WO2002086452A3 - Selective deposition of materials on contoured surfaces - Google Patents

Selective deposition of materials on contoured surfaces Download PDF

Info

Publication number
WO2002086452A3
WO2002086452A3 PCT/US2002/009149 US0209149W WO02086452A3 WO 2002086452 A3 WO2002086452 A3 WO 2002086452A3 US 0209149 W US0209149 W US 0209149W WO 02086452 A3 WO02086452 A3 WO 02086452A3
Authority
WO
WIPO (PCT)
Prior art keywords
substrate
materials
fluid
deposited
recesses
Prior art date
Application number
PCT/US2002/009149
Other languages
French (fr)
Other versions
WO2002086452A2 (en
Inventor
Emanuele Ostuni
Christopher S Chen
Donald E Ingber
George M Whitesides
Original Assignee
Harvard College
Childrens Medical Center
Emanuele Ostuni
Christopher S Chen
Donald E Ingber
George M Whitesides
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, Childrens Medical Center, Emanuele Ostuni, Christopher S Chen, Donald E Ingber, George M Whitesides filed Critical Harvard College
Priority to AU2002306862A priority Critical patent/AU2002306862A1/en
Publication of WO2002086452A2 publication Critical patent/WO2002086452A2/en
Priority to US10/668,679 priority patent/US7288394B2/en
Publication of WO2002086452A3 publication Critical patent/WO2002086452A3/en
Priority to US11/901,277 priority patent/US20080145908A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5088—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above confining liquids at a location by surface tension, e.g. virtual wells on plates, wires
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00617—Delimitation of the attachment areas by chemical means
    • B01J2219/00619—Delimitation of the attachment areas by chemical means using hydrophilic or hydrophobic regions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/0074—Biological products
    • B01J2219/00743—Cells
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815—Carrier is a synthetic polymer

Abstract

A material is selectively deposited on substrate having a contoured surface including protrusions and recesses. A first fluid is applied to the surface to contact the protrusions and not the recesses, and a first material is deposited on the substrate where the substrate is in contact with the fluid. A second fluid may be applied to contact the recesses, and a second material is deposited on the substrate where the substrate is in contact with the fluid. A third fluid may be applied, and a third material having affinity for one of the first and second materials is deposited only where one of the first and second materials is deposited. The first and second material may be a protein, and the first, second and third materials may respectively be cytophobic, cytophilic and a cell. The substrate may be formed of a polymer such as polydimethylsiloxane. A cell containment device is provided containing the substrate with a cytophobic material connected to the protrusions and a cytophilic material connected to the recesses.
PCT/US2002/009149 2001-03-23 2002-03-25 Selective deposition of materials on contoured surfaces WO2002086452A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2002306862A AU2002306862A1 (en) 2001-03-23 2002-03-25 Selective deposition of materials on contoured surfaces
US10/668,679 US7288394B2 (en) 2001-03-23 2003-09-23 Selective deposition of materials on countoured surfaces
US11/901,277 US20080145908A1 (en) 2001-03-23 2007-09-14 Selective deposition of materials on contoured surfaces

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27809201P 2001-03-23 2001-03-23
US60/278,092 2001-03-23

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US27809201P Continuation 2001-03-23 2001-03-23

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/668,679 Continuation US7288394B2 (en) 2001-03-23 2003-09-23 Selective deposition of materials on countoured surfaces

Publications (2)

Publication Number Publication Date
WO2002086452A2 WO2002086452A2 (en) 2002-10-31
WO2002086452A3 true WO2002086452A3 (en) 2003-11-27

Family

ID=23063650

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/009149 WO2002086452A2 (en) 2001-03-23 2002-03-25 Selective deposition of materials on contoured surfaces

Country Status (3)

Country Link
US (2) US7288394B2 (en)
AU (1) AU2002306862A1 (en)
WO (1) WO2002086452A2 (en)

Families Citing this family (22)

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US7329489B2 (en) 2000-04-14 2008-02-12 Matabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
WO2001078652A2 (en) 2000-04-14 2001-10-25 Metabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
AU2002306862A1 (en) 2001-03-23 2002-11-05 Children's Medical Center Corporation Selective deposition of materials on contoured surfaces
WO2004032228A2 (en) * 2002-09-30 2004-04-15 Siemens Aktiengesellschaft Substrate with a planar surface section, method for the production of a material film on the surface section of the substrate and use of said substrate
US9005549B2 (en) 2003-01-17 2015-04-14 Greiner Bio-One Gmbh High throughput polymer-based microarray slide
EP1514920A1 (en) 2003-09-12 2005-03-16 Institut Curie Methods and device for adhesive control of internal cell organisation
WO2005078425A1 (en) * 2004-02-04 2005-08-25 The Johns Hopkins University Methods and systems for producing arrays of particles
US8383378B2 (en) * 2005-10-10 2013-02-26 The Regents Of The University Of California Micro-bubble plate for patterning biological and non-biological materials
GB0523713D0 (en) * 2005-11-22 2005-12-28 Cavendish Kinetics Ltd Enclosure method
US8849577B2 (en) 2006-09-15 2014-09-30 Metabolon, Inc. Methods of identifying biochemical pathways
US20090061513A1 (en) * 2007-05-15 2009-03-05 Picovitro Ab Cell sorting and cell cultivation methods
US8748085B2 (en) * 2007-07-25 2014-06-10 The Regents Of The University Of California Use of photosensitized Epon epoxy resin 1002F for MEMS and bioMEMS applications
US9487745B2 (en) 2007-07-27 2016-11-08 The Regents Of The University Of California Micro-patterned plate composed of an array of releasable elements surrounded with solid or gel walls
EP2219027A1 (en) * 2009-02-12 2010-08-18 Centre National de la Recherche Scientifique Devices and methods for observing the cell division
EP2485050B1 (en) 2011-02-07 2015-04-01 Commissariat à l'Énergie Atomique et aux Énergies Alternatives Use of micropatterned soft substrate for measuring of cell traction forces
US20140161342A1 (en) 2011-07-20 2014-06-12 Centre National De La Recherche Scientifique Cnrs Density-based method of comparing images and detection of morphological changes using the method thereof
CN102352053B (en) * 2011-10-13 2013-01-09 吉林大学 Method for constructing protein patterning structure based on polymer film
CN104334273B (en) * 2012-03-16 2016-12-07 生命技术公司 Coated substrate for bio-reaction system
WO2013181506A1 (en) * 2012-05-31 2013-12-05 The University Of North Carolina At Chapel Hill Dissolution guided wetting of structured surfaces
US11022888B2 (en) * 2017-11-01 2021-06-01 Syracuse University Synthesis of superhydrophobic microporous surfaces via light-directed photopolymerization and phase separation
JP7322384B2 (en) * 2018-11-17 2023-08-08 東洋製罐グループホールディングス株式会社 MEDIUM FILLING LIQUID, MEDIUM FILLING METHOD, CULTURE CONTAINER, AND AIR BUBBLE REMOVAL DEVICE FOR MEDIUM FILLING
US11717202B2 (en) 2019-04-10 2023-08-08 Foothold Labs Inc. Mobile lab-on-a-chip diagnostic system

Citations (5)

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US5512131A (en) * 1993-10-04 1996-04-30 President And Fellows Of Harvard College Formation of microstamped patterns on surfaces and derivative articles
US5900160A (en) * 1993-10-04 1999-05-04 President And Fellows Of Harvard College Methods of etching articles via microcontact printing
US5976826A (en) * 1993-10-04 1999-11-02 President And Fellows Of Harvard College Device containing cytophilic islands that adhere cells separated by cytophobic regions
US6001587A (en) * 1997-04-08 1999-12-14 The United States Of America As Represented By The Secretary Of The Navy Chemically specific patterning on solid surfaces using surface immobilized enzymes
US6180239B1 (en) * 1993-10-04 2001-01-30 President And Fellows Of Harvard College Microcontact printing on surfaces and derivative articles

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WO1996029629A2 (en) 1995-03-01 1996-09-26 President And Fellows Of Harvard College Microcontact printing on surfaces and derivative articles
WO1997007429A1 (en) * 1995-08-18 1997-02-27 President And Fellows Of Harvard College Self-assembled monolayer directed patterning of surfaces
JP2002512124A (en) 1998-04-21 2002-04-23 プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ Use in the manufacture of devices including elastomeric masks and pixelated electroluminescent displays
JP2003527615A (en) * 2000-03-17 2003-09-16 プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ Cell patterning technology
AU2002306862A1 (en) 2001-03-23 2002-11-05 Children's Medical Center Corporation Selective deposition of materials on contoured surfaces

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5512131A (en) * 1993-10-04 1996-04-30 President And Fellows Of Harvard College Formation of microstamped patterns on surfaces and derivative articles
US5900160A (en) * 1993-10-04 1999-05-04 President And Fellows Of Harvard College Methods of etching articles via microcontact printing
US5976826A (en) * 1993-10-04 1999-11-02 President And Fellows Of Harvard College Device containing cytophilic islands that adhere cells separated by cytophobic regions
US6180239B1 (en) * 1993-10-04 2001-01-30 President And Fellows Of Harvard College Microcontact printing on surfaces and derivative articles
US6001587A (en) * 1997-04-08 1999-12-14 The United States Of America As Represented By The Secretary Of The Navy Chemically specific patterning on solid surfaces using surface immobilized enzymes

Also Published As

Publication number Publication date
AU2002306862A1 (en) 2002-11-05
US7288394B2 (en) 2007-10-30
US20040171135A1 (en) 2004-09-02
US20080145908A1 (en) 2008-06-19
WO2002086452A2 (en) 2002-10-31

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