WO2002085284A3 - Expandable foam-like biomaterials and methods - Google Patents

Expandable foam-like biomaterials and methods Download PDF

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Publication number
WO2002085284A3
WO2002085284A3 PCT/US2001/042987 US0142987W WO02085284A3 WO 2002085284 A3 WO2002085284 A3 WO 2002085284A3 US 0142987 W US0142987 W US 0142987W WO 02085284 A3 WO02085284 A3 WO 02085284A3
Authority
WO
WIPO (PCT)
Prior art keywords
biomaterial
foam
expandable foam
site
reaction product
Prior art date
Application number
PCT/US2001/042987
Other languages
French (fr)
Other versions
WO2002085284A2 (en
Inventor
K Umit Yuksel
Ana T Bird
Kirby S Black
Original Assignee
Cryolife Inc
K Umit Yuksel
Ana T Bird
Kirby S Black
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cryolife Inc, K Umit Yuksel, Ana T Bird, Kirby S Black filed Critical Cryolife Inc
Priority to AU2001297782A priority Critical patent/AU2001297782B2/en
Priority to JP2002582860A priority patent/JP4199004B2/en
Priority to ES01273879.5T priority patent/ES2662594T3/en
Priority to EP01273879.5A priority patent/EP1416946B1/en
Priority to CA2425935A priority patent/CA2425935C/en
Publication of WO2002085284A2 publication Critical patent/WO2002085284A2/en
Publication of WO2002085284A3 publication Critical patent/WO2002085284A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products

Abstract

Liquid, injectable, aqueous solutions are transformed in situ to an expandable foam-like, space filling, and adherent biomaterial. Preferably, the foam-like biomaterial is the reaction product of a two-part liquid system to achieve the in situ formation thereof. The liquid system is generally comprised of a protein solution and a cross linker solution which may either be premixed and then applied to a site in need of the biomaterial, or simultaneously mixed and delivered through an in-line mixing/dispensing tip directly to the site. In especially preferred embodiments, an expandable foam-like biomaterial includes the reaction product of human or animal-derived protein material and a di- or polyaldehyde in the presence of a bicarbonate and an acidic titrant amounts sufficient to impart a cellular foam structure to the material.
PCT/US2001/042987 2000-11-07 2001-11-07 Expandable foam-like biomaterials and methods WO2002085284A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2001297782A AU2001297782B2 (en) 2000-11-07 2001-11-07 Expandable foam-like biomaterials and methods
JP2002582860A JP4199004B2 (en) 2000-11-07 2001-11-07 Foamable foam-like biomaterial and method
ES01273879.5T ES2662594T3 (en) 2000-11-07 2001-11-07 Expandable foamed biomaterials and methods.
EP01273879.5A EP1416946B1 (en) 2000-11-07 2001-11-07 Expandable foam-like biomaterials and methods
CA2425935A CA2425935C (en) 2000-11-07 2001-11-07 Expandable foam-like biomaterials and methods

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24606300P 2000-11-07 2000-11-07
US60/246,063 2000-11-07

Publications (2)

Publication Number Publication Date
WO2002085284A2 WO2002085284A2 (en) 2002-10-31
WO2002085284A3 true WO2002085284A3 (en) 2004-02-26

Family

ID=22929185

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/042987 WO2002085284A2 (en) 2000-11-07 2001-11-07 Expandable foam-like biomaterials and methods

Country Status (7)

Country Link
US (3) US7226615B2 (en)
EP (1) EP1416946B1 (en)
JP (1) JP4199004B2 (en)
AU (1) AU2001297782B2 (en)
CA (1) CA2425935C (en)
ES (1) ES2662594T3 (en)
WO (1) WO2002085284A2 (en)

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Also Published As

Publication number Publication date
WO2002085284A2 (en) 2002-10-31
AU2001297782B2 (en) 2006-03-02
JP2004537136A (en) 2004-12-09
EP1416946B1 (en) 2017-12-20
US7226615B2 (en) 2007-06-05
US8071124B2 (en) 2011-12-06
US20020059001A1 (en) 2002-05-16
JP4199004B2 (en) 2008-12-17
ES2662594T3 (en) 2018-04-09
CA2425935C (en) 2011-03-29
CA2425935A1 (en) 2002-10-31
US20050163819A1 (en) 2005-07-28
EP1416946A2 (en) 2004-05-12
EP1416946A4 (en) 2009-10-28
US8057818B2 (en) 2011-11-15
US20050158364A1 (en) 2005-07-21

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