WO2002070039A2 - Intravascular device for treatment of hypertension - Google Patents
Intravascular device for treatment of hypertension Download PDFInfo
- Publication number
- WO2002070039A2 WO2002070039A2 PCT/US2002/006929 US0206929W WO02070039A2 WO 2002070039 A2 WO2002070039 A2 WO 2002070039A2 US 0206929 W US0206929 W US 0206929W WO 02070039 A2 WO02070039 A2 WO 02070039A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pump
- blood pressure
- artery
- blood flow
- renal artery
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/40—Details relating to driving
- A61M60/403—Details relating to driving for non-positive displacement blood pumps
- A61M60/408—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable
- A61M60/411—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable generated by an electromotor
- A61M60/414—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable generated by an electromotor transmitted by a rotating cable, e.g. for blood pumps mounted on a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/10—Location thereof with respect to the patient's body
- A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
- A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
- A61M60/135—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel inside a blood vessel, e.g. using grafting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/10—Location thereof with respect to the patient's body
- A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
- A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
- A61M60/135—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel inside a blood vessel, e.g. using grafting
- A61M60/139—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel inside a blood vessel, e.g. using grafting inside the aorta, e.g. intra-aortic balloon pumps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/20—Type thereof
- A61M60/205—Non-positive displacement blood pumps
- A61M60/216—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
- A61M60/226—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller the blood flow through the rotating member having mainly radial components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/30—Medical purposes thereof other than the enhancement of the cardiac output
- A61M60/31—Medical purposes thereof other than the enhancement of the cardiac output for enhancement of in vivo organ perfusion, e.g. retroperfusion
- A61M60/33—Medical purposes thereof other than the enhancement of the cardiac output for enhancement of in vivo organ perfusion, e.g. retroperfusion of kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/50—Details relating to control
- A61M60/585—User interfaces
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/80—Constructional details other than related to driving
- A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
- A61M60/833—Occluders for preventing backflow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/80—Constructional details other than related to driving
- A61M60/855—Constructional details other than related to driving of implantable pumps or pumping devices
- A61M60/861—Connections or anchorings for connecting or anchoring pumps or pumping devices to parts of the patient's body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/35—Communication
- A61M2205/3507—Communication with implanted devices, e.g. external control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1078—Urinary tract
- A61M2210/1082—Kidney
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14276—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/10—Location thereof with respect to the patient's body
- A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
- A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
- A61M60/148—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
Definitions
- the invention relates to devices used in the treatment of essential hypertension. More particularly, the invention relates to an intrarenal pump that produces a decrease in blood pressure via hormonal modulation.
- Hypertension is a primary or contributing cause in more than 10% of deaths in the United States. Hypertension is a disease often overlooked and inefficiently managed. According to the American Heart Association, about 44% of men and women age 55-64 have hypertension. Sixty percent of men and women age 65-74 are hypertensive, and after age 75, 64% of men and 77% of women have hypertension. Men are at increased risk for development of hypertension prior to age 55. After age 55, women have a slightly increased risk, and after age 75, women are at a much greater risk of developing hypertension. Hypertension is generally defined as a systolic blood pressure of greater than 140 mm Hg, or a diastolic blood pressure of 90 mm Hg or more.
- Systolic blood pressure is the transmural pressure within arteries during the contraction of the left ventricle.
- Diastolic pressure is pressure within arteries during relaxation of the left ventricle. Elevated diastolic blood pressure reflects high continuous, static pressure on arterial walls, while an elevated systolic blood pressure intermittently stresses the arterial walls with increased pressure during each heart beat.
- Essential, or primary, hypertension accounts for approximately 90% of cases of hypertension, and the cause is unknown.
- Hypertension is often called a "silent killer.” Symptoms of elevated blood pressure are rare unless the pressure is extremely high. Target organ damage can be the first manifestation of hypertension and occurs primarily in the heart, brain, eyes, and kidney.
- Organs can be damaged by labile and chronic hypertension, or by acute episodes of severe hypertension.
- Hypertension is a major risk factor for the development of arteriosclerosis.
- vascular damage develops as a result of chronically elevated blood pressure.
- high blood pressure can contribute to the buildup of arteriosclerotic plaque within vessel walls. This plaque accumulation can hinder a vessel's ability to react to hormonal and neurogenic stimuli.
- elevated blood pressure can cause rupture of thin-walled vessels.
- the exposure of inflammatory material within the vessel walls to procoagulant factors in the blood leads to thrombus (clot) formation.
- thrombus clot
- This unstable environment provides a physiologic basis for angina (chest pain caused by inadequate oxygen delivery to the heart), myocardial infarction (heart attack), peripheral vascular disease, ischemic neuropathy, transient ischemic attacks (TIAs), and stroke.
- Age is the strongest identifiable factor related to elevated blood pressure.
- Epithelial tissue declines in elasticity as people age. Blood vessels become less flexible, and their response to numerous regulatory substances is reduced. This suggests a decline in the effectiveness of endogenous mechanisms of blood pressure control with age.
- Blood pressure is normally regulated by compensatory mechanisms that respond to changes in cardiac demand. Blood pressure is mathematically equivalent to the product of cardiac output and total peripheral resistance in the vasculature. Cardiac output, in turn, is the product of cardiac stroke volume and heart rate. An increase in cardiac output (i.e., the volume of blood expelled from the heart each minute) results in a compensatory decrease in total peripheral resistance, caused by dilation of arterioles (vasodilation). Conversely, a decreased cardiac output normally leads to a compensatory increase in total peripheral resistance through vasoconstriction. In normal circumstances, this compensation occurs to maintain a normal blood pressure.
- the sympathetic nervous system can act on the heart and blood vessels by direct nerve transmission and through the release of catecholamine hormones, including epinephrine and norepinephrine.
- catecholamines stimulate alpha and beta adrenergic receptors throughout the body.
- the most prevalent receptors are alpha- 1 receptors, located in blood vessels.
- Beta-1 receptors are similar to alpha- 1 receptors, except that beta-1 receptors are located primarily in the heart. Medications that block these adrenergic receptor sites decrease blood pressure.
- Alpha- 1 receptor blockade causes blood vessels to dilate.
- Beta-1 receptor blockade causes myocardial contractility and heart rate to decrease, thereby decreasing cardiac output.
- Alpha-2 receptors located in the brain stem can be stimulated to reduce catecholamine release as part of a negative feedback mechanism. Medications that bind to these receptors can cause a decrease in the amount of catecholamines released, thereby lowering blood pressure.
- renin-angiotensin-aldosterone a complex compensatory blood pressure system located principally in the kidney. Whenever blood pressure, blood volume, or arterial sodium concentration decreases, renin is released by the kidney to ensure adequate renal perfusion.
- the renin-angiotensin system is triggered when the granular cells of the juxtaglomerular apparatus release renin in response to various stimuli, including norepinephrine release from sympathetic innervation of the kidney, reduced stretch of juxtaglomerular cells, and reduced flow of sodium to the macula densa cells of the juxtaglomerular apparatus, located in the distal tubule of the nephron.
- Renin is an enzyme that acts on angiotensinogen, also known as renin substrate, to produce angiotensin I.
- Angiotensin I is then converted to angiotensin ⁇ through the action of angiotensin converting enzyme (ACE).
- ACE angiotensin converting enzyme
- Angiotensin ⁇ is a potent vasoconstrictor that quickly increases total vascular resistance (total peripheral resistance) as a way of keeping vital organs adequately perfused.
- Angiotensin II also stimulates the production of the hormone aldosterone from the adrenal cortex.
- Aldosterone in turn, causes renal retention of sodium chloride at the level of the distal convoluted tubule and, to a lesser extent, the collecting duct, helping to maintain fluid balance and blood pressure homeostasis. Aldosterone also produces renal loss of hydrogen and potassium ions. In the presence of aldosterone, up to 99.5% of all ingested sodium is retained through renal tubular reabsorption. In the absence of aldosterone, a continued obligatory loss of approximately 20 mg of sodium per day occurs until blood pressure falls, and symptoms, such as fainting (syncope), may result.
- ACE inhibitors angiotensin converting enzyme inhibitors
- ARBs angiotensin II receptor blockers
- Some aspects of the invention include an apparatus for reducing blood pressure, comprising an intravascular pump configured to be placed within an artery.
- the pump is configured to increase antegrade blood flow in a renal artery, thereby producing a reduction in blood pressure.
- the intravascular pump is placed in a renal artery.
- it can be placed in the aorta.
- the intravascular pump further comprises a control mechanism in communication with the pump, whereby a user can adjust the mechanism producing a change in the antegrade blood flow through the pump.
- the intravascular pump further comprises a radiofrequency transmitter, wherein the user can adjust the mechanism remotely via the radiofrequency transmitter, thereby producing a change in the antegrade blood flow through the pump.
- the intravascular pump further comprises an inductive coupling controller, wherein the user can adjust the mechanism remotely via the inductive coupling controller, thereby producing a change in the antegrade blood flow through the pump.
- Some aspects of the invention include a method for reducing blood pressure, comprising placing an intravascular pump in an artery.
- the pump is configured to increase antegrade blood flow in a renal artery, thereby producing a reduction in blood pressure.
- the intravascular pump is placed in a renal artery. In other embodiments, it can be placed in the aorta.
- the method further comprises adjusting a control mechanism that is in communication with the pump, whereby said adjusting causes a change in the antegrade blood flow through the pump.
- the method further comprises using a radiofrequency transmitter to adjust the mechanism remotely, thereby producing a change in the antegrade blood flow through the pump.
- the method further comprises using an inductive coupling controller to adjust the mechanism remotely, thereby producing a change in the antegrade blood flow through the pump.
- Figure 1 is a schematic frontal view of an intravascular pump placed within the renal artery.
- Figure 2 is a schematic frontal view of an intravascular pump with a balloon fixation member placed within the renal artery.
- an intravascular pump 2 is shown, which may, for example, be placed within the renal artery or aorta or other suitable artery via percutaneous catheter 6 or via an open surgical procedure.
- a percutaneous catheter 6 may be placed via the femoral artery into the common iliac area artery 8, then fed up the aorta 10 and into a renal artery 4.
- the pump 2 may then be situated within the renal artery 4 by any suitable fixation method.
- suitable fixation method include inflation of a balloon 14, as shown in Figure 2, as well as other fixation methods known to those skilled in the art.
- the pump 2 causes an increase in forward (downstream or antegrade) flow through the renal artery 4 and into the kidney 12.
- This increased flow is perceived at the level of the macula densa of the kidney 12 as increased volume and sodium delivery to the macula densa and the juxtaglomerular apparatus.
- This increased delivery of sodium to the macula densa results in suppression of renin production and release from the granular cells of the juxtaglomerular apparatus, with consequent reduction in angiotensin II and aldosterone levels.
- This decreased aldosterone and angiotensin TJ production leads to a reduction in blood pressure.
- the intravascular pump 2 may be surgically placed directly or indirectly into the renal artery 4, the aorta 10, or other suitable artery, with or without the need for placement via a percutaneous catheter 6.
- FIG. 2 illustrates another embodiment. Again shown is the catheter 6 ascending from the aorta 10 into the renal artery 4.
- a balloon 14 or other appropriate expander may be located around the periphery of, or adjacent to, the pump 2.
- the balloon 14 can be inflated, or the expander otherwise expanded, to cause the pump 2 to be situated securely within the renal artery 4. This allows for minimal lateral and axial movement of the pump 2 within the renal artery 4.
- the pump 2 may be any suitable fluid pump known to those of skill in the art to produce an increase in blood flow in the renal artery 4 above the physiologic rate of flow.
- This pump 2 may have an internal rotary propeller, diagonal fan or propeller, or other suitable mechanism.
- the pump 2 may be powered at the proximal end of the catheter, and even outside the patient.
- a drive shaft for the pump 2 may be located within the body of the catheter 6, to which the pump 2 is attached. Alternatively, the power source may be self-contained within the pump 2 itself, or its housing, or adjacent thereto
- the pump 2 may operate continuously or in some embodiments, intermittently, as befits the need of the patient in optimally lowering blood pressure.
- the pump 2 may, in certain embodiments, be programmable to operate at various intervals and/or speeds.
- the programming of the pump 2 may be accomplished before and/or after implantation in the patient.
- the programming may be accomplished by an external electromagnetic coupling device (not shown) such as a hand-held radiofrequency transmitter that may be held by a physician over the patient's body during the programming of pump variables, such as on-off intervals and pump speed.
- a microelectrode, radiofrequency catheter, or other energy releasing device is placed within the renal artery 4 and into the substance of the kidney 12, with the tip of the microelectrode or other device in close proximity to the macula densa and juxtaglomerular apparatus.
- This device then stimulates the macula densa and juxtaglomerular apparatus with an electrical current or other type of energy transmission, such as radiofrequency transmission.
- This energy stimulation causes a suppression of renin release from the juxtaglomerular apparatus, leading to decreased sodium chloride and water retention by the kidney, and a consequent reduction in blood pressure.
- This microelectrode or micro-RF transmitter may be powered outside the patient, with an electrical wire running through a catheter body and supplying electrical power to the microelectrode, or other suitable actuator or transducer at the distal end of the catheter 6.
- An appropriate power source such as a battery, may also be located outside of the patient's body.
- the microelectrode or micro-RF transmitter may be powered by a battery, which may be located, for example, within the microelectrode or micro-RF transmitter device.
- an appropriate power source such as a battery; may also be located outside of the patient's body and power may be delivered to the device through inductive coupling, in any of various ways well known to those skilled in the art.
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002250250A AU2002250250A1 (en) | 2001-03-01 | 2002-03-01 | Intravascular device for treatment of hypertension |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27263401P | 2001-03-01 | 2001-03-01 | |
US60/272,634 | 2001-03-01 |
Publications (3)
Publication Number | Publication Date |
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WO2002070039A2 true WO2002070039A2 (en) | 2002-09-12 |
WO2002070039A3 WO2002070039A3 (en) | 2003-05-01 |
WO2002070039A8 WO2002070039A8 (en) | 2003-10-30 |
Family
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Application Number | Title | Priority Date | Filing Date |
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PCT/US2002/006929 WO2002070039A2 (en) | 2001-03-01 | 2002-03-01 | Intravascular device for treatment of hypertension |
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AU (1) | AU2002250250A1 (en) |
WO (1) | WO2002070039A2 (en) |
Cited By (85)
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WO2005037348A1 (en) * | 2003-10-15 | 2005-04-28 | Orqis Medical Corporation | Implantable heart assist system and method of applying same |
US7485104B2 (en) | 2000-10-30 | 2009-02-03 | Cvrx, Inc. | Systems and methods for controlling renovascular perfusion |
US8118724B2 (en) | 2003-09-18 | 2012-02-21 | Thoratec Corporation | Rotary blood pump |
US8224437B2 (en) | 2003-10-22 | 2012-07-17 | Cvrx, Inc. | Baroreflex activation for sedation and sleep |
US8712531B2 (en) | 2000-09-27 | 2014-04-29 | Cvrx, Inc. | Automatic baroreflex modulation responsive to adverse event |
US8852163B2 (en) | 2002-04-08 | 2014-10-07 | Medtronic Ardian Luxembourg S.A.R.L. | Renal neuromodulation via drugs and neuromodulatory agents and associated systems and methods |
US8876815B2 (en) | 2011-12-09 | 2014-11-04 | Metavention, Inc. | Energy delivery devices for hepatic neuromodulation |
US9072527B2 (en) | 2002-04-08 | 2015-07-07 | Medtronic Ardian Luxembourg S.A.R.L. | Apparatuses and methods for renal neuromodulation |
US9131978B2 (en) | 2002-04-08 | 2015-09-15 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for bilateral renal neuromodulation |
US20160022890A1 (en) * | 2013-03-13 | 2016-01-28 | Magenta Medical Ltd. | Renal pump |
CN105473089A (en) * | 2013-06-05 | 2016-04-06 | 麦特文申公司 | Modulation of targeted nerve fibers |
US9512852B2 (en) | 2006-03-31 | 2016-12-06 | Thoratec Corporation | Rotary blood pump |
US9636174B2 (en) | 2002-04-08 | 2017-05-02 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for therapeutic renal neuromodulation |
US9675740B2 (en) | 2012-05-14 | 2017-06-13 | Tc1 Llc | Impeller for catheter pump |
US9675739B2 (en) | 2015-01-22 | 2017-06-13 | Tc1 Llc | Motor assembly with heat exchanger for catheter pump |
US9675738B2 (en) | 2015-01-22 | 2017-06-13 | Tc1 Llc | Attachment mechanisms for motor of catheter pump |
US9707035B2 (en) | 2002-04-08 | 2017-07-18 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for catheter-based renal neuromodulation |
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US9770543B2 (en) | 2015-01-22 | 2017-09-26 | Tc1 Llc | Reduced rotational mass motor assembly for catheter pump |
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US9827040B2 (en) | 2002-04-08 | 2017-11-28 | Medtronic Adrian Luxembourg S.a.r.l. | Methods and apparatus for intravascularly-induced neuromodulation |
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US9968611B2 (en) | 2002-04-08 | 2018-05-15 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and devices for renal nerve blocking |
US9980766B1 (en) | 2014-03-28 | 2018-05-29 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and systems for renal neuromodulation |
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US10034708B2 (en) | 2002-04-08 | 2018-07-31 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for thermally-induced renal neuromodulation |
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US10071192B2 (en) | 2013-03-15 | 2018-09-11 | Tc1 Llp | Catheter pump assembly including a stator |
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US10086121B2 (en) | 2012-07-03 | 2018-10-02 | Tc1 Llc | Catheter pump |
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US10124195B2 (en) | 2002-04-08 | 2018-11-13 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for thermally-induced renal neuromodulation |
US10130792B2 (en) | 2002-04-08 | 2018-11-20 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for therapeutic renal neuromodulation using neuromodulatory agents or drugs |
US10179020B2 (en) | 2010-10-25 | 2019-01-15 | Medtronic Ardian Luxembourg S.A.R.L. | Devices, systems and methods for evaluation and feedback of neuromodulation treatment |
US10194979B1 (en) | 2014-03-28 | 2019-02-05 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for catheter-based renal neuromodulation |
US10194980B1 (en) | 2014-03-28 | 2019-02-05 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for catheter-based renal neuromodulation |
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Publication number | Publication date |
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AU2002250250A1 (en) | 2002-09-19 |
WO2002070039A8 (en) | 2003-10-30 |
WO2002070039A3 (en) | 2003-05-01 |
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