksident Technologies, Inc. Electrokinetic pump driven heat transfer system
TWI257553B (en) * 2004-06-04 2006-07-01 Asustek Comp Inc Multiple over-clocking main board and control method thereof
US7429317B2 (en) * 2004-12-20 2008-09-30 Eksigent Technologies Llc Electrokinetic device employing a non-newtonian liquid
CA2496481A1 (en) * 2005-02-08 2006-08-09 Mds Inc., Doing Business Through It's Mds Sciex Division Method and apparatus for sample deposition
DE602005025974D1 (en) * 2005-03-31 2011-03-03 Agilent Technologies Inc Apparatus and method for providing solvents with correction of piston movement
US7556776B2 (en) * 2005-09-08 2009-07-07 President And Fellows Of Harvard College Microfluidic manipulation of fluids and reactions
US20070183928A1 (en) * 2005-09-09 2007-08-09 Eksigent Technologies, Llc Variable flow rate system for column chromatography
US20070073277A1 (en) * 2005-09-16 2007-03-29 Medicalcv, Inc. Controlled guided ablation treatment
KR100697292B1 (en) * 2005-10-04 2007-03-20 삼성전자주식회사 Semiconductor device and method for forming thereof
EP1957794B1 (en) 2005-11-23 2014-07-02 Eksigent Technologies, LLC Electrokinetic pump designs and drug delivery systems
US20070170056A1 (en) * 2006-01-26 2007-07-26 Arnold Don W Microscale electrochemical cell and methods incorporating the cell
US8577469B2 (en) * 2006-07-12 2013-11-05 Rainbow Medical Ltd. Iontophoretic and electroosmotic disc treatment
US20080032290A1 (en) * 2006-08-03 2008-02-07 Young James E Nanopore flow cells
JP5360519B2 (en) * 2006-09-22 2013-12-04 西川 正名 Electroosmotic material, manufacturing method thereof, and electroosmotic flow pump
US7516658B2 (en) 2006-09-29 2009-04-14 Rosemount Inc. Electro-kinetic pressure/flow sensor
US8216445B2 (en) * 2006-10-31 2012-07-10 Wisconsin Alumni Research Foundation Nanoporous insulating oxide deionization device having asymmetric electrodes and method of use thereof
US20080154243A1 (en) * 2006-12-20 2008-06-26 Beta Micropump Partners Llc Delivery device for a fluid
US20080154242A1 (en) * 2006-12-20 2008-06-26 Beta Micropump Partners Llc Delivery device for a fluid
US20080152510A1 (en) * 2006-12-20 2008-06-26 Beta Micropump Partners Llc Valve for controlling flow of a primary fluid
US20080182136A1 (en) * 2007-01-26 2008-07-31 Arnold Don W Microscale Electrochemical Cell And Methods Incorporating The Cell
US7867592B2 (en) 2007-01-30 2011-01-11 Eksigent Technologies, Inc. Methods, compositions and devices, including electroosmotic pumps, comprising coated porous surfaces
WO2009042898A1 (en) * 2007-09-28 2009-04-02 Washington University In Saint Louis Irreversible gels
WO2009076134A1 (en) 2007-12-11 2009-06-18 Eksigent Technologies, Llc Electrokinetic pump with fixed stroke volume
SI22680A (en) * 2007-12-28 2009-06-30 Itw Metalflex, D.O.O. Tolmin Multipurpose transformer for device which uses water
EP2235517B1 (en) * 2007-12-31 2018-08-01 O. I. Corporation System and method for regulating flow in fluidic devices
AU2009206042A1 (en) * 2008-01-16 2009-07-23 Syngenta Participations Ag Apparatus system and method for mass analysis of a sample
US8173080B2 (en) * 2008-02-14 2012-05-08 Illumina, Inc. Flow cells and manifolds having an electroosmotic pump
JP4457155B2 (en) * 2008-02-22 2010-04-28 株式会社日立製作所 Nuclear magnetic resonance measuring apparatus and measuring method using nuclear magnetic resonance measuring apparatus
WO2009134395A2 (en) 2008-04-28 2009-11-05 President And Fellows Of Harvard College Microfluidic device for storage and well-defined arrangement of droplets
JP5430007B2 (en) * 2008-05-21 2014-02-26 株式会社フジキン Discontinuous flow rate switching control method for fluid using pressure type flow rate control device
US8252250B2 (en) * 2008-11-26 2012-08-28 Illumina, Inc. Electroosmotic pump with improved gas management
US8794052B2 (en) * 2009-04-16 2014-08-05 Shimadzu Corporation Liquid chromatograph
KR20110046867A (en) * 2009-10-29 2011-05-06 삼성전자주식회사 Microfluidic device comprising gas providing unit, and method for mixing liquids and generate emulsion using the same
WO2011075571A1 (en) * 2009-12-18 2011-06-23 Waters Technologies Corporation Flow sensors and flow sensing methods with extended linear range
GB2477287B (en) * 2010-01-27 2012-02-15 Izon Science Ltd Control of particle flow in an aperture
US8746270B2 (en) * 2010-02-10 2014-06-10 Brg Industries Incorporated Precision low flow rate fluid delivery system and methods for controlling same
CN102946988B (en) * 2010-06-09 2015-04-15 英派尔科技开发有限公司 Adjustable pressure microreactor
WO2011162666A1 (en) * 2010-06-23 2011-12-29 Ge Healthcare Bio-Sciences Ab Method of preparing liquid mixtures
JP5304749B2 (en) * 2010-08-05 2013-10-02 株式会社島津製作所 Vacuum analyzer
US8729502B1 (en) 2010-10-28 2014-05-20 The Research Foundation For The State University Of New York Simultaneous, single-detector fluorescence detection of multiple analytes with frequency-specific lock-in detection
WO2012070431A1 (en) * 2010-11-22 2012-05-31 国立大学法人北海道大学 Portable liquid chromatograph and liquid chromatography
CN108956788B (en) 2011-03-23 2022-08-02 明尼苏达大学评议会 Valve and flow diversion system for multidimensional liquid analysis
JP2014519570A (en) 2011-05-05 2014-08-14 エクシジェント テクノロジーズ, エルエルシー Gel coupling for electrokinetic delivery system
EP2712407A4 (en) * 2011-05-05 2015-06-03 Eksigent Technologies Llc System and method of differential pressure control of a reciprocating electrokinetic pump
US8727231B2 (en) 2011-11-18 2014-05-20 Dh Technologies Development Pte. Ltd. Sealed microfluidic conduit assemblies and methods for fabricating them
US8603834B2 (en) 2011-12-15 2013-12-10 General Electric Company Actuation of valves using electroosmotic pump
JP5915467B2 (en) * 2012-08-30 2016-05-11 株式会社島津製作所 Liquid feeding tube for liquid chromatograph detector and liquid chromatograph
AU2013318515A1 (en) 2012-09-21 2015-04-09 Board Of Regents Of The University Of Texas System Electro-osmotic pumps with electrodes comprising a lanthanide oxide or an actinide oxide
AU2013254946A1 (en) * 2012-11-14 2014-05-29 Krohne Ag Nuclear magnetic flow meter and method for operation of nuclear magnet flow meters
US9731122B2 (en) 2013-04-29 2017-08-15 Rainbow Medical Ltd. Electroosmotic tissue treatment
WO2015095590A1 (en) * 2013-12-18 2015-06-25 Eksigent Technologies Llc System and method of control of a reciprocating electrokinetic pump
GB2544135B (en) 2014-02-12 2021-03-10 Idex Health & Science Llc Volumetric flow regulation in multi-dimensional liquid analysis systems
US9416777B2 (en) 2014-09-26 2016-08-16 Becton, Dickinson And Company Control circuits for electrochemical pump with E-valves
KR101629329B1 (en) * 2014-12-05 2016-06-10 엘지전자 주식회사 Supplying module for mineral water
US9945762B2 (en) * 2014-12-30 2018-04-17 Agilent Technologies, Inc. Apparatus and method for introducing sample into a separation unit of a chromatography system without disrupting a mobile phase
US9616221B2 (en) 2015-07-08 2017-04-11 Rainbow Medical Ltd. Electrical treatment of Alzheimer's disease
US9733239B2 (en) 2015-07-24 2017-08-15 HJ Science & Technology, Inc. Reconfigurable microfluidic systems: scalable, multiplexed immunoassays
US9956558B2 (en) 2015-07-24 2018-05-01 HJ Science & Technology, Inc. Reconfigurable microfluidic systems: homogeneous assays
US9956557B2 (en) 2015-07-24 2018-05-01 HJ Science & Technology, Inc. Reconfigurable microfluidic systems: microwell plate interface
US10957561B2 (en) * 2015-07-30 2021-03-23 Lam Research Corporation Gas delivery system
US10898716B2 (en) 2015-10-29 2021-01-26 Rainbow Medical Ltd. Electrical substance clearance from the brain
US9724515B2 (en) 2015-10-29 2017-08-08 Rainbow Medical Ltd. Electrical substance clearance from the brain for treatment of Alzheimer's disease
US10518085B2 (en) 2015-12-29 2019-12-31 Rainbow Medical Ltd. Disc therapy
US11484706B2 (en) 2015-12-29 2022-11-01 Discure Technologies Ltd Disc therapy
US9770591B2 (en) 2015-12-29 2017-09-26 Rainbow Medical Ltd. Disc therapy
US9950156B2 (en) 2016-09-13 2018-04-24 Rainbow Medical Ltd. Disc therapy
US10825659B2 (en) 2016-01-07 2020-11-03 Lam Research Corporation Substrate processing chamber including multiple gas injection points and dual injector
US10651015B2 (en) 2016-02-12 2020-05-12 Lam Research Corporation Variable depth edge ring for etch uniformity control
US10699878B2 (en) 2016-02-12 2020-06-30 Lam Research Corporation Chamber member of a plasma source and pedestal with radially outward positioned lift pins for translation of a substrate c-ring
US10830673B2 (en) * 2016-05-06 2020-11-10 Oil & Gas Process Solutions Servo-electric controlled auto sampler system
US10569086B2 (en) 2017-01-11 2020-02-25 Rainbow Medical Ltd. Electrical microglial cell activation
WO2018187535A1 (en) * 2017-04-07 2018-10-11 Tokitae Llc Flow assay with at least one electrically-actuated fluid flow control valve and related methods
US10758722B2 (en) 2017-05-03 2020-09-01 Rainbow Medical Ltd. Electrical treatment of Parkinson's disease
DE102017119667B4 (en) * 2017-08-28 2023-05-25 Dionex Softron Gmbh Measurement of a fluid flow
CN108279522B (en) * 2018-02-02 2021-02-02 京东方科技集团股份有限公司 Reflecting device, pixel unit, display device and manufacturing method thereof
WO2019175879A1 (en) 2018-03-14 2019-09-19 Rainbow Medical Ltd. Electrical substance clearance from the brain
CA3098905A1 (en) 2018-04-30 2019-11-07 Protein Fluidics, Inc. Valveless fluidic switching flowchip and uses thereof
CN110398516B (en) * 2019-08-26 2024-03-26 南京林业大学 Partitioned electroosmosis viscosity reduction test device and method for strain control between soil body and metal interface
US11123197B2 (en) * 2019-09-03 2021-09-21 Rainbow Medical Ltd. Hydropneumatic artificial intervertebral disc
CN110673662B (en) * 2019-09-04 2022-06-14 广东工业大学 Device and method for accurately controlling drug molecules
US10881858B1 (en) 2019-09-18 2021-01-05 Rainbow Medical Ltd. Electrical substance clearance from the brain
DE102019126883A1 (en) * 2019-10-07 2021-04-08 Endress+Hauser Flowtec Ag Method for monitoring a measuring device system
CA3109577A1 (en) * 2020-02-20 2021-08-20 Well-Focused Technologies, LLC Scalable treatment system for autonomous chemical treatment
US11298530B1 (en) 2021-05-03 2022-04-12 Discure Technologies Ltd. Synergistic therapies for intervertebral disc degeneration
US11344721B1 (en) 2021-08-16 2022-05-31 Rainbow Medical Ltd. Cartilage treatment
US11413455B1 (en) 2022-02-08 2022-08-16 Rainbow Medical Ltd. Electrical treatment of Alzheimer's disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6013164A (en) * 1997-06-25 2000-01-11 Sandia Corporation Electokinetic high pressure hydraulic system
US6019882A (en) * 1997-06-25 2000-02-01 Sandia Corporation Electrokinetic high pressure hydraulic system

Family Cites Families (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US35010A (en) * 1862-04-22 Improved lamp-burner
US2615940A (en) * 1949-10-25 1952-10-28 Williams Milton Electrokinetic transducing method and apparatus
US2644900A (en) * 1951-11-27 1953-07-07 Jr Edward V Hardway Electrokinetic device
US2644902A (en) * 1951-11-27 1953-07-07 Jr Edward V Hardway Electrokinetic device and electrode arrangement therefor
US2661430A (en) * 1951-11-27 1953-12-01 Jr Edward V Hardway Electrokinetic measuring instrument
US2995714A (en) * 1955-07-13 1961-08-08 Kenneth W Hannah Electrolytic oscillator
CA662714A (en) * 1958-11-28 1963-05-07 Union Carbide Corporation Electro-osmotic cell
CA692504A (en) * 1960-04-22 1964-08-11 N. Estes Nelson Electro-osmotic integrator
GB1122586A (en) * 1964-09-02 1968-08-07 Mack Gordon Electro-hydraulic transducer
US3544237A (en) * 1968-12-19 1970-12-01 Dornier System Gmbh Hydraulic regulating device
US3682239A (en) * 1971-02-25 1972-08-08 Momtaz M Abu Romia Electrokinetic heat pipe
US3917531A (en) * 1974-02-11 1975-11-04 Spectra Physics Flow rate feedback control chromatograph
JPS50116893A (en) 1974-02-28 1975-09-12
US3923426A (en) * 1974-08-15 1975-12-02 Alza Corp Electroosmotic pump and fluid dispenser including same
US3921041A (en) * 1975-02-24 1975-11-18 American Radionic Dual capacitor
US4347131A (en) * 1981-04-28 1982-08-31 Robert Brownlee Liquid chromatographic pump module
US5040126A (en) * 1981-09-09 1991-08-13 Isco, Inc. Method for predicting steady-state conditions
US4638444A (en) * 1983-02-17 1987-01-20 Chemical Data Systems, Inc. Microprocessor-controlled back-pressure system for small volume chemical analysis applications
GB8330107D0 (en) * 1983-11-11 1983-12-21 Cosworth Eng Ltd Transferring liquid
DE3577750D1 (en) 1984-10-18 1990-06-21 Hewlett Packard Gmbh METHOD FOR TREATING A LIQUID IN A TUBE.
JPS61237717A (en) * 1985-04-15 1986-10-23 Nippon Kokudo Kaihatsu Kk Natural permeation work of chemical grout and plant therefor
US4681678A (en) * 1986-10-10 1987-07-21 Combustion Engineering, Inc. Sample dilution system for supercritical fluid chromatography
US4684465A (en) * 1986-10-10 1987-08-04 Combustion Engineering, Inc. Supercritical fluid chromatograph with pneumatically controlled pump
US4922852A (en) * 1986-10-30 1990-05-08 Nordson Corporation Apparatus for dispensing fluid materials
US4810392A (en) * 1987-04-17 1989-03-07 W. R. Grace & Co. Sample dispensing system for liquid chromatography
US4767279A (en) * 1987-06-02 1988-08-30 Millipore Corporation Fluid composition and volumetric delivery control
JPH063354B2 (en) * 1987-06-23 1994-01-12 アクトロニクス株式会社 Loop type thin tube heat pipe
JPS6468503A (en) 1987-09-07 1989-03-14 Uni Charm Corp Disposable diaper
CA1303943C (en) * 1989-02-03 1992-06-23 Robert A. Geiger Catch flow restrictor
US5249929A (en) * 1989-08-11 1993-10-05 The Dow Chemical Company Liquid chromatographic pump
US5635070A (en) * 1990-07-13 1997-06-03 Isco, Inc. Apparatus and method for supercritical fluid extraction
US5131998A (en) * 1990-11-13 1992-07-21 The University Of North Carolina At Chapel Hill Two-dimensional high-performance liquid chromatography/capillary electrophoresis
US5219020A (en) * 1990-11-22 1993-06-15 Actronics Kabushiki Kaisha Structure of micro-heat pipe
JP3015521B2 (en) 1991-07-29 2000-03-06 アサヒビール株式会社 In-line mixing control device
US5312233A (en) * 1992-02-25 1994-05-17 Ivek Corporation Linear liquid dispensing pump for dispensing liquid in nanoliter volumes
US5630706A (en) * 1992-03-05 1997-05-20 Yang; Frank J. Multichannel pump apparatus with microflow rate capability
US5664938A (en) * 1992-03-05 1997-09-09 Yang; Frank Jiann-Fu Mixing apparatus for microflow gradient pumping
JPH0618964U (en) * 1992-06-11 1994-03-11 孝雄 津田 Liquid sample concentration and desalting method
JPH0618964A (en) 1992-06-30 1994-01-28 Canon Inc Photographing device, camera and fine adjustment mechanism
US5429728A (en) * 1992-08-31 1995-07-04 Hewlett-Packard Company Electroosmotic flow control using back pressure in capillary electrophoresis
US5302264A (en) * 1992-09-02 1994-04-12 Scientronix, Inc. Capillary eletrophoresis method and apparatus
US5482608A (en) * 1993-01-19 1996-01-09 Hewlett Packard Company Capillary electrophoresis flow control system
EP0635896B1 (en) * 1993-07-20 1997-09-24 Sulzer Hexis AG Centrally symmetric fuel cell battery
JP2824443B2 (en) * 1994-05-12 1998-11-11 ティ・エフ・シィ株式会社 Preparative liquid chromatography equipment
US5573651A (en) * 1995-04-17 1996-11-12 The Dow Chemical Company Apparatus and method for flow injection analysis
CA2223166A1 (en) * 1995-06-06 1996-12-12 Paul L. Braun Method of producing micro-electrical conduits
DE19625648A1 (en) 1995-07-28 1997-01-30 Hewlett Packard Co Pump system
FR2738613B1 (en) * 1995-09-08 1997-10-24 Thomson Csf METHOD FOR CONTROLLING A HYDRAULIC SERVOVALVE THAT CAN BE SERVED BY FLOW AND PRESSURE
US6045933A (en) * 1995-10-11 2000-04-04 Honda Giken Kogyo Kabushiki Kaisha Method of supplying fuel gas to a fuel cell
JPH09281077A (en) 1996-04-16 1997-10-31 Hitachi Ltd Capillary electrophoretic apparatus
US6280967B1 (en) * 1996-08-02 2001-08-28 Axiom Biotechnologies, Inc. Cell flow apparatus and method for real-time of cellular responses
US5814742A (en) * 1996-10-11 1998-09-29 L C Packings, Nederland B.V. Fully automated micro-autosampler for micro, capillary and nano high performance liquid chromatography
US5888050A (en) * 1996-10-30 1999-03-30 Supercritical Fluid Technologies, Inc. Precision high pressure control assembly
US5797719A (en) * 1996-10-30 1998-08-25 Supercritical Fluid Technologies, Inc. Precision high pressure control assembly
US5670707A (en) * 1996-11-01 1997-09-23 Varian Associates, Inc. Calibration method for a chromatography column
CN2286429Y (en) 1997-03-04 1998-07-22 中国科学技术大学 Porous core column electroosmosis pump
US5961800A (en) * 1997-05-08 1999-10-05 Sarnoff Corporation Indirect electrode-based pumps
US6106685A (en) * 1997-05-13 2000-08-22 Sarnoff Corporation Electrode combinations for pumping fluids
WO1998057873A1 (en) * 1997-06-18 1998-12-23 Sony Corporation Storage device for members
US5942093A (en) * 1997-06-18 1999-08-24 Sandia Corporation Electro-osmotically driven liquid delivery method and apparatus
US6277257B1 (en) 1997-06-25 2001-08-21 Sandia Corporation Electrokinetic high pressure hydraulic system
US6001231A (en) * 1997-07-15 1999-12-14 Caliper Technologies Corp. Methods and systems for monitoring and controlling fluid flow rates in microfluidic systems
CA2299284C (en) * 1997-08-05 2008-07-08 Mfic Corporation Multiple stream high pressure mixer/reactor
US6004443A (en) * 1997-08-13 1999-12-21 Rhodes; Percy H. Chromatography-format fluid electrophoresis
US6012902A (en) 1997-09-25 2000-01-11 Caliper Technologies Corp. Micropump
US6139734A (en) * 1997-10-20 2000-10-31 University Of Virginia Patent Foundation Apparatus for structural characterization of biological moieties through HPLC separation
US6068243A (en) * 1998-01-05 2000-05-30 A & B Plastics, Inc. Self-locking, adjustable-width slat for chain link fences
US6167910B1 (en) * 1998-01-20 2001-01-02 Caliper Technologies Corp. Multi-layer microfluidic devices
JP2000116027A (en) 1998-03-10 2000-04-21 Fiderikkusu:Kk Power supply device
US6224728B1 (en) * 1998-04-07 2001-05-01 Sandia Corporation Valve for fluid control
US5997746A (en) * 1998-05-29 1999-12-07 New Objective Inc. Evaporative packing of capillary columns
WO1999067639A1 (en) 1998-06-25 1999-12-29 Caliper Technologies Corporation High throughput methods, systems and apparatus for performing cell based screening assays
AU5004299A (en) 1998-07-21 2000-02-14 Altea Technologies, Inc. System and method for continuous analyte monitoring
JP2000160203A (en) 1998-09-24 2000-06-13 Sumitomo Electric Ind Ltd Alloy powder, alloy sintered body and production thereof
US6086243A (en) * 1998-10-01 2000-07-11 Sandia Corporation Electrokinetic micro-fluid mixer
US6149787A (en) * 1998-10-14 2000-11-21 Caliper Technologies Corp. External material accession systems and methods
US6068767A (en) * 1998-10-29 2000-05-30 Sandia Corporation Device to improve detection in electro-chromatography
US6416642B1 (en) 1999-01-21 2002-07-09 Caliper Technologies Corp. Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection
US6428666B1 (en) * 1999-02-22 2002-08-06 Sandia National Laboratories Electrokinetic concentration of charged molecules
US6477410B1 (en) * 2000-05-31 2002-11-05 Biophoretic Therapeutic Systems, Llc Electrokinetic delivery of medicaments
US6270641B1 (en) * 1999-04-26 2001-08-07 Sandia Corporation Method and apparatus for reducing sample dispersion in turns and junctions of microchannel systems
US6846399B2 (en) * 1999-05-12 2005-01-25 Sandia National Laboratories Castable three-dimensional stationary phase for electric field-driven applications
US6406605B1 (en) * 1999-06-01 2002-06-18 Ysi Incorporated Electroosmotic flow controlled microfluidic devices
US6255551B1 (en) * 1999-06-04 2001-07-03 General Electric Company Method and system for treating contaminated media
US6287440B1 (en) 1999-06-18 2001-09-11 Sandia Corporation Method for eliminating gas blocking in electrokinetic pumping systems
US6299767B1 (en) * 1999-10-29 2001-10-09 Waters Investments Limited High pressure capillary liquid chromatography solvent delivery system
US6447410B2 (en) * 1999-11-19 2002-09-10 Stx Llc Lacrosse stick pocket shooting strings and thong elements
US6386050B1 (en) * 1999-12-21 2002-05-14 Agilent Technologies, Inc. Non-invasive fluid flow sensing based on injected heat tracers and indirect temperature monitoring
US6824900B2 (en) * 2002-03-04 2004-11-30 Mti Microfuel Cells Inc. Method and apparatus for water management of a fuel cell system
US6460420B1 (en) * 2000-04-13 2002-10-08 Sandia National Laboratories Flowmeter for pressure-driven chromatography systems
US6290909B1 (en) * 2000-04-13 2001-09-18 Sandia Corporation Sample injector for high pressure liquid chromatography
EP1179369B1 (en) * 2000-06-13 2007-08-22 Frank. B. Simpson Wrap spring clutch syringe ram and frit mixer
US6289914B1 (en) * 2000-08-16 2001-09-18 Novartis Ag Microflow splitter
DE10040084A1 (en) * 2000-08-16 2002-03-07 Siemens Ag Process for mixing fuel in water, associated device and use of this device
AU2001294986A1 (en) * 2000-10-03 2002-04-15 Dionex Corporation Method and system for peak parking in liquid chromatography-mass spectrometer (lc-ms) analysis
US6402946B1 (en) * 2000-10-26 2002-06-11 Bruker Analytik Gmbh Device for feeding a chromatography flow
DE60103924T2 (en) * 2000-11-06 2005-07-14 Nanostream, Inc., Pasadena MICROFLUID FLOW RATE DEVICE
US6805783B2 (en) * 2000-12-13 2004-10-19 Toyo Technologies, Inc. Method for manipulating a solution using a ferroelectric electro-osmotic pump
US6497975B2 (en) * 2000-12-15 2002-12-24 Motorola, Inc. Direct methanol fuel cell including integrated flow field and method of fabrication
US7070681B2 (en) * 2001-01-24 2006-07-04 The Board Of Trustees Of The Leland Stanford Junior University Electrokinetic instability micromixer
US6949176B2 (en) 2001-02-28 2005-09-27 Lightwave Microsystems Corporation Microfluidic control using dielectric pumping
US6404193B1 (en) * 2001-04-09 2002-06-11 Waters Investments Limited Solvent susceptibility compensation for coupled LC-NMR
US7465382B2 (en) * 2001-06-13 2008-12-16 Eksigent Technologies Llc Precision flow control system
US20020189947A1 (en) * 2001-06-13 2002-12-19 Eksigent Technologies Llp Electroosmotic flow controller
US6766817B2 (en) * 2001-07-25 2004-07-27 Tubarc Technologies, Llc Fluid conduction utilizing a reversible unsaturated siphon with tubarc porosity action
US6719535B2 (en) * 2002-01-31 2004-04-13 Eksigent Technologies, Llc Variable potential electrokinetic device
JP3637392B2 (en) * 2002-04-08 2005-04-13 独立行政法人産業技術総合研究所 Fuel cell
US7364647B2 (en) * 2002-07-17 2008-04-29 Eksigent Technologies Llc Laminated flow device
US20040107996A1 (en) * 2002-12-09 2004-06-10 Crocker Robert W. Variable flow control apparatus

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6013164A (en) * 1997-06-25 2000-01-11 Sandia Corporation Electokinetic high pressure hydraulic system
US6019882A (en) * 1997-06-25 2000-02-01 Sandia Corporation Electrokinetic high pressure hydraulic system

Also Published As

Publication number Publication date
EP1407330A2 (en) 2004-04-14
US8795493B2 (en) 2014-08-05
US8685218B2 (en) 2014-04-01
EP1407330A4 (en) 2005-08-17
US20020189947A1 (en) 2002-12-19
JP2010094019A (en) 2010-04-22
CA2450119C (en) 2011-08-23
AU2002312530A1 (en) 2002-12-23
CA2450119A1 (en) 2002-12-19
JP2004530221A (en) 2004-09-30
US7597790B2 (en) 2009-10-06
US20070000784A1 (en) 2007-01-04
EP1407330B1 (en) 2012-05-30
US7695603B2 (en) 2010-04-13
US20020195344A1 (en) 2002-12-26
WO2002101474A2 (en) 2002-12-19
US20110186157A1 (en) 2011-08-04
US20090090174A1 (en) 2009-04-09
US7927477B2 (en) 2011-04-19
US20100012497A1 (en) 2010-01-21
US20040163957A1 (en) 2004-08-26

Similar Documents

Publication Publication Date Title
WO2002101474A3 (en) Flow control systems
IL166674A0 (en) Systems and methods for control of pumps employinggravimetric sensing
WO2003030717A3 (en) Non-linear flow restrictor for a medical aspiration system
WO2002010874A3 (en) Optical detection system for flow cytometry
WO2003068670A3 (en) Microfluidic valve and system therefor
WO2005120605A3 (en) Flow regulator
WO2005021970A3 (en) Regulated pressure supply for a variable-displacement reversible hydraulic motor
AU2003210387A1 (en) Microfluid system
WO2002090771A3 (en) A liquid pumping system
CA2361284A1 (en) Flow-operated valve
WO2003088733A3 (en) Microfluidic system including a bubble valve for regulating fluid through a microchannel
WO2006068959A3 (en) Electrokinetic device employing a non-newtonian liquid
GB2341406A (en) Downhole pressure activated device and a method
EP0752297A3 (en) Hydraulic percussion hammer
GB2323130A (en) Pressure control system for a variable displacement hydraulic pump
WO1994025770A3 (en) Power sensing regenerator
EP1076183A4 (en) Hydraulic circuit device
AU2002218783A1 (en) Valve
CA2168152A1 (en) Pilot control valve having means for recovering exhaust fluids
WO2003087521A3 (en) Gas operated automatic, liquid pumping system for wells
CA2374242A1 (en) Pilot valve
CA2388531A1 (en) Dual chamber liquid pump
WO2000058653A3 (en) Pressure reducing valve
WO1997049924A3 (en) Improvements in, or relating to, high speed actuators and vibrators based on electro-rheological fluids
EP1262393A3 (en) Low slip steering system and improved fluid controller therefor

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2450119

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 10480691

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2003504171

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 51/CHENP/2004

Country of ref document: IN

Ref document number: 2002739909

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2002739909

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642