WO2002101353A3 - Methods and products for analyzing nucleic acids based on methylation status - Google Patents
Methods and products for analyzing nucleic acids based on methylation status Download PDFInfo
- Publication number
- WO2002101353A3 WO2002101353A3 PCT/US2002/018178 US0218178W WO02101353A3 WO 2002101353 A3 WO2002101353 A3 WO 2002101353A3 US 0218178 W US0218178 W US 0218178W WO 02101353 A3 WO02101353 A3 WO 02101353A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- methylation status
- products
- nucleic acids
- analyzing nucleic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003504066A JP2004536596A (en) | 2001-06-08 | 2002-06-10 | Methods and products for analyzing nucleic acids based on methylation status |
AU2002318336A AU2002318336A1 (en) | 2001-06-08 | 2002-06-10 | Methods and products for analyzing nucleic acids based on methylation status |
EP02747887A EP1402071A4 (en) | 2001-06-08 | 2002-06-10 | Methods and products for analyzing nucleic acids based on methylation status |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29714701P | 2001-06-08 | 2001-06-08 | |
US60/297,147 | 2001-06-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002101353A2 WO2002101353A2 (en) | 2002-12-19 |
WO2002101353A3 true WO2002101353A3 (en) | 2003-10-09 |
Family
ID=23145051
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/018178 WO2002101353A2 (en) | 2001-06-08 | 2002-06-10 | Methods and products for analyzing nucleic acids based on methylation status |
Country Status (5)
Country | Link |
---|---|
US (1) | US20020197639A1 (en) |
EP (1) | EP1402071A4 (en) |
JP (1) | JP2004536596A (en) |
AU (1) | AU2002318336A1 (en) |
WO (1) | WO2002101353A2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9249456B2 (en) | 2004-03-26 | 2016-02-02 | Agena Bioscience, Inc. | Base specific cleavage of methylation-specific amplification products in combination with mass analysis |
US9394565B2 (en) | 2003-09-05 | 2016-07-19 | Agena Bioscience, Inc. | Allele-specific sequence variation analysis |
Families Citing this family (86)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998035012A2 (en) | 1997-02-12 | 1998-08-13 | Chan Eugene Y | Methods and products for analyzing polymers |
US6927065B2 (en) | 1999-08-13 | 2005-08-09 | U.S. Genomics, Inc. | Methods and apparatus for characterization of single polymers |
US6696022B1 (en) | 1999-08-13 | 2004-02-24 | U.S. Genomics, Inc. | Methods and apparatuses for stretching polymers |
US6929907B2 (en) * | 1999-12-31 | 2005-08-16 | North Carolina State University | Methods and compositions for determining the purity of chemically synthesized nucleic acids |
US7211414B2 (en) | 2000-12-01 | 2007-05-01 | Visigen Biotechnologies, Inc. | Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity |
JP2005517382A (en) * | 2001-06-08 | 2005-06-16 | ユー.エス. ジェノミクス, インコーポレイテッド | Methods and products for analyzing nucleic acids using nick translation |
DE10151069A1 (en) * | 2001-10-05 | 2003-04-30 | Epigenomics Ag | Method for the detection of DNA methylation using labeled S-adenosylmethionine analogues |
US20110151438A9 (en) | 2001-11-19 | 2011-06-23 | Affymetrix, Inc. | Methods of Analysis of Methylation |
AU2003302463A1 (en) * | 2002-05-09 | 2004-06-18 | U.S. Genomics, Inc. | Methods for analyzing a nucleic acid |
WO2003100101A1 (en) * | 2002-05-28 | 2003-12-04 | U.S. Genomics, Inc. | Methods and apparati using single polymer analysis |
US7282330B2 (en) | 2002-05-28 | 2007-10-16 | U.S. Genomics, Inc. | Methods and apparati using single polymer analysis |
DE602004015408D1 (en) * | 2003-01-23 | 2008-09-11 | Us Genomics Inc | METHOD FOR THE ANALYSIS OF POLYMER POPULATIONS |
US20050009059A1 (en) * | 2003-05-07 | 2005-01-13 | Affymetrix, Inc. | Analysis of methylation status using oligonucleotide arrays |
FR2854903A1 (en) * | 2003-05-13 | 2004-11-19 | Centre Nat Rech Scient | In vitro diagnosis of cancer, based on detecting hypomethylation of deoxycytidine in CpG doublets present in specific sequences from the B melanoma antigen locus |
WO2005017205A2 (en) * | 2003-08-04 | 2005-02-24 | U. S. Genomics, Inc. | Nucleic acid mapping using linear analysis |
US20050042665A1 (en) * | 2003-08-21 | 2005-02-24 | U.S. Genomics, Inc. | Quantum dots and methods of use thereof |
EP1689848A2 (en) * | 2003-10-31 | 2006-08-16 | University Of Maryland Biotechnology Institute | Kahalalide-producing bacteria |
WO2005047470A2 (en) * | 2003-11-07 | 2005-05-26 | U.S. Genomics, Inc. | Intercalator fret donors or acceptors |
EP1711591A4 (en) * | 2003-12-29 | 2010-04-28 | Nugen Technologies Inc | Methods for analysis of nucleic acid methylation status and methods for fragmentation, labeling and immobilization of nucleic acids |
US7977048B2 (en) | 2004-01-13 | 2011-07-12 | Pathogenetix, Inc. | Detection and quantification of analytes in solution using polymers |
US7595160B2 (en) | 2004-01-13 | 2009-09-29 | U.S. Genomics, Inc. | Analyte detection using barcoded polymers |
US20050196790A1 (en) * | 2004-02-05 | 2005-09-08 | U.S. Genomics, Inc. | Methods for detection and quantitation of minimum length polymers |
US20050221408A1 (en) * | 2004-03-19 | 2005-10-06 | U.S. Genomics, Inc. | Compositions and methods for detection of single molecules |
US20110008327A1 (en) | 2004-03-29 | 2011-01-13 | Cheng Jin Q | Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof |
US20100028339A1 (en) * | 2004-03-29 | 2010-02-04 | Cheng Jin Q | Compositions including triciribine and trastuzumab and methods of use thereof |
US20100173864A1 (en) | 2004-03-29 | 2010-07-08 | Cheng Jin Q | Compositions including triciribine and one or more platinum compounds and methods of use thereof |
CN1984663A (en) | 2004-03-29 | 2007-06-20 | 南佛罗里达大学 | Effective treatment of tumors and cancer with triciribine and related compounds |
US20100009929A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof |
US20100009928A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and taxanes and methods of use thereof |
GB0413688D0 (en) * | 2004-06-18 | 2004-07-21 | Novartis Forschungsstiftung | Analysis of methylated nucleic acid |
WO2006017274A2 (en) * | 2004-07-13 | 2006-02-16 | U.S. Genomics, Inc. | Systems and methods for sample modification using fluidic chambers |
WO2006036388A2 (en) * | 2004-08-23 | 2006-04-06 | U.S. Genomics, Inc. | Systems and methods for detecting and analyzing polymers |
WO2006098772A2 (en) * | 2004-10-13 | 2006-09-21 | U.S. Genomics, Inc. | Systems and methods for measurement optimization |
WO2006044728A2 (en) * | 2004-10-18 | 2006-04-27 | U.S.Genomics, Inc. | Methods for isolation of nucleic acids from prokaryotic spores |
CN102220412B (en) | 2004-11-29 | 2016-04-13 | 塞昆纳姆股份有限公司 | For detecting test kit and the method for methylate DNA |
US9074013B2 (en) * | 2004-11-29 | 2015-07-07 | Sequenom, Inc. | Means and methods for detecting methylated DNA |
US7250416B2 (en) | 2005-03-11 | 2007-07-31 | Supergen, Inc. | Azacytosine analogs and derivatives |
US20060275806A1 (en) * | 2005-05-11 | 2006-12-07 | Schwartz David C | Whole genome methylation profiles via single molecule analysis |
US20060292585A1 (en) * | 2005-06-24 | 2006-12-28 | Affymetrix, Inc. | Analysis of methylation using nucleic acid arrays |
US20070128083A1 (en) * | 2005-07-18 | 2007-06-07 | U.S. Genomics, Inc. | Microfluidic methods and apparatuses for sample preparation and analysis |
DE102005034628B4 (en) * | 2005-07-19 | 2007-08-23 | Epigenomics Ag | Method for the investigation of cytosine methylations in DNA |
US7700567B2 (en) | 2005-09-29 | 2010-04-20 | Supergen, Inc. | Oligonucleotide analogues incorporating 5-aza-cytosine therein |
CN1870631B (en) * | 2005-11-11 | 2010-04-14 | 华为技术有限公司 | Gate control method of media gateway |
US20070161029A1 (en) * | 2005-12-05 | 2007-07-12 | Panomics, Inc. | High throughput profiling of methylation status of promoter regions of genes |
US7901882B2 (en) * | 2006-03-31 | 2011-03-08 | Affymetrix, Inc. | Analysis of methylation using nucleic acid arrays |
EP1862555A1 (en) * | 2006-05-29 | 2007-12-05 | Klinikum der Universität Regensburg | Means and methods for diagnosing cancer or a corresponding predisposition |
EP2049262A2 (en) | 2006-07-19 | 2009-04-22 | Bionanomatrix, Inc. | Nanonozzle device arrays: their preparation and use for macromolecular analysis |
JP2009278867A (en) * | 2006-09-05 | 2009-12-03 | Olympus Corp | Method for determining dna methylation-inhibiting action |
US8999636B2 (en) | 2007-01-08 | 2015-04-07 | Toxic Report Llc | Reaction chamber |
US20080213870A1 (en) * | 2007-03-01 | 2008-09-04 | Sean Wuxiong Cao | Methods for obtaining modified DNA from a biological specimen |
JP5211790B2 (en) * | 2007-03-26 | 2013-06-12 | 住友化学株式会社 | DNA methylation measurement method |
US8722327B2 (en) | 2007-03-28 | 2014-05-13 | Bionano Genomics, Inc. | Methods of macromolecular analysis using nanochannel arrays |
WO2009006543A1 (en) | 2007-07-02 | 2009-01-08 | Euclid Diagnostics Llc | Methods for evaluating the methylation status of a polynucleotide |
US7608402B2 (en) * | 2008-01-10 | 2009-10-27 | Weiwei Li | DNA methylation specific signal amplification |
CA2712772A1 (en) * | 2008-01-22 | 2009-07-30 | Veridex, Llc | Detection of gstp1 hypermethylation in prostate cancer |
US8242243B2 (en) * | 2008-05-15 | 2012-08-14 | Ribomed Biotechnologies, Inc. | Methods and reagents for detecting CpG methylation with a methyl CpG binding protein (MBP) |
JP2010017179A (en) * | 2008-06-11 | 2010-01-28 | Sumitomo Chemical Co Ltd | Method for determining or detecting dna |
JP2010017178A (en) * | 2008-06-11 | 2010-01-28 | Sumitomo Chemical Co Ltd | Method for determining or detecting dna |
JP5151709B2 (en) * | 2008-06-11 | 2013-02-27 | 住友化学株式会社 | Method for quantifying or detecting DNA |
CN102292451A (en) | 2008-06-30 | 2011-12-21 | 生物纳米芯股份有限公司 | Methods and devices for single-molecule whole genome analysis |
US20100041057A1 (en) * | 2008-08-18 | 2010-02-18 | Life Technologies Corporation | Dna methylation detection methods |
US8361716B2 (en) | 2008-10-03 | 2013-01-29 | Pathogenetix, Inc. | Focusing chamber |
EP2370594B1 (en) | 2008-11-18 | 2014-01-08 | BioNano Genomics, Inc. | Polynucleotide mapping and sequencing |
US9624530B2 (en) * | 2009-08-03 | 2017-04-18 | Epigenomics Ag | Methods for preservation of genomic DNA sequence complexity |
GB201004147D0 (en) * | 2010-03-12 | 2010-04-28 | Dna Electronics Ltd | Method and apparatus for sensing methylation |
JP5492696B2 (en) * | 2010-07-26 | 2014-05-14 | 大屋敷 一馬 | Determination method of DNA methylation degree by single molecule fluorescence analysis |
EP2619325B1 (en) * | 2010-09-24 | 2016-06-01 | Genomic Vision | A method for detecting, quantifying and mapping damage and/or repair of dna strands |
US8927218B2 (en) | 2011-06-27 | 2015-01-06 | Flir Systems, Inc. | Methods and compositions for segregating target nucleic acid from mixed nucleic acid samples |
CN103958697B (en) | 2011-06-27 | 2016-10-12 | 红外检测公司 | From mixing nucleic acid samples separation target nucleic acid |
BR112014004779B1 (en) | 2011-08-30 | 2022-01-18 | Astex Pharmaceuticals, Inc | DECITABINE DERIVATIVES FORMULATIONS, KIT AND RELATED PROCESSES |
CA2852949A1 (en) | 2011-10-19 | 2013-04-25 | Nugen Technologies, Inc. | Compositions and methods for directional nucleic acid amplification and sequencing |
EP3578697B1 (en) | 2012-01-26 | 2024-03-06 | Tecan Genomics, Inc. | Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation |
US9028776B2 (en) | 2012-04-18 | 2015-05-12 | Toxic Report Llc | Device for stretching a polymer in a fluid sample |
US8956815B2 (en) | 2012-04-18 | 2015-02-17 | Toxic Report Llc | Intercalation methods and devices |
US8685708B2 (en) | 2012-04-18 | 2014-04-01 | Pathogenetix, Inc. | Device for preparing a sample |
US9957549B2 (en) | 2012-06-18 | 2018-05-01 | Nugen Technologies, Inc. | Compositions and methods for negative selection of non-desired nucleic acid sequences |
US20150011396A1 (en) | 2012-07-09 | 2015-01-08 | Benjamin G. Schroeder | Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing |
EP2971130A4 (en) | 2013-03-15 | 2016-10-05 | Nugen Technologies Inc | Sequential sequencing |
CN105849264B (en) | 2013-11-13 | 2019-09-27 | 纽亘技术公司 | For identifying the composition and method that repeat sequencing reading |
US9745614B2 (en) | 2014-02-28 | 2017-08-29 | Nugen Technologies, Inc. | Reduced representation bisulfite sequencing with diversity adaptors |
MX2018000016A (en) | 2015-07-02 | 2019-01-31 | Otsuka Pharma Co Ltd | Lyophilized pharmaceutical compositions. |
US11427858B2 (en) * | 2017-07-31 | 2022-08-30 | Technion Research & Development Foundation Limited | Methods of detecting modified and unmodified DNA |
KR20200035438A (en) | 2017-08-03 | 2020-04-03 | 오쓰까 세이야꾸 가부시키가이샤 | Drug compound and purification method thereof |
US11099202B2 (en) | 2017-10-20 | 2021-08-24 | Tecan Genomics, Inc. | Reagent delivery system |
US11932899B2 (en) * | 2018-06-07 | 2024-03-19 | 10X Genomics, Inc. | Methods and systems for characterizing nucleic acid molecules |
AU2022258155A1 (en) * | 2021-04-12 | 2023-11-30 | The Chinese University Of Hong Kong | Base modification analysis using electrical signals |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5296371A (en) * | 1989-08-07 | 1994-03-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, An Israeli Corp. | DNA encoding spiroplasma sp. dna methylase |
US6017704A (en) * | 1996-06-03 | 2000-01-25 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
WO2000006587A1 (en) * | 1998-07-29 | 2000-02-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | New cofactors for methyltransferases |
US6242188B1 (en) * | 1999-07-30 | 2001-06-05 | Applied Gene Technologies, Inc. | Sample processing to release nucleic acids for direct detection |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5004809A (en) * | 1986-02-04 | 1991-04-02 | University Of Cincinnati | Nitroxide labeled nucleotides and nitroxide labeled hybridization probes |
JPH09506253A (en) * | 1993-11-30 | 1997-06-24 | マクギル・ユニヴァーシティ | Inhibition of DNA methyltransferase |
US5856090A (en) * | 1994-09-09 | 1999-01-05 | The Scripps Research Institute | DNA-methylase linking reaction |
US5871917A (en) * | 1996-05-31 | 1999-02-16 | North Shore University Hospital Research Corp. | Identification of differentially methylated and mutated nucleic acids |
US5786146A (en) * | 1996-06-03 | 1998-07-28 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
US5972705A (en) * | 1996-06-28 | 1999-10-26 | University Of Massachusetts | Sequence-specific methylation of ribonucleic acid |
FR2755149B1 (en) * | 1996-10-30 | 1999-01-15 | Pasteur Institut | METHOD FOR DIAGNOSING GENETIC DISEASES BY MOLECULAR COMBING AND DIAGNOSTIC KIT |
WO1998035012A2 (en) * | 1997-02-12 | 1998-08-13 | Chan Eugene Y | Methods and products for analyzing polymers |
US6403311B1 (en) * | 1997-02-12 | 2002-06-11 | Us Genomics | Methods of analyzing polymers using ordered label strategies |
US5876996A (en) * | 1997-07-25 | 1999-03-02 | Incyte Pharmaceuticals, Inc. | Human S-adenosyl-L-methionine methyltransferase |
ATE244771T1 (en) * | 1998-07-29 | 2003-07-15 | Keygene Nv | METHOD FOR DETECTING NUCLEIC ACID METHYLATIONS BY AFLP |
US6263286B1 (en) * | 1998-08-13 | 2001-07-17 | U.S. Genomics, Inc. | Methods of analyzing polymers using a spatial network of fluorophores and fluorescence resonance energy transfer |
US6210896B1 (en) * | 1998-08-13 | 2001-04-03 | Us Genomics | Molecular motors |
JP4187323B2 (en) * | 1998-10-13 | 2008-11-26 | Tdk株式会社 | Vacuum film forming apparatus and method |
US6331393B1 (en) * | 1999-05-14 | 2001-12-18 | University Of Southern California | Process for high-throughput DNA methylation analysis |
-
2002
- 2002-06-10 US US10/165,914 patent/US20020197639A1/en not_active Abandoned
- 2002-06-10 WO PCT/US2002/018178 patent/WO2002101353A2/en active Application Filing
- 2002-06-10 JP JP2003504066A patent/JP2004536596A/en not_active Withdrawn
- 2002-06-10 EP EP02747887A patent/EP1402071A4/en not_active Withdrawn
- 2002-06-10 AU AU2002318336A patent/AU2002318336A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5296371A (en) * | 1989-08-07 | 1994-03-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, An Israeli Corp. | DNA encoding spiroplasma sp. dna methylase |
US6017704A (en) * | 1996-06-03 | 2000-01-25 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
WO2000006587A1 (en) * | 1998-07-29 | 2000-02-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | New cofactors for methyltransferases |
US6242188B1 (en) * | 1999-07-30 | 2001-06-05 | Applied Gene Technologies, Inc. | Sample processing to release nucleic acids for direct detection |
Non-Patent Citations (1)
Title |
---|
See also references of EP1402071A4 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9394565B2 (en) | 2003-09-05 | 2016-07-19 | Agena Bioscience, Inc. | Allele-specific sequence variation analysis |
US9249456B2 (en) | 2004-03-26 | 2016-02-02 | Agena Bioscience, Inc. | Base specific cleavage of methylation-specific amplification products in combination with mass analysis |
Also Published As
Publication number | Publication date |
---|---|
JP2004536596A (en) | 2004-12-09 |
AU2002318336A1 (en) | 2002-12-23 |
US20020197639A1 (en) | 2002-12-26 |
EP1402071A4 (en) | 2005-12-14 |
EP1402071A2 (en) | 2004-03-31 |
WO2002101353A2 (en) | 2002-12-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2002101353A3 (en) | Methods and products for analyzing nucleic acids based on methylation status | |
WO2003008622A3 (en) | Exponential nucleic acid amplification using nicking endonucleases | |
WO2005014849A3 (en) | Genes associated with responses to neuropathic pain | |
ATE536376T1 (en) | HUMAN BINDING MOLECULE AGAINST CD1A | |
WO2007117438A3 (en) | Methods for the production of functional protein from dna having a nonsense mutation and the treatment of disorders associated therewith | |
WO2004044168A3 (en) | Genetically encoded fluorescent reporters of kinase, methyltransferase, and acetyl-transferase activities | |
WO2005003316A3 (en) | Rna processing protein complexes and uses thereof | |
WO2003093469A3 (en) | Methods for delivering nucleic acid molecules into cells and assessment thereof | |
WO2006018632A3 (en) | Cell therapy with exo 1 | |
WO2004007743A3 (en) | Use of cpg nucleic acids in prion-disease | |
AU2003302134A1 (en) | Methods, nucleic acid constructs and cells for treating neurodegenerative disorders | |
WO2004053103A3 (en) | METHOD OF INTRODUCING siRNA INTO ADIPOCYTES | |
AU2003216184A1 (en) | Nucleic acid molecules encoding cd1-derived endosomal targeting proteins and uses thereof | |
WO2006122971A3 (en) | Treatment of disease using an improved regulated expression system | |
WO2005047462A3 (en) | Universal control for nucleic acid amplification | |
WO2003050265A3 (en) | Compositions and methods for normalizing assays | |
WO2000017346A3 (en) | Hairpin hybridizer molecules for modulation of gene expression | |
WO2001073602A3 (en) | Clustering and examining large data sets | |
WO2004067569A8 (en) | Internalising human binding molecules against cd72 | |
WO2008125222A3 (en) | New modulation molecules for an improved regulated expression system | |
EP1383871A4 (en) | Isolated human enzyme proteins, nucleic acid molecules encoding human enzyme proteins, and uses thereof | |
AU2003298570A1 (en) | Isolated human hepsin/46 proteins, nucleic acid molecules encoding human hepsin/46 proteins, and uses thereof | |
WO2001057186A3 (en) | Methods and compositions for diagnosis and treatment of cancer based on esf | |
EP1385991A4 (en) | Isolated human enzyme proteins, nucleic acid molecules encoding human enzyme proteins, and uses thereof | |
WO2002063013A3 (en) | Human acid phosphatase gene |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2003504066 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2002747887 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 2002747887 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |