WO2002064748A3 - Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof - Google Patents

Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof Download PDF

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Publication number
WO2002064748A3
WO2002064748A3 PCT/US2002/004652 US0204652W WO02064748A3 WO 2002064748 A3 WO2002064748 A3 WO 2002064748A3 US 0204652 W US0204652 W US 0204652W WO 02064748 A3 WO02064748 A3 WO 02064748A3
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WO
WIPO (PCT)
Prior art keywords
methods
obtaining
adult stem
differentiation
sources
Prior art date
Application number
PCT/US2002/004652
Other languages
French (fr)
Other versions
WO2002064748A2 (en
WO2002064748A9 (en
WO2002064748A8 (en
Inventor
Leo T Furcht
Catherine M Verfaillie
Morayma Reyes
Original Assignee
Leo T Furcht
Catherine M Verfaillie
Morayma Reyes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US10/467,963 priority Critical patent/US7838289B2/en
Application filed by Leo T Furcht, Catherine M Verfaillie, Morayma Reyes filed Critical Leo T Furcht
Priority to JP2002565063A priority patent/JP2004529621A/en
Priority to EP02718998A priority patent/EP1367899A4/en
Priority to CA2438501A priority patent/CA2438501C/en
Priority to NZ527527A priority patent/NZ527527A/en
Priority to IL15733202A priority patent/IL157332A0/en
Publication of WO2002064748A2 publication Critical patent/WO2002064748A2/en
Publication of WO2002064748A8 publication Critical patent/WO2002064748A8/en
Priority to IL214623A priority patent/IL214623A/en
Priority to IL157332A priority patent/IL157332A/en
Priority to ZA2003/06289A priority patent/ZA200306289B/en
Publication of WO2002064748A3 publication Critical patent/WO2002064748A3/en
Priority to US11/084,809 priority patent/US20050283844A1/en
Priority to US11/587,511 priority patent/US8609412B2/en
Priority to US11/151,689 priority patent/US8075881B2/en
Priority to US11/269,736 priority patent/US8147824B2/en
Publication of WO2002064748A9 publication Critical patent/WO2002064748A9/en
Priority to US11/446,560 priority patent/US7927587B2/en
Priority to US12/093,159 priority patent/US9962407B2/en
Priority to US13/042,205 priority patent/US20110177595A1/en
Priority to US13/105,372 priority patent/US8252280B1/en
Priority to IL214623A priority patent/IL214623A0/en
Priority to US13/301,186 priority patent/US9526747B2/en
Priority to US13/345,036 priority patent/US9808485B2/en

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    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/235—Leukemia inhibitory factor [LIF]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/08—Coculture with; Conditioned medium produced by cells of the nervous system
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    • C12N2503/00—Use of cells in diagnostics
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/02—Cells from transgenic animals

Abstract

The present invention relates generally to mammalian multipotent adult stem cells (MASC), and more specifically to methods for obtaining, maintaining and differentiating MASC to cells of multiple tissue types. Uses of MASC in the therapeutic treatment of disease are also provided.
PCT/US2002/004652 1999-08-05 2002-02-14 Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof WO2002064748A2 (en)

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IL15733202A IL157332A0 (en) 2001-02-14 2002-02-14 Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
JP2002565063A JP2004529621A (en) 2001-02-14 2002-02-14 Pluripotent adult stem cells, their origin, methods of obtaining and maintaining them, methods of differentiating them, methods of their use, and cells derived therefrom
EP02718998A EP1367899A4 (en) 2001-02-14 2002-02-14 Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
CA2438501A CA2438501C (en) 2001-02-14 2002-02-14 Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
NZ527527A NZ527527A (en) 2001-02-14 2002-02-14 Mammalian multipotent adult stem cells (MASC) with the capacity to differentiate into cells of mesodermal, ectodermal or endodermal origin and uses thereof
US10/467,963 US7838289B2 (en) 2001-02-14 2002-02-14 Assay utilizing multipotent adult stem cells
IL157332A IL157332A (en) 2001-02-14 2003-08-11 Method for providing cell population from umbilical cord blood or placenta which can differentiate into cell types of the embryonic lineage
IL214623A IL214623A (en) 2001-02-14 2003-08-11 Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof. methods of use thereof and cells derived therefrom
ZA2003/06289A ZA200306289B (en) 2001-02-14 2003-08-13 Multipotent adult stem cells sources thereof methods of obtaining and maintaining same methods of differentiation thereof methods of use thereof and cells derived thereof
US11/084,809 US20050283844A1 (en) 2001-02-14 2005-03-21 Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
US11/587,511 US8609412B2 (en) 1999-08-05 2005-04-21 Mapc generation of lung tissue
US11/151,689 US8075881B2 (en) 1999-08-05 2005-06-13 Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure
US11/269,736 US8147824B2 (en) 1999-08-05 2005-11-09 Immunomodulatory properties of multipotent adult progenitor cells and uses thereof
US11/446,560 US7927587B2 (en) 1999-08-05 2006-06-02 MAPC administration for the treatment of lysosomal storage disorders
US12/093,159 US9962407B2 (en) 1999-08-05 2006-11-09 Immunomodulatory properties of multipotent adult progenitor cells and uses thereof
US13/042,205 US20110177595A1 (en) 2001-02-14 2011-03-07 Multipotent Adult Stem Cells, Sources Thereof, Methods of Obtaining and Maintaining Same, Methods of Differentiation Thereof, Methods of Use Thereof and Cells Derived Thereof
US13/105,372 US8252280B1 (en) 1999-08-05 2011-05-11 MAPC generation of muscle
IL214623A IL214623A0 (en) 2001-02-14 2011-08-11 Method for providing cell population from umbilical cord blood or placenta
US13/301,186 US9526747B2 (en) 1999-08-05 2011-11-21 Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure
US13/345,036 US9808485B2 (en) 1999-08-05 2012-01-06 Immunomodulatory properties of multipotent adult progenitor cells and uses thereof

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US26878601P 2001-02-14 2001-02-14
US60/268,786 2001-02-14
US26906201P 2001-02-15 2001-02-15
US60/269,062 2001-02-15
US31062501P 2001-08-07 2001-08-07
US60/310,625 2001-08-07
US34338601P 2001-10-25 2001-10-25
US60/343,386 2001-10-25

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PCT/US2000/021387 Continuation-In-Part WO2001011011A2 (en) 1999-08-05 2000-08-04 Multipotent adult stem cells and methods for isolation
US10/467,963 A-371-Of-International US7838289B2 (en) 1999-08-05 2002-02-14 Assay utilizing multipotent adult stem cells
US10467963 A-371-Of-International 2002-02-14
US10/048,757 Continuation-In-Part US7015037B1 (en) 1999-08-05 2002-08-21 Multiponent adult stem cells and methods for isolation
US96344404A Continuation-In-Part 1999-08-05 2004-10-11
US10/587,511 Continuation-In-Part US20070149331A1 (en) 2004-01-30 2005-01-28 Power transmission chain, manufacture method thereof and power transmission assembly
US11/084,809 Continuation US20050283844A1 (en) 2001-02-14 2005-03-21 Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
US11/446,560 Continuation-In-Part US7927587B2 (en) 1999-08-05 2006-06-02 MAPC administration for the treatment of lysosomal storage disorders
US12/907,495 Continuation US10638734B2 (en) 1999-08-05 2010-10-19 Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof

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