WO2002064093A3 - Stabilized pharmaceutical and thyroid hormone compositions and method of preparation - Google Patents

Stabilized pharmaceutical and thyroid hormone compositions and method of preparation Download PDF

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Publication number
WO2002064093A3
WO2002064093A3 PCT/US2002/004664 US0204664W WO02064093A3 WO 2002064093 A3 WO2002064093 A3 WO 2002064093A3 US 0204664 W US0204664 W US 0204664W WO 02064093 A3 WO02064093 A3 WO 02064093A3
Authority
WO
WIPO (PCT)
Prior art keywords
thyroid hormone
preparation
stabilized pharmaceutical
hormone compositions
sheet
Prior art date
Application number
PCT/US2002/004664
Other languages
French (fr)
Other versions
WO2002064093A2 (en
WO2002064093A8 (en
Original Assignee
King Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by King Pharmaceuticals Inc filed Critical King Pharmaceuticals Inc
Priority to EP02709558A priority Critical patent/EP1365745A2/en
Priority to MXPA03007337A priority patent/MXPA03007337A/en
Priority to JP2002563890A priority patent/JP2004525109A/en
Priority to BR0207297-1A priority patent/BR0207297A/en
Priority to CA002438641A priority patent/CA2438641A1/en
Priority to KR10-2003-7010807A priority patent/KR20040100835A/en
Publication of WO2002064093A2 publication Critical patent/WO2002064093A2/en
Publication of WO2002064093A3 publication Critical patent/WO2002064093A3/en
Priority to NO20033637A priority patent/NO20033637L/en
Publication of WO2002064093A8 publication Critical patent/WO2002064093A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4334—Mixers with a converging cross-section
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/80—Falling particle mixers, e.g. with repeated agitation along a vertical axis
    • B01F25/82—Falling particle mixers, e.g. with repeated agitation along a vertical axis uniting flows of material taken from different parts of a receptacle or from a set of different receptacles

Abstract

A pharmaceutical composition with B-sheet microcrygtalline cellulose with improved potency life and methods of preparation therefor. Improved thyroid hormone pharmaceutical compositions comprising 50 weight % or more of B-sheet microcrystalline cellulose.
PCT/US2002/004664 2001-02-15 2002-02-15 Stabilized pharmaceutical and thyroid hormone compositions and method of preparation WO2002064093A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP02709558A EP1365745A2 (en) 2001-02-15 2002-02-15 Stabilized pharmaceutical and thyroid hormone compositions and method of preparation
MXPA03007337A MXPA03007337A (en) 2001-02-15 2002-02-15 Stabilized pharmaceutical and thyroid hormone compositions and method of preparation.
JP2002563890A JP2004525109A (en) 2001-02-15 2002-02-15 Stabilized thyroid hormone pharmaceutical composition and method for producing the same
BR0207297-1A BR0207297A (en) 2001-02-15 2002-02-15 Pharmaceutical composition in solid form and method of preparing a solid dosage form of a pharmaceutically active ingredient.
CA002438641A CA2438641A1 (en) 2001-02-15 2002-02-15 Stabilized pharmaceutical and thyroid hormone compositions and method of preparation
KR10-2003-7010807A KR20040100835A (en) 2001-02-15 2002-02-15 Stabilized pharmaceutical and thyroid hormone compositions and method of preparation
NO20033637A NO20033637L (en) 2001-02-15 2003-08-15 Stabilized pharmaceutical and thyroid hormone compositions and methods of manufacture

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26900901P 2001-02-15 2001-02-15
US60/269,009 2001-02-15

Publications (3)

Publication Number Publication Date
WO2002064093A2 WO2002064093A2 (en) 2002-08-22
WO2002064093A3 true WO2002064093A3 (en) 2002-12-12
WO2002064093A8 WO2002064093A8 (en) 2004-09-16

Family

ID=23025455

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/004664 WO2002064093A2 (en) 2001-02-15 2002-02-15 Stabilized pharmaceutical and thyroid hormone compositions and method of preparation

Country Status (9)

Country Link
US (1) US7067148B2 (en)
EP (1) EP1365745A2 (en)
JP (1) JP2004525109A (en)
KR (1) KR20040100835A (en)
BR (1) BR0207297A (en)
CA (1) CA2438641A1 (en)
MX (1) MXPA03007337A (en)
NO (1) NO20033637L (en)
WO (1) WO2002064093A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6645526B2 (en) * 2001-11-13 2003-11-11 Mylan Pharmaceuticals, Inc. Storage stable thyroxine active drug formulations and methods for their production
US20030099699A1 (en) 2001-11-13 2003-05-29 Hanshew Dwight D. Storage stable thyroxine active drug formulations and methods for their production
ITMI20110713A1 (en) 2011-04-29 2012-10-30 Bracco Imaging Spa PROCESS FOR THE PREPARATION OF A SULFATE DERIVATIVE DI3,5-DIIODO-O- [3-IODOFENIL] -L-TIROSINA
ITMI20022394A1 (en) 2002-11-13 2004-05-14 Bracco Spa USE OF 3-SULPHATE TRIODOTHYRONIN AS A THYROIMIMETIC ACTIVITY AND RELATED PHARMACEUTICAL FORMULATIONS.
AU2004234176B2 (en) * 2003-05-02 2010-05-13 Globopharm Pharmazeutische Produktions- Und Handelsgesellschaft M.B.H. Solid pharmaceutical preparation containing levothyroxine and/or liothyronine salts
EP2019306A1 (en) * 2007-07-24 2009-01-28 Uhlmann VisioTec GmbH System for manufacturing and testing tablets
EP2932963A1 (en) 2014-04-16 2015-10-21 Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. Stable pharmaceutical dosage forms comprising Levothyroxine sodium
US9682045B2 (en) 2014-11-21 2017-06-20 Cadila Healthcare Limited Stable pharmaceutical compositions of thyroid hormone drug
KR102338803B1 (en) * 2016-05-03 2021-12-14 스펙트릭스 테라퓨틱스, 엘엘씨 Compositions and methods of providing thyroid hormone or analogs thereof
US10231931B1 (en) 2018-03-23 2019-03-19 Genus Lifesciences Inc. Thyroid hormone oral dosage forms and methods of using the same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225204A (en) * 1991-11-05 1993-07-06 Chen Jivn Ren Stable dosage of levothyroxine sodium and process of production
US5955105A (en) * 1995-11-14 1999-09-21 Knoll Pharmaceutical Company Stabilized thyroid hormone preparations and methods of making same

Family Cites Families (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2642426A (en) 1953-06-16 Method of producing ihygopbotein
US2436005A (en) 1948-02-17 Eleetrieal insulator anx method of
US2426643A (en) 1944-05-08 1947-09-02 Norton Co Method and apparatus for fusing refractory materials
GB652207A (en) 1948-12-31 1951-04-18 Glaxo Lab Ltd Improvements in or relating to the preparation of thyroxine and its derivatives
US2705726A (en) 1949-07-23 1955-04-05 Sterling Drug Inc Iodinated aminophenyl-carboxylic acids
US2802869A (en) 1952-12-08 1957-08-13 Dow Chemical Co Method of making cinnamic acid and salts thereof
US2823164A (en) 1953-02-25 1958-02-11 Nat Res Dev Method of preparing 3, 5, 3' l-tri-iodothyronine and pharmaceutical compositions thereof
US2866738A (en) 1955-01-12 1958-12-30 American Cyanamid Co Deionized corn steep liquor in production of tetracycline
US2993928A (en) 1957-01-15 1961-07-25 Glaxo Lab Ltd Preparation of triiodothyronine
US3035974A (en) 1960-02-18 1962-05-22 Israel Murray Compositions and method for the parenteral administration of thyroxine
US3380818A (en) 1964-03-18 1968-04-30 Owens Illinois Inc Glass composition and method and product
US4110470A (en) 1965-10-07 1978-08-29 Horst Kummer Pharmaceutical composition comprising d,l-α-methyl-thyroxine ethyl ester and the salts thereof and the control of cholesterol and triglyceride blood level therewith
US3452599A (en) 1966-12-22 1969-07-01 Weston Instruments Inc Temperature measuring devices
US3808332A (en) 1969-01-27 1974-04-30 Armour Pharma Pharmaceutical compositions containing the reaction product of a tertiary phosphine with thyroxine
US3666854A (en) 1969-07-30 1972-05-30 Nuclear Med Lab Test for thyroid hormone
US3826767A (en) 1972-01-26 1974-07-30 Calgon Corp Anionic dextran graft copolymers
US4288546A (en) 1976-04-09 1981-09-08 The Regents Of The University Of Minnesota Process for the large scale production of pituitary hormones by serial secondary suspension culture
US4015939A (en) 1976-05-12 1977-04-05 Bio-Rad Laboratories, Inc. Competitive binding thyroid assay with improved bound-free separation step
US4115537A (en) 1976-09-07 1978-09-19 American Hospital Supply Corporation Resin tablet and use thereof in diagnostic tests
US4344934A (en) 1978-11-20 1982-08-17 American Home Products Corporation Therapeutic compositions with enhanced bioavailability
ZA817261B (en) 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
US4479947A (en) 1981-07-13 1984-10-30 Merck & Co., Inc. Oral absorption enhancement of carboxylic acid pharmaceuticals using (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl ester group
US4654331A (en) 1981-07-13 1987-03-31 Merck & Co., Inc. Oral absorption enhancement of carboxylic acid pharmaceuticals using (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl ester group
DE3226768A1 (en) 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt DERIVATIVES OF CIS, ENDO-2-AZABICYCLO- (3.3.0) -OCTAN-3-CARBONIC ACID, METHOD FOR THE PRODUCTION THEREOF, THE MEANS CONTAINING THEM AND THE USE THEREOF
US4369172A (en) 1981-12-18 1983-01-18 Forest Laboratories Inc. Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose
US4690824A (en) 1983-07-07 1987-09-01 Redi-Rowell, Inc. Solid pharmaceutical formulations for slow, zero order release via controlled surface erosion: expanded range
US4539198A (en) 1983-07-07 1985-09-03 Rowell Laboratories, Inc. Solid pharmaceutical formulations for slow, zero order release via controlled surface erosion: expanded range
US4795436A (en) 1983-11-14 1989-01-03 Bio-Mimetics, Inc. Bioadhesive composition and method of treatment therewith
US5225196A (en) 1983-11-14 1993-07-06 Columbia Laboratories, Inc. Bioadhesive compositions and methods of treatment therewith
JPH0830004B2 (en) 1983-11-14 1996-03-27 コロンビア ラボラトリーズ インコーポレイテッド Bioadhesive composition and method of treatment therewith
US4983392A (en) 1983-11-14 1991-01-08 Bio-Mimetics, Inc. Bioadhesive compositions and methods of treatment therewith
CH658188A5 (en) 1984-03-23 1986-10-31 Ciba Geigy Ag STORAGE STABLE QUICK DISASSEMBLING PHARMACEUTICAL PRESSELS.
US4851228A (en) 1984-06-20 1989-07-25 Merck & Co., Inc. Multiparticulate controlled porosity osmotic
US4585652A (en) 1984-11-19 1986-04-29 Regents Of The University Of Minnesota Electrochemical controlled release drug delivery system
US4818531A (en) 1985-02-06 1989-04-04 Eli Lilly And Company Growth hormone and thyroid hormone
US4769319A (en) 1985-05-31 1988-09-06 Salk Institute Biotechnology Industrial Associates, Inc. Nucleic acid probes for prenatal sexing
IE63321B1 (en) 1986-02-03 1995-04-05 Elan Corp Plc Drug delivery system
JPS62210949A (en) 1986-03-11 1987-09-17 Kao Corp Substitute cacao butter composition
US4814183A (en) 1987-08-31 1989-03-21 Merck & Co., Inc. Device for the controlled release of drugs with Donnan-like modulation by charged insoluble resins
US4795644A (en) 1987-08-03 1989-01-03 Merck & Co., Inc. Device for pH independent release of drugs through the Donnan-like influence of charged insoluble resins
US4877774A (en) 1987-09-09 1989-10-31 The United States Of America As Represented By The Department Of Health And Human Services Administration of steroid hormones
US5244786A (en) 1987-10-02 1993-09-14 Microgenics Corporation Method of measuring available free thyroxine bending sites
US5656286A (en) 1988-03-04 1997-08-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
US5073555A (en) 1988-04-04 1991-12-17 George D. McAdory Medicaments intended for combined use in the improvement of lymphocyte function to lower cholesterol levels
US4980358A (en) 1988-04-04 1990-12-25 George D. McAdory Method employing gonadal hormones and dopamine agonist intended for combined use in the improvement of lymphocyte function
US5064823A (en) 1988-08-24 1991-11-12 Research Triangle Institute Pentacyclic triterpenoid compounds as topoisomerase inhibitors or cell differentiation inducers
DE3830353A1 (en) 1988-09-07 1990-03-15 Basf Ag METHOD FOR THE CONTINUOUS PRODUCTION OF SOLID PHARMACEUTICAL FORMS
US5001115A (en) 1989-05-17 1991-03-19 University Of Florida Prodrugs of biologically active hydroxyaromatic compounds
US5767227A (en) 1989-11-03 1998-06-16 Lotus Biochemical Corp. Iodothyronine polymers
US5099001A (en) 1989-12-28 1992-03-24 Nepera, Inc. Process for the production of thyroglobulin
US5158978A (en) 1990-02-05 1992-10-27 British Technology Group (U.S.A.) Thyroid hormone treatment of acute cardiovascular compromise
US5989894A (en) 1990-04-20 1999-11-23 University Of Wyoming Isolated DNA coding for spider silk protein, a replicable vector and a transformed cell containing the DNA
US5686094A (en) 1991-04-01 1997-11-11 Theratech, Inc. Controlled release formulations for the treatment of xerostomia
US5176953A (en) 1990-12-21 1993-01-05 Amoco Corporation Oriented polymeric microporous films
US5412005A (en) 1991-05-03 1995-05-02 Novamont S.P.A. Biodegradable polymeric compositions based on starch and thermoplastic polymers
DE69224809T2 (en) 1991-12-30 1998-07-09 Akzo Nobel Nv Thyroactive composition with controlled release
EP0625007A4 (en) 1992-01-27 1997-02-26 Univ North Carolina State Gene transfer in birds by introduction of dna into muscle in ovo.
US5750089A (en) 1996-01-11 1998-05-12 Neuro Imaging Technologies, Llc Halogenated neuroprobe for mapping monoamine reuptake sites
US5310912A (en) 1992-02-25 1994-05-10 Research Biochemicals Limited Partnership Iodinated neuroprobe for mapping monoamine reuptake sites
US5698179A (en) 1992-02-25 1997-12-16 Neuro Imaging Technologies, Llc Iodinated neuroprobe for mapping monoamine reuptake sites
US5461140A (en) 1992-04-30 1995-10-24 Pharmaceutical Delivery Systems Bioerodible polymers for solid controlled release pharmaceutical compositions
US5607691A (en) 1992-06-12 1997-03-04 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
JPH07509702A (en) 1992-08-05 1995-10-26 エフ・エイチ・フォールディング・アンド・カンパニー・リミテッド pellet drug composition
US5811547A (en) 1992-10-14 1998-09-22 Nippon Shinyaju Co., Ltd. Method for inducing crystalline state transition in medicinal substance
ATE175132T1 (en) 1992-10-26 1999-01-15 Sanol Arznei Schwarz Gmbh METHOD FOR PRODUCING MICRO CAPSULES
TW260612B (en) * 1993-01-05 1995-10-21 Asahi Chemical Ind
US5496934A (en) 1993-04-14 1996-03-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Nucleic acids encoding a cellulose binding domain
US5449522A (en) 1993-08-24 1995-09-12 Hill; Albert F. Pharmaceutical composition for immunoenhancement therapy
US5718969A (en) 1993-08-25 1998-02-17 Fmc Corporation Nonaggregating hydrocolloid microparticulates, intermediates therefor, and processes for their preparation
GB9401892D0 (en) * 1994-02-01 1994-03-30 Boots Co Plc Therapeutic agents
US5670380A (en) 1994-05-04 1997-09-23 Wu; Sing-Yung Assay for fetal thyroid function
US5618338A (en) 1994-07-08 1997-04-08 Canon Kabushiki Kaisha Liquid composition, ink set and image-forming method and apparatus which employ the same
US5910569A (en) 1994-11-22 1999-06-08 Lotus Biochemical Corporation Iodothyronine polymers
EP0797424B1 (en) 1994-12-16 2000-07-12 Warner-Lambert Company Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process
US6245350B1 (en) * 1994-12-16 2001-06-12 Warner-Lambert Company Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process
US5888774A (en) 1994-12-19 1999-03-30 Cangene Corporation Recombinant DNA molecules and expression vectors for erythropoietin
DE4446470A1 (en) 1994-12-23 1996-06-27 Basf Ag Process for the production of dividable tablets
DE4446468A1 (en) 1994-12-23 1996-06-27 Basf Ag Process for the production of coated tablets
US6030613A (en) 1995-01-17 2000-02-29 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of therapeutics
DE19504832A1 (en) 1995-02-14 1996-08-22 Basf Ag Solid drug preparations
DE19509806A1 (en) 1995-03-21 1996-09-26 Basf Ag Storage stable dosage forms
US6183596B1 (en) * 1995-04-07 2001-02-06 Tokushu Paper Mfg. Co., Ltd. Super microfibrillated cellulose, process for producing the same, and coated paper and tinted paper using the same
ATE401315T1 (en) 1995-09-13 2008-08-15 Takeda Pharmaceutical 5-(2,3-DIALKOXYPHENYL)-4,1-BENZOXAZEPINE-2-ONE AS ANTI-HYPERLIPIDEMIC AGENT
DE19536394A1 (en) * 1995-09-29 1997-04-03 Basf Ag Solid pharmaceutical forms, obtainable by extrusion of a polymer-active substance melt containing isomalt
DE19539361A1 (en) 1995-10-23 1997-04-24 Basf Ag Process for the preparation of multilayer, solid pharmaceutical forms for oral or rectal administration
DE19541128C2 (en) * 1995-10-27 1997-11-27 Henning Berlin Gmbh & Co Stabilized thyroid hormone-containing medicines
US5635209A (en) 1995-10-31 1997-06-03 Vintage Pharmaceuticals, Inc. Stabilized composition of levothyroxine sodium medication and method for its production
HUT75956A (en) 1995-11-29 1997-05-28 Cyclolab Pharmaceutical composition containing thyroxine
DE19629753A1 (en) 1996-07-23 1998-01-29 Basf Ag Process for the production of solid dosage forms
US6261537B1 (en) * 1996-10-28 2001-07-17 Nycomed Imaging As Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors
US5958453A (en) * 1996-10-31 1999-09-28 Takeda Chemical Industries, Ltd. Solid pharmaceutical preparation with improved buccal disintegrability and/or dissolubility
US6080383A (en) 1997-01-13 2000-06-27 Rose; Samuel Method and composition for the treatment of cancer by the enzymatic conversion of soluble radioactive toxic agents into radioactive toxic precipitates in the cancer
DE19710213A1 (en) 1997-03-12 1998-09-17 Basf Ag Process for the manufacture of solid combination dosage forms
US6117911A (en) 1997-04-11 2000-09-12 Neorx Corporation Compounds and therapies for the prevention of vascular and non-vascular pathologies
US6403675B1 (en) * 1997-04-30 2002-06-11 Guilford Pharmaceuticals, Inc. Biodegradable compositions comprising poly(cycloaliphatic phosphoester) compounds, articles, and methods for using the same
US6046177A (en) 1997-05-05 2000-04-04 Cydex, Inc. Sulfoalkyl ether cyclodextrin based controlled release solid pharmaceutical formulations
US5916910A (en) 1997-06-04 1999-06-29 Medinox, Inc. Conjugates of dithiocarbamates with pharmacologically active agents and uses therefore
WO1998058012A1 (en) 1997-06-18 1998-12-23 Guilford Pharmaceuticals Inc. Two-stage solution polymerization of high molecular weight poly(phosphoesters)
US6028163A (en) 1997-06-27 2000-02-22 Guilford Pharmaceuticals Inc. Solution polymerization of high molecular weight poly(phosphoesters) in toluene
US6268197B1 (en) * 1997-07-07 2001-07-31 Novozymes A/S Xyloglucan-specific alkaline xyloglucanase from bacillus
US6221402B1 (en) * 1997-11-20 2001-04-24 Pfizer Inc. Rapidly releasing and taste-masking pharmaceutical dosage form
TW589174B (en) * 1997-12-10 2004-06-01 Takeda Chemical Industries Ltd Agent for treating high-risk impaired glucose tolerance
FR2772615B1 (en) * 1997-12-23 2002-06-14 Lipha MULTILAYER TABLET FOR INSTANT RELEASE THEN PROLONGED ACTIVE SUBSTANCES
US6190696B1 (en) * 1998-06-08 2001-02-20 Pieter J. Groenewoud Stabilized thyroxine medications
DE19830246A1 (en) * 1998-07-07 2000-01-13 Merck Patent Gmbh Pharmaceutical preparation
DE19840256A1 (en) * 1998-09-03 2000-03-09 Basf Ag Widely applicable, continuous method for preparing coated solid dosage forms, comprises extruding mixture of drug and thermoplastic binder then applying coating composition in liquid or vapor form
DE19847618A1 (en) * 1998-10-15 2000-04-20 Basf Ag Production of solid dosage forms, used for e.g. pharmaceuticals or insecticides, by preparation of plastic mixture from polymeric binder and active agent under controlled conditions
EP1154991B1 (en) * 1999-02-18 2004-07-28 The Regents of the University of California Salicylamide-lanthanide complexes for use as luminescent markers
US6383471B1 (en) * 1999-04-06 2002-05-07 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
US6395300B1 (en) * 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
PH12000002657B1 (en) * 1999-10-12 2006-02-21 Bristol Myers Squibb Co C-aryl glucoside SGLT2 inhibitors
US6340471B1 (en) * 1999-12-30 2002-01-22 Alvin Kershman Method for preparing solid delivery system for encapsulated and non-encapsulated pharmaceuticals
US6399101B1 (en) * 2000-03-30 2002-06-04 Mova Pharmaceutical Corp. Stable thyroid hormone preparations and method of making same
US6555581B1 (en) * 2001-02-15 2003-04-29 Jones Pharma, Inc. Levothyroxine compositions and methods

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225204A (en) * 1991-11-05 1993-07-06 Chen Jivn Ren Stable dosage of levothyroxine sodium and process of production
US5955105A (en) * 1995-11-14 1999-09-21 Knoll Pharmaceutical Company Stabilized thyroid hormone preparations and methods of making same

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US7067148B2 (en) 2006-06-27
BR0207297A (en) 2005-04-19
JP2004525109A (en) 2004-08-19
MXPA03007337A (en) 2005-03-07
CA2438641A1 (en) 2002-08-22
WO2002064093A2 (en) 2002-08-22
US20030119911A1 (en) 2003-06-26
WO2002064093A8 (en) 2004-09-16
NO20033637L (en) 2003-10-15
NO20033637D0 (en) 2003-08-15
KR20040100835A (en) 2004-12-02
EP1365745A2 (en) 2003-12-03

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