WO2002083708A3 - Selective covalent-binding compounds having therapeutic diagnostic and analytical applications - Google Patents

Selective covalent-binding compounds having therapeutic diagnostic and analytical applications Download PDF

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Publication number
WO2002083708A3
WO2002083708A3 PCT/IL2002/000307 IL0200307W WO02083708A3 WO 2002083708 A3 WO2002083708 A3 WO 2002083708A3 IL 0200307 W IL0200307 W IL 0200307W WO 02083708 A3 WO02083708 A3 WO 02083708A3
Authority
WO
WIPO (PCT)
Prior art keywords
covalent
substances
binding
cobalts
preselected
Prior art date
Application number
PCT/IL2002/000307
Other languages
French (fr)
Other versions
WO2002083708A2 (en
Inventor
Bernard S Green
Original Assignee
Semorex Inc
Bernard S Green
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Semorex Inc, Bernard S Green filed Critical Semorex Inc
Priority to US10/474,042 priority Critical patent/US20040121405A1/en
Priority to JP2002581463A priority patent/JP2004525973A/en
Priority to IL15843002A priority patent/IL158430A0/en
Priority to EP02761961A priority patent/EP1385988A4/en
Priority to CA002446921A priority patent/CA2446921A1/en
Publication of WO2002083708A2 publication Critical patent/WO2002083708A2/en
Publication of WO2002083708A3 publication Critical patent/WO2002083708A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2600/00—Assays involving molecular imprinted polymers/polymers created around a molecular template

Abstract

Novel compounds are provided having enhanced affinity for a desired, preselected, target substance (a small molecule; a macromolecule such as a protein, a carbohydrate, a nucleic acid, a cell, a viral particle, etc.) by modification with chemical groups that allow these substances to form stong bonds, such as irreversible covalent bonds, with the desired target substance. These qualities of tight, specific binding are eminiscent of antibody-like affinity; hence the new substances are termed COBALT, and acronym for Covalent-Binding Antibody-Like Trap. The present invention includes a process wherein a target species is chosen and then, by synthetic chemical procedures and modifications, novel substances (COBALTs) are obtained that exhibit selective and covalent binding to the preselected target species. The applications of the COBALTs include diagnostic, analytical, therapeutic and industrial applications.
PCT/IL2002/000307 2001-04-16 2002-04-16 Selective covalent-binding compounds having therapeutic diagnostic and analytical applications WO2002083708A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US10/474,042 US20040121405A1 (en) 2002-04-16 2002-04-16 Selective covalent-binding compounds having therapeutic diagnostic and analytical applications
JP2002581463A JP2004525973A (en) 2001-04-16 2002-04-16 Selective covalent compounds with therapeutic, diagnostic, and analytical applications
IL15843002A IL158430A0 (en) 2001-04-16 2002-04-16 Selective covalent-binding compounds having therapeutic diagnostic and analytical applications
EP02761961A EP1385988A4 (en) 2001-04-16 2002-04-16 Selective covalent-binding compounds having therapeutic diagnostic and analytical applications
CA002446921A CA2446921A1 (en) 2001-04-16 2002-04-16 Selective covalent-binding compounds having therapeutic diagnostic and analytical applications

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28364501P 2001-04-16 2001-04-16
US60/283,645 2001-04-16

Publications (2)

Publication Number Publication Date
WO2002083708A2 WO2002083708A2 (en) 2002-10-24
WO2002083708A3 true WO2002083708A3 (en) 2003-10-23

Family

ID=23086975

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2002/000307 WO2002083708A2 (en) 2001-04-16 2002-04-16 Selective covalent-binding compounds having therapeutic diagnostic and analytical applications

Country Status (5)

Country Link
EP (1) EP1385988A4 (en)
JP (1) JP2004525973A (en)
CA (1) CA2446921A1 (en)
IL (1) IL158430A0 (en)
WO (1) WO2002083708A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2547418A1 (en) 2003-12-08 2005-06-23 The Research Foundation Of State University Of New York Site selectively tagged and templated molecularly imprinted polymers for sensor applications
US8357275B2 (en) * 2007-02-26 2013-01-22 Council Of Scientific & Industrial Research Potentiometric cholesterol sensor for the quantitative estimation of total cholesterol in human blood serum
US10400232B2 (en) 2013-10-03 2019-09-03 Carnegie Mellon University Polymer engineered regenerating bioscavengers
JP6925604B2 (en) * 2015-12-25 2021-08-25 ステラケミファ株式会社 Monofluorophosphate ester salt, its production method and fluorine ion-releasing composition
US11472894B2 (en) 2018-07-23 2022-10-18 Carnegie Mellon University Enzyme-assisted ATRP procedures

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5630978A (en) * 1995-06-07 1997-05-20 Yissum Research Development Co. Of The Hebrew University Of Jerusalem Preparation of biologically active molecules by molecular imprinting
US6255461B1 (en) * 1996-04-05 2001-07-03 Klaus Mosbach Artificial antibodies to corticosteroids prepared by molecular imprinting
US6310110B1 (en) * 1999-07-30 2001-10-30 Michael A. Markowitz Molecularly-imprinted material made by template-directed synthesis

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4728196A (en) * 1995-02-21 1996-09-11 Minister Of Agriculture Fisheries And Food In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland, The Specific binding materials

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5630978A (en) * 1995-06-07 1997-05-20 Yissum Research Development Co. Of The Hebrew University Of Jerusalem Preparation of biologically active molecules by molecular imprinting
US5858296A (en) * 1995-06-07 1999-01-12 Yissum Research Development Co. Of The Hebrew University Of Jerusalem Preparation of biologically active molecules by molecular imprinting
US6255461B1 (en) * 1996-04-05 2001-07-03 Klaus Mosbach Artificial antibodies to corticosteroids prepared by molecular imprinting
US6310110B1 (en) * 1999-07-30 2001-10-30 Michael A. Markowitz Molecularly-imprinted material made by template-directed synthesis

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANDERSSON ET AL.: "Antibody mimics obtained by noncovalent molecular imprinting", ACS SYMPOSIUM SERIES, vol. 586, 1995, pages 89 - 96, XP002966692 *
LI ET AL.: "Design, synthesis and application of a protein A mimetic", NATURE BIOTECH., vol. 16, February 1998 (1998-02-01), pages 190 - 195, XP002966694 *
RAMSTROM ET AL.: "Artificial antibodies to corticosteroids prepared by molecular imprinting", CHEMISTRY & BIOLOGY, vol. 3, June 1996 (1996-06-01), pages 471 - 477, XP002966693 *

Also Published As

Publication number Publication date
CA2446921A1 (en) 2002-10-24
EP1385988A2 (en) 2004-02-04
WO2002083708A2 (en) 2002-10-24
JP2004525973A (en) 2004-08-26
IL158430A0 (en) 2004-05-12
EP1385988A4 (en) 2008-04-09

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