WO2002083869A3 - Product and process for transformation of thraustochytriales microorganisms - Google Patents
Product and process for transformation of thraustochytriales microorganisms Download PDFInfo
- Publication number
- WO2002083869A3 WO2002083869A3 PCT/US2002/012040 US0212040W WO02083869A3 WO 2002083869 A3 WO2002083869 A3 WO 2002083869A3 US 0212040 W US0212040 W US 0212040W WO 02083869 A3 WO02083869 A3 WO 02083869A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- thraustochytriales
- transformation
- microorganisms
- promoter
- thraustochytriales microorganisms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y202/00—Transferases transferring aldehyde or ketonic groups (2.2)
- C12Y202/01—Transketolases and transaldolases (2.2.1)
- C12Y202/01006—Acetolactate synthase (2.2.1.6)
Abstract
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10178886.7A EP2325319B1 (en) | 2001-04-16 | 2002-04-16 | Product and process for transformation of Thraustochytriales microorganisms |
JP2002582208A JP4536324B2 (en) | 2001-04-16 | 2002-04-16 | Products and Methods for Transformation of Trout Chitriales Microorganisms |
AT02719515T ATE533844T1 (en) | 2001-04-16 | 2002-04-16 | ACETOLACTATE SYNTHASE AND METHOD FOR TRANSFORMING THRAUSTOCHYTRIALES MICROORGANISMS |
CN028120590A CN1556850B (en) | 2001-04-16 | 2002-04-16 | Product and process for transformation of thraustochytriales microorganisms |
ES02719515T ES2377557T3 (en) | 2001-04-16 | 2002-04-16 | Acetolactate synthase and procedure for the transformation of Thraustochytriales microorganisms |
EP02719515A EP1414941B1 (en) | 2001-04-16 | 2002-04-16 | Acetolactate synthase and process for transformation of thraustochytriales microorganisms |
CA2443908A CA2443908C (en) | 2001-04-16 | 2002-04-16 | Product and process for transformation of thraustochytriales microorganisms |
AU2002250592A AU2002250592C1 (en) | 2001-04-16 | 2002-04-16 | Product and process for transformation of thraustochytriales microorganisms |
EP10178911.3A EP2314706B1 (en) | 2001-04-16 | 2002-04-16 | Promotor and process for transformation of thraustochytriales microorganisms |
HK04108611.8A HK1065819A1 (en) | 2001-04-16 | 2004-11-02 | Acetolactate synthase and process for transformation of thraustochytriales microorganisms |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28411601P | 2001-04-16 | 2001-04-16 | |
US60/284,116 | 2001-04-16 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2002083869A2 WO2002083869A2 (en) | 2002-10-24 |
WO2002083869A3 true WO2002083869A3 (en) | 2004-02-26 |
WO2002083869A9 WO2002083869A9 (en) | 2004-05-21 |
Family
ID=23088908
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/012040 WO2002083869A2 (en) | 2001-04-16 | 2002-04-16 | Product and process for transformation of thraustochytriales microorganisms |
Country Status (11)
Country | Link |
---|---|
US (5) | US7001772B2 (en) |
EP (3) | EP2325319B1 (en) |
JP (4) | JP4536324B2 (en) |
CN (3) | CN1556850B (en) |
AT (1) | ATE533844T1 (en) |
AU (1) | AU2002250592C1 (en) |
CA (1) | CA2443908C (en) |
ES (3) | ES2377557T3 (en) |
HK (2) | HK1065819A1 (en) |
TW (3) | TWI324181B (en) |
WO (1) | WO2002083869A2 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7807849B2 (en) | 2004-04-22 | 2010-10-05 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
US7834250B2 (en) | 2004-04-22 | 2010-11-16 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
US8816111B2 (en) | 2012-06-15 | 2014-08-26 | Commonwealth Scientific And Industrial Research Organisation | Lipid comprising polyunsaturated fatty acids |
US10005713B2 (en) | 2014-06-27 | 2018-06-26 | Commonwealth Scientific And Industrial Research Organisation | Lipid compositions comprising triacylglycerol with long-chain polyunsaturated fatty acids at the sn-2 position |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6566583B1 (en) * | 1997-06-04 | 2003-05-20 | Daniel Facciotti | Schizochytrium PKS genes |
US7217856B2 (en) * | 1999-01-14 | 2007-05-15 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
US20070244192A1 (en) * | 1999-01-14 | 2007-10-18 | Martek Biosciences Corporation | Plant seed oils containing polyunsaturated fatty acids |
US7211418B2 (en) * | 1999-01-14 | 2007-05-01 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
US7247461B2 (en) * | 1999-01-14 | 2007-07-24 | Martek Biosciences Corporation | Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof |
US8003772B2 (en) | 1999-01-14 | 2011-08-23 | Martek Biosciences Corporation | Chimeric PUFA polyketide synthase systems and uses thereof |
TWI324181B (en) | 2001-04-16 | 2010-05-01 | Martek Biosciences Corp | Product and process for transformation of thraustochytriales microorganisms |
US7211656B2 (en) † | 2002-01-30 | 2007-05-01 | Abbott Laboratories | Desaturase genes, enzymes encoded thereby, and uses thereof |
AU2003290453A1 (en) * | 2002-12-20 | 2004-07-14 | Chromagenics B.V. | Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors |
US7208590B2 (en) * | 2003-07-15 | 2007-04-24 | Abbott Laboratories | Genes involved in polyketide synthase pathways and uses thereof |
US20100136616A1 (en) * | 2004-11-08 | 2010-06-03 | Chromagenics B.V. | Selection of Host Cells Expressing Protein at High Levels |
US8999667B2 (en) * | 2004-11-08 | 2015-04-07 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
US20060195935A1 (en) | 2004-11-08 | 2006-08-31 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
CA2581422C (en) * | 2004-11-08 | 2012-05-22 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
NZ553700A (en) * | 2004-11-08 | 2010-09-30 | Chromagenics Bv | Selection of host cells expressing protein at high levels using a selectable marker with a non-optimal start codon |
JP4796786B2 (en) * | 2005-04-28 | 2011-10-19 | 富士フイルム株式会社 | A vector capable of transforming Labyrinthula |
JP4796787B2 (en) * | 2005-04-28 | 2011-10-19 | 富士フイルム株式会社 | Gene transfer to Labyrinthula |
CA2611324C (en) | 2005-06-07 | 2017-02-14 | Ocean Nutrition Canada Limited | Eukaryotic microorganisms for producing lipids and antioxidants |
EP1957641A2 (en) | 2005-11-23 | 2008-08-20 | E.I. Du Pont De Nemours And Company | Delta-9 elongases and their use in making polyunsaturated fatty acids |
EP1818411A1 (en) | 2006-02-13 | 2007-08-15 | Lonza AG | Process for the preparation of optically active chiral amines |
KR101524398B1 (en) * | 2006-03-15 | 2015-06-04 | 디에스엠 아이피 어셋츠 비.브이. | Polyunsaturated Fatty Acid Production in Heterologous Organisms Using PUFA Polyketide Synthase Systems |
TW200806184A (en) * | 2006-04-11 | 2008-02-01 | Martek Biosciences Corp | Food products comprising long chain polyunsaturated fatty acids and methods for preparing the same |
EP2034973B2 (en) | 2006-06-22 | 2022-01-19 | DSM IP Assets B.V. | Encapsulated labile compound compositions and methods of making the same |
CN101981201A (en) * | 2006-08-01 | 2011-02-23 | 加拿大海洋营养食品有限公司 | Oil producing microbes and methods of modification thereof |
US8816106B2 (en) | 2006-08-29 | 2014-08-26 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of fatty acids |
BRPI0714732A2 (en) | 2006-08-29 | 2014-09-23 | Martek Biosciences Corp | Use of DPA (n-6) Oils in Infant Formula |
KR100860111B1 (en) * | 2006-10-02 | 2008-09-25 | 인제대학교 산학협력단 | Newly isolated Thraustochytrium sp. KJS-1, Bacillus polyfermenticus KJS-2 and Feed additives for cultivated fish including Thraustochytrium sp. KJS-1, Bacillus polyfermenticus KJS-2 and Bacillus licheniformis, Feed containing above feed additives |
PL2390339T3 (en) | 2006-10-23 | 2013-12-31 | Du Pont | Delta-8 desaturases and their use in making polyunsaturated fatty acids |
US8188338B2 (en) | 2007-04-10 | 2012-05-29 | E. I. Du Pont De Nemours And Company | Delta-8 desaturases and their use in making polyunsaturated fatty acids |
US7794701B2 (en) | 2007-04-16 | 2010-09-14 | E.I. Du Pont De Nemours And Company | Δ-9 elongases and their use in making polyunsaturated fatty acids |
US7943365B2 (en) | 2007-05-03 | 2011-05-17 | E.I. Du Pont De Nemours And Company | Δ-5 desaturases and their use in making polyunsaturated fatty acids |
MX2010000263A (en) * | 2007-06-29 | 2010-03-11 | Martek Biosciences Corp | Production and purification of esters of polyunsaturated fatty acids. |
JP2010538642A (en) | 2007-09-12 | 2010-12-16 | マーテック バイオサイエンシーズ コーポレーション | Biological oil and its production and use |
US20110076379A1 (en) * | 2008-06-13 | 2011-03-31 | Means Michael M | High omega saturated fat free meat products |
AR074364A1 (en) | 2008-11-18 | 2011-01-12 | Commw Scient Ind Res Org | ENZYMES AND METHOD TO PRODUCE OMEGA FATTY ACIDS -3 |
EP2358862B1 (en) | 2008-12-18 | 2017-08-02 | E. I. du Pont de Nemours and Company | Reducing byproduction of malonates in a fermentation process |
JP5415896B2 (en) | 2009-01-29 | 2014-02-12 | Jfeスチール株式会社 | Indirect spot welding method |
AU2010225930B2 (en) | 2009-03-16 | 2017-01-12 | Dsm Ip Assets B.V. | Protein production in microorganisms of the phylum Labyrinthulomycota |
CA2755639C (en) | 2009-03-19 | 2018-09-25 | Martek Biosciences Corporation | Polyunsaturated fatty acid synthase nucleic acid molecules and polypeptides, compositions, and methods of making and uses thereof |
US8207363B2 (en) | 2009-03-19 | 2012-06-26 | Martek Biosciences Corporation | Thraustochytrids, fatty acid compositions, and methods of making and uses thereof |
EP2443248B1 (en) | 2009-06-16 | 2017-12-27 | E. I. du Pont de Nemours and Company | IMPROVEMENT OF LONG CHAIN OMEGA-3 AND OMEGA-6 POLYUNSATURATED FATTY ACID BIOSYNTHESIS BY EXPRESSION OF ACYL-CoA LYSOPHOSPHOLIPID ACYLTRANSFERASES |
KR20170116226A (en) * | 2009-09-24 | 2017-10-18 | 고쿠리쓰다이가쿠호진 규슈다이가쿠 | Method for transforming stramenopile |
WO2011090708A2 (en) * | 2009-12-28 | 2011-07-28 | Merial Limited | Recombinant ndv antigen and uses thereof |
IN2012DN06277A (en) * | 2009-12-28 | 2015-09-25 | Dsm Ip Assets Bv | |
ES2651313T3 (en) * | 2009-12-28 | 2018-01-25 | Dsm Ip Assets B.V. | Recombinant traustoquids growing in xylose, and compositions, methods of preparation and uses thereof |
CN107858297A (en) * | 2009-12-28 | 2018-03-30 | Dsm Ip资产公司 | Restructuring thraustochytriale and its composition, the Preparation method and use grown on sucrose |
CN103068984B (en) * | 2009-12-28 | 2017-12-01 | Dsm Ip资产公司 | The production of hemagglutinin neuraminidase albumen in microalgae |
KR20150013667A (en) | 2010-01-19 | 2015-02-05 | 디에스엠 아이피 어셋츠 비.브이. | Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof |
AU2011224188B2 (en) | 2010-03-12 | 2015-01-22 | Boehringer Ingelheim Animal Health USA Inc. | Bluetongue virus recombinant vaccines and uses thereof |
WO2012027698A1 (en) | 2010-08-26 | 2012-03-01 | E.I. Du Pont De Nemours And Company | Mutant hpgg motif and hdash motif delta-5 desaturases and their use in making polyunsaturated fatty acids |
BR112013004356A2 (en) | 2010-08-26 | 2017-06-27 | Du Pont | isolated polynucleotide, mutant polypeptide, recombinant construct, transformed cell, method for producing a polyunsaturated fatty acid, microbial oil and recombinant microbial host cell. |
AU2012226528B2 (en) * | 2011-03-07 | 2015-08-20 | Dsm Nutritional Products Ag | Engineering thraustochytrid microorganisms |
CN108771240A (en) | 2011-07-21 | 2018-11-09 | 帝斯曼知识产权资产管理有限公司 | Aliphatic acid composition |
US9347075B2 (en) | 2012-06-19 | 2016-05-24 | E I Du Pont De Nemours And Company | Nucleic acids encoding mutant acyl-CoA:lysophosphatidylcholine acyltransferases |
PT2970926T (en) | 2013-03-13 | 2018-03-22 | Dsm Nutritional Products Ag | Engineering microorganisms |
WO2015089587A1 (en) | 2013-12-18 | 2015-06-25 | Commonwealth Scientific And Industrial Research Organisation | Lipid comprising long chain polyunsaturated fatty acids |
CN105567715B (en) * | 2014-10-17 | 2021-06-29 | 丰益(上海)生物技术研发中心有限公司 | Schizochytrium limacinum alpha-tubulin related sequence and application thereof |
EP3265567B1 (en) | 2015-03-02 | 2020-07-29 | Conagen Inc. | Regulatory elements from labyrinthulomycetes microorganisms |
AR104042A1 (en) | 2015-03-26 | 2017-06-21 | Mara Renewables Corp | HIGH-DENSITY PRODUCTION OF BIOMASS AND OIL USING GLUCEROL IN GROSS |
PL3302032T3 (en) | 2015-06-06 | 2022-06-20 | Dsm Ip Assets B.V. | Production of polyunsaturated fatty acids (pufas) using a novel modular docosahexaenoic acid (dha) synthase |
US10542961B2 (en) | 2015-06-15 | 2020-01-28 | The Research Foundation For The State University Of New York | System and method for infrasonic cardiac monitoring |
MX2018000502A (en) * | 2015-07-13 | 2018-09-07 | Mara Renewables Corp | Enhancing microalgal metabolism of xylose. |
IL241462A0 (en) | 2015-09-10 | 2015-11-30 | Yeda Res & Dev | Heterologous engineering of betalain pigments in plants |
WO2017161005A1 (en) | 2016-03-16 | 2017-09-21 | Synthetic Genomics, Inc. | Production of proteins in labyrinthulomycetes |
CN109477079A (en) * | 2016-05-12 | 2019-03-15 | 帝斯曼知识产权资产管理有限公司 | Increase the method for omega-3 polyunsaturated fatty acids yield in microalgae |
US10851395B2 (en) | 2016-06-10 | 2020-12-01 | MARA Renewables Corporation | Method of making lipids with improved cold flow properties |
EP3484994A4 (en) | 2016-07-13 | 2020-01-22 | DSM IP Assets B.V. | A crispr-cas system for an algal host cell |
IL247752A0 (en) | 2016-09-11 | 2016-11-30 | Yeda Res & Dev | Compositions and methods for regulating gene expression for targeted mutagenesis |
US10633454B2 (en) | 2016-11-01 | 2020-04-28 | Conagen Inc. | Expression of modified glycoproteins and glycopeptides |
WO2019078359A1 (en) | 2017-10-19 | 2019-04-25 | 味の素株式会社 | Method for producing sterol |
CN111954713A (en) * | 2018-03-05 | 2020-11-17 | 科纳根公司 | Organisms and methods for producing sugar molecules with low sulfation |
CN112074608A (en) * | 2018-05-01 | 2020-12-11 | 科纳根公司 | Recombinant organisms and methods for producing sugar molecules with high glycan occupancy |
US11613728B2 (en) * | 2018-08-10 | 2023-03-28 | Kyowa Hakko Bio Co., Ltd. | Microorganism producing eicosapentaenoic acid and method for producing eicosapentaenoic acid |
CN109777815B (en) * | 2019-03-28 | 2021-10-29 | 昆明理工大学 | HMG-CoA synthetase gene RKHMGCS and application thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0257993A2 (en) * | 1986-08-26 | 1988-03-02 | E.I. Du Pont De Nemours And Company | Nucleic acid fragment encoding herbicide resistant plant acetolactate synthase |
US5605011A (en) * | 1986-08-26 | 1997-02-25 | E. I. Du Pont De Nemours And Company | Nucleic acid fragment encoding herbicide resistant plant acetolactate synthase |
US5853973A (en) * | 1995-04-20 | 1998-12-29 | American Cyanamid Company | Structure based designed herbicide resistant products |
Family Cites Families (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE545283A (en) | ||||
LU35839A1 (en) | ||||
US3223456A (en) * | 1963-11-14 | 1965-12-14 | Siemens Ag | Conveying apparatus for fine-granular material |
US4381897A (en) * | 1980-10-06 | 1983-05-03 | Krupp Polysius Ag | Installation for transporting fine-grained material |
US4626505A (en) * | 1984-02-24 | 1986-12-02 | E. I. Du Pont De Nemours And Company | Selectable markers for yeast transformation |
US5130242A (en) * | 1988-09-07 | 1992-07-14 | Phycotech, Inc. | Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids |
US5340742A (en) | 1988-09-07 | 1994-08-23 | Omegatech Inc. | Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids |
US5426040A (en) * | 1989-08-17 | 1995-06-20 | Northeastern University | Methods for producing improved strains of seaweed by fusion of spore-protoplasts, and resultant seaweeds and phycocolloids |
IL100908A0 (en) | 1991-02-22 | 1992-11-15 | Salk Inst Biotech Ind | Invertase genes and their use |
US5804408A (en) * | 1991-03-13 | 1998-09-08 | Yoshihide Hagiwara | Expression of human SOD in blue green algae |
US5661017A (en) * | 1993-09-14 | 1997-08-26 | Dunahay; Terri Goodman | Method to transform algae, materials therefor, and products produced thereby |
IL113375A (en) * | 1995-04-13 | 1997-09-30 | Fortress U & T Ltd | Internationally regulated system for one to one cryptographic communications with national sovereignty without key escrow |
US6576455B1 (en) * | 1995-04-20 | 2003-06-10 | Basf Corporation | Structure-based designed herbicide resistant products |
DE19529475A1 (en) * | 1995-08-11 | 1997-02-13 | Marcus Weis | Sieve for separating fibre and fibre containing material from mixture - using channel shaped sieves with progressively larger mesh making use of fibre property to form clouds during certain movement patterns |
WO1997020854A1 (en) | 1995-12-05 | 1997-06-12 | University Of Massachusetts | Recombinant gas vesicles and uses thereof |
US6027900A (en) * | 1996-04-12 | 2000-02-22 | Carnegie Institution Of Washington | Methods and tools for transformation of eukaryotic algae |
US6194167B1 (en) * | 1997-02-18 | 2001-02-27 | Washington State University Research Foundation | ω-3 fatty acid desaturase |
US5968809A (en) * | 1997-04-11 | 1999-10-19 | Abbot Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
ES2125195B1 (en) | 1997-04-18 | 1999-10-01 | Antibioticos Sa | INACTIVATION PROCEDURE OF GENES CODING FOR ENZYMES OF PHENYLACETATE CATABOLISM, INTERVENING PLASMIDS AND STRAINS TRANSFORMED WITH THEM. |
US7247461B2 (en) * | 1999-01-14 | 2007-07-24 | Martek Biosciences Corporation | Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof |
US8003772B2 (en) | 1999-01-14 | 2011-08-23 | Martek Biosciences Corporation | Chimeric PUFA polyketide synthase systems and uses thereof |
FR2791699B1 (en) * | 1999-03-29 | 2004-10-29 | Meristem Therapeutics | CHIMERIC EXPRESSION PROMOTERS, EXPRESSION CASSETTES, VECTORS, TRANSGENIC PLANTS AND SEEDS CONTAINING THEM, AND METHODS OF OBTAINING THEM |
KR20000075076A (en) * | 1999-05-28 | 2000-12-15 | 최태진 | A method for production of foreign protein using transformed microalgae |
EP2322644A1 (en) | 2000-06-28 | 2011-05-18 | GlycoFi, Inc. | Methods for producing modified glycoproteins |
US7625756B2 (en) | 2000-06-28 | 2009-12-01 | GycoFi, Inc. | Expression of class 2 mannosidase and class III mannosidase in lower eukaryotic cells |
US20060029604A1 (en) | 2000-06-28 | 2006-02-09 | Gerngross Tillman U | Immunoglobulins comprising predominantly a GlcNAc2Man3GlcNAc2 glycoform |
US20060257399A1 (en) | 2000-06-28 | 2006-11-16 | Glycofi, Inc. | Immunoglobulins comprising predominantly a Man5GIcNAc2 glycoform |
US7795002B2 (en) | 2000-06-28 | 2010-09-14 | Glycofi, Inc. | Production of galactosylated glycoproteins in lower eukaryotes |
CN105483142A (en) * | 2000-09-28 | 2016-04-13 | 生物源食物及科学公司 | FAD4, FAD5, FAD5-2, and FAD6, novel fatty acid desaturase family members and uses thereof |
US6419425B1 (en) * | 2001-02-28 | 2002-07-16 | Neu Transf'air | Granular material distributing apparatus comprising at least two transfer vessels that operate in alternation |
TWI324181B (en) * | 2001-04-16 | 2010-05-01 | Martek Biosciences Corp | Product and process for transformation of thraustochytriales microorganisms |
US7332299B2 (en) | 2003-02-20 | 2008-02-19 | Glycofi, Inc. | Endomannosidases in the modification of glycoproteins in eukaryotes |
EP1629004B1 (en) | 2003-06-05 | 2008-08-13 | Wyeth Holdings Corporation | Immunogenic compositions comprising venezuelan equine encephalitis virus replicon vectors and paramyxovirus protein antigens |
JP4796786B2 (en) | 2005-04-28 | 2011-10-19 | 富士フイルム株式会社 | A vector capable of transforming Labyrinthula |
JP4796787B2 (en) | 2005-04-28 | 2011-10-19 | 富士フイルム株式会社 | Gene transfer to Labyrinthula |
PT103331A (en) | 2005-08-05 | 2007-02-28 | Fundacao Da Faculdade De Cienc | EXPRESSION OF AN ACTIVE CONVEYOR OF XYLOSIS IN SACCHAROMYCES CEREVISIAE GENETICALLY MODIFIED |
KR101524398B1 (en) | 2006-03-15 | 2015-06-04 | 디에스엠 아이피 어셋츠 비.브이. | Polyunsaturated Fatty Acid Production in Heterologous Organisms Using PUFA Polyketide Synthase Systems |
CN101981201A (en) | 2006-08-01 | 2011-02-23 | 加拿大海洋营养食品有限公司 | Oil producing microbes and methods of modification thereof |
CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
JP2010538642A (en) | 2007-09-12 | 2010-12-16 | マーテック バイオサイエンシーズ コーポレーション | Biological oil and its production and use |
EP2090648A1 (en) | 2008-02-12 | 2009-08-19 | Institut Francais de Recherche pour l'Exploitation de la Mere(Ifremer) | Production of glycosylated polypeptides in microalgae |
CN104561150A (en) | 2008-04-09 | 2015-04-29 | 索拉兹米公司 | Direct chemical modification of microbial biomass and microbial oils |
ES2651313T3 (en) | 2009-12-28 | 2018-01-25 | Dsm Ip Assets B.V. | Recombinant traustoquids growing in xylose, and compositions, methods of preparation and uses thereof |
CN107858297A (en) | 2009-12-28 | 2018-03-30 | Dsm Ip资产公司 | Restructuring thraustochytriale and its composition, the Preparation method and use grown on sucrose |
CN103068984B (en) | 2009-12-28 | 2017-12-01 | Dsm Ip资产公司 | The production of hemagglutinin neuraminidase albumen in microalgae |
IN2012DN06277A (en) | 2009-12-28 | 2015-09-25 | Dsm Ip Assets Bv |
-
2002
- 2002-04-15 TW TW091107634A patent/TWI324181B/en not_active IP Right Cessation
- 2002-04-15 TW TW100112656A patent/TWI377253B/en not_active IP Right Cessation
- 2002-04-15 TW TW098130758A patent/TWI350854B/en not_active IP Right Cessation
- 2002-04-16 CN CN028120590A patent/CN1556850B/en not_active Expired - Fee Related
- 2002-04-16 EP EP10178886.7A patent/EP2325319B1/en not_active Expired - Lifetime
- 2002-04-16 ES ES02719515T patent/ES2377557T3/en not_active Expired - Lifetime
- 2002-04-16 JP JP2002582208A patent/JP4536324B2/en not_active Expired - Fee Related
- 2002-04-16 CN CNB2006100842683A patent/CN100513564C/en not_active Expired - Fee Related
- 2002-04-16 CA CA2443908A patent/CA2443908C/en not_active Expired - Fee Related
- 2002-04-16 ES ES10178911T patent/ES2698473T3/en not_active Expired - Lifetime
- 2002-04-16 EP EP10178911.3A patent/EP2314706B1/en not_active Expired - Lifetime
- 2002-04-16 ES ES10178886.7T patent/ES2688953T3/en not_active Expired - Lifetime
- 2002-04-16 AU AU2002250592A patent/AU2002250592C1/en not_active Ceased
- 2002-04-16 EP EP02719515A patent/EP1414941B1/en not_active Expired - Lifetime
- 2002-04-16 US US10/124,807 patent/US7001772B2/en not_active Expired - Lifetime
- 2002-04-16 AT AT02719515T patent/ATE533844T1/en active
- 2002-04-16 WO PCT/US2002/012040 patent/WO2002083869A2/en active Search and Examination
- 2002-04-16 CN CN200910141898A patent/CN101760469A/en active Pending
-
2004
- 2004-11-02 HK HK04108611.8A patent/HK1065819A1/en not_active IP Right Cessation
- 2004-12-22 US US11/021,712 patent/US8206984B2/en not_active Expired - Fee Related
-
2007
- 2007-01-22 HK HK07100765.6A patent/HK1094711A1/en not_active IP Right Cessation
- 2007-10-27 US US11/925,885 patent/US7851191B2/en not_active Expired - Fee Related
-
2010
- 2010-02-01 JP JP2010019881A patent/JP5248536B2/en not_active Expired - Lifetime
- 2010-11-09 US US12/942,759 patent/US20110086390A1/en not_active Abandoned
-
2012
- 2012-09-28 JP JP2012215905A patent/JP2013005817A/en not_active Withdrawn
-
2013
- 2013-06-21 US US13/923,481 patent/US8945875B2/en not_active Expired - Fee Related
-
2015
- 2015-12-25 JP JP2015253726A patent/JP6211577B2/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0257993A2 (en) * | 1986-08-26 | 1988-03-02 | E.I. Du Pont De Nemours And Company | Nucleic acid fragment encoding herbicide resistant plant acetolactate synthase |
US5605011A (en) * | 1986-08-26 | 1997-02-25 | E. I. Du Pont De Nemours And Company | Nucleic acid fragment encoding herbicide resistant plant acetolactate synthase |
US5853973A (en) * | 1995-04-20 | 1998-12-29 | American Cyanamid Company | Structure based designed herbicide resistant products |
Non-Patent Citations (3)
Title |
---|
BEKKAOUI ET AL.: "Isolation and structure of an acetolactate synthase gene from schizosaccharomyces pombe and complementation of the ilv2 mutation in saccharomyces cerevisiae", CURR. GENET., vol. 24, 1993, pages 544 - 547, XP002969804 * |
FALCO ET AL.: "Nucleotide sequence of the yeast ILV2 gene which encodes acetolacetate synthase", NUCLEIC ACIDS RESEARCH, vol. 13, no. 11, 1985, pages 4011 - 4027, XP002005712 * |
KAESTNER ET AL.: "Universal beta-galacotosidase cloning vectors for promoter analysis and gene targeting", GENE, vol. 148, 1994, pages 67 - 70, XP002969803 * |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9458410B2 (en) | 2004-04-22 | 2016-10-04 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cell |
US7834250B2 (en) | 2004-04-22 | 2010-11-16 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
US7932438B2 (en) | 2004-04-22 | 2011-04-26 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
US8071341B2 (en) | 2004-04-22 | 2011-12-06 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
US8106226B2 (en) | 2004-04-22 | 2012-01-31 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
US8158392B1 (en) | 2004-04-22 | 2012-04-17 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
US9453183B2 (en) | 2004-04-22 | 2016-09-27 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cell |
US7807849B2 (en) | 2004-04-22 | 2010-10-05 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
US8816111B2 (en) | 2012-06-15 | 2014-08-26 | Commonwealth Scientific And Industrial Research Organisation | Lipid comprising polyunsaturated fatty acids |
US8946460B2 (en) | 2012-06-15 | 2015-02-03 | Commonwealth Scientific And Industrial Research Organisation | Process for producing polyunsaturated fatty acids in an esterified form |
US9550718B2 (en) | 2012-06-15 | 2017-01-24 | Commonwealth Scientific And Industrial Research Organisation | Lipid comprising polyunsaturated fatty acids |
US9556102B2 (en) | 2012-06-15 | 2017-01-31 | Commonwealth Scientific And Industrial Research Organisation | Process for producing ethyl esters of polyunsaturated fatty acids |
US10005713B2 (en) | 2014-06-27 | 2018-06-26 | Commonwealth Scientific And Industrial Research Organisation | Lipid compositions comprising triacylglycerol with long-chain polyunsaturated fatty acids at the sn-2 position |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2002083869A3 (en) | Product and process for transformation of thraustochytriales microorganisms | |
US5756316A (en) | Molecular cloning by multimerization of plasmids | |
AU2002345083A1 (en) | Process for the preparation of l-amino acids using strains of the enterobacteriaceae family which contain an enhanced rsea or rsec gene | |
HUP0202705A2 (en) | Methods and microorganisms or production of panto-compounds | |
EP1033405A3 (en) | Sequence-determined DNA fragments and corresponding polypeptides encoded thereby | |
WO1999034003A3 (en) | Proteases from gram positive organisms | |
WO2002081722A3 (en) | Process for the production of l-amino acids using strains of the family enterobacteriaceae that contain an attenuated acea gene | |
WO2003038106A3 (en) | A process for the production of l-amino acids using strains of the enterobacteriaceae family which contain an enhanced fadr or iclr gene | |
AU3868197A (en) | Yeast vectors and process for producing proteins with the use of the same | |
EP0926240A3 (en) | Candida biodinii Formate Dehydrogenase mutants, gene sequences encoding them and use of these Formate Dehydrogenase mutants | |
WO2003040180A3 (en) | Genes of corynebacterium glutamicum encoding for genetic stability, gene expression and folding proteins | |
DE60233748D1 (en) | NEW, TOLERANT FORMATHYDROGENASE AGAINST HALOGEN COMPOUNDS AND METHOD FOR THE MANUFACTURE THEREOF | |
GB2297090A (en) | Alpha-1,4-glucan lyase from a fungus infected algae, its purification, gene cloning and expression in microorganisms | |
ATE264917T1 (en) | INTEGRATION VECTORS AND METHODS FOR PRODUCING RECOMBINANT PROTEINS IN MUSHROOMS | |
WO2004005517A3 (en) | L-amidase from rhizobium huautlense | |
CA2302828A1 (en) | Sequence-determined dna fragments and corresponding polypeptides encoded thereby | |
WO1999034001A3 (en) | Proteases from gram positive organisms | |
WO2003076636A3 (en) | Process for the preparation of l-amino acids using strains of the enterobacteriaceae family | |
WO1999033959A3 (en) | Proteases from gram positive organisms | |
WO2002092852A3 (en) | Method for induction of genome instability |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2002250592 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2443908 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2002582208 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2002719515 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 028120590 Country of ref document: CN |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWP | Wipo information: published in national office |
Ref document number: 2002719515 Country of ref document: EP |
|
COP | Corrected version of pamphlet |
Free format text: PUBLISHED INTERNATIONAL SEARCH REPORT (3 PAGES) REPLACED BY CORRECT INTERNATIONAL SEARCH REPORT (3 PAGES) |