WO2002072268A1 - Device for holding a substrate - Google Patents

Device for holding a substrate Download PDF

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Publication number
WO2002072268A1
WO2002072268A1 PCT/EP2002/002446 EP0202446W WO02072268A1 WO 2002072268 A1 WO2002072268 A1 WO 2002072268A1 EP 0202446 W EP0202446 W EP 0202446W WO 02072268 A1 WO02072268 A1 WO 02072268A1
Authority
WO
WIPO (PCT)
Prior art keywords
opening
plates
openings
shielding member
plate
Prior art date
Application number
PCT/EP2002/002446
Other languages
French (fr)
Inventor
Hendrik Sibolt Van Damme
Wilhelmus Marinus Carpaij
Original Assignee
Pamgene B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pamgene B.V. filed Critical Pamgene B.V.
Priority to EP02724203A priority Critical patent/EP1370360B1/en
Priority to JP2002571220A priority patent/JP2004531707A/en
Priority to DE60212089T priority patent/DE60212089T2/en
Publication of WO2002072268A1 publication Critical patent/WO2002072268A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B01L3/50255—Multi-well filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces

Definitions

  • H H- 13 03 ⁇ 0 ⁇ ⁇ ⁇ ⁇ ⁇ tQ ⁇ 0 ⁇ ⁇ 3 ⁇ ⁇ ! 3 ⁇ i ⁇ rt ⁇ ⁇ 13 * t-> ⁇ ii •d M Ml ⁇ - ⁇ ft ) 03 Mi r rt 0 ⁇ ii ⁇ ⁇ rt ii
  • Figs. 2 and 3 show a device for holding the substrate 1 during performing an assay.
  • the device 5 comprises upper and lower plates 6,7, wherein in the embodiment shown each plate 6,7 is provided with an array of four openings 8,9.
  • the upper and lower plates 6,7 are made of a suitable plastic material in an injection moulding process for example.
  • the upper and lower plates 6,7 are adapted to receive the substrate 1 sandwiched in the interface 10 between the plates 6,7.
  • the openings 8,9 are partially aligned, wherein the axes of openings 9 in the lower plate 7 are staggered with respect to the axes of openings 8 in the upper plate 6.
  • each opening 8 of the upper plate 6 is surrounded by an upwardly projecting rim 11 and each opening 9 in the lower plate 7 is surrounded by a downwardly projecting rim 12.
  • the openings 8,9 are circular and the rims 11,12 are made as cylindrical structures.
  • Each shielding member 13 has a wedge-shaped cross-section in the embodiment shown having a preferably flat upper surface 14 inclined with respect to the interface 10 of the plates 6,7. In this manner a fluid passing through the capillary channels will gradually contact the upper surface 14 from the left to right according to the cross- section of fig. 3 thus avoiding enclosing of air bubbles.
  • the angle of inclination of the upper surface 14 of the shielding member 13 is preferably at least 5°.
  • the staggering of the lower openings 9 with respect to the upper openings 8 allows for a complete screening of the openings 9 if the device 5 is viewed from the top side. In this manner a real time reading of the areas 4 of the substrate 1 is possible when the sample fluid is fully transported to the lower side of the sub- strate 1. Any background signal caused by free label in the sample fluid under the substrate 1 is avoided.
  • the shape of the shielding member 13 with the inclined upper surface 14 further improves the mixing of the sample fluid during transporting the sample fluid through the capil- lary channels of the substrate 1.

Abstract

A device for holding a substrate comprises upper and lower plates adapted to receive the substrate sandwiched in the interface between the plates. Each plate has at least one opening with a projecting rim surrounding the opening and directed away from the interface. The openings in the upper and lower plates are at least partially aligned in the sandwiched position of the plates. Each opening in the lower plate can be provided with a shielding member partially shielding the opening of the lower plate.

Description

Figure imgf000003_0001
φ K rt T3 Ml Ml •ϋ H- SD μ- 0 μ- m μ- ϋ T3 * μ- μ- 0 J μ- 0 03 3 tr r ø α
0 Φ t 0 0 Φ 0 ø Ό ø ft) N ft) ϋ 0 0 ø IX 0 03 •0 rt Φ 0 Φ Φ
Ω ø Φ ø K ii ii μ- iQ φ in ø φ rt 0 3 U3 μ- M Φ ii P. < 03 03 <!
01 Q. rr 0) U3 03 0 Q1 Φ < Si rt Si 0 μ- μ- μ- t 0 μ-
H- 0 Φ Ό ø ø 0 ø μ- &) $ Si Φ μ- 0 03 φ Φ μ- μ. 13 ø ø tr Ω
0 13 •d Φ 0 φ H- ø rt μ- tr ø X 0 fi ω 0 rt iQ Pi 03 Φ l-h iQ φ H- H P. Φ 0 iQ Ω ^ tr rt U2 μ- if rt Tf IQ 0 Φ Φ rt
0 03 Ml S ) S3 H" 1 t ø- 03 0 rt 0 03 Mi 0 <! ϋ Hi rt 0 H- 0 ii 03 μ- rt ft) φ φ 0 Φ ft) Φ rt t 03 03 T3 μ- ø 0 T Mi 0 T3 H H IQ O ^ ID ø øJ ø ft) Si TS rt Ml ø * M φ μ- 0 rt • Ω μj rt t-3 H
Φ IQ M 3 3 Φ 3 • ! Φ 0. 03 w ø1 ii 03 * 03 ø Φ 0 P. 0 H Φ Φ 0 Φ & rr 0 μ- 4 Φ 3 rt rt μ- Φ Ω Φ ft) ø Φ rt Ω H 0 0 μ- M • Φ ^
0 13* 0 <! ø ø H ft) 3 PJ ø Si ø ii Ω ø tr ii Φ Mi IΩ μ-' rt 3 »d μ- TJ O
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0 03 rt Φ ii 0) 0 Φ 0 03 φ Φ Φ J ø Si ft) ii Φ • • 3 rt Φ μ- Hi P. P. φ μ-
H- ø • φ 3 CQ !3J ii 03 ft) M Ω Φ Si H- 0 ft) 03 M tr ø 0 0 Φ a 03 ø
0 if Φ Mi Φ rt 0 rt 0 0 • ; Mi rt Φ Φ 0 Φ Ω *ϋ 3 0 03 to Φ iQ ω 03 3 φ ø Φ O i ft) Φ TJ μ- tQ rt Φ 0 03 ø tf V 0 Ω o 0 m rr H- ϋ 03 O 03 2 Mi s: ø (i Φ ø 0 μ- 03 rt Φ Ω Φ 0 0 £, (i o rt ø
H 0 rt ii 03 Mi 0 μ- & 0 rt $ r Ω ft) Si 0 0 0 0 H X 3 Φ μ-
H- ø s; i-T Φ 0 m w rt Ω ft) μ- Φ Φ 0 ft) ø μ- rt CQ ■ϋ Hi μ- μ- H σ ) μ- 03
01 rr Φ P-. * 03 Φ øJ ø- S ø ϋ H H "ϋ H 0 03 μ- 0 P- ø Φ (1^ ø ø
Φ ϋ Su 0 H 0 μ- φ 0 ft) IQ Hi r μ- <1 μ- 0 rt 0 φ μ- P. OD J tr rt φ 3 H <! 03 s; ■ ft) Ό ø' rt Φ ø φ 0 ^ ty P. 0 ø cπ Φ 03
H H- 13 03 ► 0 Φ ^ Ω Φ Φ tQ ø 0 φ ø 3 ■<! 3 σi ø rt ø ω 13* t-> ø ii •d M Ml μ- Φ ft) 03 Mi r rt 0 ϋ ii φ ø rt ii
3 0) μ- 0 Φ 0 - φ 0 ii rt rt μ- rt •σ μ- øJ Hi ■•< 0 0 Φ 0 H Pi 0 μ- ø
CQ •0 rr φ P. P- <! 03 w 0 øJ tr φ ø 0 φ o φ ϋ s X 03 φ Hi 0 rt rø 0 Φ μ- Mi Φ rr μ- μ- 3 Φ 03 < Si μ- ii ø r Ω Φ φ φ μ- ø Φ o 03 • 0, 3 H Q. ø- Ω rt ft) ft) rt φ Φ α. Mi Ω PJ øJ ø H X 0 ø rt
4 03 μ- φ ø Φ φ μ- rt rt ft) ø <! 0 ft) ft) φ ø 03 T3 φ Hi 03 tr t rt H- H ø 3 μ- tr 0 Φ øJ Ό Φ Si rr μ- ϋ μ- 'd 0 0 . Φ φ
Φ tr 3 IQ rt p. ■ ; O r 0 03 Φ ii Φ ft) μ- Ω 0 3 3 μ- 03 0 ø 0 03 *ϋ 0 p. T) 1 0 ø TJ 0 φ μ- 03 0 Φ 0 J φ > 03 0
Φ rt 3 Φ <! rt Φ Φ 0 ft) μ- j. rt 0 ø ø 3 H1 Si φ 0 0 rt rt r φ 0) 0 tr 0 Mi H ø φ rt Φ 0 3 IQ rt ft) tJ 03 ii * 03 0 3 Φ
O 3 H- Ω Φ H- 03 Φ CT Ω ' Si r K Φ O ϋ rt 03 tr rt 3 Φ 03
0J 03 & tr 0 0 rt Φ rt Φ ø' 03 ft) ; Φ 0 & • •<! 0 μ- μ- rr Φ φ 3 Ό iQ r ø" ft) ϋ μ- rt Φ 03 0 * Hi Φ ii Ω ø ø rt tr 0 3 h 0 Φ ii 03 Φ rt Mi 0 •d 0 0 :> ii Ω Ml Ό ø ø Ό 0
Φ 0) *ϋ 03 0 0 r ft) IQ fi tr ø* ft) 0 ø4 rr 03 ii 3 rt 13 r 0 •ϋ Φ ii ii Ό Ω ft) H Φ 03 μ- 03 <^ ø 0 tr ø Pi 0 μ- ø Φ ø tr 0 ø 0 rt φ ft) φ Φ H rt Φ < rt Ω 03 μ- ø μ- Φ 3 ii <! rr rr Pi μ-
0 Φ Φ μ- O Ω 0 rt ft) ft) - μ- Φ Ω μ- ii ø- ft) ϋ ø P *d 0 μ- •<! Φ Ω Pi
3 ii rr 3 rt Ό Φ rt 03 3 03 Φ Ω ft) > Φ Φ 03 TJ P H ø ø Φ
Φ 03 μ- IQ tr μ- Φ Φ rt € μ- φ rt Ω tr r Φ μ- 0 μ- ii ø < ϋ 0) 0) ø φ ø 0 Ω 03 øJ 03 <! Φ ft) ft) ft) 03 *<; H 0 ø Hi ø H, rt μ-
3 μ- iQ H- ft) • 3 φ 0 Φ Φ μ- • 0 H μ- Hi Hi iQ ø Ω
03 T3 ii M ø SD 0 0 ft) ii ft) 03 H Si 0 3 3 M ø *< ø φ
H- t-1 φ •<; Ω 4 (Q ϋ Φ ϋ Ω rt tr 0 φ Hi φ 0 03 Ω H ø 1 ø
P. Φ ø rt Ω μ- 03 tr rt μ- 0 0" t Ω Φ S <! 0 0 μ- 0 μ- Φ ø 3 Hi φ H" 03 tr 0 ø Φ μ- ø 0 Φ 0" μ- μ- rt 0 Hi Si 3 ii ø Pi φ ø 0
Hi P" Φ 3 iQ H- ft) 0 V ft) ft) ø Ω tr 03 13 Ω 03 ^ ø H
0 rt μ- 3 03 0 * rt Si 03 H Ω IQ φ Φ 0 μ- 0 ø * ø
Mι 0 H- φ 0 ft) ø' μ- SD 0 ft) Ω 0 03 Φ 0 ø H tr
H- 3 0 S- ø rr 0 ■^ φ ø rr tr Ω 0 rt Mi 0 Mi 0 0 Hi 0 < 0 rt P. φ p. 3 su ø1 Si LQ Φ 03 rt 3 0 0 3 rt Mi M μ- 0 rt tT μ- Φ rt Φ O rt Φ 3 H 0 tr μ- ii rt ø Φ μ- Pi
Φ H- P ϋ Φ 0 Φ • rt t ii ii 0 μ- 3 μ- ø ø 0 tr rt Ω μ-
3 ifl P. :> 0 ϋ Φ ø' ft) ft) 1 1 3 μ- μ- φ Φ ø ø Φ rt I ø ø μ- ø 1 1 ø Si ø 03 P, ii
1 Φ 1 1 3 1 I
Figure imgf000004_0001
Pi 03 •d *X) 0 ø ø CQ rt TJ 0 tr
Φ μ- 0 Q tr M i tr H Φ μ-
03 0 03 Ml 0 Mi Φ 0 Φ 0 LQ
H- 0 Φ \ <! 0 ø 0 X 03 tr
K 03 P- Φ H ts 03 μ-
Φ o 1 rr ^ 0 3 μ-
P. 0 0 o 3 tr 0 tr 0 ø H hi ϋ o Φ Φ 0 Mi 03 rt 0
Φ Φ \ ø ii Ml rt Φ rt
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3 03 > μ- rt tr 0 < Φ φ ∞ 0 Φ tr 0 rt O ø 0 oo 0 03 Φ ø Φ μ> 03 H rt Hi in Φ Ω
. ø LΠ rt 0 μ- P. »i 03 Φ μ- o H Ω
0 ft μ- 0 ø 1 μ- rt
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P. rt μ- rt Ω H o 0 ø
03 S Φ 0 H 0 O Mi tr 0 μ- M 0 0 ø ø ø
^ tr ø rt >0 3 0 φ
03 ø 0 Φ tr 03 3
^ r rt Mi Φ 0 Q1 ø H tr μ- μ> 0 * 3 0
* 0 Φ O rt μ- Mi tr μ- P. rt 0 tr 3 ø Φ ø μ-
0 Φ ø ø Φ ø P. Ω H μ- 3
Hi ø μ- tr Φ 0 φ
P. 03 Ω 0 μ- 3 ø
Φ r Φ •d 0 tr 0 ø ø rt
X tr ii 0 tr ø rt ø 0
0 φ 03 rr 03 < Φ Φ 0 X 0
3 rt Φ rt Φ P. H μ- Ml
V ø 0 0 ii 03 tr
0 0 rt ø ø ø μ- Φ rt φ P. rt *ϋ 03 0 ø tr
U ø Φ *d r P. 3 Φ
0 Φ rt TS H ø μ- ø ø H - <τs H 0 ø ø ^ 03 ø Φ X tQ 0
^ 0 rt μ- Hi μ- 0 03 tr tr
Mi Ω φ 3 rt > 03 0 03
0 rt 0 ii ø 0 0 <! rt
0 ϋ tr rt Φ r 0 Ω tr φ ϋ
P. 0 Φ μ- 0 Φ M μ- 03 ø rt 0 Ω ø rt 0 rt
3 03 0 ø Φ tQ ø Φ ø 0 0 0 03
*< ø μ- - rt 0 Ω T) H
0 ! 03 o Mi Φ 0 - tr P. Φ o ø Ω
Φ i 3 M t μ- μ- rt rt ø Pi Φ O 03 ø tr
< tr 0 0 ø O LQ Φ
0 φ Hi Φ rt • tr ii 03 "0 0 0 Ω μ- i φ rt . M 3 0 Mi tr
Φ μ- X 0 ø 0 0
Pi 3 1 •TJ Ω Pi 0 ø
Φ rt O tr w 1 ø ø tr M rt 1
CD φ O
Figure imgf000004_0002
Figs. 2 and 3 show a device for holding the substrate 1 during performing an assay. The device 5 comprises upper and lower plates 6,7, wherein in the embodiment shown each plate 6,7 is provided with an array of four openings 8,9. The upper and lower plates 6,7 are made of a suitable plastic material in an injection moulding process for example. As shown in figs. 1 and 2 the upper and lower plates 6,7 are adapted to receive the substrate 1 sandwiched in the interface 10 between the plates 6,7. In the sandwiched position of the plates 6,7, the openings 8,9 are partially aligned, wherein the axes of openings 9 in the lower plate 7 are staggered with respect to the axes of openings 8 in the upper plate 6.
Each opening 8 of the upper plate 6 is surrounded by an upwardly projecting rim 11 and each opening 9 in the lower plate 7 is surrounded by a downwardly projecting rim 12. In the embodiment shown, the openings 8,9 are circular and the rims 11,12 are made as cylindrical structures.
As described in the above-mentioned international patent application PCT/US00/24885, a sample fluid disposed within the upper cylindrical structures 11 will pass through the capillary channels of the strip of aluminium oxide under an appropriate pressure difference over substrate 1. The cylindrical structures 11 allow for a larger range of sample fluid volumes to be accommodated. In the device shown in the figs. 2 and 3, each opening
9 in the lower plate 7 is provided with a shielding member 13 partially shielding the opening 9. Each shielding member 13 has a wedge-shaped cross-section in the embodiment shown having a preferably flat upper surface 14 inclined with respect to the interface 10 of the plates 6,7. In this manner a fluid passing through the capillary channels will gradually contact the upper surface 14 from the left to right according to the cross- section of fig. 3 thus avoiding enclosing of air bubbles. The angle of inclination of the upper surface 14 of the shielding member 13 is preferably at least 5°.
As can be seen in fig. 3 in particular, the staggering of the lower openings 9 with respect to the upper openings 8 allows for a complete screening of the openings 9 if the device 5 is viewed from the top side. In this manner a real time reading of the areas 4 of the substrate 1 is possible when the sample fluid is fully transported to the lower side of the sub- strate 1. Any background signal caused by free label in the sample fluid under the substrate 1 is avoided.
The shape of the shielding member 13 with the inclined upper surface 14 further improves the mixing of the sample fluid during transporting the sample fluid through the capil- lary channels of the substrate 1.
The invention is not restricted to the above-described embodiment which can be varied in a number of ways within the scope of the claims .

Claims

1. Device for holding a substrate, characterized by upper and lower plates adapted to receive the substrate sandwiched in the interface between the plates, each plate having at least one opening with a projecting rim surrounding the opening and directed away from the interface, wherein the openings in the upper and lower plates are at least partially aligned in the sandwiched position of the plates.
2. Device according to claim 1, wherein the openings are circular and the projecting rims are cylindrical struc- tures .
3. Device according to claim 1 or 2 , wherein each opening in the lower plate is provided with a shielding member partially shielding the opening of the lower plate.
4. Device according to claim 3 , wherein each shielding member has an upper surface inclined with respect to the interface of the plates.
5. Device according to claim 4 , wherein the angle of inclination of the upper surface of the shielding member is at least 5°.
6. Device according to any one of claims 3-5, wherein the opening (s) in the lower plate is (are) staggered with respect to the openings in the upper plate, wherein the shielding member (s) in the lower plate openings fully shield the lower plate opening (s) with respect to the upper plate openings.
7. Device according to any one of claims 3-6, wherein the shielding member (s) have a wedge-shaped cross-section.
PCT/EP2002/002446 2001-03-13 2002-03-05 Device for holding a substrate WO2002072268A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP02724203A EP1370360B1 (en) 2001-03-13 2002-03-05 Device for holding a substrate
JP2002571220A JP2004531707A (en) 2001-03-13 2002-03-05 Substrate holding device
DE60212089T DE60212089T2 (en) 2001-03-13 2002-03-05 STOP SYSTEM FOR A SUBSTRATE

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01200947 2001-03-13
EP01200947.8 2001-03-13

Publications (1)

Publication Number Publication Date
WO2002072268A1 true WO2002072268A1 (en) 2002-09-19

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ID=8180010

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/002446 WO2002072268A1 (en) 2001-03-13 2002-03-05 Device for holding a substrate

Country Status (6)

Country Link
EP (1) EP1370360B1 (en)
JP (1) JP2004531707A (en)
AT (1) ATE328665T1 (en)
DE (1) DE60212089T2 (en)
ES (1) ES2266488T3 (en)
WO (1) WO2002072268A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4687756B2 (en) * 2008-07-07 2011-05-25 株式会社村田製作所 Probe array and manufacturing method thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4427415A (en) * 1979-01-05 1984-01-24 Cleveland Patrick H Manifold vacuum biochemical test method and device
US4549655A (en) * 1983-12-05 1985-10-29 E. I. Du Pont De Nemours And Company Container for a layered chemical analysis system
US4948564A (en) * 1986-10-28 1990-08-14 Costar Corporation Multi-well filter strip and composite assemblies
US5366902A (en) * 1990-10-30 1994-11-22 Hypoguard (Uk) Limited Collection and display device
WO1999023475A1 (en) * 1997-10-31 1999-05-14 Dade Behring Inc. Chromogenic and turbidimetric assay device
WO1999061152A1 (en) * 1998-05-26 1999-12-02 Mj Research, Inc. Automation-compatible slide format sample cartridge
WO2001019517A1 (en) * 1999-09-14 2001-03-22 Pamgene, B.V. Analytical test device with substrate having oriented through going channels and improved methods and apparatus for using same

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4427415A (en) * 1979-01-05 1984-01-24 Cleveland Patrick H Manifold vacuum biochemical test method and device
US4549655A (en) * 1983-12-05 1985-10-29 E. I. Du Pont De Nemours And Company Container for a layered chemical analysis system
US4948564A (en) * 1986-10-28 1990-08-14 Costar Corporation Multi-well filter strip and composite assemblies
US5366902A (en) * 1990-10-30 1994-11-22 Hypoguard (Uk) Limited Collection and display device
WO1999023475A1 (en) * 1997-10-31 1999-05-14 Dade Behring Inc. Chromogenic and turbidimetric assay device
WO1999061152A1 (en) * 1998-05-26 1999-12-02 Mj Research, Inc. Automation-compatible slide format sample cartridge
WO2001019517A1 (en) * 1999-09-14 2001-03-22 Pamgene, B.V. Analytical test device with substrate having oriented through going channels and improved methods and apparatus for using same

Also Published As

Publication number Publication date
DE60212089T2 (en) 2007-01-04
DE60212089D1 (en) 2006-07-20
ES2266488T3 (en) 2007-03-01
JP2004531707A (en) 2004-10-14
EP1370360B1 (en) 2006-06-07
EP1370360A1 (en) 2003-12-17
ATE328665T1 (en) 2006-06-15

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