WO2002100433A1 - Medicinal compositions - Google Patents

Medicinal compositions Download PDF

Info

Publication number: WO2002100433A1
Authority: WO; WIPO (PCT)
Prior art keywords: salt; compound; group; pyridyl group; inhibiotry
Prior art date: 2001-06-11

Application number

PCT/JP2002/005726

Other languages

English (en)

French (fr)

Inventor

Shigenori Ohkawa

Ken-Ichi Naruo

Shigeru Morimoto

Yoshinori Nagase

Seiji Miwatashi

Original Assignee

Takeda Chemical Industries, Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-11

Filing date

2002-06-10

Publication date

2002-12-19

2002-06-10 Application filed by Takeda Chemical Industries, Ltd. filed Critical Takeda Chemical Industries, Ltd.

2002-06-10 Priority to EP20020733431 priority Critical patent/EP1402900A1/en

2002-06-10 Priority to US10/480,551 priority patent/US20050080113A1/en

2002-06-10 Priority to CA002450400A priority patent/CA2450400A1/en

2002-12-19 Publication of WO2002100433A1 publication Critical patent/WO2002100433A1/ja

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

PCT/JP2002/005726 2001-06-11 2002-06-10 Medicinal compositions WO2002100433A1 (en)

Priority Applications (3)

Application Number	Priority Date	Filing Date	Title
EP20020733431 EP1402900A1 (en)	2001-06-11	2002-06-10	Medicinal compositions
US10/480,551 US20050080113A1 (en)	2001-06-11	2002-06-10	Medicinal compositions
CA002450400A CA2450400A1 (en)	2001-06-11	2002-06-10	Medicinal compositions

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP2001175273		2001-06-11
JP2001-175273		2001-06-11
JP2001-175224		2001-06-11
JP2001175224		2001-06-11

Publications (1)

Publication Number	Publication Date
WO2002100433A1 true WO2002100433A1 (en)	2002-12-19

Family

ID=26616680

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PCT/JP2002/005726 WO2002100433A1 (en)	2001-06-11	2002-06-10	Medicinal compositions

Country Status (4)

Country	Link
US (1)	US20050080113A1 (ja)
EP (1)	EP1402900A1 (ja)
CA (1)	CA2450400A1 (ja)
WO (1)	WO2002100433A1 (ja)

Cited By (12)

* Cited by examiner, † Cited by third party
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WO2004021988A2 (en) *	2002-09-05	2004-03-18	Scios Inc.	Treatment of pain by inhibition of p38 map kinase
WO2004026307A1 (en) *	2002-09-18	2004-04-01	Pfizer Products Inc.	Triazole derivatives as transforming growth factor (tgf) inhibitors
WO2006137658A1 (en) *	2005-06-20	2006-12-28	Dongbu Hitek Co., Ltd.	New substituted 1,3-thiazole derivatives or pharmaceutically acceptable salts thereof having immunosuppression and inflammation inhibitory acitivity, intermediate compounds or pharmaceutically acceptable salts thereof, a process for the preparation thereof, and pharmaceutical composition comprising the same
WO2006137527A1 (ja)	2005-06-23	2006-12-28	Kyowa Hakko Kogyo Co., Ltd.	チアゾール誘導体
US7273936B2 (en)	2002-09-18	2007-09-25	Pfizer Inc.	Oxazole and thiazole compounds as transforming growth factor (TGF) inhibitors
US7410988B2 (en)	2004-08-13	2008-08-12	Genentech, Inc.	2-Amido-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
US8049016B2 (en)	2008-02-20	2011-11-01	Novartis Ag	Thiazole derivatives which inhibit stearoyl-CoA desaturase enzymes
US8063084B2 (en)	2006-08-15	2011-11-22	Novartis Ag	Heterocyclic compounds suitable for the treatment of diseases related to elevated lipid levels
US20130267509A1 (en) *	2003-12-26	2013-10-10	Kyowa Hakko Kirin Co., Ltd.	Thiazole derivatives
US9663529B2 (en)	2013-07-02	2017-05-30	Bristol-Myers Squibb Company	Tricyclic pyrido-carboxamide derivatives as rock inhibitors
US9914740B2 (en)	2013-07-02	2018-03-13	Bristol-Myers Squibb Company	Tricyclic pyrido-carboxamide derivatives as rock inhibitors
CN111757881A (zh) *	2018-01-15	2020-10-09	澳升控股有限公司	作为治疗剂的5-(嘧啶-4-基)噻唑-2-基脲衍生物

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US7101899B1 (en) *	1999-04-23	2006-09-05	Takeda Pharmaceutical Company Limited	5-pyridyl-1,3-azole compounds, process for producing the same and use thereof
US8273347B2 (en) *	2003-05-13	2012-09-25	Depuy Spine, Inc.	Autologous treatment of degenerated disc with cells
US7344716B2 (en) *	2003-05-13	2008-03-18	Depuy Spine, Inc.	Transdiscal administration of specific inhibitors of pro-inflammatory cytokines
US7429378B2 (en) *	2003-05-13	2008-09-30	Depuy Spine, Inc.	Transdiscal administration of high affinity anti-MMP inhibitors
US8895540B2 (en)	2003-11-26	2014-11-25	DePuy Synthes Products, LLC	Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor
US7137864B2 (en) *	2004-07-12	2006-11-21	Swanson Melvin J	Methods and reagents for treating honeybees for parasitic mites
WO2006051826A1 (ja)	2004-11-10	2006-05-18	Ono Pharmaceutical Co., Ltd.	含窒素複素環化合物およびその医薬用途
AU2005314133B2 (en)	2004-12-06	2012-03-08	Medicinova, Inc.	Ibudilast for treating neuropathic pain and associated syndromes
CA2636077C (en) *	2006-01-18	2012-01-03	Amgen Inc.	Thiazole compounds as protein kinase b (pkb) inhibitors
CH698658B1 (de) *	2006-04-24	2009-09-30	Mepha Ag	Orale pharmazeutische Formulierung mit schneller Freisetzung für Pyridylmethylsulfinyl-Benzimidazole.
US20080181876A1 (en) *	2007-01-30	2008-07-31	Johnson Kirk W	Methods for treating acute and subchronic pain
US20080287402A1 (en) *	2007-05-03	2008-11-20	Johnson Kirk W	Use of a glial attenuator to prevent amplified pain responses caused by glial priming
CA2693473A1 (en) *	2007-07-17	2009-01-22	Amgen Inc.	Thiadiazole modulators of pkb
AU2008276521B2 (en)	2007-07-17	2011-11-03	Amgen Inc.	Heterocyclic modulators of PKB
US8986696B2 (en) *	2007-12-21	2015-03-24	Depuy Mitek, Inc.	Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints
US20090162351A1 (en) *	2007-12-21	2009-06-25	Depuy Spine, Inc.	Transdiscal administration of inhibitors of p38 MAP kinase
EP2268268A2 (en) *	2008-03-24	2011-01-05	Wockhardt Research Centre	Orally disintegrating compositions of rhein or diacerein
RU2011108420A (ru) *	2008-08-14	2012-09-20	Киорин Фармасьютикал Ко., Лтд. (Jp)	Стабилизированный фармацевтический состав
EP2198710A1 (de) *	2008-12-19	2010-06-23	Bayer CropScience AG	Verwendung von 5-Pyridin-4yl-(1,3)Thiazole zur Bekämpfung phytopathogener Pilze
US20130137728A1 (en) *	2010-03-24	2013-05-30	MUSC Foundation for Research and Development	Compositions and Methods for the Treatment of Degenerative Diseases
WO2012085650A1 (en) *	2010-12-22	2012-06-28	Purdue Pharma L.P.	Substituted pyridines as sodium channel blockers
JP6527305B2 (ja)	2011-01-10	2019-06-05	インヴィオン，インコーポレイテッド	禁煙のためのβ−アドレナリン作動性インバースアゴニストの使用
AU2012320578B2 (en)	2011-10-06	2017-03-02	Bayer Intellectual Property Gmbh	Heterocyclylpyri(mi)dinylpyrazole
EP2763987B1 (en)	2011-10-06	2018-07-18	Bayer CropScience AG	Heterocyclylpyri(mi)dinylpyrazole as fungicidals
KR101665231B1 (ko) *	2015-01-30	2016-10-13	순천향대학교 산학협력단	티오페닐 그룹을 갖는 티아졸계 화합물 및 이를 유효성분으로 포함하는 항진균제
EP3325473A4 (en) *	2015-07-22	2019-06-26	The Royal Institution for the Advancement of Learning / McGill University	Compounds and uses thereof in the treatment of cancer and other medical disorders
US20180296478A1 (en) *	2016-02-12	2018-10-18	Synergistic Therapeutics, Llc	Sublingual antidepressant and antianxiety tablet
CN107050021B (zh) *	2017-01-23	2019-11-26	广州中大南沙科技创新产业园有限公司	噻唑酰胺衍生物在制备抗骨质疏松药物中的应用
CN109293652B (zh) *	2017-07-24	2021-10-22	四川科伦博泰生物医药股份有限公司	一种取代的噻唑衍生物及其用途
CN109730999B (zh) *	2018-12-28	2021-12-24	中山大学	噻唑苯甲酰胺衍生在制备抗骨质疏松、抗骨关节炎药物中的应用
CN109939109B (zh) *	2018-12-28	2021-03-23	中山大学	N-噻唑-乙酰胺衍生物作为破骨细胞分化抑制剂在制备抗骨质疏松药物中的应用
GB202011996D0 (en) *	2020-07-31	2020-09-16	Adorx Therapeutics Ltd	Antagonist compounds

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2000063204A2 (en) *	1999-04-14	2000-10-26	Novartis Ag	Substituted azoles
WO2000064894A1 (fr) *	1999-04-23	2000-11-02	Takeda Chemical Industries, Ltd.	Composes 5-pyridyle-1,3-azole, leur procede de fabrication et leur utilisation
WO2000075131A1 (fr) *	1999-06-03	2000-12-14	Teikoku Hormone Mfg. Co., Ltd.	Composes a base de pyrazole substitue
WO2001001986A1 (en) *	1999-07-02	2001-01-11	Lipton Stuart A	Method of reducing neuronal injury or apoptosis
WO2001010865A1 (fr) *	1999-08-06	2001-02-15	Takeda Chemical Industries, Ltd.	INHIBITEURS DE p38MAP KINASE

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6046208A (en) *	1996-01-11	2000-04-04	Smithkline Beecham Corporation	Substituted imidazole compounds

2002
- 2002-06-10 CA CA002450400A patent/CA2450400A1/en not_active Abandoned
- 2002-06-10 US US10/480,551 patent/US20050080113A1/en not_active Abandoned
- 2002-06-10 WO PCT/JP2002/005726 patent/WO2002100433A1/ja not_active Application Discontinuation
- 2002-06-10 EP EP20020733431 patent/EP1402900A1/en not_active Withdrawn

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2000063204A2 (en) *	1999-04-14	2000-10-26	Novartis Ag	Substituted azoles
WO2000064894A1 (fr) *	1999-04-23	2000-11-02	Takeda Chemical Industries, Ltd.	Composes 5-pyridyle-1,3-azole, leur procede de fabrication et leur utilisation
WO2000075131A1 (fr) *	1999-06-03	2000-12-14	Teikoku Hormone Mfg. Co., Ltd.	Composes a base de pyrazole substitue
WO2001001986A1 (en) *	1999-07-02	2001-01-11	Lipton Stuart A	Method of reducing neuronal injury or apoptosis
WO2001010865A1 (fr) *	1999-08-06	2001-02-15	Takeda Chemical Industries, Ltd.	INHIBITEURS DE p38MAP KINASE

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHU I. ET AL.: "Validation of higher-throughput high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry assays to conduct cytochrome P450s CYP2D6 and CYP3A4 enzyme inhibition studies in human liver microsomes", RAPID COMMUN. MASS. SPECTROM., vol. 14, no. 4, 2000, pages 207 - 214, XP002955900 *
MATSUMOTO MASAHITO ET AL.: "Activation of p38 mitogen-activated protein kinase is crucial in osteoclastogenesis induced by tumor necrosis factor", FEBS LETTERS, vol. 486, no. 1, 2000, pages 23 - 28, XP002955899 *

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2004021988A3 (en) *	2002-09-05	2004-08-26	Scios Inc	Treatment of pain by inhibition of p38 map kinase
WO2004021988A2 (en) *	2002-09-05	2004-03-18	Scios Inc.	Treatment of pain by inhibition of p38 map kinase
WO2004026307A1 (en) *	2002-09-18	2004-04-01	Pfizer Products Inc.	Triazole derivatives as transforming growth factor (tgf) inhibitors
US7053095B2 (en)	2002-09-18	2006-05-30	Pfizer Inc.	Triazole compounds as transforming growth factor (TGF) inhibitors
US7273936B2 (en)	2002-09-18	2007-09-25	Pfizer Inc.	Oxazole and thiazole compounds as transforming growth factor (TGF) inhibitors
US20130267509A1 (en) *	2003-12-26	2013-10-10	Kyowa Hakko Kirin Co., Ltd.	Thiazole derivatives
US8889718B2 (en) *	2003-12-26	2014-11-18	Kyowa Hakko Kirin Co., Ltd.	Thiazole derivatives
US7410988B2 (en)	2004-08-13	2008-08-12	Genentech, Inc.	2-Amido-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
US7795290B2 (en)	2004-08-13	2010-09-14	Genentech, Inc.	2-amido-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
WO2006137658A1 (en) *	2005-06-20	2006-12-28	Dongbu Hitek Co., Ltd.	New substituted 1,3-thiazole derivatives or pharmaceutically acceptable salts thereof having immunosuppression and inflammation inhibitory acitivity, intermediate compounds or pharmaceutically acceptable salts thereof, a process for the preparation thereof, and pharmaceutical composition comprising the same
WO2006137527A1 (ja)	2005-06-23	2006-12-28	Kyowa Hakko Kogyo Co., Ltd.	チアゾール誘導体
US8063084B2 (en)	2006-08-15	2011-11-22	Novartis Ag	Heterocyclic compounds suitable for the treatment of diseases related to elevated lipid levels
US8293768B2 (en)	2006-08-15	2012-10-23	Novartis Ag	Organic compounds
US8318949B2 (en)	2008-02-20	2012-11-27	Novartis Ag	Organic compounds
US8049016B2 (en)	2008-02-20	2011-11-01	Novartis Ag	Thiazole derivatives which inhibit stearoyl-CoA desaturase enzymes
US9663529B2 (en)	2013-07-02	2017-05-30	Bristol-Myers Squibb Company	Tricyclic pyrido-carboxamide derivatives as rock inhibitors
US9914740B2 (en)	2013-07-02	2018-03-13	Bristol-Myers Squibb Company	Tricyclic pyrido-carboxamide derivatives as rock inhibitors
CN111757881A (zh) *	2018-01-15	2020-10-09	澳升控股有限公司	作为治疗剂的5-(嘧啶-4-基)噻唑-2-基脲衍生物
JP2021510704A (ja) *	2018-01-15	2021-04-30	オーセントラホールディングスピーティーワイエルティーディーＡｕｃｅｎｔｒａＨｏｌｄｉｎｇｓＰｔｙＬｔｄ	治療薬としての５−（ピリミジン−４−イル）チアゾール−２−イル尿素誘導体
JP7406808B2 (ja)	2018-01-15	2023-12-28	オーセントラセラピュティクスピーティーワイエルティーディー	治療薬としての５－（ピリミジン－４－イル）チアゾール－２－イル尿素誘導体

Also Published As

Publication number	Publication date
CA2450400A1 (en)	2002-12-19
US20050080113A1 (en)	2005-04-14
EP1402900A1 (en)	2004-03-31

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