WO2002077194A3 - Polymer synthesis - Google Patents

Polymer synthesis Download PDF

Info

Publication number
WO2002077194A3
WO2002077194A3 PCT/US2002/009333 US0209333W WO02077194A3 WO 2002077194 A3 WO2002077194 A3 WO 2002077194A3 US 0209333 W US0209333 W US 0209333W WO 02077194 A3 WO02077194 A3 WO 02077194A3
Authority
WO
WIPO (PCT)
Prior art keywords
substrate
array
electrostatic deposition
chemical compounds
chemical
Prior art date
Application number
PCT/US2002/009333
Other languages
French (fr)
Other versions
WO2002077194A2 (en
Inventor
Tai-Nang Huang
Original Assignee
Linden Technologies Inc
Tai-Nang Huang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Linden Technologies Inc, Tai-Nang Huang filed Critical Linden Technologies Inc
Priority to AU2002303159A priority Critical patent/AU2002303159A1/en
Publication of WO2002077194A2 publication Critical patent/WO2002077194A2/en
Publication of WO2002077194A3 publication Critical patent/WO2002077194A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00385—Printing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00608—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00628—Ionic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/0063—Other, e.g. van der Waals forces, hydrogen bonding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00646—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports
    • B01J2219/00648—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports by the use of solid beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides

Abstract

An array of chemical compounds can be produced by the electrostatic deposition of its components onto a substrate. The subunit building blocks are coupled to the chemical groups on the substrate to synthesize a complex compound. By localizing the electrostatic deposition, different building blocks can be coupled at different positions on the substrate. Thus, a diverse and addressable set of chemical compounds is produced on the substrate to form an array of chemical compounds, e.g., of biological polymers. One application of this concept is the production of an oligonucleotide array. Other concepts provided here can be used in combination with the electrostatic deposition method or with other chemical synthetic methods. The invention provides, in part, methods of dispensing the nucleic acid subunits as a dry composition ( e.g., a particulate composition) that can be triboelectrically charged for the in-situ synthesis of nucleic acid polymers.
PCT/US2002/009333 2001-03-26 2002-03-26 Polymer synthesis WO2002077194A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002303159A AU2002303159A1 (en) 2001-03-26 2002-03-26 Polymer synthesis

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US27900401P 2001-03-26 2001-03-26
US60/279,004 2001-03-26
US32236201P 2001-09-14 2001-09-14
US60/322,362 2001-09-14

Publications (2)

Publication Number Publication Date
WO2002077194A2 WO2002077194A2 (en) 2002-10-03
WO2002077194A3 true WO2002077194A3 (en) 2003-03-20

Family

ID=26959404

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/009333 WO2002077194A2 (en) 2001-03-26 2002-03-26 Polymer synthesis

Country Status (4)

Country Link
US (4) US20020168669A1 (en)
AU (1) AU2002303159A1 (en)
TW (1) TWI242045B (en)
WO (1) WO2002077194A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2788101A (en) 2000-01-11 2001-07-24 Maxygen, Inc. Integrated systems and methods for diversity generation and screening
WO2002077194A2 (en) * 2001-03-26 2002-10-03 Linden Technologies, Inc. Polymer synthesis
WO2003006676A2 (en) * 2001-07-13 2003-01-23 Nanosphere, Inc. Method for immobilizing molecules onto surfaces
US7297553B2 (en) * 2002-05-28 2007-11-20 Nanosphere, Inc. Method for attachment of silylated molecules to glass surfaces
US20040180368A1 (en) * 2002-12-23 2004-09-16 Affymetrix, Inc. Method for producing a high density nucleic acid array using activators
AU2003903295A0 (en) * 2003-06-30 2003-07-10 Raustech Pty Ltd Substrate for combinatorial chemistry
AU2003903296A0 (en) * 2003-06-30 2003-07-10 Raustech Pty Ltd Chemical compositions of matter
AU2004252184B2 (en) * 2003-06-30 2009-02-26 Raustech Pty Ltd Substrates for spatially selective micron and nanometer scale deposition and combinatorial modification and fabrication
US7334881B2 (en) * 2004-07-12 2008-02-26 Hewlett-Packard Development Company, L.P. Method and system to deposit drops
US20090136505A1 (en) * 2005-02-23 2009-05-28 Johanna Bentz Intranasal Administration of Active Agents to the Central Nervous System
JP4641476B2 (en) * 2005-09-15 2011-03-02 キヤノン株式会社 Probe array manufacturing equipment
US20100081009A1 (en) * 2008-09-26 2010-04-01 General Electric Company Spray Application of Liquid Precursors for CMAS Resistant Coatings
US9228136B2 (en) 2011-07-25 2016-01-05 The Texas A&M University System Processing of dielectric fluids with mobile charge carriers
CN112675850A (en) * 2020-12-23 2021-04-20 江苏广域化学有限公司 Nickel catalyst, preparation method thereof and synthesis method of pyrimidine derivatives
CN114891059A (en) * 2022-05-09 2022-08-12 深圳市华云智能健康有限公司 Electromagnetic radiation synthesis method and device of high-density molecular array chip

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5541061A (en) * 1992-04-29 1996-07-30 Affymax Technologies N.V. Methods for screening factorial chemical libraries
US5667976A (en) * 1990-05-11 1997-09-16 Becton Dickinson And Company Solid supports for nucleic acid hybridization assays
US5800992A (en) * 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US44530A (en) * 1864-10-04 Improved mode of fastenings on buckles
US618552A (en) * 1899-01-31 Collar-crimper
US2221776A (en) 1938-09-08 1940-11-19 Chester F Carlson Electron photography
US2297691A (en) * 1939-04-04 1942-10-06 Chester F Carlson Electrophotography
US2618552A (en) * 1947-07-18 1952-11-18 Battelle Development Corp Development of electrophotographic images
US2874063A (en) 1953-03-23 1959-02-17 Rca Corp Electrostatic printing
US3166432A (en) 1959-05-07 1965-01-19 Xerox Corp Image development
US3653893A (en) * 1967-06-05 1972-04-04 Xerox Corp Imaging system
US3795617A (en) * 1972-03-21 1974-03-05 Eastman Kodak Co Electrographic carrier vehicle and developer composition
US3957367A (en) * 1974-09-16 1976-05-18 Xerox Corporation Color elastrostatographic printing machine
US4324851A (en) * 1979-12-20 1982-04-13 Xerox Corporation Positive color toners
US4500707A (en) 1980-02-29 1985-02-19 University Patents, Inc. Nucleosides useful in the preparation of polynucleotides
US4973679A (en) 1981-03-27 1990-11-27 University Patents, Inc. Process for oligonucleo tide synthesis using phosphormidite intermediates
US4403848A (en) 1982-02-17 1983-09-13 Xerox Corporation Electronic color printing system
US4828979A (en) 1984-11-08 1989-05-09 Life Technologies, Inc. Nucleotide analogs for nucleic acid labeling and detection
US6022714A (en) * 1985-05-02 2000-02-08 Genetics Institute Methods for attachment of a polynucleotide to a preselected material
US5153319A (en) 1986-03-31 1992-10-06 University Patents, Inc. Process for preparing polynucleotides
US5047519A (en) 1986-07-02 1991-09-10 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
US4956225A (en) * 1987-04-02 1990-09-11 Xerox Corporation Transparency with a polymeric substrate and toner receptive coating
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US5700637A (en) * 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US6054270A (en) * 1988-05-03 2000-04-25 Oxford Gene Technology Limited Analying polynucleotide sequences
US5424186A (en) * 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US4997697A (en) * 1989-06-29 1991-03-05 Xerox Corporation Transparencies
WO1992007882A1 (en) 1990-10-26 1992-05-14 Genta Incorporated Non-aromatic organic polymeric reagents for solid phase synthesis of oligomers
WO1992021694A1 (en) 1991-06-06 1992-12-10 Baylor College Of Medicine Molecular diagnosis of autosomal dominant charcot-marie-tooth disease
US5474796A (en) 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
AU675054B2 (en) 1991-11-22 1997-01-23 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
US5472672A (en) 1993-10-22 1995-12-05 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and method for polymer synthesis using arrays
US6015880A (en) 1994-03-16 2000-01-18 California Institute Of Technology Method and substrate for performing multiple sequential reactions on a matrix
US5552471A (en) * 1994-08-17 1996-09-03 The Perkin-Elmer Corporation Solid support reagents for the synthesis of 3'-Nitrogen containing polynucleotides
US6239273B1 (en) * 1995-02-27 2001-05-29 Affymetrix, Inc. Printing molecular library arrays
US5908926A (en) * 1995-03-16 1999-06-01 Duke University 5'to 3' nucleic acid synthesis using 3'-photoremovable protecting group
US5714007A (en) * 1995-06-06 1998-02-03 David Sarnoff Research Center, Inc. Apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrate
US5753302A (en) * 1996-04-09 1998-05-19 David Sarnoff Research Center, Inc. Acoustic dispenser
US5672424A (en) * 1996-06-03 1997-09-30 Xerox Corporation Ink jet transparencies
US5683793A (en) 1996-06-03 1997-11-04 Xerox Corporation Ink jet transparencies
US5871010A (en) 1996-06-10 1999-02-16 Sarnoff Corporation Inhaler apparatus with modified surfaces for enhanced release of dry powders
US5870223A (en) * 1996-07-22 1999-02-09 Nikon Corporation Microscope system for liquid immersion observation
DE19633605A1 (en) * 1996-08-21 1998-02-26 Reinhold Grundke Device for deriving uncontrolled urination
US5753599A (en) 1996-12-03 1998-05-19 Lever Brothers Company, Division Of Conopco, Inc. Thiadiazole dioxides as bleach enhancers
US5874554A (en) 1996-12-13 1999-02-23 Incyte Pharmaceuticals, Inc. Methods and solvent vehicles for reagent delivery in oligonucleotide synthesis using automated pulse jetting devices
DE59706460D1 (en) * 1996-12-18 2002-03-28 Oce Printing Systems Gmbh METHOD FOR OPERATING AN ELECTROGRAFIC PRINTER OR COPIER WITH AT LEAST TWO DEVELOPER UNITS
US6001311A (en) 1997-02-05 1999-12-14 Protogene Laboratories, Inc. Apparatus for diverse chemical synthesis using two-dimensional array
US6028189A (en) 1997-03-20 2000-02-22 University Of Washington Solvent for oligonucleotide synthesis and methods of use
WO1998041531A2 (en) 1997-03-20 1998-09-24 University Of Washington Solvent for biopolymer synthesis, solvent microdroplets and methods of use
JP4433100B2 (en) * 1997-06-20 2010-03-17 ニューヨーク ユニヴァーシティ Electrostatic spraying of substance solutions in mass production of chips and libraries
US6045753A (en) 1997-07-29 2000-04-04 Sarnoff Corporation Deposited reagents for chemical processes
US6004752A (en) * 1997-07-29 1999-12-21 Sarnoff Corporation Solid support with attached molecules
US6511803B1 (en) * 1997-10-10 2003-01-28 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
US6177558B1 (en) * 1997-11-13 2001-01-23 Protogene Laboratories, Inc. Method and composition for chemical synthesis using high boiling point organic solvents to control evaporation
US6235871B1 (en) 1997-12-03 2001-05-22 Massachusetts Institute Of Technology Synthesis of oligoarylamines, and uses and reagents related thereto
DE69909972T2 (en) 1998-02-11 2004-05-13 University Of Houston, Houston DEVICE FOR CARRYING OUT CHEMICAL AND BIOCHEMICAL REACTIONS USING PHOTO-GENERATED REAGENTS
US6117602A (en) * 1999-01-19 2000-09-12 Xerox Corporation Electrostatic printing method and apparatus having enhanced image resolution characteristics
JP2003508043A (en) * 1999-08-27 2003-03-04 ピコグラム， インコーポレイテッド Method and device for performing operations at a charged microlocation
ATE246583T1 (en) 1999-08-31 2003-08-15 Engel Maschb Gmbh DEVICE FOR ADDITING GAS TO A PLASTIC MELTS
WO2001055451A1 (en) * 2000-01-28 2001-08-02 Linden Technologies, Inc. C-3' protected monomeric nucleotides and synthesis of oligonucleotides on solid support
WO2002077194A2 (en) * 2001-03-26 2002-10-03 Linden Technologies, Inc. Polymer synthesis
US20020136772A1 (en) * 2001-03-26 2002-09-26 Tai-Nang Huang Polymer synthesis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5800992A (en) * 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5667976A (en) * 1990-05-11 1997-09-16 Becton Dickinson And Company Solid supports for nucleic acid hybridization assays
US5541061A (en) * 1992-04-29 1996-07-30 Affymax Technologies N.V. Methods for screening factorial chemical libraries

Also Published As

Publication number Publication date
US6838447B2 (en) 2005-01-04
TWI242045B (en) 2005-10-21
US20040013573A1 (en) 2004-01-22
US20020137719A1 (en) 2002-09-26
US20020168669A1 (en) 2002-11-14
AU2002303159A1 (en) 2002-10-08
US20020136978A1 (en) 2002-09-26
US6855501B2 (en) 2005-02-15
WO2002077194A2 (en) 2002-10-03

Similar Documents

Publication Publication Date Title
WO2002077194A3 (en) Polymer synthesis
WO2006099162A3 (en) Polymeric salen compounds and methods thereof
ATE214396T1 (en) COMBINATORIAL LIBRARIES OF LABELED BIOCHEMICAL COMPOUNDS AND METHODS FOR THEIR PRODUCTION
WO2006116629A3 (en) The preparation of molecular imaging probes using click chemistry
WO2003053846A3 (en) Spatial localization of dispersed single walled carbon nanotubes into useful structures
WO2002093131A3 (en) Methods for isolating and labeling sample molecules
CA2410180A1 (en) Binder for mineral wool products
AU3372800A (en) Manipulation of microparticles in microfluidic systems
ATE460985T1 (en) COATED ION EXCHANGE SUBSTRATE AND PRODUCTION METHOD THEREOF
WO2000033084A3 (en) Arrays of organic compounds attached to surfaces
WO2008042289A3 (en) Polymer synthetic technique
BRPI0409735A (en) curable coating composition, methods for producing a coating, a multiple coating system and a molded article
WO2004076059A3 (en) System and process for the synthesis of polymers
WO2008013569A3 (en) Small molecule printing
EP1731517A4 (en) Linker compound, ligand complex and process for producing them
DK1397675T3 (en) Preparation of Molecular Arrays
Pieper et al. Process development for synthesizing the cephalosporin antibiotic cefotaxime in batch and flow mode
WO2002069898A3 (en) Compositions and methods using platinum compounds for nucleic acid labeling
EP1535942A4 (en) Process for producing dendrimer, building block compound, and process for producing thiophene compound
AU6823800A (en) Polyamines comprising urea groups, method for their production, and their use as hardeners for epoxide resins
WO2003025567A3 (en) Production of support-bonded molecules by means of oligonucleotide tags
AU2003289297A1 (en) Phosphorus-containing organosilicon compounds, process for production thereof, and resin compositions or coating compositions containing the same
WO2003033437A3 (en) A method of forming neuraminidase inhibitors by dynamic combinatorial chemistry and compounds obtained
WO2004041896A8 (en) Carbamate functional materials, a method of making said materials, and curable coating compositions containing said materials
WO2000065098A3 (en) Nucleotide extension on a microarray of gel-immobilized primers

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP