WO2002096366A3 - Metallotetrapyrrolic photosensitizing agents for use in photodynamic therapy - Google Patents

Metallotetrapyrrolic photosensitizing agents for use in photodynamic therapy Download PDF

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Publication number
WO2002096366A3
WO2002096366A3 PCT/US2002/017180 US0217180W WO02096366A3 WO 2002096366 A3 WO2002096366 A3 WO 2002096366A3 US 0217180 W US0217180 W US 0217180W WO 02096366 A3 WO02096366 A3 WO 02096366A3
Authority
WO
WIPO (PCT)
Prior art keywords
metallotetrapyrrolic
photodynamic therapy
photosensitizing agents
compounds
photosensitizing
Prior art date
Application number
PCT/US2002/017180
Other languages
French (fr)
Other versions
WO2002096366A2 (en
Inventor
Byron C Robinson
Ian M Leitch
Stephanie Greene
Stev Rychnovsky
Original Assignee
Miravant Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miravant Pharm Inc filed Critical Miravant Pharm Inc
Priority to AU2002344234A priority Critical patent/AU2002344234B2/en
Priority to JP2002592879A priority patent/JP2004532251A/en
Priority to CA002448562A priority patent/CA2448562A1/en
Priority to EP02744204A priority patent/EP1401506A4/en
Publication of WO2002096366A2 publication Critical patent/WO2002096366A2/en
Publication of WO2002096366A3 publication Critical patent/WO2002096366A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0036—Porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Metallotetrapyrrolic compounds having photherapeutics properties useful in photodetection and phototherapy of target issues, particularly porphyrins and azaporphyrins that including gallium in the central pyrrolic core. Also disclosed are methods of using metallotetrapyrrolic compounds for the treatment or detection of cardiovascular disease.
PCT/US2002/017180 2001-05-31 2002-05-31 Metallotetrapyrrolic photosensitizing agents for use in photodynamic therapy WO2002096366A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2002344234A AU2002344234B2 (en) 2001-05-31 2002-05-31 Metallotetrapyrrolic photosensitizing agents for use in photodynamic therapy
JP2002592879A JP2004532251A (en) 2001-05-31 2002-05-31 Metallotetrapyrrole photosensitizers used in photodynamic therapy
CA002448562A CA2448562A1 (en) 2001-05-31 2002-05-31 Metallotetrapyrrolic photosensitizing agents for use in photodynamic therapy
EP02744204A EP1401506A4 (en) 2001-05-31 2002-05-31 Metallotetrapyrrolic photosensitizing agents for use in photodynamic therapy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29534501P 2001-05-31 2001-05-31
US60/295,345 2001-05-31

Publications (2)

Publication Number Publication Date
WO2002096366A2 WO2002096366A2 (en) 2002-12-05
WO2002096366A3 true WO2002096366A3 (en) 2003-03-20

Family

ID=23137301

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/017180 WO2002096366A2 (en) 2001-05-31 2002-05-31 Metallotetrapyrrolic photosensitizing agents for use in photodynamic therapy

Country Status (6)

Country Link
US (2) US6827926B2 (en)
EP (1) EP1401506A4 (en)
JP (1) JP2004532251A (en)
AU (1) AU2002344234B2 (en)
CA (1) CA2448562A1 (en)
WO (1) WO2002096366A2 (en)

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