WO2002066965A3 - Assay apparatus, assay method and probe array for use in same - Google Patents

Assay apparatus, assay method and probe array for use in same Download PDF

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Publication number
WO2002066965A3
WO2002066965A3 PCT/GB2002/000717 GB0200717W WO02066965A3 WO 2002066965 A3 WO2002066965 A3 WO 2002066965A3 GB 0200717 W GB0200717 W GB 0200717W WO 02066965 A3 WO02066965 A3 WO 02066965A3
Authority
WO
WIPO (PCT)
Prior art keywords
assay
same
probe array
reaction volume
probe means
Prior art date
Application number
PCT/GB2002/000717
Other languages
French (fr)
Other versions
WO2002066965A2 (en
Inventor
Peter Georg Laitenberger
Darrin Matthew Disley
Miles William Noel Hember
Aled Wynne Jones
Original Assignee
Scient Generics Ltd
Peter Georg Laitenberger
Darrin Matthew Disley
Miles William Noel Hember
Aled Wynne Jones
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0104009A external-priority patent/GB0104009D0/en
Priority claimed from GB0104010A external-priority patent/GB0104010D0/en
Application filed by Scient Generics Ltd, Peter Georg Laitenberger, Darrin Matthew Disley, Miles William Noel Hember, Aled Wynne Jones filed Critical Scient Generics Ltd
Publication of WO2002066965A2 publication Critical patent/WO2002066965A2/en
Publication of WO2002066965A3 publication Critical patent/WO2002066965A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G01N21/6454—Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"

Abstract

Assay apparatus is disclosed which comprises: probe means; a reaction volume (7) for exposing said probe means to an analyte; and sensor means (2, 4, 8) for detecting radiation emitted by said probe means in response to excitation; wherein said probe means comprises a plurality of probes (6) arrayed in said reaction volume (7), and said sensor means (2, 4, 8) and said reaction volume (7) are coupled such that selective or simultaneous detection of radiation emitted from plural probes is permitted.
PCT/GB2002/000717 2001-02-19 2002-02-19 Assay apparatus, assay method and probe array for use in same WO2002066965A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0104009A GB0104009D0 (en) 2001-02-19 2001-02-19 Improvements in and/or relating to sample handling & delivery methods for bio-chips
GB0104009.6 2001-02-19
GB0104010.4 2001-02-19
GB0104010A GB0104010D0 (en) 2001-02-19 2001-02-19 Optical waveguide sensor array

Publications (2)

Publication Number Publication Date
WO2002066965A2 WO2002066965A2 (en) 2002-08-29
WO2002066965A3 true WO2002066965A3 (en) 2003-02-13

Family

ID=26245728

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/000717 WO2002066965A2 (en) 2001-02-19 2002-02-19 Assay apparatus, assay method and probe array for use in same

Country Status (1)

Country Link
WO (1) WO2002066965A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005018337A1 (en) * 2005-04-20 2006-11-02 Micronas Gmbh Micro-optical detection system and method for determining temperature-dependent parameters of analytes
FI20106259A (en) * 2010-11-30 2012-05-31 Medisize Oy Arrangement

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5577137A (en) * 1995-02-22 1996-11-19 American Research Corporation Of Virginia Optical chemical sensor and method using same employing a multiplicity of fluorophores contained in the free volume of a polymeric optical waveguide or in pores of a ceramic waveguide
US5599668A (en) * 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
US5779978A (en) * 1996-02-29 1998-07-14 Avl Medical Instruments Ag Measuring assembly for luminescence analysis
US5812272A (en) * 1997-01-30 1998-09-22 Hewlett-Packard Company Apparatus and method with tiled light source array for integrated assay sensing
US5846842A (en) * 1993-05-18 1998-12-08 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry and providing enhanced sensitivity
WO2001001112A1 (en) * 1999-06-26 2001-01-04 Packard Instrument Company, Inc. Microplate reader

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5846842A (en) * 1993-05-18 1998-12-08 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry and providing enhanced sensitivity
US5599668A (en) * 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
US5577137A (en) * 1995-02-22 1996-11-19 American Research Corporation Of Virginia Optical chemical sensor and method using same employing a multiplicity of fluorophores contained in the free volume of a polymeric optical waveguide or in pores of a ceramic waveguide
US5779978A (en) * 1996-02-29 1998-07-14 Avl Medical Instruments Ag Measuring assembly for luminescence analysis
US5812272A (en) * 1997-01-30 1998-09-22 Hewlett-Packard Company Apparatus and method with tiled light source array for integrated assay sensing
WO2001001112A1 (en) * 1999-06-26 2001-01-04 Packard Instrument Company, Inc. Microplate reader

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HUEBNER J ET AL: "INTEGRATED OPTICAL MEASUREMENT SYSTEM FOR FLUORESCENCE SPECTROSCOPY IN MICROFLUIDIC CHANNELS", REVIEW OF SCIENTIFIC INSTRUMENTS, AMERICAN INSTITUTE OF PHYSICS. NEW YORK, US, vol. 1, no. 72, January 2001 (2001-01-01), pages 229 - 233, XP001072939, ISSN: 0034-6748 *
LEINER M J P: "Optical sensors for in vitro blood gas analysis", SENSORS AND ACTUATORS B, ELSEVIER SEQUOIA S.A., LAUSANNE, CH, vol. 29, no. 1, 1 October 1995 (1995-10-01), pages 169 - 173, XP004000868, ISSN: 0925-4005 *

Also Published As

Publication number Publication date
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