WO2002072779A3 - Nucleic acid labeling compounds - Google Patents

Nucleic acid labeling compounds Download PDF

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Publication number
WO2002072779A3
WO2002072779A3 PCT/US2002/007584 US0207584W WO02072779A3 WO 2002072779 A3 WO2002072779 A3 WO 2002072779A3 US 0207584 W US0207584 W US 0207584W WO 02072779 A3 WO02072779 A3 WO 02072779A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
labeling compounds
acid labeling
compounds
derivative
Prior art date
Application number
PCT/US2002/007584
Other languages
French (fr)
Other versions
WO2002072779A2 (en
Inventor
Glenn Mcgall
Anthony D Barone
Original Assignee
Affymetrix Inc
Glenn Mcgall
Anthony D Barone
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affymetrix Inc, Glenn Mcgall, Anthony D Barone filed Critical Affymetrix Inc
Priority to CA002440615A priority Critical patent/CA2440615A1/en
Priority to EP02728452A priority patent/EP1385829A4/en
Priority to AU2002258502A priority patent/AU2002258502A1/en
Publication of WO2002072779A2 publication Critical patent/WO2002072779A2/en
Publication of WO2002072779A3 publication Critical patent/WO2002072779A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/06—Heterocyclic radicals

Abstract

Nucleic acid labeling compounds are disclosed. The compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofuranose derivative). The labeling compounds are suitable for enzymatic attachment to a nucleic acid, either terminally or internally, to provide a mechanism of nucleic acid detection.
PCT/US2002/007584 2001-03-12 2002-03-12 Nucleic acid labeling compounds WO2002072779A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002440615A CA2440615A1 (en) 2001-03-12 2002-03-12 Nucleic acid labeling compounds
EP02728452A EP1385829A4 (en) 2001-03-12 2002-03-12 Nucleic acid labeling compounds
AU2002258502A AU2002258502A1 (en) 2001-03-12 2002-03-12 Nucleic acid labeling compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27520201P 2001-03-12 2001-03-12
US60/275,202 2001-03-12

Publications (2)

Publication Number Publication Date
WO2002072779A2 WO2002072779A2 (en) 2002-09-19
WO2002072779A3 true WO2002072779A3 (en) 2003-11-20

Family

ID=23051286

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/007584 WO2002072779A2 (en) 2001-03-12 2002-03-12 Nucleic acid labeling compounds

Country Status (5)

Country Link
US (5) US7468243B2 (en)
EP (1) EP1385829A4 (en)
AU (1) AU2002258502A1 (en)
CA (1) CA2440615A1 (en)
WO (1) WO2002072779A2 (en)

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US9540689B2 (en) 1998-05-01 2017-01-10 Life Technologies Corporation Method of determining the nucleotide sequence of oligonucleotides and DNA molecules

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CA2463719A1 (en) * 2003-04-05 2004-10-05 F. Hoffmann-La Roche Ag Nucleotide analogs with six membered rings
EP1466919A1 (en) * 2003-04-05 2004-10-13 Roche Diagnostics GmbH Nucleotide analogs with six membered rings
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
EP1716254B1 (en) 2004-02-19 2010-04-07 Helicos Biosciences Corporation Methods for analyzing polynucleotide sequences
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
US11180756B2 (en) 2017-03-09 2021-11-23 Ionis Pharmaceuticals Morpholino modified oligomeric compounds
US11655504B2 (en) * 2017-07-24 2023-05-23 Quantum-Si Incorporated High intensity labeled reactant compositions and methods for sequencing
US11613772B2 (en) 2019-01-23 2023-03-28 Quantum-Si Incorporated High intensity labeled reactant compositions and methods for sequencing

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9540689B2 (en) 1998-05-01 2017-01-10 Life Technologies Corporation Method of determining the nucleotide sequence of oligonucleotides and DNA molecules

Also Published As

Publication number Publication date
AU2002258502A1 (en) 2002-09-24
CA2440615A1 (en) 2002-09-19
US20110082289A1 (en) 2011-04-07
US20140187434A1 (en) 2014-07-03
US8026057B2 (en) 2011-09-27
US20020182625A1 (en) 2002-12-05
US8497064B2 (en) 2013-07-30
EP1385829A4 (en) 2005-10-19
EP1385829A2 (en) 2004-02-04
WO2002072779A2 (en) 2002-09-19
US7468243B2 (en) 2008-12-23
US8076072B2 (en) 2011-12-13
US20120053336A1 (en) 2012-03-01
US20080287667A1 (en) 2008-11-20

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