WO2002088170A2 - Cripto blocking antibodies and uses thereof - Google Patents
Cripto blocking antibodies and uses thereof Download PDFInfo
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- WO2002088170A2 WO2002088170A2 PCT/US2002/011950 US0211950W WO02088170A2 WO 2002088170 A2 WO2002088170 A2 WO 2002088170A2 US 0211950 W US0211950 W US 0211950W WO 02088170 A2 WO02088170 A2 WO 02088170A2
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- cripto
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims
Priority Applications (37)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MXPA03009797A MXPA03009797A (en) | 2001-04-26 | 2002-04-17 | Cripto blocking antibodies and uses thereof. |
EP02731384A EP1390389B1 (en) | 2001-04-26 | 2002-04-17 | Cripto blocking antibodies and uses thereof |
EA200301158A EA007469B1 (en) | 2001-04-26 | 2002-04-17 | Cripto blocking antibodies and uses thereof |
EEP200300528A EE200300528A (en) | 2001-04-26 | 2002-04-17 | Cripto protein blocking antibodies and their use |
CA2443840A CA2443840C (en) | 2001-04-26 | 2002-04-17 | Cripto blocking antibodies and uses thereof |
SI200230804T SI1390389T1 (en) | 2001-04-26 | 2002-04-17 | Cripto blocking antibodies and uses thereof |
YU84903A RS51635B (en) | 2001-04-26 | 2002-04-17 | Cripto blocking antibodies and uses thereof |
KR1020037014078A KR100592357B1 (en) | 2001-04-26 | 2002-04-17 | Cryptoblocking antibodies and uses thereof |
JP2002585468A JP4307845B2 (en) | 2001-04-26 | 2002-04-17 | Antibodies that block Cripto and uses thereof |
BRPI0209254-9A BR0209254A (en) | 2001-04-26 | 2002-04-17 | crypto blocking antibodies and uses thereof |
DE60230868T DE60230868D1 (en) | 2001-04-26 | 2002-04-17 | CRIPTOBLOCKING ANTIBODIES AND THEIR USE |
DK02731384T DK1390389T3 (en) | 2001-04-26 | 2002-04-17 | Crypto-blocking antibodies and uses thereof |
SK1443-2003A SK14432003A3 (en) | 2001-04-26 | 2002-04-17 | Cripto blocking antibodies and uses thereof |
HU0501113A HUP0501113A3 (en) | 2001-04-26 | 2002-04-17 | Cripto blocking antibodies and uses thereof |
IL15857302A IL158573A0 (en) | 2000-03-20 | 2002-04-17 | Cripto blocking antibodies and uses thereof |
AT02807155T ATE490981T1 (en) | 2002-03-22 | 2002-10-01 | CRIPTO-SPECIFIC ANTIBODIES |
DE60238559T DE60238559D1 (en) | 2002-03-22 | 2002-10-01 | CRIPT-SPECIFIC ANTIBODIES |
JP2003580477A JP2005520566A (en) | 2002-03-22 | 2002-10-01 | Cripto specific antibodies |
DK02807155.3T DK1494693T3 (en) | 2002-03-22 | 2002-10-01 | Crypto-specific antibodies |
AU2002334799A AU2002334799B2 (en) | 2001-04-26 | 2002-10-01 | Cripto-specific antibodies |
PCT/US2002/031462 WO2003083041A2 (en) | 2002-03-22 | 2002-10-01 | Cripto-specific antibodies |
EP02807155A EP1494693B1 (en) | 2002-03-22 | 2002-10-01 | Cripto-specific antibodies |
CA2480119A CA2480119C (en) | 2002-03-22 | 2002-10-01 | Cripto-specific antibodies |
PT02807155T PT1494693E (en) | 2002-03-22 | 2002-10-01 | Cripto-specific antibodies |
US10/693,538 US7531174B2 (en) | 2001-04-26 | 2003-10-23 | Cripto blocking antibodies and uses thereof |
IS6999A IS2662B (en) | 2001-04-26 | 2003-10-24 | Antibodies that block the Cripto protein and their use |
NO20034805A NO20034805L (en) | 2001-04-26 | 2003-10-27 | CRIPTO-blocking antibody and its use |
BG108363A BG108363A (en) | 2001-04-26 | 2003-11-14 | Cripto blocking antibodies and use thereof |
HK04101788.0A HK1058935A1 (en) | 2001-04-26 | 2004-03-11 | Cripto blocking antibodies and uses thereof |
US10/945,853 US7582299B2 (en) | 2001-04-26 | 2004-09-20 | Cripto-specific antibodies |
HK05105887.0A HK1072381A1 (en) | 2002-03-22 | 2005-07-11 | Cripto-specific antibodies cripto-specific |
US11/799,361 US7674462B2 (en) | 2001-04-26 | 2007-04-30 | Cripto blocking antibodies and uses thereof |
US12/317,476 US8003763B2 (en) | 2001-04-26 | 2008-12-22 | Cripto blocking antibodies and uses thereof |
US12/353,913 US20090285818A1 (en) | 2001-04-26 | 2009-01-14 | Cripto Blocking Antibodies and Uses Thereof |
JP2009020949A JP2009161539A (en) | 2002-03-22 | 2009-01-30 | Cripto-specific antibody |
US12/415,659 US7888052B2 (en) | 2001-04-26 | 2009-03-31 | Cripto blocking antibodies and uses thereof |
US13/213,499 US8673303B2 (en) | 2001-04-26 | 2011-08-19 | Cripto blocking antibodies and uses thereof |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28678201P | 2001-04-26 | 2001-04-26 | |
US60/286,782 | 2001-04-26 | ||
US29302001P | 2001-05-17 | 2001-05-17 | |
US60/293,020 | 2001-05-17 | ||
US30109101P | 2001-06-26 | 2001-06-26 | |
US60/301,091 | 2001-06-26 | ||
US36700202P | 2002-03-22 | 2002-03-22 | |
US60/367,002 | 2002-03-22 |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/031462 Continuation WO2003083041A2 (en) | 2001-04-26 | 2002-10-01 | Cripto-specific antibodies |
US10/693,538 Continuation US7531174B2 (en) | 2001-04-26 | 2003-10-23 | Cripto blocking antibodies and uses thereof |
US10/945,853 Continuation US7582299B2 (en) | 2001-04-26 | 2004-09-20 | Cripto-specific antibodies |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002088170A2 true WO2002088170A2 (en) | 2002-11-07 |
WO2002088170A3 WO2002088170A3 (en) | 2003-12-24 |
Family
ID=27501437
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/011950 WO2002088170A2 (en) | 2000-03-20 | 2002-04-17 | Cripto blocking antibodies and uses thereof |
Country Status (34)
Country | Link |
---|---|
US (6) | US7531174B2 (en) |
EP (3) | EP1974749B1 (en) |
JP (4) | JP4307845B2 (en) |
KR (1) | KR100592357B1 (en) |
CN (1) | CN100352501C (en) |
AR (3) | AR037223A1 (en) |
AT (2) | ATE533508T1 (en) |
BG (1) | BG108363A (en) |
BR (1) | BR0209254A (en) |
CA (2) | CA2443840C (en) |
CL (1) | CL2009002199A1 (en) |
CY (1) | CY1108960T1 (en) |
CZ (1) | CZ20033208A3 (en) |
DE (1) | DE60230868D1 (en) |
DK (1) | DK1390389T3 (en) |
EA (1) | EA007469B1 (en) |
EE (1) | EE200300528A (en) |
ES (1) | ES2321065T3 (en) |
GE (1) | GEP20074091B (en) |
HK (1) | HK1058935A1 (en) |
HU (1) | HUP0501113A3 (en) |
IS (1) | IS2662B (en) |
MX (1) | MXPA03009797A (en) |
MY (2) | MY157382A (en) |
NO (1) | NO20034805L (en) |
NZ (1) | NZ566268A (en) |
PL (1) | PL207087B1 (en) |
PT (1) | PT1390389E (en) |
RS (2) | RS20110024A (en) |
SG (1) | SG157951A1 (en) |
SI (1) | SI1390389T1 (en) |
SK (1) | SK14432003A3 (en) |
TR (1) | TR200301846T2 (en) |
WO (1) | WO2002088170A2 (en) |
Cited By (90)
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WO2005000899A2 (en) | 2003-06-27 | 2005-01-06 | Biogen Idec Ma Inc. | Modified binding molecules comprising connecting peptides |
EP1494693A2 (en) * | 2002-03-22 | 2005-01-12 | Biogen Inc. | Cripto-specific antibodies |
EP1670511A2 (en) * | 2003-09-15 | 2006-06-21 | Research Development Foundation | Cripto antagonism of activin and tgf-b signaling |
WO2006074397A2 (en) * | 2005-01-05 | 2006-07-13 | Biogen Idec Ma Inc. | Cripto binding molecules |
US7318924B2 (en) | 2001-03-26 | 2008-01-15 | The Austin Research Institute | Antibodies against cancer |
WO2008150530A2 (en) * | 2007-06-01 | 2008-12-11 | Biogen Idec Ma Inc. | Cripto binding molecules |
US7531174B2 (en) | 2001-04-26 | 2009-05-12 | Biogen Idec Ma Inc. | Cripto blocking antibodies and uses thereof |
US7582299B2 (en) | 2001-04-26 | 2009-09-01 | Biogen Idec Ma Inc. | Cripto-specific antibodies |
EP2260858A2 (en) | 2003-11-06 | 2010-12-15 | Seattle Genetics, Inc. | Monomethylvaline compounds capable of conjugation to ligands |
EP2286844A2 (en) | 2004-06-01 | 2011-02-23 | Genentech, Inc. | Antibody-drug conjugates and methods |
WO2011031870A1 (en) | 2009-09-09 | 2011-03-17 | Centrose, Llc | Extracellular targeted drug conjugates |
WO2011056983A1 (en) | 2009-11-05 | 2011-05-12 | Genentech, Inc. | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
WO2011130598A1 (en) | 2010-04-15 | 2011-10-20 | Spirogen Limited | Pyrrolobenzodiazepines and conjugates thereof |
EP2385069A2 (en) | 2003-11-12 | 2011-11-09 | Biogen Idec MA Inc. | Neonatal Fc rReceptor (FcRn)- binding polypeptide variants, dimeric Fc binding proteins and methods related thereto |
WO2011156328A1 (en) | 2010-06-08 | 2011-12-15 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
US8084026B2 (en) | 2005-01-05 | 2011-12-27 | Biogen Idec Ma Inc. | Multispecific binding molecules comprising connecting peptides |
WO2012074757A1 (en) | 2010-11-17 | 2012-06-07 | Genentech, Inc. | Alaninyl maytansinol antibody conjugates |
WO2012143496A2 (en) | 2011-04-21 | 2012-10-26 | Bayer Intellectual Property Gmbh | Novel binder-drug conjugates (adcs) and their use |
WO2012155019A1 (en) | 2011-05-12 | 2012-11-15 | Genentech, Inc. | Multiple reaction monitoring lc-ms/ms method to detect therapeutic antibodies in animal samples using framework signature pepides |
WO2013012733A1 (en) | 2011-07-15 | 2013-01-24 | Biogen Idec Ma Inc. | Heterodimeric fc regions, binding molecules comprising same, and methods relating thereto |
WO2013130093A1 (en) | 2012-03-02 | 2013-09-06 | Genentech, Inc. | Biomarkers for treatment with anti-tubulin chemotherapeutic compounds |
WO2014057074A1 (en) | 2012-10-12 | 2014-04-17 | Spirogen Sàrl | Pyrrolobenzodiazepines and conjugates thereof |
WO2014140862A2 (en) | 2013-03-13 | 2014-09-18 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
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