WO2002096262A3 - Non-alloying core shell nanoparticles - Google Patents

Non-alloying core shell nanoparticles Download PDF

Info

Publication number
WO2002096262A3
WO2002096262A3 PCT/US2001/050825 US0150825W WO02096262A3 WO 2002096262 A3 WO2002096262 A3 WO 2002096262A3 US 0150825 W US0150825 W US 0150825W WO 02096262 A3 WO02096262 A3 WO 02096262A3
Authority
WO
WIPO (PCT)
Prior art keywords
shell nanoparticles
core shell
core
relates
alloying
Prior art date
Application number
PCT/US2001/050825
Other languages
French (fr)
Other versions
WO2002096262A2 (en
Inventor
Chad A Mirkin
Yunwei Cao
Rongchao Jin
Original Assignee
Univ Northwestern
Chad A Mirkin
Yunwei Cao
Rongchao Jin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Northwestern, Chad A Mirkin, Yunwei Cao, Rongchao Jin filed Critical Univ Northwestern
Priority to AU2002239726A priority Critical patent/AU2002239726A1/en
Priority to AT02775688T priority patent/ATE356826T1/en
Priority to PCT/US2002/016382 priority patent/WO2003008539A2/en
Priority to AU2002341539A priority patent/AU2002341539B2/en
Priority to EP02775688A priority patent/EP1392872B1/en
Priority to DE60218840T priority patent/DE60218840T2/en
Priority to JP2003514082A priority patent/JP3885054B2/en
Priority to US10/153,483 priority patent/US7147687B2/en
Publication of WO2002096262A2 publication Critical patent/WO2002096262A2/en
Publication of WO2002096262A3 publication Critical patent/WO2002096262A3/en
Priority to US11/636,392 priority patent/US20070190551A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
    • B22F1/10—Metallic powder containing lubricating or binding agents; Metallic powder containing organic material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
    • B22F1/10—Metallic powder containing lubricating or binding agents; Metallic powder containing organic material
    • B22F1/102—Metallic powder coated with organic material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
    • B22F1/17—Metallic particles coated with metal
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
    • B22F1/18—Non-metallic particles coated with metal
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F9/00—Making metallic powder or suspensions thereof
    • B22F9/16—Making metallic powder or suspensions thereof using chemical processes
    • B22F9/18—Making metallic powder or suspensions thereof using chemical processes with reduction of metal compounds
    • B22F9/24—Making metallic powder or suspensions thereof using chemical processes with reduction of metal compounds starting from liquid metal compounds, e.g. solutions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y25/00—Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B19/00—Selenium; Tellurium; Compounds thereof
    • C01B19/007—Tellurides or selenides of metals
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G11/00—Compounds of cadmium
    • C01G11/02—Sulfides
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G49/00—Compounds of iron
    • C01G49/02—Oxides; Hydroxides
    • C01G49/08—Ferroso-ferric oxide (Fe3O4)
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G7/00—Compounds of gold
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/5434—Magnetic particles using magnetic particle immunoreagent carriers which constitute new materials per se
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553—Metal or metal coated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/0036—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties showing low dimensional magnetism, i.e. spin rearrangements due to a restriction of dimensions, e.g. showing giant magnetoresistivity
    • H01F1/0045—Zero dimensional, e.g. nanoparticles, soft nanoparticles for medical/biological use
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/0036—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties showing low dimensional magnetism, i.e. spin rearrangements due to a restriction of dimensions, e.g. showing giant magnetoresistivity
    • H01F1/0045—Zero dimensional, e.g. nanoparticles, soft nanoparticles for medical/biological use
    • H01F1/0054—Coated nanoparticles, e.g. nanoparticles coated with organic surfactant
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L29/00—Semiconductor devices adapted for rectifying, amplifying, oscillating or switching, or capacitors or resistors with at least one potential-jump barrier or surface barrier, e.g. PN junction depletion layer or carrier concentration layer; Details of semiconductor bodies or of electrodes thereof  ; Multistep manufacturing processes therefor
    • H01L29/02—Semiconductor bodies ; Multistep manufacturing processes therefor
    • H01L29/12—Semiconductor bodies ; Multistep manufacturing processes therefor characterised by the materials of which they are formed
    • H01L29/122—Single quantum well structures
    • H01L29/127—Quantum box structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F2998/00—Supplementary information concerning processes or compositions relating to powder metallurgy
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2002/00—Crystal-structural characteristics
    • C01P2002/80—Crystal-structural characteristics defined by measured data other than those specified in group C01P2002/70
    • C01P2002/82—Crystal-structural characteristics defined by measured data other than those specified in group C01P2002/70 by IR- or Raman-data
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/01—Particle morphology depicted by an image
    • C01P2004/04—Particle morphology depicted by an image obtained by TEM, STEM, STM or AFM
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/60—Particles characterised by their size
    • C01P2004/64—Nanometer sized, i.e. from 1-100 nanometer
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/80—Particles consisting of a mixture of two or more inorganic phases
    • C01P2004/82—Particles consisting of a mixture of two or more inorganic phases two phases having the same anion, e.g. both oxidic phases
    • C01P2004/84—Particles consisting of a mixture of two or more inorganic phases two phases having the same anion, e.g. both oxidic phases one phase coated with the other
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00—Physical properties of inorganic compounds
    • C01P2006/42—Magnetic properties
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/701—Integrated with dissimilar structures on a common substrate
    • Y10S977/702—Integrated with dissimilar structures on a common substrate having biological material component
    • Y10S977/704—Nucleic acids, e.g. DNA or RNA
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/701—Integrated with dissimilar structures on a common substrate
    • Y10S977/72—On an electrically conducting, semi-conducting, or semi-insulating substrate
    • Y10S977/722—On a metal substrate
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/81—Of specified metal or metal alloy composition
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/12—All metal or with adjacent metals
    • Y10T428/12014—All metal or with adjacent metals having metal particles

Abstract

The present invention relates composite core/shell nanoparticles and a two-step method for their preparation. The present invention further relates to biomolecule-core/shell nanoparticle conjugates and methods for their preparation. The invention also relates to methods of detection of biomolecules comprising the biomolecule or specific binding substance-core/shell nanoparticle conjugates.
PCT/US2001/050825 2001-05-25 2001-12-28 Non-alloying core shell nanoparticles WO2002096262A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AU2002239726A AU2002239726A1 (en) 2001-05-25 2001-12-28 Non-alloying core shell nanoparticles
AT02775688T ATE356826T1 (en) 2001-05-25 2002-05-22 NON-ALLOYING CORE-SHELL NANOPARTICLES
PCT/US2002/016382 WO2003008539A2 (en) 2001-05-25 2002-05-22 Non-alloying core shell nanoparticles
AU2002341539A AU2002341539B2 (en) 2001-05-25 2002-05-22 Non-alloying core shell nanoparticles
EP02775688A EP1392872B1 (en) 2001-05-25 2002-05-22 Non-alloying core shell nanoparticles
DE60218840T DE60218840T2 (en) 2001-05-25 2002-05-22 Non-alloyed core-shell nanoparticles
JP2003514082A JP3885054B2 (en) 2001-05-25 2002-05-22 Non-alloy core-shell nanoparticles
US10/153,483 US7147687B2 (en) 2001-05-25 2002-05-22 Non-alloying core shell nanoparticles
US11/636,392 US20070190551A1 (en) 2001-05-25 2006-12-08 Non-alloying core shell nanoparticles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29386101P 2001-05-25 2001-05-25
US60/293,861 2001-05-25

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10/034,451 Continuation-In-Part US7238472B2 (en) 2001-05-25 2001-12-28 Non-alloying core shell nanoparticles
US10/153,483 Continuation-In-Part US7147687B2 (en) 2001-05-25 2002-05-22 Non-alloying core shell nanoparticles

Publications (2)

Publication Number Publication Date
WO2002096262A2 WO2002096262A2 (en) 2002-12-05
WO2002096262A3 true WO2002096262A3 (en) 2003-02-20

Family

ID=23130903

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2001/050825 WO2002096262A2 (en) 2001-05-25 2001-12-28 Non-alloying core shell nanoparticles
PCT/US2002/016382 WO2003008539A2 (en) 2001-05-25 2002-05-22 Non-alloying core shell nanoparticles

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2002/016382 WO2003008539A2 (en) 2001-05-25 2002-05-22 Non-alloying core shell nanoparticles

Country Status (7)

Country Link
US (2) US7238472B2 (en)
EP (1) EP1392872B1 (en)
JP (1) JP3885054B2 (en)
AT (1) ATE356826T1 (en)
AU (2) AU2002239726A1 (en)
DE (1) DE60218840T2 (en)
WO (2) WO2002096262A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8999947B2 (en) 2005-06-14 2015-04-07 Northwestern University Nucleic acid functionalized nanoparticles for therapeutic applications
US9376690B2 (en) 2009-10-30 2016-06-28 Northwestern University Templated nanoconjugates
US9506056B2 (en) 2006-06-08 2016-11-29 Northwestern University Nucleic acid functionalized nanoparticles for therapeutic applications

Families Citing this family (171)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7098320B1 (en) 1996-07-29 2006-08-29 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6984491B2 (en) * 1996-07-29 2006-01-10 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7169556B2 (en) * 1996-07-29 2007-01-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en) * 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US6750016B2 (en) * 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6506564B1 (en) * 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6974669B2 (en) * 2000-03-28 2005-12-13 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified nanoparticles
US20050037397A1 (en) * 2001-03-28 2005-02-17 Nanosphere, Inc. Bio-barcode based detection of target analytes
US20030096321A1 (en) * 1999-05-19 2003-05-22 Jose Remacle Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips
JP2004501340A (en) * 2000-01-13 2004-01-15 ナノスフェアー　インコーポレイテッド Oligonucleotide-attached nanoparticles and methods of use
US6743395B2 (en) * 2000-03-22 2004-06-01 Ebara Corporation Composite metallic ultrafine particles and process for producing the same
WO2002004681A2 (en) * 2000-07-11 2002-01-17 Northwestern University Method of detection by enhancement of silver staining
US20060040286A1 (en) * 2001-03-28 2006-02-23 Nanosphere, Inc. Bio-barcode based detection of target analytes
US20030113740A1 (en) * 2001-04-26 2003-06-19 Mirkin Chad A. Oligonucleotide-modified ROMP polymers and co-polymers
US7238472B2 (en) * 2001-05-25 2007-07-03 Nanosphere, Inc. Non-alloying core shell nanoparticles
US7147687B2 (en) * 2001-05-25 2006-12-12 Nanosphere, Inc. Non-alloying core shell nanoparticles
JP4220397B2 (en) 2001-11-09 2009-02-04 ナノスフェアー インコーポレイテッド Bioconjugate-nanoparticle probe
GR1004178B (en) * 2001-11-29 2003-03-05 "����������" Integrated optoelectronic silicon biosensor for the detection of biomolecules labeled with chromophore groups or nanoparticles
US7282710B1 (en) * 2002-01-02 2007-10-16 International Business Machines Corporation Scanning probe microscopy tips composed of nanoparticles and methods to form same
WO2003072830A1 (en) * 2002-02-22 2003-09-04 Purdue Research Foundation Magnetic nanomaterials and methods for detection of biological materials
US20030190475A1 (en) * 2002-04-09 2003-10-09 Everett Carpenter Magnetic nanoparticles having passivated metallic cores
US20030211488A1 (en) 2002-05-07 2003-11-13 Northwestern University Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
CA2491093A1 (en) * 2002-06-28 2004-01-08 Purdue Research Foundation Magnetic nanomaterials and methods for detection of biological materials
EP1540006B1 (en) * 2002-07-02 2009-01-07 Nanosphere, Inc. Nanoparticle polyanion conjugates and methods of use thereof in detecting analytes
TWI242478B (en) * 2002-08-01 2005-11-01 Masami Nakamoto Metal nanoparticle and process for producing the same
US20040156846A1 (en) * 2003-02-06 2004-08-12 Triton Biosystems, Inc. Therapy via targeted delivery of nanoscale particles using L6 antibodies
WO2005001143A2 (en) * 2003-02-27 2005-01-06 Nanosphere, Inc. Label-free gene expression profiling with universal nanoparticle probes in microarray assay format
WO2004085988A2 (en) * 2003-03-12 2004-10-07 Intel Corporation Chemical enhancement in surface enhanced raman scattering using lithium chloride
WO2004083290A2 (en) * 2003-03-17 2004-09-30 University Of Rochester Core-shell magnetic nanoparticles and nanocomposite materials formed therefrom
US20050250094A1 (en) * 2003-05-30 2005-11-10 Nanosphere, Inc. Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes
US7232474B2 (en) * 2003-07-09 2007-06-19 National Research Council Of Canada Process for producing gold nanoparticles
JP5082187B2 (en) * 2003-10-06 2012-11-28 日産自動車株式会社 Method for producing electrode catalyst particles for polymer electrolyte fuel cell
JP4207754B2 (en) * 2003-10-31 2009-01-14 和光純薬工業株式会社 Immunological measurement method using magnetic substance
US20050191665A1 (en) * 2003-12-29 2005-09-01 Xing Su Composite organic-inorganic nanoclusters
JP3912391B2 (en) * 2004-05-26 2007-05-09 ソニー株式会社 Metallic magnetic nanoparticles and production method thereof
US7718094B2 (en) * 2004-06-18 2010-05-18 The Research Foundation Of State University Of New York Preparation of metallic nanoparticles
EP1771583A2 (en) * 2004-07-26 2007-04-11 Nanosphere, Inc. Method for distinguishing methicillin resistant s. aureus from methicillin sensitive s. aureus in a mixed culture
US9494581B2 (en) 2004-08-24 2016-11-15 University Of Wyoming System and method for Raman spectroscopy assay using paramagnetic particles
US7776547B2 (en) * 2004-08-26 2010-08-17 Intel Corporation Cellular analysis using Raman surface scanning
WO2007018562A2 (en) * 2004-09-22 2007-02-15 Nanolab, Inc. Nanospearing for molecular transportation into cells
ZA200703604B (en) * 2004-10-21 2009-10-28 Pharma Diagnostics M V Stable metal/conductive polymer composite colloids and methods for making and using the same
US7485471B1 (en) 2004-12-17 2009-02-03 Intel Corporation Detection of enhanced multiplex signals by surface enhanced Raman spectroscopy
US7855021B2 (en) * 2004-12-22 2010-12-21 Brookhaven Science Associates, Llc Electrocatalysts having platium monolayers on palladium, palladium alloy, and gold alloy core-shell nanoparticles, and uses thereof
US8084275B2 (en) * 2005-02-08 2011-12-27 Fujifilm Corporation Magnetic composite body, production method thereof, method for removing substance with mannose on its surface, and method for concentrating substance with mannose on its surface
JP4791867B2 (en) * 2005-03-31 2011-10-12 日立マクセル株式会社 Detection method of test substance using precious metal coated magnetic particles
JP4665144B2 (en) * 2005-03-31 2011-04-06 独立行政法人物質・材料研究機構 Humidity sensor using stress change with volume expansion of polymer film
US7700193B2 (en) * 2005-04-08 2010-04-20 Industrial Technology Research Institute Core-shell structure with magnetic, thermal, and optical characteristics and manufacturing method thereof
US20060281076A1 (en) * 2005-05-18 2006-12-14 Nanosphere, Inc. Substrate functionalization method for high sensitivity applications
US8062552B2 (en) * 2005-05-19 2011-11-22 Brookhaven Science Associates, Llc Electrocatalyst for oxygen reduction with reduced platinum oxidation and dissolution rates
US20070154903A1 (en) * 2005-06-23 2007-07-05 Nanosphere, Inc. Selective isolation and concentration of nucleic acids from complex samples
JP2007040978A (en) * 2005-06-30 2007-02-15 Fujifilm Corp Method for separating objective element using magnetic nanoparticles
US7704919B2 (en) * 2005-08-01 2010-04-27 Brookhaven Science Associates, Llc Electrocatalysts having gold monolayers on platinum nanoparticle cores, and uses thereof
KR102103541B1 (en) 2005-08-12 2020-04-23 캄브리오스 필름 솔루션스 코포레이션 Nanowires-based transparent conductors
EP1915466B1 (en) * 2005-08-19 2010-11-24 Nanosphere, Inc. Methods for preparing hybrid substrates comprising dna and antibodies and uses thereof
US7736910B2 (en) * 2005-10-04 2010-06-15 Calypte Biomedical Corporation One-step production of gold sols
US20070098640A1 (en) * 2005-11-02 2007-05-03 General Electric Company Nanoparticle-based imaging agents for X-ray/computed tomography
WO2007059630A1 (en) * 2005-11-28 2007-05-31 National Research Council Of Canada Multifunctional nanostructure and method
US20070166730A1 (en) 2006-01-19 2007-07-19 Menon & Associates, Inc. Magnetic resonance system and method to detect and confirm analytes
JP2007205911A (en) * 2006-02-02 2007-08-16 Sekisui Chem Co Ltd Gold/iron oxide composite magnetic particle, magnetic particle for measuring immunity, and immunoassay
US7790066B2 (en) * 2006-03-03 2010-09-07 William Marsh Rice University Nanorice particles: hybrid plasmonic nanostructures
EP1993758A2 (en) * 2006-03-08 2008-11-26 Northwestern University Photoinduced phase separation of gold in two-component nanoparticles to form nanoprisms
WO2007121032A2 (en) 2006-03-23 2007-10-25 The Research Foundation Of State University Of New York Optical methods and systems for detecting a constituent in a gas containing oxygen in harsh environments
GB0605965D0 (en) * 2006-03-24 2006-05-03 Univ East Anglia Fluorescence based detection of substances
US20080085508A1 (en) * 2006-05-11 2008-04-10 Nanosphere, Inc. Non-nucleic acid based biobarcode assay for detection of biological materials
US7625637B2 (en) * 2006-05-31 2009-12-01 Cabot Corporation Production of metal nanoparticles from precursors having low reduction potentials
US20100035243A1 (en) * 2006-07-10 2010-02-11 Nanosphere, Inc. Ultra-sensitive detection of analytes
ITFI20060180A1 (en) * 2006-07-20 2008-01-21 Acta Spa ANODIC CATALYSTS CONSISTING OF NOBLE METALS SPONTANEOUSLY DEPOSITED ON NANOSTRUCTURED CATALYSTS BASED ON TRANSITIONAL METALS, THEIR PREPARATION AND USE AND FUEL CELLS THAT CONTAIN THEM.
US7502106B2 (en) * 2006-09-21 2009-03-10 Honeywell International Inc. SERS analyzer
US8018568B2 (en) 2006-10-12 2011-09-13 Cambrios Technologies Corporation Nanowire-based transparent conductors and applications thereof
KR101545219B1 (en) 2006-10-12 2015-08-18 캄브리오스 테크놀로지즈 코포레이션 Nanowire-based transparent conductors and applications thereof
US7727776B2 (en) * 2006-10-24 2010-06-01 Honeywell International Inc. Core-shell nanoparticles for detection based on SERS
EP2092077A2 (en) * 2006-11-08 2009-08-26 Northwestern University Colorimetric detection of metallic ions in aqueous media using functionlized nanoparticles
EP2121987B1 (en) 2007-02-09 2012-06-13 Northwestern University Particles for detecting intracellular targets
JP2008196927A (en) * 2007-02-13 2008-08-28 Fujifilm Corp Detection method of object material accompanied by removal of probe
CA2679586A1 (en) * 2007-02-27 2008-10-23 Northwestern University Molecule attachment to nanoparticles
JP4854547B2 (en) * 2007-03-09 2012-01-18 独立行政法人科学技術振興機構 Silver fine particle and nucleic acid complex and method for producing the same
EP2147466B9 (en) 2007-04-20 2014-07-16 Cambrios Technologies Corporation Composite transparent conductors
EP2140957A4 (en) * 2007-04-25 2012-09-19 Toyota Motor Co Ltd Process for producing core/shell composite nanoparticle
US20080293588A1 (en) * 2007-05-11 2008-11-27 Northwestern University Nanodisk codes
US7807372B2 (en) 2007-06-04 2010-10-05 Northwestern University Screening sequence selectivity of oligonucleotide-binding molecules using nanoparticle based colorimetric assay
CN103757663A (en) 2007-07-11 2014-04-30 Gr智力储备股份有限公司 Continuous methods for treating liquids and manufacturing certain constituents (e.g., nanoparticles) in liquids, apparatuses and nanoparticles and nanoparticle/liquid solution(s) resulting therefrom
AU2008317794B2 (en) * 2007-09-27 2012-06-14 Basf Se Isolable and redispersable transition metal nanoparticles their preparation and use as IR absorbers
US7829735B2 (en) * 2007-10-26 2010-11-09 Northwestern University Universal phosphoramidite for preparation of modified biomolecules and surfaces
US8679458B2 (en) 2007-11-07 2014-03-25 Battelle Memorial Institute Functionalized magnetic nanoparticle analyte sensor
US20100105024A1 (en) * 2008-01-14 2010-04-29 Transgenex Nanobiotech, Inc. Rapid test including genetic sequence probe
US20090181361A1 (en) * 2008-01-14 2009-07-16 Weidong Xu Rapid test for detecting infection
WO2009090748A1 (en) 2008-01-17 2009-07-23 Applied Nanoparticle Laboratory Corporation Silver composite nanoparticle and process and apparatus for producing the same
DK2288336T3 (en) 2008-04-25 2017-03-13 Univ Northwestern NANOSTRUCTURES SUITABLE FOR COMPLEXATION OF CHOLESTEROL
KR101153748B1 (en) * 2008-05-07 2012-06-14 재단법인서울대학교산학협력재단 NOVEL Au/Ag CORE SHELL COMPOSITE USEFUL FOR BIOSENNOVEL Au/Ag CORE SHELL COMPOSITE USEFUL FOR BIOSENSOR SOR
US8389175B2 (en) * 2008-05-16 2013-03-05 Utc Power Corporation Fuel cell having a stabilized cathode catalyst
US8304365B2 (en) * 2008-05-16 2012-11-06 Utc Power Corporation Stabilized platinum catalyst
KR20110028632A (en) 2008-06-23 2011-03-21 이섬 리서치 디벨러프먼트 컴파니 오브 더 히브루 유니버시티 오브 예루살렘 엘티디. Core-shell metallic nanoparticles, methods of production thereof, and ink compositions containing the same
WO2010016798A1 (en) * 2008-08-06 2010-02-11 Agency For Science, Technology And Research Nanocomposites
DK2365803T3 (en) 2008-11-24 2018-01-22 Univ Northwestern POLYVALENT RNA NANOPARTICLE COMPOSITIONS
US7879625B1 (en) 2008-12-03 2011-02-01 The United States Of America As Represented By The Secretary Of The Navy Preparation of SERS substrates on silica-coated magnetic microspheres
US20100233270A1 (en) 2009-01-08 2010-09-16 Northwestern University Delivery of Oligonucleotide-Functionalized Nanoparticles
US9387452B2 (en) 2009-01-14 2016-07-12 Gr Intellectual Reserve, Llc. Continuous methods for treating liquids and manufacturing certain constituents (e.g., nanoparticles) in liquids, apparatuses and nanoparticles and nanoparticle/liquid solution(s) resulting therefrom
KR101712682B1 (en) 2009-01-15 2017-03-07 클레네 나노메디슨, 인크. Continuous semicontinuous and batch methods for treating liquids and manufacturing certain constituents (e.g., nanoparticles) in liquids, apparatuses and nanoparticles and nanoparticle/liquid solution(s) and colloids resulting therefrom
KR101546673B1 (en) * 2009-01-15 2015-08-25 삼성전자주식회사 Toner for electrophotographic and process for preparing the same
US20110033940A1 (en) * 2009-01-30 2011-02-10 Northwestern University Click chemistry, molecular transport junctions, and colorimetric detection of copper
US20120014878A1 (en) * 2009-03-23 2012-01-19 Yeditepe Universitesi Synthesis of Oligonucleotide Mediated Gold Core- Silver Shell Nanoparticles
JP6145270B2 (en) 2009-04-15 2017-06-07 ノースウェスタン ユニバーシティ Delivery of oligonucleotide functionalized nanoparticles
KR101040903B1 (en) 2009-06-24 2011-06-16 성균관대학교산학협력단 A platinium catalyst coated by gold nanoparticle and a method for preparation thereof
CA2767428C (en) 2009-07-08 2018-03-13 Gr Intellectual Reserve, Llc Novel gold-based nanocrystals for medical treatments and electrochemical manufacturing processes therefor
WO2011031999A2 (en) * 2009-09-10 2011-03-17 Purdue Research Foundation Multi-component nanoparticle structure having detectable magnetic resonance properties
RU2542386C2 (en) * 2009-12-11 2015-02-20 Корея Рисерч Инститьют Оф Кемикал Текнолоджи Dimeric occludant nanostructure, labelled with molecule, active with respect to raman scattering, located in inter-particle compound, application and method of obtaining thereof
EP2525780B1 (en) 2010-01-19 2022-09-07 Northwestern University Synthetic nanostructures including nucleic acids and/or other entities
EP2531566B1 (en) 2010-02-05 2018-09-12 CAM Holding Corporation Photosensitive ink compositions and transparent conductors and method of using the same
US20130101512A1 (en) 2010-03-12 2013-04-25 Chad A. Mirkin Crosslinked polynucleotide structure
US20130084385A1 (en) * 2010-06-13 2013-04-04 Mingjie Zhou Method for producing core-shell magnetic alloy nanoparticle
FR2965719B1 (en) * 2010-10-07 2014-05-23 Oreal PARTICLE COMPRISING TWO PLASMONIC METALS
CN102554252A (en) * 2010-12-17 2012-07-11 中国科学技术大学 Synthesizing method of porous bimetal nanostructure
EP2670549A4 (en) 2011-02-03 2017-10-25 Metallo Therapy Ltd Surface-modified heavy metal nanoparticles, compositions and uses thereof
CN102672167B (en) * 2011-03-16 2014-04-02 首都师范大学 Preparation and application of novel triangular sliver-silver sulfide nanocomposite particle
CN102407340B (en) * 2011-04-18 2013-06-12 中国人民解放军总后勤部军需装备研究所 Preparation method of micro powder with silver/carbon nuclear shell structure
US9605304B2 (en) * 2011-07-20 2017-03-28 The Hong Kong Polytechnic University Ultra-stable oligonucleotide-gold and-silver nanoparticle conjugates and method of their preparation
CN102298055B (en) * 2011-07-21 2013-12-11 南京博天科智生物技术有限公司 Human blood H-FABP nano-gold labeled test paper and preparation method thereof
US20150086985A1 (en) 2011-09-11 2015-03-26 Aurasense, Llc Cellular uptake control systems
CA2847698C (en) 2011-09-14 2020-09-01 Northwestern University Nanoconjugates able to cross the blood-brain barrier
CN102380335B (en) * 2011-09-15 2014-03-12 东南大学 Core-shell hydrogel colloid crystal microballoon, its preparation method and its purpose
US9079249B2 (en) * 2011-09-30 2015-07-14 Uchicago Argonne, Llc Intermetallic nanoparticles
CN102519948B (en) * 2011-11-24 2014-05-07 中国科学院宁波材料技术与工程研究所 Detection method for hexavalent chromium ions
WO2013170229A1 (en) * 2012-05-11 2013-11-14 Vanderbilt University Detecting antigens such as bacterial quorum sensing proteins
WO2014010012A1 (en) * 2012-07-09 2014-01-16 トヨタ自動車株式会社 Catalyst for emission gas purification and production method thereof
US9512468B2 (en) 2012-11-06 2016-12-06 Industrial Technology Research Institute Detection method uses magnetic and detectable nanoparticles with oligonucleotides attached thereto
CN102962474B (en) * 2012-12-13 2014-10-22 北京航空航天大学 Controllable synthetic method for preparing gold-nickel core-shell nanostructure with ethylene glycol system
US9557324B2 (en) * 2013-02-19 2017-01-31 Samsung Electronics., Ltd. Conjugate of a metal nanoparticle and a light emitting material
CN103159771B (en) * 2013-03-29 2015-04-08 山东科技大学 Technique for synthesizing porphyrin-functionalized cobalt oxide nanoparticles by one-step method
CN103265950B (en) * 2013-06-09 2015-09-02 南京大学 Boron nitride nanosheet/gold nanoclusters matrix material and method for making thereof and the application in bioanalysis
JP6697384B2 (en) 2013-07-25 2020-05-20 イグジキュア, インコーポレーテッドExicure, Inc. Spherical nucleic acid-based constructs as immunostimulants for prophylactic and therapeutic use
US20160194642A1 (en) 2013-07-25 2016-07-07 Exicure, Inc Spherical nucleic acid-based constructs as immunoregulatory agents
US10568898B2 (en) 2013-08-13 2020-02-25 Northwestern University Lipophilic nanoparticles for drug delivery
CN103447547B (en) * 2013-08-28 2015-06-24 同济大学 Method for preparing ferroferric oxide/gold nano-composite particles of star-like structure in micro-emulsion
US10301622B2 (en) 2013-11-04 2019-05-28 Northwestern University Quantification and spatio-temporal tracking of a target using a spherical nucleic acid (SNA)
KR101427146B1 (en) 2013-11-13 2014-08-07 단국대학교 산학협력단 Kit for analyzing biomolecules and method for analyzing biomolecules using the same
WO2015182770A1 (en) * 2014-05-30 2015-12-03 大日本塗料株式会社 Suspension of gold-coated silver nanoplates
AU2015269412B2 (en) 2014-06-04 2020-03-12 Exicure Operating Company Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
CN104096849B (en) * 2014-07-15 2016-10-19 中国石油大学(华东) The preparation method of gold core silver shell nano-probe and the application in cyanide ion colorimetric detection thereof
AU2015328242A1 (en) 2014-10-06 2017-04-27 Exicure, Inc. Anti-TNF compounds
WO2016081911A2 (en) 2014-11-21 2016-05-26 Northwestern University The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
CN104439276B (en) * 2014-11-30 2016-04-13 湖南科技大学 A kind of quick method and product preparing hollow porous silica/argentum nano composite material
US9821061B2 (en) 2015-03-03 2017-11-21 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Enhanced plasmonic nanoparticles for cancer therapy and diagnostics
CN104668580A (en) * 2015-03-06 2015-06-03 天津大学 Preparation of ferroferric oxide/gold nanometer composite material and method for rapidly detecting rhodamine molecules by using ferroferric oxide/gold nanometer composite material
US10078092B2 (en) 2015-03-18 2018-09-18 Northwestern University Assays for measuring binding kinetics and binding capacity of acceptors for lipophilic or amphiphilic molecules
AU2016301375B2 (en) 2015-08-04 2022-03-03 Zoetis Services Llc Signal amplification in solution-based plasmonic specific-binding partner assays
US9627115B2 (en) * 2015-09-14 2017-04-18 Elwha Llc Magnetic plasmonic nanoparticle dimer
US9627114B2 (en) 2015-09-14 2017-04-18 Elwha Llc Magnetic plasmonic nanoparticle positioned on a magnetic plasmonic substrate
JP2017150865A (en) * 2016-02-23 2017-08-31 コニカミノルタ株式会社 Gas detection method and gas detection device
CN105598442B (en) * 2016-02-25 2019-01-22 天津工业大学 One-dimensional chain Au-Ag core-shell nanostructure, self-assembly preparation method thereof and SERS application
CN109415731A (en) 2016-05-06 2019-03-01 埃克西奎雷股份有限公司 Present liposome spherical shape nucleic acid (SNA) construct that the antisense oligonucleotides (ASO) of low interleukin-17 acceptor mRNA is struck for specificity
CN105903979B (en) * 2016-05-13 2017-12-26 吉林师范大学 A kind of Fe3O4The preparation method of@Au nucleocapsid functional materials
CN106111974B (en) * 2016-07-26 2017-11-28 江南大学 A kind of preparation method and application of gold and silver core-shell particles gold nanorods self-assembled structures
WO2018039629A2 (en) 2016-08-25 2018-03-01 Northwestern University Micellar spherical nucleic acids from thermoresponsive, traceless templates
CA3042036A1 (en) * 2016-10-26 2018-05-03 Integrated Nano-Technologies, Inc. Systems and methods for optical sensing of biomolecular targets
CN106735287B (en) * 2016-11-28 2018-08-28 东北大学 A kind of monodispersed FePt/Fe3O4Mix the preparation method of nano particle
US11696954B2 (en) 2017-04-28 2023-07-11 Exicure Operating Company Synthesis of spherical nucleic acids using lipophilic moieties
US11433131B2 (en) 2017-05-11 2022-09-06 Northwestern University Adoptive cell therapy using spherical nucleic acids (SNAs)
US10178735B1 (en) 2017-08-22 2019-01-08 Northrop Grumman Systems Corporation Dynamically tunable materials for parity-time symmetric electro-optical devices
KR102064961B1 (en) * 2017-12-13 2020-01-10 주식회사 포스코 Magnetic nanoparticles and method for amplification of signal in lateral flow assay by using the same
CN108097950A (en) * 2017-12-25 2018-06-01 浙江理工大学 A kind of nucleocapsid Ag@Fe3O4Complex microsphere, preparation method and applications
CN110756796B (en) * 2018-07-25 2021-08-27 石家庄铁道大学 Composite powder with core-shell structure and preparation method thereof
CN110227816B (en) * 2019-07-15 2021-11-02 福州大学 Honeysuckle nano-flower particles with core-shell structure and preparation method and application thereof
WO2021096154A1 (en) * 2019-11-12 2021-05-20 충남대학교산학협력단 Magnetic plasmonic particles and structure comprising same
CN111266599B (en) * 2020-01-21 2022-06-21 王海龙 Preparation method and application of multipole local surface plasma resonance absorber
CN112062235B (en) * 2020-09-09 2022-12-27 重庆科技学院 Oil-water separation device based on composite magnet
CN112588256A (en) * 2021-01-28 2021-04-02 华东交通大学 Magnetic nano bimetal oxide adsorbent and application thereof
CN113059176A (en) * 2021-02-22 2021-07-02 西安市第九医院 Preparation method and application of cobalt-silver nanoparticles
CN113000836B (en) * 2021-03-08 2022-11-08 昆明理工大学 Nickel coating surface treatment method for NaCl particles
CN113433110B (en) * 2021-06-22 2023-03-14 西安邮电大学 Preparation method for generating substrate with honeysuckle dendritic crystal flower-like nano structure by in-situ substitution method
CN113984685B (en) * 2021-09-30 2023-03-10 南京航空航天大学 Analysis method of silver nanostructure growth mechanism
CN116727678B (en) * 2023-06-15 2024-03-12 东南大学 Gold nanoparticle with Yolk-Shell structure and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000033079A1 (en) * 1998-11-30 2000-06-08 Nanosphere, Inc. Nanoparticles with polymer shells

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4193983A (en) 1978-05-16 1980-03-18 Syva Company Labeled liposome particle compositions and immunoassays therewith
NL7807532A (en) 1978-07-13 1980-01-15 Akzo Nv METAL IMMUNO TEST.
US4318707A (en) 1978-11-24 1982-03-09 Syva Company Macromolecular fluorescent quencher particle in specific receptor assays
US4256834A (en) 1979-04-09 1981-03-17 Syva Company Fluorescent scavenger particle immunoassay
US4261968A (en) 1979-05-10 1981-04-14 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4650770A (en) 1981-04-27 1987-03-17 Syntex (U.S.A.) Inc. Energy absorbing particle quenching in light emitting competitive protein binding assays
US4713348A (en) 1983-04-05 1987-12-15 Syntex (U.S.A.) Inc. Fluorescent multiparameter particle analysis
US5288609A (en) 1984-04-27 1994-02-22 Enzo Diagnostics, Inc. Capture sandwich hybridization method and composition
US4868104A (en) 1985-09-06 1989-09-19 Syntex (U.S.A.) Inc. Homogeneous assay for specific polynucleotides
US4996143A (en) 1985-12-23 1991-02-26 Syngene, Inc. Fluorescent stokes shift probes for polynucleotide hybridization
US5137827A (en) 1986-03-25 1992-08-11 Midwest Research Technologies, Inc. Diagnostic element for electrical detection of a binding reaction
US5514602A (en) 1986-06-09 1996-05-07 Ortho Diagnostic Systems, Inc. Method of producing a metal sol reagent containing colloidal metal particles
US5360895A (en) 1987-04-22 1994-11-01 Associated Universities, Inc. Derivatized gold clusters and antibody-gold cluster conjugates
US4853335A (en) 1987-09-28 1989-08-01 Olsen Duane A Colloidal gold particle concentration immunoassay
US5460831A (en) 1990-06-22 1995-10-24 The Regents Of The University Of California Targeted transfection nanoparticles
WO1992008133A1 (en) 1990-10-29 1992-05-14 Dekalb Plant Genetics Isolation of biological materials using magnetic particles
US5665582A (en) 1990-10-29 1997-09-09 Dekalb Genetics Corp. Isolation of biological materials
US5294369A (en) 1990-12-05 1994-03-15 Akzo N.V. Ligand gold bonding
EP0613585A4 (en) 1991-11-22 1995-06-21 Univ California Semiconductor nanocrystals covalently bound to solid inorganic surfaces using self-assembled monolayers.
US5225064A (en) 1992-01-15 1993-07-06 Enzyme Technology Research Group, Inc. Peroxidase colloidal gold oxidase biosensors for mediatorless glucose determination
US5472881A (en) 1992-11-12 1995-12-05 University Of Utah Research Foundation Thiol labeling of DNA for attachment to gold surfaces
US5637508A (en) 1993-03-26 1997-06-10 Geo-Centers, Inc. Biomolecules bound to polymer or copolymer coated catalytic inorganic particles, immunoassays using the same and kits containing the same
US5384265A (en) 1993-03-26 1995-01-24 Geo-Centers, Inc. Biomolecules bound to catalytic inorganic particles, immunoassays using the same
US5681943A (en) 1993-04-12 1997-10-28 Northwestern University Method for covalently linking adjacent oligonucleotides
US5543158A (en) 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
DE4405156C1 (en) * 1994-02-18 1995-10-26 Univ Karlsruhe Process for the production of coated polymeric microparticles
US5521289A (en) 1994-07-29 1996-05-28 Nanoprobes, Inc. Small organometallic probes
US5599668A (en) 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
US5609907A (en) 1995-02-09 1997-03-11 The Penn State Research Foundation Self-assembled metal colloid monolayers
US6025202A (en) 1995-02-09 2000-02-15 The Penn State Research Foundation Self-assembled metal colloid monolayers and detection methods therewith
ATE357663T1 (en) 1996-04-25 2007-04-15 Genicon Sciences Corp ANALYTICAL TASSAY USING PARTICLE MARKER
US6750016B2 (en) * 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7169556B2 (en) 1996-07-29 2007-01-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
ES2287956T3 (en) 1996-07-29 2007-12-16 Nanosphere Inc. NANOPARTICLES THAT HAVE OLIGONUCLEOTIDES UNITED TO THE SAME AND USES OF THE SAME.
US6984491B2 (en) 1996-07-29 2006-01-10 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6506564B1 (en) 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6361944B1 (en) 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US5830986A (en) 1996-10-28 1998-11-03 Massachusetts Institute Of Technology Methods for the synthesis of functionalizable poly(ethylene oxide) star macromolecules
US5900481A (en) 1996-11-06 1999-05-04 Sequenom, Inc. Bead linkers for immobilizing nucleic acids to solid supports
US5922537A (en) 1996-11-08 1999-07-13 N.o slashed.AB Immunoassay, Inc. Nanoparticles biosensor
US5939021A (en) 1997-01-23 1999-08-17 Hansen; W. Peter Homogeneous binding assay
AU748939B2 (en) 1997-02-20 2002-06-13 Regents Of The University Of California, The Plasmon resonant particles, methods and apparatus
US6852252B2 (en) 1997-03-12 2005-02-08 William Marsh Rice University Use of metalnanoshells to impede the photo-oxidation of conjugated polymer
US6344272B1 (en) 1997-03-12 2002-02-05 Wm. Marsh Rice University Metal nanoshells
US6974669B2 (en) 2000-03-28 2005-12-13 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified nanoparticles
US6149868A (en) 1997-10-28 2000-11-21 The Penn State Research Foundation Surface enhanced raman scattering from metal nanoparticle-analyte-noble metal substrate sandwiches
US5990479A (en) 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US5972615A (en) 1998-01-21 1999-10-26 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate disease
US6428811B1 (en) 1998-03-11 2002-08-06 Wm. Marsh Rice University Temperature-sensitive polymer/nanoshell composites for photothermally modulated drug delivery
US6699724B1 (en) 1998-03-11 2004-03-02 Wm. Marsh Rice University Metal nanoshells for biosensing applications
DE19822996C1 (en) * 1998-05-22 1999-04-22 Siemens Ag Temperature-resistant gradient material for heat shield or gas turbine blade
US6290839B1 (en) 1998-06-23 2001-09-18 Clinical Micro Sensors, Inc. Systems for electrophoretic transport and detection of analytes
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6738163B2 (en) * 1998-07-17 2004-05-18 Gary Hochman Method for transmission of facsimile image data
US6306610B1 (en) 1998-09-18 2001-10-23 Massachusetts Institute Of Technology Biological applications of quantum dots
US6251303B1 (en) 1998-09-18 2001-06-26 Massachusetts Institute Of Technology Water-soluble fluorescent nanocrystals
US6203989B1 (en) 1998-09-30 2001-03-20 Affymetrix, Inc. Methods and compositions for amplifying detectable signals in specific binding assays
US6277489B1 (en) 1998-12-04 2001-08-21 The Regents Of The University Of California Support for high performance affinity chromatography and other uses
US6159378A (en) 1999-02-23 2000-12-12 Battelle Memorial Institute Apparatus and method for handling magnetic particles in a fluid
DE60027578T2 (en) * 1999-07-16 2007-01-25 WM. Marsh Rice University, Houston Method of detecting bioanalytes using metallic nanoshells
AU6504900A (en) 1999-07-30 2001-02-19 Penn State Research Foundation, The Instruments, methods and reagents for surface plasmon resonance
JP2004501340A (en) 2000-01-13 2004-01-15 ナノスフェアー　インコーポレイテッド Oligonucleotide-attached nanoparticles and methods of use
US6530944B2 (en) 2000-02-08 2003-03-11 Rice University Optically-active nanoparticles for use in therapeutic and diagnostic methods
US6773823B2 (en) * 2000-04-07 2004-08-10 University Of New Orleans Research And Technology Foundation, Inc. Sequential synthesis of core-shell nanoparticles using reverse micelles
WO2002004681A2 (en) * 2000-07-11 2002-01-17 Northwestern University Method of detection by enhancement of silver staining
WO2002059226A2 (en) 2000-11-03 2002-08-01 Wm. Marsh Rice University Partial coverage metal nanoshells and method of making same
WO2002046483A2 (en) 2000-12-06 2002-06-13 Northwestern University Silver stain removal from dna detection chips by cyanide etching or sonication
US20030113740A1 (en) 2001-04-26 2003-06-19 Mirkin Chad A. Oligonucleotide-modified ROMP polymers and co-polymers
US7238472B2 (en) 2001-05-25 2007-07-03 Nanosphere, Inc. Non-alloying core shell nanoparticles
US7147687B2 (en) 2001-05-25 2006-12-12 Nanosphere, Inc. Non-alloying core shell nanoparticles
JP4347053B2 (en) 2001-08-03 2009-10-21 ナノスフェアー インコーポレイテッド Nanoparticle imaging system and method
KR100438408B1 (en) * 2001-08-16 2004-07-02 한국과학기술원 Method for Synthesis of Core-Shell type and Solid Solution type Metallic Alloy Nanoparticles via Transmetalation Reactions and Their Applications
AU2002343413A1 (en) 2001-09-26 2003-04-07 Rice University Optically-absorbing nanoparticles for enhanced tissue repair
US6778316B2 (en) 2001-10-24 2004-08-17 William Marsh Rice University Nanoparticle-based all-optical sensors
JP4220397B2 (en) 2001-11-09 2009-02-04 ナノスフェアー インコーポレイテッド Bioconjugate-nanoparticle probe
US6875475B2 (en) 2002-04-01 2005-04-05 William Marsh Rice University Methods for producing submicron metal line and island arrays
US20030211488A1 (en) * 2002-05-07 2003-11-13 Northwestern University Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
EP1540006B1 (en) 2002-07-02 2009-01-07 Nanosphere, Inc. Nanoparticle polyanion conjugates and methods of use thereof in detecting analytes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000033079A1 (en) * 1998-11-30 2000-06-08 Nanosphere, Inc. Nanoparticles with polymer shells

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8999947B2 (en) 2005-06-14 2015-04-07 Northwestern University Nucleic acid functionalized nanoparticles for therapeutic applications
US9506056B2 (en) 2006-06-08 2016-11-29 Northwestern University Nucleic acid functionalized nanoparticles for therapeutic applications
US9376690B2 (en) 2009-10-30 2016-06-28 Northwestern University Templated nanoconjugates

Also Published As

Publication number Publication date
DE60218840T2 (en) 2007-11-29
EP1392872A4 (en) 2004-08-11
US20040038255A1 (en) 2004-02-26
US7135055B2 (en) 2006-11-14
DE60218840D1 (en) 2007-04-26
WO2003008539A3 (en) 2003-08-21
JP2005520125A (en) 2005-07-07
JP3885054B2 (en) 2007-02-21
ATE356826T1 (en) 2007-04-15
US20020177143A1 (en) 2002-11-28
AU2002239726A1 (en) 2002-12-09
WO2003008539A2 (en) 2003-01-30
EP1392872A2 (en) 2004-03-03
EP1392872B1 (en) 2007-03-14
AU2002341539B2 (en) 2007-06-28
US7238472B2 (en) 2007-07-03
WO2002096262A2 (en) 2002-12-05

Similar Documents

Publication Publication Date Title
WO2002096262A3 (en) Non-alloying core shell nanoparticles
AU2001264946A1 (en) Bispecific immunoglobulin-like antigen binding proteins and method of production
AUPR725701A0 (en) Functionalised nanoparticle concentrates
WO2002019963A3 (en) Synthetic erythropoiesis stimulating proteins
WO2004083290A3 (en) Core-shell magnetic nanoparticles and nanocomposite materials formed therefrom
HK1062743A1 (en) Electrically conductive polymer composite compositions, method for making, and method for electricalconductivity enhancement
AU2002367156A1 (en) Method of preparing functional microcapsule incorporating silver nanoparticles
AU2001236838A1 (en) Methods and systems for making secure electronic payments
AU2002212112A1 (en) Profile composite component and method for the production thereof
HUP0203386A3 (en) Magnetic glass particles, method for their preparation and uses thereof
DE69915797D1 (en) METHOD FOR PRODUCING SEALED PARTS BY UNIAXIAL PRESSING AGGLOMERED SPHERICAL METAL POWDER.
EP1447824B8 (en) Composite magnetic material producing method
AU2002341706A1 (en) Method of producing objects through free forming using powders
EP1193723A4 (en) Magnetic ferrite powder, magnetic ferrite sinter, layered ferrite part, and process for producing layered ferrite part
AU2001291677A1 (en) Method for producing lipoic acid and dihydrolipoic acid
AU2002215483A1 (en) Method and device for the preparation of foundry sand
IL160910A0 (en) Precious metal catalyst composite and methods for making the same
AU2002317095A1 (en) Magnetic nanoparticles for bioseparation application and methods for producing same
AU2002306748A1 (en) Anti-gpe antibodies, their uses, and analytical methods for gpe
AU2002246747A1 (en) Processes for making cryopreserved composite living constructs and products resulting therefrom
AU2002352510A1 (en) Method of producing composite metal powders
AU2002223128A1 (en) Hydrogen-occluding alloy and method for production thereof
AU2002226059A1 (en) Improved compositions and methods for producing antibodies to low molecular weight analytes
AU2002237206A1 (en) Method for the manufacture of gradient gels and method for analysing biomolecules on ultra-long ipg gels
AU4645401A (en) Flat composite component and method for the production thereof

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP