WO2002067883A1

WO2002067883A1 - Cleansing compositions for oral cavity

Info

Publication number: WO2002067883A1
Application number: PCT/JP2002/001832
Authority: WO
Inventors: Naomi Yasuda
Original assignee: Sunstar Inc.
Priority date: 2001-02-28
Filing date: 2002-02-28
Publication date: 2002-09-06
Also published as: JP2002255769A; JP5084075B2

Abstract

It is intended to provide cleansing compositions for oral cavity which can be conveniently used as mouth cleanser, impart a feel in using and a cleansing effect comparable to toothbrushes, and exert a massaging effect on the gingiva; and a method of cleansing the inside of the oral cavity. The cleansing compositions for oral cavity is characterized by containing a gel, while the method of cleansing the inside of the oral cavity is characterized in that the gel is finely divided in the oral cavity during using.

Description

Specification

Oral cleansing composition

The present invention relates to a mouthwash composition containing a gel and a mouthwash method. Landscape technology

In order to remove plaque which causes caries or periodontal disease, brushing with a dentifrice or mouthwash with a mouthwash has been conventionally performed.

Brushing the dentifrice and toothbrush lacks simplicity of mouth stains may take and is not intended as water for rinsing can be everywhere because it is necessary. On the other hand, although the mouthwash only needs to be spit out in the mouth, there is a problem that the feeling of use and the cleaning effect are poor. Mouthwash is usually required to be thoroughly rinsed in the mouth for about 20 to 30 seconds, but if it is used daily, it is generally exhaled in less than 10 seconds. In many cases.

An object of the present invention is to provide a mouthwash composition having the simplicity of a mouthwash, the feeling of use such as brushing, the cleaning effect, and the massaging effect on gingiva. Disclosure of the invention

As a result of intensive studies to achieve the above object, the present inventor has found that, when the dosage form is in the form of a gel, it is easy to use, and there is a real feeling of use due to the stress that breaks down the gel by including it in the mouth and squeezing the gel. The present inventors have found that dirt can be effectively removed, and have completed the present invention. That is, the present invention provides the inventions according to the following items.

Item 1 An oral cavity cleaning composition comprising a gel. Item 2 The composition according to Item 1, comprising a gel formed from at least one selected from the group consisting of dielan gum, pectin, sodium alginate, carrageenan, agar, gelatin, and phaserelan. object.

Item 3. The composition according to Item 2, wherein the composition is a gel formed from a polyvalent cation and at least one member selected from the group consisting of dielan gum, pectin, sodium alginate, and larginan.

Item 4 The composition according to Item 3, wherein the polyvalent cation is a calcium ion.

Item 5 The composition according to Item 1, wherein the gel is a gel formed by mixing 30 to 90% by weight of water based on the total weight of the gel.

Item 6: The gel contains at least one selected from the group consisting of hydroxyethyl cellulose, sodium carboxymethylcellulose, sodium polyacrylate, and a polyoxyethylene-polypropylene copolymer. Item 2. The oral cavity cleaning composition according to Item 1, which is characterized in that:

Item 7. A method for washing the oral cavity, wherein the gel is used while being finely divided in the oral cavity.

Item 8 The washing method according to Item 7, wherein the gel is a gel formed from at least one selected from the group consisting of dielan gum, pectin, sodium alginate, carrageenan, agar, gelatin, and phaseleran. . Hereinafter, the present invention will be described in more detail.

The composition of the present invention is a gel itself or a gel-containing gel having a moderate hardness and a brittle touch, for example, crushing with a tongue and a hard palate without using teeth. The hardness is such that The gel of the present invention is not particularly limited as long as the desired effects of the present invention are exhibited.For example, a polymer selected from dielan gum, agar, gelatin, pectin, sodium alginate, carrageenan, and furcellane (Hereinafter, these may be referred to as "the specific polymer of the present invention.") It is preferable that the gel be a force-formed gel. No. Among them, a gel formed from a polymer selected from dielan gum, pectin, sodium alginate and carrageenan is preferable, and a gel formed from a polymer selected from dielan gum, pectin and power raginan is more preferable. Further, a gel formed from a polymer selected from lactic acid and pectin is more preferable, and a gel formed from dielan gum is most preferable.

These specific polymers of the present invention may be used alone or in combination of two or more.

The amount of the gel formed by using the above-mentioned specific polymer of the present invention is not particularly limited as long as the intended effect of the present invention is achieved, and can be appropriately set. It is preferably about 0.005 to 5% by weight, particularly preferably about 0.05 to 3% by weight, and more preferably about 0.05 to 1% by weight based on the total weight. If the concentration of the specific polymer is 0.005% by weight or more, sufficient tactile sensation, practical feeling, and cleaning effect can be obtained when stuffed into the mouth. This is preferable because a gel having an appropriate hardness that can be broken is obtained. When ions are required to form a gel, that is, when at least one of dielan gum, pectin, sodium alginate and carrageenan is used, the gel is preferably formed in the presence of a polyvalent cation. .

Examples of polyvalent cations include divalent cations (eg, alkaline earth metal ions such as Mg ^{2 +} and Ca ^{2 +} ), and trivalent cations (eg, Al ^{3 +} ). Of these, divalent cations are preferred, and calcium ions are particularly preferred. Examples of the cation source include, but are not limited to, organic acids such as calcium lactate, magnesium lactate, calcium dalconate, calcium glycerate phosphate, magnesium chloride, calcium chloride, magnesium sulfate, and aluminum lactate. Alternatively, a water-soluble polyvalent metal salt of an inorganic acid may be mentioned. Among them, a salt of an organic acid is preferable, and calcium lactate is particularly preferable.

These cation sources can be used alone or in combination of two or more.

The combination of at least one of the above-mentioned dielan gum, pectin, sodium alginate and carrageenan and a polyvalent cation is particularly useful as long as a desired gel can be obtained. Although not limited, for example, dielan gum and calcium ions, zinc and calcium ions, carrageenan and calcium ions are preferred. The blending amount of the water-soluble polyvalent metal salt as a cation source is not particularly limited as long as a desired gel can be obtained, and at least one kind and amount of dielan gum, pectin, sodium alginate and carrageenan is used. It can be appropriately set according to the desired gel hardness, but is usually about 0.01 to 2% by weight, particularly about 0.05 to 1% by weight, and more preferably about 0 to 1% by weight based on the total amount of the composition. It is preferably about 0.5 to 0.7% by weight. For example, when calcium lactate is used as a cation source, the amount of calcium lactate may be about 0.01 to 1% by weight, preferably about 0.05 to 0.5% by weight, based on the total weight of the composition. It is about. The amount used when another cation source is used can be appropriately set with reference to the above range.

The amount of water used in preparing the gel of the composition of the present invention is not particularly limited as long as the desired effect of the present invention can be obtained, and can be appropriately set, but is usually based on the total weight of the gel. It is about 30 to 90% by weight, preferably about 50 to 90% by weight, and more preferably about 65 to 90% by weight.

The pH of the mouthwash composition of the present invention is preferably about 5.5 to 7.5, and more preferably about 6 to 7. When the pH is 5.5 or more, there is no risk of decarburization of the teeth when applied to the oral cavity, and when the pH is 7.5 or less, the hardened steel has sufficient stress to clean the oral cavity. This is preferable because a gel having a thickness of 10 μm can be formed.

In the present invention, it is preferable to add a chelating agent so that the formed gel is homogeneous. Examples of the chelating agent include sodium salts and potassium salts of cunic acid, malic acid, tartaric acid, acetic acid, phosphoric acid and the like. The amount of the chelating agent is usually about 0.01 to 0.5% by weight based on the total amount of the composition.

The gel of the present invention contains a conventionally known component usually used in a mouthwash composition, for example, a wetting agent, a dispersing agent, a surfactant, an active ingredient, a flavoring agent, a coloring agent, a cleaning aid, and the like. Can be blended.

Specific examples of the wetting agent include ethanol, glycerin, sorbitol, ethylene glycol, propylene glycol, 1,3-butylendalcol, polyethylene glycol, polypropylene glycol, xylitol, maltitol, and lamellar. Coutitol, erythritol, palatinose, palatinit and the like. The amount of the wetting agent is usually about 1 to 50% by weight, preferably about 5 to 30% by weight, based on the total amount of the composition.

Examples of dispersants include cellulose derivatives such as sodium carboxymethylcellulose, methylcellulose, and hydroxyethyl cellulose; gums such as tragacanth gum, karaya gum, arabic gum, xanthan gum, and mouth-to-cast bean gum; sodium polyacrylate; And synthetic water-soluble polymers such as oxyshethylene polyoxypropylene copolymer, polyvinyl alcohol, propyloxyvinyl polymer, and polyvinylpyrrolidone. The amount of the dispersant is usually about 0.05 to 1% by weight based on the total amount of the composition.

As the dispersant, hydroxyethyl cellulose, sodium carboxymethylcellulose, sodium polyacrylate and polyoxyethylenepolypropylene copolymer are preferred.

It is preferable to mix these dispersants, because the effect of lowering the water separation rate due to the change over time is exhibited.

Surfactants include anionic surfactants such as sodium lauryl sulfate, sodium myristyl sulfate, N-lauroyl sarcosinate, lauroyl methyl taurine salt, and acyl amino acid salt; sucrose fatty acid ester, decaglyceryl laurate, myristinic acid Examples include nonionic surfactants such as diethanolamide and polyoxyethylene hydrogenated castor oil. The amount of the surfactant is usually from 0.05 to about 0% by weight, preferably from 0.1 to about 0% by weight, based on the total amount of the composition. Active ingredients (medicinal ingredients) include fluorine compounds such as sodium fluoride, sodium monofluorophosphate, stannous fluoride; enzymes such as dextranase, mutanase, protease, and lysozyme; tranexamic acid, ε-aminocaproic acid, Aluminum chloride hydroxy allantoin, allantoin, dihydrocholesterol, dalytileritic acid, bisabolol, isopropylmethylphenol, dali cerophosphate, chlorophyll, copper dalconate, sodium chloride, 7] <soluble inorganic phosphate compounds, chlorhexidine salts , Triclosan, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride; acetic acid d1-α-tocopherol, etc. Vitamin E; Vitamin B such as pyridoxine acetate; Vitamin C such as ascorbic acid; plant extracts such as thyme extract and oegone extract, etc., which are generally incorporated as active ingredients (medicinal ingredients) in oral compositions. Such components are included. The amount of the active ingredient may be appropriately set according to the type of the active ingredient, but is usually 0.000 ;! with respect to the total amount of the composition. About 10% by weight.

As flavor and sweetner, saccharin sodium, acesulfame potassium, stepioside, glycyrrhizin, asparatyl fenyl araradin methyl ester, menthol, annel, carvone, eugenol, limonene, peppermint oil, spearmint oil, wing oil green Oils, methyl salicylate, sionaire, zimole, clove oil, eucalyptus oil, rosemary oil, sage oil, lemon oil, orange oil, ocimene oil, citronellol, methyl eugenol, etc. Can be blended. The amount of the flavoring agent is usually about 0.001 to 5% by weight, preferably about 0.05 to 3% by weight, based on the total amount of the composition.

As colorants, Red No. 3 (Acid Red 51), Red No. 105 (Acid Red 94), Red No. 106 (Acid Red 52), Yellow No. 4 (Acid Yellow 23), Blue No. 1 (Food Blue) 2), Blue No. 2 (Acid Blue 74), Green No. 3 (Food Green 3), Green No. 201 (Acid Green 25), etc. Tar dyes and acids that can be used in foods, pharmaceuticals and cosmetics ^ Pigments such as titanium, gunjiyou and kojiyou can be used alone or in combination of two or more.

The amount of the coloring agent may be appropriately set according to the type of the coloring agent so that the gel has a desired color.

Further, as a cleaning agent (abrasive agent), precipitated silica, zirconosilicate, aluminosilicate, calcium phosphate, calcium carbonate, aluminum hydroxide, aluminum oxide and the like can be blended. The amount of the cleaning aid is usually about 1 to 10% by weight based on the total amount of the composition.

The amounts of these optional components may be such that the effects of the present invention are not impaired, and are generally such that they are incorporated into a composition intended to clean the oral cavity. The method for producing the mouthwash composition of the present invention is not particularly limited. For example, it can be manufactured as follows.

First, a component for forming a gel in water, for example, the specific polymer of the present invention is added to water, and if necessary, heat is applied to dissolve the resultant to form an aqueous solution.Other components are added to the aqueous solution, and the mixture is stirred. Thereafter, if necessary, the gel can be obtained by cooling to about room temperature. When a polyvalent cation is used to form a gel, other components are added to the aqueous solution of the polymer, and after stirring, the mixture is cooled to about room temperature as needed, and an aqueous solution containing a polyvalent cation is added. Mixing can form a gel. As the mouthwash composition of the present invention, the gel obtained as described above may be used as it is, or after gelation, cut into an appropriate size by stirring or passing through a mesh. Also included are free flowing gels.

In addition, the gel can be formed into a fluid gel by discharging the gel from a pump container or by squeezing the gel from a soft container having a narrow mouth. The composition of the present invention can be used as described above, and the gel having fluidity obtained in this manner is also included in the composition for cleaning oral cavity of the present invention. If such a gel is used to remove plaque that is the cause of dental caries or periodontal disease, it can be contained in the oral cavity, broken down physically, and fragmented to form a gel. The dirt in the mouth can be removed by the stress. In addition, when the mouth is swallowed with such a gel, the mass of the gel is further broken down, and the gel can move smoothly in the oral cavity, such as between teeth. It is convenient because you can know the standard between them. In addition to not only cleaning the oral cavity, it can also be expected to have a gingival massage effect.

The composition of the present invention also includes a composition containing a gel, water, and other components as described above in a range not to impair the intended effects of the present invention. As described above, the intraoral cleansing composition of the present invention can be used to clean the inside of the mouth by physically squeezing the gel, as in a normal mouthwash, by physically squeezing the gel. It is exhaled from the mouth without swallowing after use. The period of time for the oral cavity is not particularly limited, but is usually about 10 to 30 seconds, preferably about 20 to 30 seconds. The amount of the oral cavity cleaning composition used is not particularly limited, but is usually about 5 to 25 ml, preferably about 10 to 2 Om1. BEST MODE FOR CARRYING OUT THE INVENTION

Hereinafter, the present invention will be described specifically with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples. In addition, all% in each case are weight%.

Examples 1-2 and Comparative Example 1

An oral cavity cleaning composition was prepared according to each composition shown below, and the cleanability and the feeling upon use were evaluated.

(Example 1)

Ingredients Amount (wt%)

0 2

Glycerin 7 0

Ethanol 70

Polyoxyethylene hydrogenated castor oil (60E.O.) 50

0

Calcium lactate 0 2 5

Sodium citrate 0 0 2

Spice

purified water

[Production method] All components except calcium lactate were put in purified water and dissolved while heating.After stirring, an aqueous solution of calcium lactate was added, and the mixture was cooled to about room temperature to solidify to obtain a gel. . Thereafter, a mouthwash composition containing a gel of an appropriate size (maximum size that can be contained in the mouth at a time) was obtained by stirring. pH was 6.3. The gel obtained in this way has a moderate hardness (can be broken without using teeth) ), Which acted to massage gingiva and changed into a liquid state by physically subdividing the gel in the oral cavity.

(Example 2)

Ingredients Amount (wt%)

0 5

Sorbi!

Sodium lauryl sulfate 0

Polyxylene xylene ethylene castor oil (60E.0.) 5 0

0

Glycemic calcium phosphate 0 5

Sodium citrate 0 3

Fragrance Total 100.0%

[Production method] All components except calcium daricellophosphate were added to purified water, and the mixture was stirred while heating, and then an aqueous solution of calcium phosphate of glycerol was added. The mixture was cooled to about room temperature and solidified to obtain a gel. By stirring, an oral cavity washing composition containing a gel of an appropriate size was obtained. pH was 6.0.

The gel thus obtained had a moderate hardness and a tactile sensation to wipe off dirt in the oral cavity, and became liquid by being physically subdivided in the oral cavity.

(Comparative Example 1)

Ingredients Amount (wt%)

Glycerin 7.0

Ethanol 7.0

Polyoxyethylene hydrogenated castor oil (60E.O.) 5.0

0.1

Sodium citrate 0.3 Perfume total 100.0.0%

[Production method] A conventional mouthwash (liquid) was prepared according to a conventional method.

(1) Evaluation of mouth washing time

Mouthwash times were compared by 10 panelists who regularly use mouthwash. For the mouthwash composition of the present invention (Examples 1 and 2), the point when the gel was contained in the mouth was defined as the starting point, and the point when the gel was completely liquid was defined as the end point. The mouthwash (Comparative Example 1) was measured with the mouth as the starting point, mouthwashed as usual, and the end point as spouted as the end point.

(2) Sensory evaluation of detergency

A panel of 10 panelists for evaluating the feeling of use performed a sensory evaluation on the feeling of stain removal in the oral cavity. Immediately after eating a normal meal, each of the mouthwash compositions of the present invention of Examples 1 and 2 and the mouthwash of Comparative Example 1 each containing 10 ml of the mouth were washed for 30 seconds. Was performed. The sensory evaluation was made on the feeling of dirt removal immediately after spitting. The stain feeling was evaluated according to the following criteria.

1. No dirt feeling

2. Almost no dirt feeling

3. Some feeling of dirt removal

4. There is quite a feeling of dirt removal

5. Very dirty feeling,

Table 1 shows the results (average value) of the tests of the mouth washing time and the feeling of soiling by sensory evaluation according to the above test method. table 1

Commercially available mouthwashes are usually used in the mouth for 20 to 30 seconds and then exhaled (rinsing) .In the liquid mouthwash of Comparative Example 1, the panelers average It was found that only 8 seconds remained in the oral cavity (Comparative Example 1). On the other hand, in the case of the gel compositions of Examples 1 and 2, if the time when the gel becomes liquid in the oral cavity is the end point, it means that the gel has been cooked for 20 seconds or more, and the use time is reduced. Estimated end point is easily understood.

Examples 1 and 2 (especially Example 1) also have a better feeling of stain removal than Comparative Example 1.

(Example 3)

Ingredients Amount (wt%)

Sodium alginate 0 5

7 0

Ethanol 50

Polyoxyethylene hydrogenated castor oil (60E.O.) 50

0

Magnesium lactate 0 2

Sodium malate 0 3

Perfume total 100.0.0%

[Preparation method] All components except magnesium lactate were put in purified water, heated and stirred, an aqueous solution of magnesium lactate was added, and the mixture was cooled to about room temperature and solidified to obtain a gel. By stirring, an oral cavity cleaning composition containing a gel of an appropriate size was obtained. pH was 6.7. ADVANTAGE OF THE INVENTION According to the mouthwashing composition and the washing method which have a specific polymer gel, such as dielan gum, of this invention, the simplicity like a conventional mouthwash, the feeling of use like brushing, and the cleaning effect are acquired. Can be Further, according to the mouthwashing composition containing the gel of the present invention, the effect of indicating the end point (approximately 20 to 30 seconds) at the time of sucking in the mouth is easy and easy. It is also expected to have a gingival mass effect.

Claims

The scope of the claims

1. A mouthwash composition comprising a gel.

2. The composition according to claim 1, comprising a gel formed from at least one selected from the group consisting of dielan gum, pectin, sodium alginate, carrageenan, agar, gelatin, and furceleran. .

3. The composition according to claim 2, wherein the composition is a gel formed from a polyvalent cation and at least one selected from the group consisting of dielan gum, pectin, sodium alginate, and arginin.

4. The composition according to claim 3, wherein the polyvalent cation is a calcium ion.

5. The composition according to claim 1, wherein the gel is a gel formed by mixing 30 to 90% by weight of water based on the total weight of the gel.

6. The gel contains at least one selected from the group consisting of hydroxyethylcellulose, sodium carboxymethylcellulose, sodium polyacrylate, and a poly (xylethylenepolyoxypropylene copolymer). The oral cavity cleaning composition according to claim 1, wherein:

7. An intraoral washing method characterized in that the gel is used while being finely divided in the oral cavity.

8. The washing according to claim 7, wherein the gel is a gel formed from at least one selected from the group consisting of dielan gum, pectin, sodium alginate, carrageenan, agar, gelatin, and furceleran. Method.