WO2002088170A3 - Cripto blocking antibodies and uses thereof - Google Patents

Cripto blocking antibodies and uses thereof Download PDF

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Publication number
WO2002088170A3
WO2002088170A3 PCT/US2002/011950 US0211950W WO02088170A3 WO 2002088170 A3 WO2002088170 A3 WO 2002088170A3 US 0211950 W US0211950 W US 0211950W WO 02088170 A3 WO02088170 A3 WO 02088170A3
Authority
WO
WIPO (PCT)
Prior art keywords
cripto
antibodies
bind
modulate
tumor growth
Prior art date
Application number
PCT/US2002/011950
Other languages
French (fr)
Other versions
WO2002088170A2 (en
Inventor
Michele Sanicola-Nadel
Kevin Williams
Susan Schiffer
Paul Rayhorn
Original Assignee
Biogen Inc
Michele Sanicola-Nadel
Kevin Williams
Susan Schiffer
Paul Rayhorn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27501437&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2002088170(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to KR1020037014078A priority Critical patent/KR100592357B1/en
Priority to YU84903A priority patent/RS51635B/en
Priority to EA200301158A priority patent/EA007469B1/en
Priority to EEP200300528A priority patent/EE200300528A/en
Priority to JP2002585468A priority patent/JP4307845B2/en
Priority to SI200230804T priority patent/SI1390389T1/en
Priority to EP02731384A priority patent/EP1390389B1/en
Application filed by Biogen Inc, Michele Sanicola-Nadel, Kevin Williams, Susan Schiffer, Paul Rayhorn filed Critical Biogen Inc
Priority to CA2443840A priority patent/CA2443840C/en
Priority to BRPI0209254-9A priority patent/BR0209254A/en
Priority to DE60230868T priority patent/DE60230868D1/en
Priority to DK02731384T priority patent/DK1390389T3/en
Priority to SK1443-2003A priority patent/SK14432003A3/en
Priority to HU0501113A priority patent/HUP0501113A3/en
Priority to IL15857302A priority patent/IL158573A0/en
Priority to MXPA03009797A priority patent/MXPA03009797A/en
Priority to AU2002334799A priority patent/AU2002334799B2/en
Priority to DK02807155.3T priority patent/DK1494693T3/en
Priority to DE60238559T priority patent/DE60238559D1/en
Priority to PCT/US2002/031462 priority patent/WO2003083041A2/en
Priority to EP02807155A priority patent/EP1494693B1/en
Priority to CA2480119A priority patent/CA2480119C/en
Priority to PT02807155T priority patent/PT1494693E/en
Priority to JP2003580477A priority patent/JP2005520566A/en
Priority to AT02807155T priority patent/ATE490981T1/en
Publication of WO2002088170A2 publication Critical patent/WO2002088170A2/en
Priority to US10/693,538 priority patent/US7531174B2/en
Priority to IS6999A priority patent/IS2662B/en
Priority to NO20034805A priority patent/NO20034805L/en
Priority to BG108363A priority patent/BG108363A/en
Publication of WO2002088170A3 publication Critical patent/WO2002088170A3/en
Priority to HK04101788.0A priority patent/HK1058935A1/en
Priority to US10/945,853 priority patent/US7582299B2/en
Priority to HK05105887.0A priority patent/HK1072381A1/en
Priority to US11/799,361 priority patent/US7674462B2/en
Priority to US12/317,476 priority patent/US8003763B2/en
Priority to US12/353,913 priority patent/US20090285818A1/en
Priority to JP2009020949A priority patent/JP2009161539A/en
Priority to US12/415,659 priority patent/US7888052B2/en
Priority to US13/213,499 priority patent/US8673303B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides Cripto blocking antibodies, or biologically functional fragments thereof, and uses thereof. Antibodies which bind Cripto and modulate Cripto signaling are provided. Antibodies which bind Cripto and block the interaction between Cripto and ALK4 are provided. Antibodies which bind Cripto and modulate tumor growth are also provided. Antibodies which bind Cripto, modulate signaling, and modulate tumor growth are also provided. Antibodies which bind Cripto, block the interaction between Cripto and ALK4 and modulate tumor growth are provided. The invention also provides methods of using these antibodies in therapeutic, diagnostic, and research applications.
PCT/US2002/011950 2000-03-20 2002-04-17 Cripto blocking antibodies and uses thereof WO2002088170A2 (en)

Priority Applications (37)

Application Number Priority Date Filing Date Title
MXPA03009797A MXPA03009797A (en) 2001-04-26 2002-04-17 Cripto blocking antibodies and uses thereof.
EP02731384A EP1390389B1 (en) 2001-04-26 2002-04-17 Cripto blocking antibodies and uses thereof
EA200301158A EA007469B1 (en) 2001-04-26 2002-04-17 Cripto blocking antibodies and uses thereof
EEP200300528A EE200300528A (en) 2001-04-26 2002-04-17 Cripto protein blocking antibodies and their use
CA2443840A CA2443840C (en) 2001-04-26 2002-04-17 Cripto blocking antibodies and uses thereof
SI200230804T SI1390389T1 (en) 2001-04-26 2002-04-17 Cripto blocking antibodies and uses thereof
YU84903A RS51635B (en) 2001-04-26 2002-04-17 Cripto blocking antibodies and uses thereof
KR1020037014078A KR100592357B1 (en) 2001-04-26 2002-04-17 Cryptoblocking antibodies and uses thereof
JP2002585468A JP4307845B2 (en) 2001-04-26 2002-04-17 Antibodies that block Cripto and uses thereof
BRPI0209254-9A BR0209254A (en) 2001-04-26 2002-04-17 crypto blocking antibodies and uses thereof
DE60230868T DE60230868D1 (en) 2001-04-26 2002-04-17 CRIPTOBLOCKING ANTIBODIES AND THEIR USE
DK02731384T DK1390389T3 (en) 2001-04-26 2002-04-17 Crypto-blocking antibodies and uses thereof
SK1443-2003A SK14432003A3 (en) 2001-04-26 2002-04-17 Cripto blocking antibodies and uses thereof
HU0501113A HUP0501113A3 (en) 2001-04-26 2002-04-17 Cripto blocking antibodies and uses thereof
IL15857302A IL158573A0 (en) 2000-03-20 2002-04-17 Cripto blocking antibodies and uses thereof
AT02807155T ATE490981T1 (en) 2002-03-22 2002-10-01 CRIPTO-SPECIFIC ANTIBODIES
DE60238559T DE60238559D1 (en) 2002-03-22 2002-10-01 CRIPT-SPECIFIC ANTIBODIES
JP2003580477A JP2005520566A (en) 2002-03-22 2002-10-01 Cripto specific antibodies
DK02807155.3T DK1494693T3 (en) 2002-03-22 2002-10-01 Crypto-specific antibodies
AU2002334799A AU2002334799B2 (en) 2001-04-26 2002-10-01 Cripto-specific antibodies
PCT/US2002/031462 WO2003083041A2 (en) 2002-03-22 2002-10-01 Cripto-specific antibodies
EP02807155A EP1494693B1 (en) 2002-03-22 2002-10-01 Cripto-specific antibodies
CA2480119A CA2480119C (en) 2002-03-22 2002-10-01 Cripto-specific antibodies
PT02807155T PT1494693E (en) 2002-03-22 2002-10-01 Cripto-specific antibodies
US10/693,538 US7531174B2 (en) 2001-04-26 2003-10-23 Cripto blocking antibodies and uses thereof
IS6999A IS2662B (en) 2001-04-26 2003-10-24 Antibodies that block the Cripto protein and their use
NO20034805A NO20034805L (en) 2001-04-26 2003-10-27 CRIPTO-blocking antibody and its use
BG108363A BG108363A (en) 2001-04-26 2003-11-14 Cripto blocking antibodies and use thereof
HK04101788.0A HK1058935A1 (en) 2001-04-26 2004-03-11 Cripto blocking antibodies and uses thereof
US10/945,853 US7582299B2 (en) 2001-04-26 2004-09-20 Cripto-specific antibodies
HK05105887.0A HK1072381A1 (en) 2002-03-22 2005-07-11 Cripto-specific antibodies cripto-specific
US11/799,361 US7674462B2 (en) 2001-04-26 2007-04-30 Cripto blocking antibodies and uses thereof
US12/317,476 US8003763B2 (en) 2001-04-26 2008-12-22 Cripto blocking antibodies and uses thereof
US12/353,913 US20090285818A1 (en) 2001-04-26 2009-01-14 Cripto Blocking Antibodies and Uses Thereof
JP2009020949A JP2009161539A (en) 2002-03-22 2009-01-30 Cripto-specific antibody
US12/415,659 US7888052B2 (en) 2001-04-26 2009-03-31 Cripto blocking antibodies and uses thereof
US13/213,499 US8673303B2 (en) 2001-04-26 2011-08-19 Cripto blocking antibodies and uses thereof

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US28678201P 2001-04-26 2001-04-26
US60/286,782 2001-04-26
US29302001P 2001-05-17 2001-05-17
US60/293,020 2001-05-17
US30109101P 2001-06-26 2001-06-26
US60/301,091 2001-06-26
US36700202P 2002-03-22 2002-03-22
US60/367,002 2002-03-22

Related Child Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2002/031462 Continuation WO2003083041A2 (en) 2001-04-26 2002-10-01 Cripto-specific antibodies
US10/693,538 Continuation US7531174B2 (en) 2001-04-26 2003-10-23 Cripto blocking antibodies and uses thereof
US10/945,853 Continuation US7582299B2 (en) 2001-04-26 2004-09-20 Cripto-specific antibodies

Publications (2)

Publication Number Publication Date
WO2002088170A2 WO2002088170A2 (en) 2002-11-07
WO2002088170A3 true WO2002088170A3 (en) 2003-12-24

Family

ID=27501437

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/011950 WO2002088170A2 (en) 2000-03-20 2002-04-17 Cripto blocking antibodies and uses thereof

Country Status (34)

Country Link
US (6) US7531174B2 (en)
EP (3) EP1974749B1 (en)
JP (4) JP4307845B2 (en)
KR (1) KR100592357B1 (en)
CN (1) CN100352501C (en)
AR (3) AR037223A1 (en)
AT (2) ATE533508T1 (en)
BG (1) BG108363A (en)
BR (1) BR0209254A (en)
CA (2) CA2443840C (en)
CL (1) CL2009002199A1 (en)
CY (1) CY1108960T1 (en)
CZ (1) CZ20033208A3 (en)
DE (1) DE60230868D1 (en)
DK (1) DK1390389T3 (en)
EA (1) EA007469B1 (en)
EE (1) EE200300528A (en)
ES (1) ES2321065T3 (en)
GE (1) GEP20074091B (en)
HK (1) HK1058935A1 (en)
HU (1) HUP0501113A3 (en)
IS (1) IS2662B (en)
MX (1) MXPA03009797A (en)
MY (2) MY157382A (en)
NO (1) NO20034805L (en)
NZ (1) NZ566268A (en)
PL (1) PL207087B1 (en)
PT (1) PT1390389E (en)
RS (2) RS20110024A (en)
SG (1) SG157951A1 (en)
SI (1) SI1390389T1 (en)
SK (1) SK14432003A3 (en)
TR (1) TR200301846T2 (en)
WO (1) WO2002088170A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9562049B2 (en) 2012-12-21 2017-02-07 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
US9567340B2 (en) 2012-12-21 2017-02-14 Medimmune Limited Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases

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WO2003083041A2 (en) * 2002-03-22 2003-10-09 Biogen, Inc. Cripto-specific antibodies
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