WO2002066986A3 - Polymers functionalized with fluorescent boronate motifs - Google Patents

Polymers functionalized with fluorescent boronate motifs Download PDF

Info

Publication number
WO2002066986A3
WO2002066986A3 PCT/US2002/004355 US0204355W WO02066986A3 WO 2002066986 A3 WO2002066986 A3 WO 2002066986A3 US 0204355 W US0204355 W US 0204355W WO 02066986 A3 WO02066986 A3 WO 02066986A3
Authority
WO
WIPO (PCT)
Prior art keywords
matrices
fluorescent
motifs
polymers functionalized
polymer matrices
Prior art date
Application number
PCT/US2002/004355
Other languages
French (fr)
Other versions
WO2002066986A2 (en
Inventor
Glenn Noronha
Jonathan Reilly
Joseph Charles Walsh
Brooks Cochran
Aaron M Heiss
Bill C Ponder
David J Vachon
Original Assignee
Medtronic Minimed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic Minimed Inc filed Critical Medtronic Minimed Inc
Priority to AU2002251944A priority Critical patent/AU2002251944A1/en
Publication of WO2002066986A2 publication Critical patent/WO2002066986A2/en
Publication of WO2002066986A3 publication Critical patent/WO2002066986A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y10T436/144444—Glucose

Abstract

Improved polymer matrices which incorporate fluorescent biosensor molecules as well as methods of making and using these polymer matrices are described. Such matrices can be used in fluorescent biosensors and biosensor systems, including those which are used in the detection of polyhydroxylated analytes such as glucose. The properties of the polymer matrices of the invention renders biosensors utilizing such matrices particularly well-suited for detecting and measuring in vivo glucose concentrations.
PCT/US2002/004355 2001-02-15 2002-02-14 Polymers functionalized with fluorescent boronate motifs WO2002066986A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002251944A AU2002251944A1 (en) 2001-02-15 2002-02-14 Polymers functionalized with fluorescent boronate motifs

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26922601P 2001-02-15 2001-02-15
US60/269,226 2001-02-15

Publications (2)

Publication Number Publication Date
WO2002066986A2 WO2002066986A2 (en) 2002-08-29
WO2002066986A3 true WO2002066986A3 (en) 2003-10-30

Family

ID=23026344

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/004355 WO2002066986A2 (en) 2001-02-15 2002-02-14 Polymers functionalized with fluorescent boronate motifs

Country Status (3)

Country Link
US (1) US6927246B2 (en)
AU (1) AU2002251944A1 (en)
WO (1) WO2002066986A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9414777B2 (en) 2004-07-13 2016-08-16 Dexcom, Inc. Transcutaneous analyte sensor

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8346337B2 (en) 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6949816B2 (en) 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
US7195923B2 (en) * 2001-01-31 2007-03-27 Scripps Laboratories, Inc. Ratiometric determination of glycated protein
EP1397068A2 (en) 2001-04-02 2004-03-17 Therasense, Inc. Blood glucose tracking apparatus and methods
US9493806B2 (en) 2001-06-01 2016-11-15 Colorado State University Research Foundation Enzymatic biosensing systems
US9493805B2 (en) 2001-06-01 2016-11-15 Colorado State University Research Foundation Enzymatic biosensors with enhanced activity retention for detection of organic compounds
US10022078B2 (en) 2004-07-13 2018-07-17 Dexcom, Inc. Analyte sensor
US7955483B2 (en) * 2002-03-18 2011-06-07 Honeywell International Inc. Carbon nanotube-based glucose sensor
WO2004044557A2 (en) * 2002-11-12 2004-05-27 Argose, Inc. Non-invasive measurement of analytes
US20040106163A1 (en) * 2002-11-12 2004-06-03 Workman Jerome James Non-invasive measurement of analytes
AU2003303597A1 (en) 2002-12-31 2004-07-29 Therasense, Inc. Continuous glucose monitoring system and methods of use
US8216854B2 (en) * 2003-01-07 2012-07-10 Biotex, Inc. Device and method for measuring analytes
US7166458B2 (en) * 2003-01-07 2007-01-23 Bio Tex, Inc. Assay and method for analyte sensing by detecting efficiency of radiation conversion
FR2852148B1 (en) * 2003-03-07 2014-04-11 Batscap Sa MATERIAL FOR COMPOSITE ELECTRODE, PROCESS FOR PREPARING THE SAME
US8066639B2 (en) 2003-06-10 2011-11-29 Abbott Diabetes Care Inc. Glucose measuring device for use in personal area network
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US20050232817A1 (en) * 2003-09-26 2005-10-20 The University Of Cincinnati Functional on-chip pressure generator using solid chemical propellant
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
GB0329161D0 (en) * 2003-12-16 2004-01-21 Precisense As Reagant for detecting an analyte
GB0329849D0 (en) * 2003-12-23 2004-01-28 Precisense As Fluorometers
US8029765B2 (en) * 2003-12-24 2011-10-04 Masimo Laboratories, Inc. SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors
EP1718198A4 (en) 2004-02-17 2008-06-04 Therasense Inc Method and system for providing data communication in continuous glucose monitoring and management system
GB0411162D0 (en) * 2004-05-19 2004-06-23 Precisense As Optical sensor for in vivo detection of analyte
DE602005000858T2 (en) * 2004-07-23 2008-01-17 Terumo K.K. Saccharide-measuring fluorescent monomer, saccharide-measuring fluorescent sensor substance and implantable saccharide-measuring sensor
GB0416732D0 (en) * 2004-07-27 2004-09-01 Precisense As A method and apparatus for measuring the phase shift induced in a light signal by a sample
GB0426822D0 (en) * 2004-12-07 2005-01-12 Precisense As Sensor for detection of glucose
GB0426823D0 (en) * 2004-12-07 2005-01-12 Precisense As Sensor for detection of glucose
US8112240B2 (en) 2005-04-29 2012-02-07 Abbott Diabetes Care Inc. Method and apparatus for providing leak detection in data monitoring and management systems
US7766829B2 (en) 2005-11-04 2010-08-03 Abbott Diabetes Care Inc. Method and system for providing basal profile modification in analyte monitoring and management systems
JP2009516030A (en) * 2005-11-10 2009-04-16 ベックマン コールター，インコーポレイティド Covalently bonded Nile Blue derivatives for optical sensors
US8242203B2 (en) 2005-11-10 2012-08-14 Eric Bakker Covalently attached nile blue derivatives for optical sensors
US7620438B2 (en) 2006-03-31 2009-11-17 Abbott Diabetes Care Inc. Method and system for powering an electronic device
US8226891B2 (en) 2006-03-31 2012-07-24 Abbott Diabetes Care Inc. Analyte monitoring devices and methods therefor
US7920907B2 (en) 2006-06-07 2011-04-05 Abbott Diabetes Care Inc. Analyte monitoring system and method
US8930203B2 (en) 2007-02-18 2015-01-06 Abbott Diabetes Care Inc. Multi-function analyte test device and methods therefor
US8732188B2 (en) 2007-02-18 2014-05-20 Abbott Diabetes Care Inc. Method and system for providing contextual based medication dosage determination
US8123686B2 (en) 2007-03-01 2012-02-28 Abbott Diabetes Care Inc. Method and apparatus for providing rolling data in communication systems
US8622991B2 (en) 2007-03-19 2014-01-07 Insuline Medical Ltd. Method and device for drug delivery
AU2008227875B2 (en) 2007-03-19 2014-06-12 Insuline Medical Ltd. Drug delivery device
US9220837B2 (en) 2007-03-19 2015-12-29 Insuline Medical Ltd. Method and device for drug delivery
US9796998B2 (en) 2007-04-09 2017-10-24 Colorado State University Research Foundation Oxygenase-based biosensing systems for measurement of halogenated alkene concentrations
US8456301B2 (en) 2007-05-08 2013-06-04 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US7928850B2 (en) 2007-05-08 2011-04-19 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US8665091B2 (en) 2007-05-08 2014-03-04 Abbott Diabetes Care Inc. Method and device for determining elapsed sensor life
US8461985B2 (en) 2007-05-08 2013-06-11 Abbott Diabetes Care Inc. Analyte monitoring system and methods
FR2917226B1 (en) * 2007-06-06 2009-09-11 Inst Nat Sciences Appliq PROCESS FOR MARKING MATERIALS BASED ON THERMOPLASTIC OR THERMOSETTING POLYMERIC ORGANIC DIES
US20090014340A1 (en) * 2007-06-15 2009-01-15 Williams John R Devices, systems, and methods for measuring glucose
US20090247984A1 (en) * 2007-10-24 2009-10-01 Masimo Laboratories, Inc. Use of microneedles for small molecule metabolite reporter delivery
EP2231229A1 (en) 2007-12-18 2010-09-29 Insuline Medical Ltd. Drug delivery device with sensor for closed-loop operation
US8181531B2 (en) * 2008-06-27 2012-05-22 Edwin Carlen Accessible stress-based electrostatic monitoring of chemical reactions and binding
US9011670B2 (en) * 2008-08-14 2015-04-21 The Charles Stark Draper Laboratory, Inc. Three-dimensional metal ion sensor arrays on printed circuit boards
EP2355758A2 (en) 2008-11-07 2011-08-17 Insuline Medical Ltd. Device and method for drug delivery
US8103456B2 (en) 2009-01-29 2012-01-24 Abbott Diabetes Care Inc. Method and device for early signal attenuation detection using blood glucose measurements
US9226701B2 (en) 2009-04-28 2016-01-05 Abbott Diabetes Care Inc. Error detection in critical repeating data in a wireless sensor system
WO2010138856A1 (en) 2009-05-29 2010-12-02 Abbott Diabetes Care Inc. Medical device antenna systems having external antenna configurations
WO2011026148A1 (en) 2009-08-31 2011-03-03 Abbott Diabetes Care Inc. Analyte monitoring system and methods for managing power and noise
WO2011026147A1 (en) 2009-08-31 2011-03-03 Abbott Diabetes Care Inc. Analyte signal processing device and methods
US9320461B2 (en) 2009-09-29 2016-04-26 Abbott Diabetes Care Inc. Method and apparatus for providing notification function in analyte monitoring systems
US8660628B2 (en) 2009-12-21 2014-02-25 Medtronic Minimed, Inc. Analyte sensors comprising blended membrane compositions and methods for making and using them
CN102933144B (en) * 2010-02-19 2015-08-12 格莱苏有限公司 intravascular glucose sensor
US10010272B2 (en) 2010-05-27 2018-07-03 Profusa, Inc. Tissue-integrating electronic apparatus
US20130217039A1 (en) * 2010-06-18 2013-08-22 Queen's University At Kingston Optical pathogen detection system and quality control materials for use in same
CN110604585B (en) 2010-10-06 2023-04-18 普罗弗萨股份有限公司 Tissue-integrating sensor
US10024797B2 (en) 2010-11-22 2018-07-17 Colorado State University Research Foundation Biosensing systems for measurement of lactose
WO2013019982A2 (en) 2011-08-02 2013-02-07 Colorado State University Research Foundation Biosensing system with extended lifetime via cofactor recycling
JP6443802B2 (en) 2011-11-07 2018-12-26 アボット ダイアベティス ケア インコーポレイテッドＡｂｂｏｔｔ Ｄｉａｂｅｔｅｓ Ｃａｒｅ Ｉｎｃ． Analyte monitoring apparatus and method
US9897565B1 (en) 2012-09-11 2018-02-20 Aseko, Inc. System and method for optimizing insulin dosages for diabetic subjects
US9171343B1 (en) 2012-09-11 2015-10-27 Aseko, Inc. Means and method for improved glycemic control for diabetic patients
US9968306B2 (en) 2012-09-17 2018-05-15 Abbott Diabetes Care Inc. Methods and apparatuses for providing adverse condition notification with enhanced wireless communication range in analyte monitoring systems
US9750445B2 (en) 2013-06-28 2017-09-05 Verily Life Sciences Llc Porous polymeric formulation prepared using porogens
US9828620B2 (en) 2013-06-28 2017-11-28 Verily Life Sciences Llc Porous polymeric formulation prepared using monomer
US9763605B2 (en) 2013-11-27 2017-09-19 Verily Life Sciences Llc Adjustment of sensor sensitivity by controlling copolymer film thickness through a controlled drying step
US9617578B2 (en) 2013-12-06 2017-04-11 Verily Life Sciences Llc Sensor membrane with low temperature coefficient
US9486580B2 (en) 2014-01-31 2016-11-08 Aseko, Inc. Insulin management
US9898585B2 (en) 2014-01-31 2018-02-20 Aseko, Inc. Method and system for insulin management
JP2015151426A (en) 2014-02-12 2015-08-24 セイコーエプソン株式会社 Stimuli-responsive gel material
JP2015151427A (en) * 2014-02-12 2015-08-24 セイコーエプソン株式会社 Stimuli-responsive gel material and production method thereof
JP2015151436A (en) 2014-02-13 2015-08-24 セイコーエプソン株式会社 Stimulation responsive gel material
US11081226B2 (en) 2014-10-27 2021-08-03 Aseko, Inc. Method and controller for administering recommended insulin dosages to a patient
EP3050023B1 (en) 2014-10-27 2021-08-25 Aseko, Inc. Subcutaneous outpatient management
WO2017031440A1 (en) 2015-08-20 2017-02-23 Aseko, Inc. Diabetes management therapy advisor
JP6999581B2 (en) 2016-08-26 2022-01-18 カーディアック ペースメイカーズ， インコーポレイテッド Systems and methods for determining the presence of analytes using implantable medical devices
WO2018119400A1 (en) 2016-12-22 2018-06-28 Profusa, Inc. System and single-channel luminescent sensor for and method of determining analyte value

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991004488A1 (en) * 1989-09-21 1991-04-04 Russell Anthony P Method and means for detecting polyhydroxyl compounds
WO1997019188A1 (en) * 1995-11-22 1997-05-29 Minimed, Inc. Detection of biological molecules using chemical amplification and optical sensors
WO1998022820A1 (en) * 1996-11-21 1998-05-28 Lawrence Livermore National Laboratory Detection of biological molecules using boronate-based chemical amplification and optical sensors

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1026778B (en) 1973-12-06 1978-10-20 Hoechst Ag LUMINESCENT PIGMENTS IN THE DAYLIGHT PROCESS FOR THEIR PREPARATION AND THEIR USE
US4236071A (en) * 1979-05-21 1980-11-25 Exxon Research & Engineering Co. Detection of uranium by light induced luminescence
US4401122A (en) * 1979-08-02 1983-08-30 Children's Hospital Medical Center Cutaneous methods of measuring body substances
US4496722A (en) * 1981-05-01 1985-01-29 The Children's Medical Center Corporation Reporter compounds
US4428366A (en) * 1981-05-06 1984-01-31 Alfred B. Kurtz Electromagnetic apparatus and method for the reduction of serum glucose levels
US4455741A (en) * 1982-02-11 1984-06-26 At&T Bell Laboratories Fabrication of solid state electronic devices using fluorescent imaging of surface temperature profiles
JPS5972049A (en) * 1982-10-19 1984-04-23 Horiba Ltd Measuring apparatus of light emission life of sample
US4542987A (en) * 1983-03-08 1985-09-24 Regents Of The University Of California Temperature-sensitive optrode
US4655225A (en) * 1985-04-18 1987-04-07 Kurabo Industries Ltd. Spectrophotometric method and apparatus for the non-invasive
US4680268A (en) * 1985-09-18 1987-07-14 Children's Hospital Medical Center Implantable gas-containing biosensor and method for measuring an analyte such as glucose
US4875486A (en) * 1986-09-04 1989-10-24 Advanced Techtronics, Inc. Instrument and method for non-invasive in vivo testing for body fluid constituents
US4923819A (en) * 1987-03-27 1990-05-08 Chimerix Corporation Time-resolved fluorescence immunoassay
US4924009A (en) * 1987-06-03 1990-05-08 Bowling Green State University Xanthene dye complexes
US4861728A (en) * 1987-07-24 1989-08-29 Becton, Dickinson And Company Immunoassay of glycosylated hemoglobin using a labeled boron reagent
US4805623A (en) * 1987-09-04 1989-02-21 Vander Corporation Spectrophotometric method for quantitatively determining the concentration of a dilute component in a light- or other radiation-scattering environment
US4974929A (en) * 1987-09-22 1990-12-04 Baxter International, Inc. Fiber optical probe connector for physiologic measurement devices
US4882492A (en) * 1988-01-19 1989-11-21 Biotronics Associates, Inc. Non-invasive near infrared measurement of blood analyte concentrations
JP2907342B2 (en) * 1988-01-29 1999-06-21 ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア Ion infiltration non-invasive sampling or delivery device
US5362307A (en) * 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
US4929387A (en) * 1988-08-31 1990-05-29 Schott Glass Technologies, Inc. Phosphate glass useful in high power lasers
US5049738A (en) * 1988-11-21 1991-09-17 Conoco Inc. Laser-enhanced oil correlation system
US5028787A (en) * 1989-01-19 1991-07-02 Futrex, Inc. Non-invasive measurement of blood glucose
US5077476A (en) * 1990-06-27 1991-12-31 Futrex, Inc. Instrument for non-invasive measurement of blood glucose
US5086229A (en) * 1989-01-19 1992-02-04 Futrex, Inc. Non-invasive measurement of blood glucose
US5032315A (en) * 1989-04-03 1991-07-16 Schott Glass Technologies, Inc. Phosphate glass useful in high power lasers
US5112124A (en) * 1990-04-19 1992-05-12 Worcester Polytechnic Institute Method and apparatus for measuring the concentration of absorbing substances
US5101814A (en) * 1989-08-11 1992-04-07 Palti Yoram Prof System for monitoring and controlling blood glucose
ATA194989A (en) * 1989-08-17 1990-04-15 Koller Ernst METHOD FOR DETECTING AND DETERMINING HUMAN SERUM ALBUMINE IN BIOLOGICAL LIQUIDS WITH THE AID OF FLUOROGENIC CYANINE DYES
US5512246A (en) * 1989-09-21 1996-04-30 Anthony P. Russell Method and means for detecting polyhydroxyl compounds
US5198670A (en) * 1989-09-29 1993-03-30 Packard Instrument Company Scintillation counting system for in-situ measurement of radioactive samples in a multiple-well plate
US6040194A (en) * 1989-12-14 2000-03-21 Sensor Technologies, Inc. Methods and device for detecting and quantifying substances in body fluids
US5342789A (en) * 1989-12-14 1994-08-30 Sensor Technologies, Inc. Method and device for detecting and quantifying glucose in body fluids
US5070874A (en) * 1990-01-30 1991-12-10 Biocontrol Technology, Inc. Non-invasive determination of glucose concentration in body of patients
US5054487A (en) * 1990-02-02 1991-10-08 Boston Advanced Technologies, Inc. Laser systems for material analysis based on reflectance ratio detection
US5648270A (en) * 1995-02-06 1997-07-15 Molecular Probes, Inc. Methods of sensing with fluorescent conjugates of metal-chelating nitrogen heterocycles
WO1992000388A1 (en) * 1990-07-02 1992-01-09 The Regents Of The University Of California Detection of analytes using fluorescent energy transfer
EP0552241B1 (en) * 1990-10-10 2000-06-28 The University Of Maryland Method and apparatus for performing phase fluorescence lifetime measurements in flow cytometry
US5173456A (en) * 1990-12-20 1992-12-22 Schott Glass Technologies, Inc. Phosphate glass useful in high energy lasers
EP0493745A1 (en) * 1990-12-21 1992-07-08 Dojindo Laboratories Fluorescent compound, complex, reagent, and specific binding assay employing said reagent
WO1992013265A1 (en) * 1991-01-24 1992-08-06 The University Of Maryland Method and apparatus for multi-dimensional phase fluorescence lifetime imaging
US5196709A (en) * 1991-05-03 1993-03-23 University Of Maryland Systems Fluorometry method and apparatus using a semiconductor laser diode as a light source
US5203328A (en) * 1991-07-17 1993-04-20 Georgia Tech Research Corporation Apparatus and methods for quantitatively measuring molecular changes in the ocular lens
US5281825A (en) * 1991-09-05 1994-01-25 The University Of Maryland School Of Medicine Phase fluorometry using a modulated electroluminescent lamp as a light source
US5235606A (en) * 1991-10-29 1993-08-10 University Of Michigan Amplification of ultrashort pulses with nd:glass amplifiers pumped by alexandrite free running laser
JP2821050B2 (en) * 1991-10-31 1998-11-05 浜松ホトニクス株式会社 Nucleic acid base identification method
US5353790A (en) * 1992-01-17 1994-10-11 Board Of Regents, The University Of Texas System Method and apparatus for optical measurement of bilirubin in tissue
US5246867A (en) * 1992-01-17 1993-09-21 University Of Maryland At Baltimore Determination and quantification of saccharides by luminescence lifetimes and energy transfer
US5284140A (en) * 1992-02-11 1994-02-08 Eli Lilly And Company Acrylic copolymer membranes for biosensors
US5235045A (en) * 1992-03-19 1993-08-10 Microbiomed Corporation Non-azo naphthalimide dyes
US5590141A (en) * 1992-04-24 1996-12-31 Electro Scientific Industries, Inc. Method and apparatus for generating and employing a high density of excited ions in a lasant
US5270548A (en) * 1992-07-31 1993-12-14 The United States Of America As Represented By The United States Department Of Energy Phase-sensitive flow cytometer
US5313485A (en) * 1992-10-26 1994-05-17 Sandia Corporation Luminescent light source for laser pumping and laser system containing same
JP2575270B2 (en) * 1992-11-10 1997-01-22 浜松ホトニクス株式会社 Method for determining base sequence of nucleic acid, method for detecting single molecule, apparatus therefor and method for preparing sample
US5308773A (en) * 1992-11-16 1994-05-03 Microbiomed Corp. Non-azo 1,8-naphthalimide dyes for the detection and quantitation of a paramagnetic metal cation in a non-aqueous medium
US5409835A (en) * 1992-12-30 1995-04-25 The University Of Maryland At Baltimore Long-wavelength fluorescent probe compounds for calcium ions and their use in ratiometrically measuring calcium ion concentrations
IL108497A0 (en) * 1993-02-01 1994-05-30 Seq Ltd Methods and apparatus for dna sequencing
JP3598123B2 (en) * 1993-07-15 2004-12-08 浜松ホトニクス株式会社 Nucleic acid denaturation detector
GB2284809B (en) 1993-11-07 1998-04-29 Japan Res Dev Corp A fluorescent phenylboronic acid suitable for use in the detection of saccharides
US5445611A (en) * 1993-12-08 1995-08-29 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal delivery with ultrasound and chemical enhancers
US5458140A (en) * 1993-11-15 1995-10-17 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers
JP3448090B2 (en) * 1994-02-16 2003-09-16 浜松ホトニクス株式会社 Energy transfer detection method and apparatus
US5515864A (en) * 1994-04-21 1996-05-14 Zuckerman; Ralph Method and apparatus for the in vivo measurement of oxygen concentration levels by the indirect determination of fluoescence lifetime
US5605152A (en) 1994-07-18 1997-02-25 Minimed Inc. Optical glucose sensor
US5528611A (en) * 1995-02-16 1996-06-18 Scheps; Richard Repetitively Q-switched laser pumped by laer diodes and Q-switched with an intracavity variable speed moving aperture
JP2799837B2 (en) * 1995-03-03 1998-09-21 科学技術振興事業団 Boronic acid compounds having a binaphthyl group
US5628310A (en) * 1995-05-19 1997-05-13 Joseph R. Lakowicz Method and apparatus to perform trans-cutaneous analyte monitoring
CN1106061C (en) * 1995-05-19 2003-04-16 株式会社拓普康 Laser oscillation device and laser source driving method
AU1130797A (en) * 1995-08-24 1997-03-19 Purdue Research Foundation Fluorescence lifetime-based imaging and spectroscopy in tissues and other random media
US5952236A (en) * 1995-10-26 1999-09-14 Thompson; Richard B. Enzyme-based fluorescence biosensor for chemical analysis
US5784157A (en) * 1995-11-21 1998-07-21 The Research Foundation Of State University Of New York Method and apparatus for identifying fluorophores
US6002954A (en) * 1995-11-22 1999-12-14 The Regents Of The University Of California Detection of biological molecules using boronate-based chemical amplification and optical sensors
US5666373A (en) * 1996-02-06 1997-09-09 Raytheon Company Laser having a passive pulse modulator and method of making same
US5814820A (en) * 1996-02-09 1998-09-29 The Board Of Trustees Of The University Of Illinois Pump probe cross correlation fluorescence frequency domain microscope and microscopy
US5776482A (en) * 1996-03-29 1998-07-07 University Of Iowa Research Foundation Tetrahydroquinoline analogues for use in glaucoma treatment
CA2201576A1 (en) * 1996-04-17 1997-10-17 James Edward Dickinson, Jr. Rare earth doped oxyhalide laser glass
US5909278A (en) * 1996-07-29 1999-06-01 The Regents Of The University Of California Time-resolved fluorescence decay measurements for flowing particles
US5691145A (en) * 1996-08-27 1997-11-25 Becton, Dickinson And Company Detection of nucleic acids using G-quartets
US5818582A (en) * 1996-09-19 1998-10-06 Ciencia, Inc. Apparatus and method for phase fluorometry
US5994707A (en) * 1997-03-18 1999-11-30 Physical Optics Corporation Modular fiber optic fluorometer and method of use thereof
US5846726A (en) * 1997-05-13 1998-12-08 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching
US5928869A (en) * 1997-05-30 1999-07-27 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching
JPH1195120A (en) * 1997-09-19 1999-04-09 Olympus Optical Co Ltd Observing method of microscope
US5935791A (en) * 1997-09-23 1999-08-10 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching
US5955737A (en) * 1997-10-27 1999-09-21 Systems & Processes Engineering Corporation Chemometric analysis for extraction of individual fluorescence spectrum and lifetimes from a target mixture
US5981957A (en) * 1997-10-27 1999-11-09 Systems&Processes Engineering Corporation Signal generation and mixing electronics for frequency-domain lifetime and spectral fluorometry
JPH11132953A (en) * 1997-10-29 1999-05-21 Bunshi Bio Photonics Kenkyusho:Kk Method and apparatus for measurement of fluorescent life
DK1042664T3 (en) * 1997-12-23 2002-03-11 Evotec Ag Method for detecting reactions by coincidence analysis
US6214628B1 (en) * 1998-01-14 2001-04-10 Joseph R. Lakowicz Method of conducting an assay of a sample containing an analyte of interest
US6344360B1 (en) 1998-03-11 2002-02-05 Sensors For Medicine And Science, Inc. Detection of analytes by fluorescent lanthanide metal chelate complexes containing substituted ligands
US5987049A (en) * 1998-04-24 1999-11-16 Time-Bandwidth Products Ag Mode locked solid-state laser pumped by a non-diffraction-limited pumping source and method for generating pulsed laser radiation by pumping with a non-diffraction-limited pumping beam
US6157037A (en) * 1998-12-04 2000-12-05 Photosense, Llc Sensing device and method for measuring emission time delay during irradiation of targeted samples
US6334360B1 (en) * 2000-05-09 2002-01-01 Po-Huei Chen Water level controller with conductance terminals

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991004488A1 (en) * 1989-09-21 1991-04-04 Russell Anthony P Method and means for detecting polyhydroxyl compounds
WO1997019188A1 (en) * 1995-11-22 1997-05-29 Minimed, Inc. Detection of biological molecules using chemical amplification and optical sensors
US6011984A (en) * 1995-11-22 2000-01-04 Minimed Inc. Detection of biological molecules using chemical amplification and optical sensors
WO1998022820A1 (en) * 1996-11-21 1998-05-28 Lawrence Livermore National Laboratory Detection of biological molecules using boronate-based chemical amplification and optical sensors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
APPLETON B ET AL: "Detection of total sugar concentration using photoinduced electron transfer materials: development of operationally stable, reusable optical sensors", SENSORS AND ACTUATORS B, ELSEVIER SEQUOIA S.A., LAUSANNE, CH, vol. 65, no. 1-3, 30 June 2000 (2000-06-30), pages 302 - 304, XP004208664, ISSN: 0925-4005 *
PATTERSON S ET AL: "Tuning the Affinity of a Synthetic Sialic Acid Receptor Using Combinatorial Chemistry", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 39, no. 20, 14 May 1998 (1998-05-14), pages 3111 - 3114, XP004116206, ISSN: 0040-4039 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9414777B2 (en) 2004-07-13 2016-08-16 Dexcom, Inc. Transcutaneous analyte sensor

Also Published As

Publication number Publication date
WO2002066986A2 (en) 2002-08-29
AU2002251944A1 (en) 2002-09-04
US20020197724A1 (en) 2002-12-26
US6927246B2 (en) 2005-08-09

Similar Documents

Publication Publication Date Title
WO2002066986A3 (en) Polymers functionalized with fluorescent boronate motifs
WO2001059453A3 (en) Biosensor compositions and methods of use
Zhao et al. Fibrous strips decorated with cleavable aggregation-induced emission probes for visual detection of Hg2+
WO2001075450A3 (en) Fluorescent lifetime assays for non-invasive quantification of analytes
WO2006137891A8 (en) Membrane with nanochannels for detection of molecules
EP2330219A3 (en) Method for drug discovery, disease treatment and diagnosis using metabolomics
WO2005065241A3 (en) Smmr (small molecule metabolite reporters) for use as in vivo glucose biosensors
WO2003042396A3 (en) Electronic detection of biological molecules using thin layers
EP1557422A3 (en) Detection of analytes in aqueous environments
WO2005040742A3 (en) A method and device for detecting a small number of molecules using surface-enhanced coherent anti-stokes raman spectroscopy
WO2003085372A3 (en) Biosensor membranes composed of polymers containing heterocyclic nitrogens
WO2008070865A3 (en) Materials and methods for efficient and accurate detection of analytes
WO2006107312A8 (en) Nanosensors
ATE330038T1 (en) NUCLEIC ACID BIOSENSOR
WO2002086448A3 (en) Detection of microsatellite instability and its use in diagnosis of tumors
WO2009008720A3 (en) Small rna molecules, precursors thereof, means and methods for detecting them, and uses thereof in typing samples
WO2008146569A1 (en) Biosensor
Parnianchi et al. Highly selective and sensitive molecularly imprinting electrochemical sensing platform for bilirubin detection in saliva
Wen et al. Ultrasensitive DNAzyme based amperometric determination of uranyl ion using mesoporous silica nanoparticles loaded with Methylene Blue
WO2004053483A3 (en) Multi-analyte reference solutions
WO2003033731A3 (en) Methods for detecting ovarian cancer
WO2004016160A3 (en) Redox polymer nanoparticles
EP1445329A3 (en) Method and test strip for determining glucose in blood
Fabbri et al. Poly (ethylene oxide)–silica hybrids entrapping sensitive dyes for biomedical optical pH sensors: Molecular dynamics and optical response
WO2005038419A8 (en) A method and device for detecting small numbers of molecules using surface-enhanced coherent anti-stokes raman spectroscopy

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP