WO2002072189A2 - Method of manufacturing microneedle structures using soft lithography and photolithography - Google Patents
Method of manufacturing microneedle structures using soft lithography and photolithography Download PDFInfo
- Publication number
- WO2002072189A2 WO2002072189A2 PCT/US2002/007543 US0207543W WO02072189A2 WO 2002072189 A2 WO2002072189 A2 WO 2002072189A2 US 0207543 W US0207543 W US 0207543W WO 02072189 A2 WO02072189 A2 WO 02072189A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- microneedles
- layer
- microneedle
- substrate
- moldable material
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/14—Devices for taking samples of blood ; Measuring characteristics of blood in vivo, e.g. gas concentration within the blood, pH-value of blood
- A61B5/1405—Devices for taking blood samples
- A61B5/1411—Devices for taking blood samples by percutaneous method, e.g. by lancet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
- A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
- A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150022—Source of blood for capillary blood or interstitial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150274—Manufacture or production processes or steps for blood sampling devices
- A61B5/150282—Manufacture or production processes or steps for blood sampling devices for piercing elements, e.g. blade, lancet, canula, needle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
- A61B5/150381—Design of piercing elements
- A61B5/150412—Pointed piercing elements, e.g. needles, lancets for piercing the skin
- A61B5/150419—Pointed piercing elements, e.g. needles, lancets for piercing the skin comprising means for capillary action
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150977—Arrays of piercing elements for simultaneous piercing
- A61B5/150984—Microneedles or microblades
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
- B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
- B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
- B81C1/00023—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems without movable or flexible elements
- B81C1/00111—Tips, pillars, i.e. raised structures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
- B81B2201/00—Specific applications of microelectromechanical systems
- B81B2201/05—Microfluidics
- B81B2201/055—Microneedles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
- B81C2201/00—Manufacture or treatment of microstructural devices or systems
- B81C2201/03—Processes for manufacturing substrate-free structures
- B81C2201/034—Moulding
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE60228065T DE60228065D1 (en) | 2001-03-14 | 2002-03-13 | PROCESS FOR THE PRODUCTION OF MICRONADEL STRUCTURES WITH SOFT LITHOGRAPHY AND PHOTOLITHOGRAPHY |
JP2002571146A JP4778669B2 (en) | 2001-03-14 | 2002-03-13 | Method for manufacturing microneedles structures using soft lithography and photolithography |
CA002436207A CA2436207C (en) | 2001-03-14 | 2002-03-13 | Method of manufacturing microneedle structures using soft lithography and photolithography |
EP02750607A EP1377338B9 (en) | 2001-03-14 | 2002-03-13 | Method of manufacturing microneedle structures using soft lithography and photolithography |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/808,534 | 2001-03-14 | ||
US09/808,534 US6663820B2 (en) | 2001-03-14 | 2001-03-14 | Method of manufacturing microneedle structures using soft lithography and photolithography |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002072189A2 true WO2002072189A2 (en) | 2002-09-19 |
WO2002072189A3 WO2002072189A3 (en) | 2003-03-20 |
Family
ID=25199058
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/007543 WO2002072189A2 (en) | 2001-03-14 | 2002-03-13 | Method of manufacturing microneedle structures using soft lithography and photolithography |
Country Status (8)
Country | Link |
---|---|
US (2) | US6663820B2 (en) |
EP (1) | EP1377338B9 (en) |
JP (1) | JP4778669B2 (en) |
AT (1) | ATE403465T1 (en) |
CA (1) | CA2436207C (en) |
DE (1) | DE60228065D1 (en) |
ES (1) | ES2311615T3 (en) |
WO (1) | WO2002072189A2 (en) |
Cited By (36)
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WO2003020359A2 (en) * | 2001-09-05 | 2003-03-13 | 3M Innovative Properties Company | Microneedle arrays and methods of manufacturing the same |
US6821281B2 (en) | 2000-10-16 | 2004-11-23 | The Procter & Gamble Company | Microstructures for treating and conditioning skin |
WO2005082596A1 (en) * | 2004-02-23 | 2005-09-09 | 3M Innovative Properties Company | Method of molding for microneedle arrays |
EP1594683A2 (en) * | 2003-01-16 | 2005-11-16 | Lee, Seung-seob | Method for manufacturing of polymer micro needle array with liga process |
JP2006526510A (en) * | 2003-06-02 | 2006-11-24 | コリウム インターナショナル, インコーポレイテッド | Method for producing perforated microstructures by using a fluid jet |
JP2007505747A (en) * | 2003-09-17 | 2007-03-15 | ナノコムス・パテンツ・リミテッド | Microstructure device and manufacturing method thereof |
WO2007040938A1 (en) * | 2005-09-30 | 2007-04-12 | Tti Ellebeau, Inc. | Functionalized microneedles transdermal drug delivery systems, devices, and methods |
SG134178A1 (en) * | 2006-01-09 | 2007-08-29 | Agency Science Tech & Res | Microstructure formation technique |
WO2009059089A1 (en) * | 2007-11-01 | 2009-05-07 | 3M Innovative Properties Company | Method for replicating master molds |
WO2010111009A1 (en) | 2009-03-23 | 2010-09-30 | The Boeing Company | Durable transparent intelligent coatings for polymeric transparencies |
US7828827B2 (en) | 2002-05-24 | 2010-11-09 | Corium International, Inc. | Method of exfoliation of skin using closely-packed microstructures |
US8017145B2 (en) | 2003-12-22 | 2011-09-13 | Conopco, Inc. | Exfoliating personal care wipe article containing an array of projections |
US8192787B2 (en) | 2004-08-16 | 2012-06-05 | Innoture Limited | Method of producing a microneedle or microimplant |
US8309650B2 (en) | 2007-10-30 | 2012-11-13 | 3M Innovative Properties Company | High refractive index adhesives |
WO2012170204A1 (en) * | 2011-06-08 | 2012-12-13 | 3M Innovative Properties Company | Photoresists containing polymer-tethered nanoparticles |
US8378046B2 (en) | 2007-10-19 | 2013-02-19 | 3M Innovative Properties Company | High refractive index pressure-sensitive adhesives |
US8383027B2 (en) | 2008-03-12 | 2013-02-26 | Fujifilm Corporation | Method of fabricating a template for a concave array mold, a concave array mold and a needle array sheet |
CN102988039A (en) * | 2012-12-17 | 2013-03-27 | 中国科学院半导体研究所 | Manufacture method microneedle array-based skin dry electrode |
US8551391B2 (en) | 2004-02-17 | 2013-10-08 | Avery Dennison Corporation | Method of making microneedles |
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US9687641B2 (en) | 2010-05-04 | 2017-06-27 | Corium International, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
WO2017151806A1 (en) | 2016-03-01 | 2017-09-08 | Kitotech Medical, Inc. | Microstructure-based systems, apparatus, and methods for wound closure |
US10195409B2 (en) | 2013-03-15 | 2019-02-05 | Corium International, Inc. | Multiple impact microprojection applicators and methods of use |
US10238848B2 (en) | 2007-04-16 | 2019-03-26 | Corium International, Inc. | Solvent-cast microprotrusion arrays containing active ingredient |
US10245422B2 (en) | 2013-03-12 | 2019-04-02 | Corium International, Inc. | Microprojection applicators and methods of use |
US10384045B2 (en) | 2013-03-15 | 2019-08-20 | Corium, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
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CN112373061A (en) * | 2020-10-13 | 2021-02-19 | 航天特种材料及工艺技术研究所 | Composite material member and manufacturing method thereof |
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Also Published As
Publication number | Publication date |
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JP4778669B2 (en) | 2011-09-21 |
ES2311615T3 (en) | 2009-02-16 |
US6663820B2 (en) | 2003-12-16 |
EP1377338A2 (en) | 2004-01-07 |
WO2002072189A3 (en) | 2003-03-20 |
ATE403465T1 (en) | 2008-08-15 |
CA2436207A1 (en) | 2002-09-19 |
DE60228065D1 (en) | 2008-09-18 |
US20020133129A1 (en) | 2002-09-19 |
EP1377338B9 (en) | 2008-11-05 |
EP1377338B1 (en) | 2008-08-06 |
US20040146611A1 (en) | 2004-07-29 |
JP2004526581A (en) | 2004-09-02 |
CA2436207C (en) | 2008-12-02 |
US7763203B2 (en) | 2010-07-27 |
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