WO2002099982A3 - Methods for improving signal detection from an array - Google Patents

Methods for improving signal detection from an array Download PDF

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Publication number
WO2002099982A3
WO2002099982A3 PCT/US2002/006327 US0206327W WO02099982A3 WO 2002099982 A3 WO2002099982 A3 WO 2002099982A3 US 0206327 W US0206327 W US 0206327W WO 02099982 A3 WO02099982 A3 WO 02099982A3
Authority
WO
WIPO (PCT)
Prior art keywords
array
methods
signal detection
improving signal
improving
Prior art date
Application number
PCT/US2002/006327
Other languages
French (fr)
Other versions
WO2002099982A2 (en
Inventor
Todd Dickinson
Arnold Oliphant
Original Assignee
Illumina Inc
Todd Dickinson
Arnold Oliphant
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illumina Inc, Todd Dickinson, Arnold Oliphant filed Critical Illumina Inc
Priority to AU2002326290A priority Critical patent/AU2002326290A1/en
Publication of WO2002099982A2 publication Critical patent/WO2002099982A2/en
Publication of WO2002099982A3 publication Critical patent/WO2002099982A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form

Abstract

The invention relates methods of improving signal detection from an array and methods for background subtraction in an array. The invention provides for novel array compositions including arrays with wells with different shapes, or surfaces coated with reflective or selectively absorptive coatings. In addition, the array include a signal transducer element.
PCT/US2002/006327 2001-03-01 2002-03-01 Methods for improving signal detection from an array WO2002099982A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002326290A AU2002326290A1 (en) 2001-03-01 2002-03-01 Methods for improving signal detection from an array

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27280301P 2001-03-01 2001-03-01
US60/272,803 2001-03-01

Publications (2)

Publication Number Publication Date
WO2002099982A2 WO2002099982A2 (en) 2002-12-12
WO2002099982A3 true WO2002099982A3 (en) 2003-11-20

Family

ID=23041359

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/006327 WO2002099982A2 (en) 2001-03-01 2002-03-01 Methods for improving signal detection from an array

Country Status (2)

Country Link
AU (1) AU2002326290A1 (en)
WO (1) WO2002099982A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9399795B2 (en) 1998-06-24 2016-07-26 Illumina, Inc. Multiplex decoding of array sensors with microspheres

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7019828B2 (en) 2003-03-12 2006-03-28 Intel Corporation Chemical enhancement in surface enhanced raman scattering using lithium salts
EP1606610A2 (en) * 2003-03-12 2005-12-21 Intel Corporation Chemical enhancement in surface enhanced raman scattering using lithium chloride
JP4685650B2 (en) * 2005-02-14 2011-05-18 富士フイルム株式会社 Raman spectroscopy device and Raman spectroscopy apparatus
CN110016499B (en) 2011-04-15 2023-11-14 约翰·霍普金斯大学 Safety sequencing system
CN109457030B (en) 2012-10-29 2022-02-18 约翰·霍普金斯大学 Papanicolaou test for ovarian and endometrial cancer
WO2017027653A1 (en) 2015-08-11 2017-02-16 The Johns Hopkins University Assaying ovarian cyst fluid
WO2017112025A2 (en) * 2015-10-05 2017-06-29 The University Of North Carolina At Chapel Hill Decoding methods for multiplexing assays and associated fluidic devices, kits, and solid supports
JP6808940B2 (en) * 2016-01-29 2021-01-06 凸版印刷株式会社 Array device, biomolecule analysis kit and solvent sealing method
US20200377956A1 (en) 2017-08-07 2020-12-03 The Johns Hopkins University Methods and materials for assessing and treating cancer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5412087A (en) * 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
US6023540A (en) * 1997-03-14 2000-02-08 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
US6045996A (en) * 1993-10-26 2000-04-04 Affymetrix, Inc. Hybridization assays on oligonucleotide arrays

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5412087A (en) * 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
US6045996A (en) * 1993-10-26 2000-04-04 Affymetrix, Inc. Hybridization assays on oligonucleotide arrays
US6023540A (en) * 1997-03-14 2000-02-08 Trustees Of Tufts College Fiber optic sensor with encoded microspheres

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9399795B2 (en) 1998-06-24 2016-07-26 Illumina, Inc. Multiplex decoding of array sensors with microspheres

Also Published As

Publication number Publication date
WO2002099982A2 (en) 2002-12-12
AU2002326290A1 (en) 2002-12-16

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