WO2002092075A3 - Therapeutic delivery of carbon monoxide - Google Patents
Therapeutic delivery of carbon monoxide Download PDFInfo
- Publication number
- WO2002092075A3 WO2002092075A3 PCT/GB2002/002268 GB0202268W WO02092075A3 WO 2002092075 A3 WO2002092075 A3 WO 2002092075A3 GB 0202268 W GB0202268 W GB 0202268W WO 02092075 A3 WO02092075 A3 WO 02092075A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- carbonyl
- carbon monoxide
- metal
- therapeutic delivery
- shock
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System compounds of the platinum group
- C07F15/0046—Ruthenium compounds
- C07F15/0053—Ruthenium compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
- C07F15/02—Iron compounds
- C07F15/025—Iron compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F17/00—Metallocenes
- C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic System
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02769517A EP1399147A2 (en) | 2001-05-15 | 2002-05-15 | Therapeutic delivery of carbon monoxide |
JP2002588992A JP2004532244A (en) | 2001-05-15 | 2002-05-15 | Therapeutic release of carbon monoxide |
CA002447275A CA2447275A1 (en) | 2001-05-15 | 2002-05-15 | Therapeutic delivery of carbon monoxide |
AU2002307959A AU2002307959B2 (en) | 2001-05-15 | 2002-05-15 | Therapeutic delivery of carbon monoxide |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0111872.8A GB0111872D0 (en) | 2001-05-15 | 2001-05-15 | Therapeutic agents and methods |
GB0111872.8 | 2001-05-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002092075A2 WO2002092075A2 (en) | 2002-11-21 |
WO2002092075A3 true WO2002092075A3 (en) | 2004-01-08 |
Family
ID=9914684
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2002/002268 WO2002092075A2 (en) | 2001-05-15 | 2002-05-15 | Therapeutic delivery of carbon monoxide |
Country Status (8)
Country | Link |
---|---|
US (2) | US7045140B2 (en) |
EP (2) | EP2135605A3 (en) |
JP (2) | JP2004532244A (en) |
CN (1) | CN1561207A (en) |
AU (2) | AU2002307959B2 (en) |
CA (1) | CA2447275A1 (en) |
GB (1) | GB0111872D0 (en) |
WO (1) | WO2002092075A2 (en) |
Cited By (4)
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---|---|---|---|---|
US8389572B2 (en) | 2006-01-24 | 2013-03-05 | Hemocorm Limited | Therapeutic delivery of carbon monoxide |
US9023402B2 (en) | 2002-02-04 | 2015-05-05 | ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. | Method for treating a mammal by administration of a compound having the ability to release CO |
US9062089B2 (en) | 2011-07-21 | 2015-06-23 | Alfama, Inc. | Ruthenium carbon monoxide releasing molecules and uses thereof |
US9163044B2 (en) | 2011-04-19 | 2015-10-20 | Alfama, Inc. | Carbon monoxide releasing molecules and uses thereof |
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US8128963B2 (en) * | 1996-09-27 | 2012-03-06 | The Trustees Of Columbia University In The City Of New York | Methods for treating ischemic disorders using carbon monoxide |
US7678390B2 (en) | 1999-04-01 | 2010-03-16 | Yale University | Carbon monoxide as a biomarker and therapeutic agent |
GB0111872D0 (en) * | 2001-05-15 | 2001-07-04 | Northwick Park Inst For Medica | Therapeutic agents and methods |
SK15942003A3 (en) | 2001-06-21 | 2004-08-03 | Beth Israel Deaconess Medical Center, Inc. | Carbon monoxide improves outcomes in tissue and organ transplants apoptosis |
US20080026984A1 (en) * | 2002-02-04 | 2008-01-31 | Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
US7968605B2 (en) * | 2002-02-04 | 2011-06-28 | ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
JP2005525848A (en) * | 2002-02-13 | 2005-09-02 | ベス イスラエル ディコネス メディカル センター | Treatment method of vascular disease |
AU2003216368B2 (en) * | 2002-04-15 | 2007-08-09 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Methods of treating ileus |
AU2003223562B2 (en) | 2002-04-15 | 2009-04-09 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Methods of treating necrotizing enterocolitis |
US8097585B2 (en) | 2002-04-15 | 2012-01-17 | Beth Israel Deaconess Medical Center, Inc. | Methods of treating inflammation by administration of heme oxygenase-1 and products of heme degradation |
US20040052866A1 (en) | 2002-05-17 | 2004-03-18 | Otterbein Leo E. | Methods of treating hepatitis |
CA2487413A1 (en) * | 2002-06-05 | 2003-12-18 | Yale University | Methods of treating angiogenesis, tumor growth, and metastasis |
PL375161A1 (en) * | 2002-06-21 | 2005-11-28 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Pharmaceutical use of nitric oxide, heme oxygenase-1 and products of heme degradation |
US20040228930A1 (en) * | 2002-11-07 | 2004-11-18 | Billiar Timothy R. | Treatment for hemorrhagic shock |
GB2395431A (en) * | 2002-11-20 | 2004-05-26 | Northwick Park Inst For Medica | Combination of a metal carbonyl compound and a guanylate cyclase stimulant or stabilizer for the therapeutic delivery of carbon monoxide |
GB2395432B (en) * | 2002-11-20 | 2005-09-14 | Northwick Park Inst For Medica | Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs |
US20070065485A1 (en) * | 2003-08-04 | 2007-03-22 | Motterlini Roberto A | Therapeutic delivery of carbon monoxide |
US20050136125A1 (en) * | 2003-10-22 | 2005-06-23 | Roth Mark B. | Methods, compositions and devices for inducing stasis in cells, tissues, organs, and organisms |
US20050170019A1 (en) * | 2003-10-22 | 2005-08-04 | Fred Hutchinson Cancer Research Center | Methods, compositions and devices for inducing stasis in cells |
WO2005041655A1 (en) * | 2003-10-22 | 2005-05-12 | Fred Hutchinson Cancer Research Center | Methods, compositions and devices for inducing stasis in cells, tissues, organs, and organisms |
EP1809305A4 (en) * | 2004-10-15 | 2009-12-30 | Altairnano Inc | Phosphate binder with reduced pill burden |
US7575959B2 (en) * | 2004-11-26 | 2009-08-18 | Semiconductor Energy Laboratory Co., Ltd. | Manufacturing method of semiconductor device |
CA2600927C (en) | 2005-03-07 | 2017-04-18 | Sangart, Inc. | Compositions and methods for delivering carbon monoxide (co) and nitric oxide (no) to tissue using heme proteins as carriers |
PT1879599E (en) * | 2005-04-20 | 2014-01-23 | Hutchinson Fred Cancer Res | Methods, compositions and articles of manufacture for enhancing survivability of cells, tissues, organs, and organisms |
WO2007073226A1 (en) * | 2005-12-20 | 2007-06-28 | Alfama - Investigação E Desenvolvimento De Produtos Farmacêuticos Lda | Method for treating a mammal by administration of a compound having the ability to release co |
US20070207993A1 (en) * | 2005-12-20 | 2007-09-06 | Alfama - Investigacao E Desenvolvimetno De Productos Farmaceuticos Lda | Molybdenum carbonyl complexes for treating rheumatoid arthritis and other inflammatory diseases |
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2002
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US9023402B2 (en) | 2002-02-04 | 2015-05-05 | ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. | Method for treating a mammal by administration of a compound having the ability to release CO |
US8389572B2 (en) | 2006-01-24 | 2013-03-05 | Hemocorm Limited | Therapeutic delivery of carbon monoxide |
US9163044B2 (en) | 2011-04-19 | 2015-10-20 | Alfama, Inc. | Carbon monoxide releasing molecules and uses thereof |
US9062089B2 (en) | 2011-07-21 | 2015-06-23 | Alfama, Inc. | Ruthenium carbon monoxide releasing molecules and uses thereof |
Also Published As
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GB0111872D0 (en) | 2001-07-04 |
US8236339B2 (en) | 2012-08-07 |
EP2135605A2 (en) | 2009-12-23 |
EP1399147A2 (en) | 2004-03-24 |
AU2008207438A1 (en) | 2008-09-11 |
US7045140B2 (en) | 2006-05-16 |
AU2002307959B2 (en) | 2008-05-22 |
CA2447275A1 (en) | 2002-11-21 |
WO2002092075A2 (en) | 2002-11-21 |
EP2135605A3 (en) | 2010-07-14 |
JP2009215311A (en) | 2009-09-24 |
US20060115542A1 (en) | 2006-06-01 |
US20030064114A1 (en) | 2003-04-03 |
CN1561207A (en) | 2005-01-05 |
JP2004532244A (en) | 2004-10-21 |
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