WO2002088170A3 - Cripto blocking antibodies and uses thereof - Google Patents
Cripto blocking antibodies and uses thereof Download PDFInfo
- Publication number
- WO2002088170A3 WO2002088170A3 PCT/US2002/011950 US0211950W WO02088170A3 WO 2002088170 A3 WO2002088170 A3 WO 2002088170A3 US 0211950 W US0211950 W US 0211950W WO 02088170 A3 WO02088170 A3 WO 02088170A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cripto
- antibodies
- bind
- modulate
- tumor growth
- Prior art date
Links
- 101100369076 Mus musculus Tdgf1 gene Proteins 0.000 title abstract 10
- 230000000903 blocking effect Effects 0.000 title abstract 2
- 230000004614 tumor growth Effects 0.000 abstract 3
- 102100034134 Activin receptor type-1B Human genes 0.000 abstract 2
- 101000799189 Homo sapiens Activin receptor type-1B Proteins 0.000 abstract 2
- 230000003993 interaction Effects 0.000 abstract 2
- 230000011664 signaling Effects 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Abstract
Priority Applications (37)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020037014078A KR100592357B1 (en) | 2001-04-26 | 2002-04-17 | Cryptoblocking antibodies and uses thereof |
EEP200300528A EE200300528A (en) | 2001-04-26 | 2002-04-17 | Cripto protein blocking antibodies and their use |
EP02731384A EP1390389B1 (en) | 2001-04-26 | 2002-04-17 | Cripto blocking antibodies and uses thereof |
DK02731384T DK1390389T3 (en) | 2001-04-26 | 2002-04-17 | Crypto-blocking antibodies and uses thereof |
YU84903A RS51635B (en) | 2001-04-26 | 2002-04-17 | Cripto blocking antibodies and uses thereof |
SK1443-2003A SK14432003A3 (en) | 2001-04-26 | 2002-04-17 | Cripto blocking antibodies and uses thereof |
IL15857302A IL158573A0 (en) | 2000-03-20 | 2002-04-17 | Cripto blocking antibodies and uses thereof |
CA2443840A CA2443840C (en) | 2001-04-26 | 2002-04-17 | Cripto blocking antibodies and uses thereof |
EA200301158A EA007469B1 (en) | 2001-04-26 | 2002-04-17 | Cripto blocking antibodies and uses thereof |
BRPI0209254-9A BR0209254A (en) | 2001-04-26 | 2002-04-17 | crypto blocking antibodies and uses thereof |
DE60230868T DE60230868D1 (en) | 2001-04-26 | 2002-04-17 | CRIPTOBLOCKING ANTIBODIES AND THEIR USE |
MXPA03009797A MXPA03009797A (en) | 2001-04-26 | 2002-04-17 | Cripto blocking antibodies and uses thereof. |
HU0501113A HUP0501113A3 (en) | 2001-04-26 | 2002-04-17 | Cripto blocking antibodies and uses thereof |
SI200230804T SI1390389T1 (en) | 2001-04-26 | 2002-04-17 | Cripto blocking antibodies and uses thereof |
JP2002585468A JP4307845B2 (en) | 2001-04-26 | 2002-04-17 | Antibodies that block Cripto and uses thereof |
DK02807155.3T DK1494693T3 (en) | 2002-03-22 | 2002-10-01 | Crypto-specific antibodies |
AT02807155T ATE490981T1 (en) | 2002-03-22 | 2002-10-01 | CRIPTO-SPECIFIC ANTIBODIES |
CA2480119A CA2480119C (en) | 2002-03-22 | 2002-10-01 | Cripto-specific antibodies |
DE60238559T DE60238559D1 (en) | 2002-03-22 | 2002-10-01 | CRIPT-SPECIFIC ANTIBODIES |
JP2003580477A JP2005520566A (en) | 2002-03-22 | 2002-10-01 | Cripto specific antibodies |
PCT/US2002/031462 WO2003083041A2 (en) | 2002-03-22 | 2002-10-01 | Cripto-specific antibodies |
PT02807155T PT1494693E (en) | 2002-03-22 | 2002-10-01 | Cripto-specific antibodies |
AU2002334799A AU2002334799B2 (en) | 2001-04-26 | 2002-10-01 | Cripto-specific antibodies |
EP02807155A EP1494693B1 (en) | 2002-03-22 | 2002-10-01 | Cripto-specific antibodies |
US10/693,538 US7531174B2 (en) | 2001-04-26 | 2003-10-23 | Cripto blocking antibodies and uses thereof |
IS6999A IS2662B (en) | 2001-04-26 | 2003-10-24 | Antibodies that block the Cripto protein and their use |
NO20034805A NO20034805L (en) | 2001-04-26 | 2003-10-27 | CRIPTO-blocking antibody and its use |
BG108363A BG108363A (en) | 2001-04-26 | 2003-11-14 | Cripto blocking antibodies and use thereof |
HK04101788.0A HK1058935A1 (en) | 2001-04-26 | 2004-03-11 | Cripto blocking antibodies and uses thereof |
US10/945,853 US7582299B2 (en) | 2001-04-26 | 2004-09-20 | Cripto-specific antibodies |
HK05105887.0A HK1072381A1 (en) | 2002-03-22 | 2005-07-11 | Cripto-specific antibodies cripto-specific |
US11/799,361 US7674462B2 (en) | 2001-04-26 | 2007-04-30 | Cripto blocking antibodies and uses thereof |
US12/317,476 US8003763B2 (en) | 2001-04-26 | 2008-12-22 | Cripto blocking antibodies and uses thereof |
US12/353,913 US20090285818A1 (en) | 2001-04-26 | 2009-01-14 | Cripto Blocking Antibodies and Uses Thereof |
JP2009020949A JP2009161539A (en) | 2002-03-22 | 2009-01-30 | Cripto-specific antibody |
US12/415,659 US7888052B2 (en) | 2001-04-26 | 2009-03-31 | Cripto blocking antibodies and uses thereof |
US13/213,499 US8673303B2 (en) | 2001-04-26 | 2011-08-19 | Cripto blocking antibodies and uses thereof |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28678201P | 2001-04-26 | 2001-04-26 | |
US60/286,782 | 2001-04-26 | ||
US29302001P | 2001-05-17 | 2001-05-17 | |
US60/293,020 | 2001-05-17 | ||
US30109101P | 2001-06-26 | 2001-06-26 | |
US60/301,091 | 2001-06-26 | ||
US36700202P | 2002-03-22 | 2002-03-22 | |
US60/367,002 | 2002-03-22 |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/031462 Continuation WO2003083041A2 (en) | 2001-04-26 | 2002-10-01 | Cripto-specific antibodies |
US10/693,538 Continuation US7531174B2 (en) | 2001-04-26 | 2003-10-23 | Cripto blocking antibodies and uses thereof |
US10/945,853 Continuation US7582299B2 (en) | 2001-04-26 | 2004-09-20 | Cripto-specific antibodies |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002088170A2 WO2002088170A2 (en) | 2002-11-07 |
WO2002088170A3 true WO2002088170A3 (en) | 2003-12-24 |
Family
ID=27501437
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/011950 WO2002088170A2 (en) | 2000-03-20 | 2002-04-17 | Cripto blocking antibodies and uses thereof |
Country Status (34)
Country | Link |
---|---|
US (6) | US7531174B2 (en) |
EP (3) | EP1974749B1 (en) |
JP (4) | JP4307845B2 (en) |
KR (1) | KR100592357B1 (en) |
CN (1) | CN100352501C (en) |
AR (3) | AR037223A1 (en) |
AT (2) | ATE533508T1 (en) |
BG (1) | BG108363A (en) |
BR (1) | BR0209254A (en) |
CA (2) | CA2443840C (en) |
CL (1) | CL2009002199A1 (en) |
CY (1) | CY1108960T1 (en) |
CZ (1) | CZ20033208A3 (en) |
DE (1) | DE60230868D1 (en) |
DK (1) | DK1390389T3 (en) |
EA (1) | EA007469B1 (en) |
EE (1) | EE200300528A (en) |
ES (1) | ES2321065T3 (en) |
GE (1) | GEP20074091B (en) |
HK (1) | HK1058935A1 (en) |
HU (1) | HUP0501113A3 (en) |
IS (1) | IS2662B (en) |
MX (1) | MXPA03009797A (en) |
MY (2) | MY157382A (en) |
NO (1) | NO20034805L (en) |
NZ (1) | NZ566268A (en) |
PL (1) | PL207087B1 (en) |
PT (1) | PT1390389E (en) |
RS (2) | RS51635B (en) |
SG (1) | SG157951A1 (en) |
SI (1) | SI1390389T1 (en) |
SK (1) | SK14432003A3 (en) |
TR (1) | TR200301846T2 (en) |
WO (1) | WO2002088170A2 (en) |
Cited By (2)
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---|---|---|---|---|
US9562049B2 (en) | 2012-12-21 | 2017-02-07 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
US9567340B2 (en) | 2012-12-21 | 2017-02-14 | Medimmune Limited | Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases |
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AUPR395801A0 (en) | 2001-03-26 | 2001-04-26 | Austin Research Institute, The | Antibodies against cancer |
US20090123470A1 (en) * | 2001-03-26 | 2009-05-14 | The Macfarlane Burnet Istitute For Medical Research And Public Health Ltd. | Antibodies Against Cancer |
EA007469B1 (en) | 2001-04-26 | 2006-10-27 | Байоджен Айдек Эмэй Инк. | Cripto blocking antibodies and uses thereof |
US7582299B2 (en) | 2001-04-26 | 2009-09-01 | Biogen Idec Ma Inc. | Cripto-specific antibodies |
EP1494693B1 (en) * | 2002-03-22 | 2010-12-08 | Biogen Idec MA Inc. | Cripto-specific antibodies |
JP5068072B2 (en) | 2003-06-27 | 2012-11-07 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | Modified binding molecule comprising a linking peptide |
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