WO2002064186A3 - Systems, methods, and compositions for achieving closure of vascular puncture sites - Google Patents

Systems, methods, and compositions for achieving closure of vascular puncture sites Download PDF

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Publication number
WO2002064186A3
WO2002064186A3 PCT/US2002/003639 US0203639W WO02064186A3 WO 2002064186 A3 WO2002064186 A3 WO 2002064186A3 US 0203639 W US0203639 W US 0203639W WO 02064186 A3 WO02064186 A3 WO 02064186A3
Authority
WO
WIPO (PCT)
Prior art keywords
systems
methods
compositions
vascular puncture
puncture sites
Prior art date
Application number
PCT/US2002/003639
Other languages
French (fr)
Other versions
WO2002064186A2 (en
Inventor
Olexander Hnojewyj
Original Assignee
Neomend Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neomend Inc filed Critical Neomend Inc
Priority to AU2002238065A priority Critical patent/AU2002238065A1/en
Publication of WO2002064186A2 publication Critical patent/WO2002064186A2/en
Publication of WO2002064186A3 publication Critical patent/WO2002064186A3/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38Albumins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36Blood coagulation or fibrinolysis factors
    • A61K38/363Fibrinogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/046Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00004(bio)absorbable, (bio)resorbable, resorptive
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491Surgical glue applicators
    • A61B2017/00495Surgical glue applicators for two-component glue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00646Type of implements
    • A61B2017/0065Type of implements the implement being an adhesive

Abstract

Systems and methods for sealing a puncture site in a blood vessel with a closure material (94) being inserted into a cacheter (220). The closure material (94) comprises a mixture of first and second components which upon mixing undergo a reaction to form a solid closure material composition.
PCT/US2002/003639 2001-02-09 2002-02-08 Systems, methods, and compositions for achieving closure of vascular puncture sites WO2002064186A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002238065A AU2002238065A1 (en) 2001-02-09 2002-02-08 Systems, methods, and compositions for achieving closure of vascular puncture sites

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/780,014 US6830756B2 (en) 1998-11-06 2001-02-09 Systems, methods, and compositions for achieving closure of vascular puncture sites
US09/780,014 2001-02-09

Publications (2)

Publication Number Publication Date
WO2002064186A2 WO2002064186A2 (en) 2002-08-22
WO2002064186A3 true WO2002064186A3 (en) 2002-11-14

Family

ID=25118291

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/003639 WO2002064186A2 (en) 2001-02-09 2002-02-08 Systems, methods, and compositions for achieving closure of vascular puncture sites

Country Status (3)

Country Link
US (4) US6830756B2 (en)
AU (1) AU2002238065A1 (en)
WO (1) WO2002064186A2 (en)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7335220B2 (en) 2004-11-05 2008-02-26 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
US6994686B2 (en) * 1998-08-26 2006-02-07 Neomend, Inc. Systems for applying cross-linked mechanical barriers
US7279001B2 (en) * 1998-11-06 2007-10-09 Neomend, Inc. Systems, methods, and compositions for achieving closure of vascular puncture sites
US6830756B2 (en) * 1998-11-06 2004-12-14 Neomend, Inc. Systems, methods, and compositions for achieving closure of vascular puncture sites
US6899889B1 (en) * 1998-11-06 2005-05-31 Neomend, Inc. Biocompatible material composition adaptable to diverse therapeutic indications
US7351249B2 (en) * 1998-11-06 2008-04-01 Neomend, Inc. Systems, methods, and compositions for achieving closure of suture sites
US7331979B2 (en) * 2003-06-04 2008-02-19 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
US9289195B2 (en) 2003-06-04 2016-03-22 Access Closure, Inc. Auto-retraction apparatus and methods for sealing a vascular puncture
CA2576040A1 (en) * 2003-10-21 2005-04-28 Bioartificial Gel Technologies Inc. Hydrogel-containing medical articles and methods of using and making the same
US7670282B2 (en) 2004-06-14 2010-03-02 Pneumrx, Inc. Lung access device
US7553810B2 (en) 2004-06-16 2009-06-30 Pneumrx, Inc. Lung volume reduction using glue composition
US7608579B2 (en) 2004-06-16 2009-10-27 Pneumrx, Inc. Lung volume reduction using glue compositions
US7678767B2 (en) 2004-06-16 2010-03-16 Pneumrx, Inc. Glue compositions for lung volume reduction
US20050281799A1 (en) 2004-06-16 2005-12-22 Glen Gong Targeting damaged lung tissue using compositions
US7766938B2 (en) 2004-07-08 2010-08-03 Pneumrx, Inc. Pleural effusion treatment device, method and material
US7766891B2 (en) 2004-07-08 2010-08-03 Pneumrx, Inc. Lung device with sealing features
US8348971B2 (en) 2004-08-27 2013-01-08 Accessclosure, Inc. Apparatus and methods for facilitating hemostasis within a vascular puncture
US20060062768A1 (en) * 2004-09-23 2006-03-23 Olexander Hnojewyj Biocompatible hydrogel compositions
US8262693B2 (en) * 2004-11-05 2012-09-11 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
CA2587857C (en) 2004-11-23 2017-10-10 Pneumrx, Inc. Steerable device for accessing a target site and methods
US20060161110A1 (en) * 2004-12-30 2006-07-20 Neomend, Inc. Method and apparatus for percutaneous wound sealing
US7806856B2 (en) 2005-04-22 2010-10-05 Accessclosure, Inc. Apparatus and method for temporary hemostasis
US8002742B2 (en) * 2005-04-22 2011-08-23 Accessclosure, Inc. Apparatus and methods for sealing a puncture in tissue
US8460357B2 (en) 2005-05-31 2013-06-11 J.W. Medical Systems Ltd. In situ stent formation
US8157837B2 (en) 2006-03-13 2012-04-17 Pneumrx, Inc. Minimally invasive lung volume reduction device and method
US9402633B2 (en) 2006-03-13 2016-08-02 Pneumrx, Inc. Torque alleviating intra-airway lung volume reduction compressive implant structures
US8888800B2 (en) 2006-03-13 2014-11-18 Pneumrx, Inc. Lung volume reduction devices, methods, and systems
US7789893B2 (en) * 2006-09-12 2010-09-07 Boston Scientific Scimed, Inc. Method and apparatus for promoting hemostasis of a blood vessel puncture
WO2008033964A2 (en) 2006-09-13 2008-03-20 Accessclosure, Inc. Apparatus for sealing a vascular puncture
US8932560B2 (en) 2007-09-04 2015-01-13 University of Maryland, College Parke Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells
US9066885B2 (en) * 2007-03-16 2015-06-30 University Of Maryland, College Park Advanced functional biocompatible polymeric matrix containing nano-compartments
US8092837B2 (en) * 2007-04-27 2012-01-10 Biomet Manufacturing Corp Fibrin based glue with functionalized hydrophilic polymer protein binding agent
US20080287633A1 (en) * 2007-05-18 2008-11-20 Drumheller Paul D Hydrogel Materials
US7993367B2 (en) 2007-09-28 2011-08-09 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
WO2009059217A2 (en) 2007-11-02 2009-05-07 Incept, Llc Apparatus and methods for sealing a vascular puncture
US8241324B2 (en) * 2008-03-03 2012-08-14 Eilaz Babaev Ultrasonic vascular closure device
US9364206B2 (en) 2008-04-04 2016-06-14 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
US8029533B2 (en) 2008-04-04 2011-10-04 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
JP5616891B2 (en) 2008-08-26 2014-10-29 セント ジュード メディカル インコーポレイテッドSt. Jude Medical, Inc. Method and system for sealing a percutaneous puncture
US9173669B2 (en) 2008-09-12 2015-11-03 Pneumrx, Inc. Enhanced efficacy lung volume reduction devices, methods, and systems
JP2012508618A (en) 2008-11-12 2012-04-12 アクセスクロージャー,インク. Device and method for closing a vascular puncture
JP5684239B2 (en) 2009-05-04 2015-03-11 インセプト・リミテッド・ライアビリティ・カンパニーIncept Llc Biomaterial for track and puncture closure
CN102573700B (en) 2009-05-18 2014-12-17 纽姆克斯股份有限公司 Cross-sectional modification during deployment of an elongate lung volume reduction device
US20110081398A1 (en) * 2009-10-01 2011-04-07 Tyco Healthcare Group Lp Multi-mechanism surgical compositions
US20110081701A1 (en) * 2009-10-02 2011-04-07 Timothy Sargeant Surgical compositions
US8968785B2 (en) * 2009-10-02 2015-03-03 Covidien Lp Surgical compositions
WO2011060390A2 (en) 2009-11-13 2011-05-19 University Of Maryland, College Park Advanced functional biocompatible foam used as a hemostatic agent for compressible and non-compressible acute wounds
US9179900B2 (en) * 2009-12-08 2015-11-10 Phillips Medical Llc Hemostatic device and its methods of use
US9993236B2 (en) 2009-12-08 2018-06-12 Phillips Medical, LLC Hemostatic device and its methods of use
WO2011127045A2 (en) 2010-04-05 2011-10-13 Neomend, Inc. Method and apparatus for wound sealant application
EP2555812B1 (en) * 2010-04-05 2019-09-04 Neomend, Inc. Systems, devices, methods for delivering hydrogel compositions with self-purging to prevent clogging
AU2011243001B2 (en) 2010-04-19 2016-03-31 Phillips Medical Llc A hemostatic device and its methods of use
EP2603246B1 (en) 2010-08-13 2019-04-03 University of Maryland, College Park Method and system for reversal of interactions between hydrophobically modified biopolymers and vesicles or cell membranes
US8858883B2 (en) 2010-12-02 2014-10-14 University Of Maryland, College Park Method and system for capture and use of intact vesicles on electrodeposited hydrophobically modified biopolymer films
EP3821820A1 (en) 2011-01-19 2021-05-19 Access Closure, Inc. Apparatus and methods of manufacturing a sealing a vascular puncture
US9820728B2 (en) 2011-01-19 2017-11-21 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
US9386968B2 (en) 2011-05-11 2016-07-12 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
US8846849B2 (en) 2011-05-13 2014-09-30 Ethicon, Inc. Tissue sealants from plasma derived proteins
US9205241B2 (en) 2011-07-12 2015-12-08 Warsaw Orthopedic, Inc. Medical devices and methods comprising an adhesive material
US9132194B2 (en) 2011-07-12 2015-09-15 Warsaw Orthopedic, Inc. Medical devices and methods comprising an adhesive sheet containing a drug depot
US8721680B2 (en) 2012-03-23 2014-05-13 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US9757105B2 (en) 2012-03-23 2017-09-12 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US9642604B2 (en) 2012-04-12 2017-05-09 Phillips Medical Llc Hemostatic system and its methods of use
US8735504B2 (en) 2012-05-02 2014-05-27 Warsaw Orthopedic, Inc. Methods for preparing polymers having low residual monomer content
US9468428B2 (en) 2012-06-13 2016-10-18 Phillips Medical Llc Hemostatic device and its methods of use
WO2014031148A1 (en) * 2012-08-24 2014-02-27 St. Jude Medical Puerto Rico Llc Bioadhesive mixing and delivery device and methods
US9446166B2 (en) 2013-01-24 2016-09-20 Ethicon, Inc. Fibrin sealant compositions with chemical crosslinking
US9107646B2 (en) * 2013-03-11 2015-08-18 St. Jude Medical Puerto Rico Llc Active securement detachable sealing tip for extra-vascular closure device and methods
CA2914610C (en) 2013-03-13 2022-08-02 University Of Maryland Advanced functional biocompatible polymer putty used as a hemostatic agent for treating damaged tissue and cells
US9724081B2 (en) 2013-06-04 2017-08-08 Phillips Medical Llc Hemostatic system and its methods of use
US10085730B2 (en) 2013-07-12 2018-10-02 Phillips Medical, LLC Hemostatic device and its methods of use
US9839416B2 (en) 2013-07-12 2017-12-12 Phillips Medical, LLC Hemostatic device and its methods of use
EP3160342A4 (en) 2014-06-25 2018-01-10 Neomend, Inc. Pleural air leak test system
US10390838B1 (en) 2014-08-20 2019-08-27 Pneumrx, Inc. Tuned strength chronic obstructive pulmonary disease treatment
US9295752B1 (en) 2014-09-30 2016-03-29 Covidien Lp Bioadhesive for occluding vessels
US20160296466A1 (en) * 2015-04-13 2016-10-13 Cook Medical Technologies Llc Injectable albumin based vascular occluder
WO2019094502A1 (en) 2017-11-07 2019-05-16 Prescient Surgical, Inc. Methods and apparatus for prevention of surgical site infection
US10980913B2 (en) 2018-03-05 2021-04-20 Ethicon Llc Sealant foam compositions for lung applications
US20190269819A1 (en) * 2018-03-05 2019-09-05 Ethicon Llc Sealant foam compositions for lung applications
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent
US20240033399A1 (en) * 2020-12-18 2024-02-01 Ethicon, Inc. Methods and Devices for Changing the Flow Rates of PH Modifying Fluids for Controlling Cross-Linking Rates of Reactive Components of Biocompatible Sealing Compositions
US20220265938A1 (en) 2021-02-19 2022-08-25 Ethicon, Inc. Systems, devices and methods for dispensing biocompatible reactive formulations and controlling cross-linking of the reactive components of the biocompatible reactive formulations

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6302898B1 (en) * 1994-06-24 2001-10-16 Advanced Closure Systems, Inc. Devices for sealing punctures in body vessels

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4464468A (en) * 1968-03-29 1984-08-07 Agence Nationale De Valorisation De La Recherche (Anvar) Immobilization of active protein by cross-linking to inactive protein
IL47468A (en) * 1975-06-12 1979-05-31 Rehovot Res Prod Process for the cross-linking of proteins using water soluble cross-linking agents
CH625702A5 (en) * 1977-01-18 1981-10-15 Delalande Sa
US4839345A (en) * 1985-03-09 1989-06-13 Nippon Oil And Fats Co., Ltd. Hydrated adhesive gel and method for preparing the same
PT83746B (en) * 1985-11-15 1988-08-17 Gist Brocades Nv PROCESS FOR THE PREPARATION OF NEW IMMOBILIZED BIOCATALYZERS AND FOR THE PRODUCTION OF ETHANOL BY FERMENTATION
EP0326618A1 (en) * 1987-03-04 1989-08-09 Nippon Hypox Laboratories Incorporated Medicinal composition containing albumin as carrier and process for its preparation
US6858409B1 (en) * 1988-05-27 2005-02-22 Amgen Inc. Nucleic acids encoding interleukin-1 inhibitors and processes for preparing interleukin-1 inhibitors
US5936035A (en) 1988-11-21 1999-08-10 Cohesion Technologies, Inc. Biocompatible adhesive compositions
US5051292A (en) * 1989-02-01 1991-09-24 Teijin Limited Biaxially oriented film of polyethylene-2,6-naphthalate
US5318524A (en) * 1990-01-03 1994-06-07 Cryolife, Inc. Fibrin sealant delivery kit
US5071417A (en) * 1990-06-15 1991-12-10 Rare Earth Medical Lasers, Inc. Laser fusion of biological materials
US5391183A (en) 1990-09-21 1995-02-21 Datascope Investment Corp Device and method sealing puncture wounds
US5108421A (en) 1990-10-01 1992-04-28 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5618790A (en) * 1990-10-05 1997-04-08 Queen's University At Kingston Protease mediated drug delivery system
US5626863A (en) 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5252714A (en) * 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
US5129882A (en) * 1990-12-27 1992-07-14 Novoste Corporation Wound clotting device and method of using same
US5419765A (en) 1990-12-27 1995-05-30 Novoste Corporation Wound treating device and method for treating wounds
EP0572526A4 (en) 1991-02-13 1995-12-06 Interface Biomedical Lab Corp Filler material for use in tissue welding
JPH06503840A (en) 1991-07-09 1994-04-28 ヴィタフォア コーポレイション Collagen composites for controlled drug release
US5676689A (en) 1991-11-08 1997-10-14 Kensey Nash Corporation Hemostatic puncture closure system including vessel location device and method of use
US5282827A (en) 1991-11-08 1994-02-01 Kensey Nash Corporation Hemostatic puncture closure system and method of use
CA2117588C (en) 1992-02-28 1998-08-25 Jeffrey A. Hubbell Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5573934A (en) 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US5403278A (en) * 1992-04-15 1995-04-04 Datascope Investment Corp. Device and method for treating hematomas and false aneurysms
US5514379A (en) 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
US5871985A (en) * 1992-09-28 1999-02-16 Brown University Research Foundation Particulate non cross-linked chitosan core matrices for encapsulated cells
US5520885A (en) 1993-01-19 1996-05-28 Thermogenesis Corporation Fibrinogen processing apparatus, method and container
JP3269694B2 (en) * 1993-03-01 2002-03-25 富士通株式会社 Electronic trading system
US5800373A (en) 1995-03-23 1998-09-01 Focal, Inc. Initiator priming for improved adherence of gels to substrates
US5422261A (en) 1993-04-16 1995-06-06 Baxter International Inc. Composition containing collagenase and chymopapain for hydrolyzing connective tissue to isolate cells
US5951583A (en) 1993-05-25 1999-09-14 Vascular Solutions, Inc. Thrombin and collagen procoagulant and process for making the same
US5383896A (en) * 1993-05-25 1995-01-24 Gershony; Gary Vascular sealing device
US5626601A (en) 1995-10-27 1997-05-06 Gary Gershony Vascular sealing apparatus and method
US5653730A (en) 1993-09-28 1997-08-05 Hemodynamics, Inc. Surface opening adhesive sealer
US5383899A (en) 1993-09-28 1995-01-24 Hammerslag; Julius G. Method of using a surface opening adhesive sealer
US5759194A (en) 1993-09-28 1998-06-02 Hemodynamics, Inc. Vascular patch applicator
US5843124A (en) 1993-09-28 1998-12-01 Hemodynamics, Inc. Surface opening adhesive sealer
US5446090A (en) 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
US5555787A (en) * 1993-11-12 1996-09-17 Recot, Inc. Replaceable blade cartridge for a centrifugal type food slicer
DK0705298T3 (en) 1993-12-01 2002-07-08 Bioartificial Gel Technologies Inc Albumin-based hydrogel
JP3107726B2 (en) 1994-05-13 2000-11-13 株式会社クラレ Water-swellable polymer gel
US5583114A (en) 1994-07-27 1996-12-10 Minnesota Mining And Manufacturing Company Adhesive sealant composition
DE69532492T2 (en) * 1994-08-31 2004-12-02 Mitsubishi Pharma Corp. Process for the purification of recombinant human serum albumin
CA2202511A1 (en) 1994-10-12 1996-04-25 Laurence A. Roth Targeted delivery via biodegradable polymers
FR2726571B1 (en) 1994-11-03 1997-08-08 Izoret Georges BIOLOGICAL GLUE, PREPARATION METHOD AND APPLICATION DEVICE FOR BIOLOGICAL GLUE, AND HARDENERS FOR BIOLOGICAL GLUE
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
JP2871516B2 (en) * 1995-03-22 1999-03-17 株式会社移動体通信先端技術研究所 Oxide superconducting thin film device
US5900245A (en) 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants
US6214331B1 (en) 1995-06-06 2001-04-10 C. R. Bard, Inc. Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained
US5672662A (en) 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
US5752974A (en) * 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
EP0876165B1 (en) 1995-12-18 2006-06-21 Angiotech BioMaterials Corp. Crosslinked polymer compositions and methods for their use
EP0902687A1 (en) 1996-03-11 1999-03-24 Focal, Inc. Polymeric delivery of radionuclides and radiopharmaceuticals
US5791352A (en) 1996-06-19 1998-08-11 Fusion Medical Technologies, Inc. Methods and compositions for inhibiting tissue adhesion
US20020064546A1 (en) 1996-09-13 2002-05-30 J. Milton Harris Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor
WO1998012274A1 (en) 1996-09-23 1998-03-26 Chandrashekar Pathak Methods and devices for preparing protein concentrates
ZA978537B (en) 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
US6258351B1 (en) 1996-11-06 2001-07-10 Shearwater Corporation Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
US5782860A (en) 1997-02-11 1998-07-21 Biointerventional Corporation Closure device for percutaneous occlusion of puncture sites and tracts in the human body and method
US5951589A (en) 1997-02-11 1999-09-14 Biointerventional Corporation Expansile device for use in blood vessels and tracts in the body and tension application device for use therewith and method
AU6169998A (en) 1997-02-14 1998-09-08 Chandrashekar Pathak Biocompatible polymers and methods for their use
US6371975B2 (en) * 1998-11-06 2002-04-16 Neomend, Inc. Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers
US5990237A (en) 1997-05-21 1999-11-23 Shearwater Polymers, Inc. Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
ZA987019B (en) 1997-08-06 1999-06-04 Focal Inc Hemostatic tissue sealants
US6033427A (en) * 1998-01-07 2000-03-07 Lee; Benjamin I. Method and device for percutaneous sealing of internal puncture sites
JP3159953B2 (en) * 1998-02-04 2001-04-23 旭光学工業株式会社 Endoscope treatment tool
EP1061954B1 (en) 1998-03-12 2004-06-09 Nektar Therapeutics Al, Corporation Poly(ethylene glycol) derivatives with proximal reactive groups
EP1073449A4 (en) 1998-04-24 2003-01-02 Dimensional Pharm Inc Amino acid amidinohydrazones, alkoxyguanidines and aminoguanidines as protease inhibitors
US6514534B1 (en) 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
US6179862B1 (en) 1998-08-14 2001-01-30 Incept Llc Methods and apparatus for in situ formation of hydrogels
US6152943A (en) * 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
ATE502670T1 (en) 1998-08-14 2011-04-15 Incept Llc APPARATUS FOR IN-SITU FORMATION OF HYDROGELS
WO2000012018A1 (en) * 1998-08-26 2000-03-09 Advanced Closure Systems, Inc. Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers or covering structures
US6458147B1 (en) * 1998-11-06 2002-10-01 Neomend, Inc. Compositions, systems, and methods for arresting or controlling bleeding or fluid leakage in body tissue
US6022361A (en) 1998-10-09 2000-02-08 Biointerventional Corporation Device for introducing and polymerizing polymeric biomaterials in the human body and method
US6899889B1 (en) * 1998-11-06 2005-05-31 Neomend, Inc. Biocompatible material composition adaptable to diverse therapeutic indications
US7351249B2 (en) * 1998-11-06 2008-04-01 Neomend, Inc. Systems, methods, and compositions for achieving closure of suture sites
US6830756B2 (en) * 1998-11-06 2004-12-14 Neomend, Inc. Systems, methods, and compositions for achieving closure of vascular puncture sites
WO2000033764A1 (en) 1998-12-04 2000-06-15 Pathak Chandrashekhar P Biocompatible crosslinked polymers
US6312725B1 (en) * 1999-04-16 2001-11-06 Cohesion Technologies, Inc. Rapid gelling biocompatible polymer composition
US6303111B1 (en) * 1999-06-08 2001-10-16 National Research Labs Nontoxic biocompatible deodorizing compositions
DK1218437T3 (en) 1999-08-27 2009-10-19 Angiodevice Internat Gmbh Preparations forming interpenetrating polymer networks for use as high-strength medical sealants
US6586586B1 (en) * 2000-01-31 2003-07-01 Isis Pharmaceuticals, Inc. Purification of oligonucleotides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6302898B1 (en) * 1994-06-24 2001-10-16 Advanced Closure Systems, Inc. Devices for sealing punctures in body vessels

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US8383144B2 (en) 2013-02-26
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US7318933B2 (en) 2008-01-15
US8034367B2 (en) 2011-10-11
AU2002238065A1 (en) 2002-08-28
US20080108577A1 (en) 2008-05-08
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US20010051813A1 (en) 2001-12-13
US20100173843A1 (en) 2010-07-08

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