WO2002060575A3 - Well-based biosensor for detecting molecular or cellular events - Google Patents

Well-based biosensor for detecting molecular or cellular events Download PDF

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Publication number
WO2002060575A3
WO2002060575A3 PCT/US2002/003181 US0203181W WO02060575A3 WO 2002060575 A3 WO2002060575 A3 WO 2002060575A3 US 0203181 W US0203181 W US 0203181W WO 02060575 A3 WO02060575 A3 WO 02060575A3
Authority
WO
WIPO (PCT)
Prior art keywords
well
interior surface
signal transmission
well structure
cellular events
Prior art date
Application number
PCT/US2002/003181
Other languages
French (fr)
Other versions
WO2002060575A2 (en
Inventor
Mark A Rhodes
Barrett J Bartell
Kurt D Kramer
Hong Peng
Henry H Liu
Original Assignee
Signature Bioscience Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Signature Bioscience Inc filed Critical Signature Bioscience Inc
Priority to AU2002250009A priority Critical patent/AU2002250009A1/en
Publication of WO2002060575A2 publication Critical patent/WO2002060575A2/en
Publication of WO2002060575A3 publication Critical patent/WO2002060575A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00653—Making arrays on substantially continuous surfaces the compounds being bound to electrodes embedded in or on the solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Abstract

A well-based biosensor for detecting molecular or cellular events includes a well structure and a signal transmission structure. The well structure has an interior surface which defines an interior cavity. The signal transmission structure is formed on at least a portion of the interior surface of the well structure and is operable to support the propagation of an electromagnetic signal above 10MHz. In a specific embodiment the signal transmission structure includes a signal line formed on at least a portion of the interior surface of the well structure and is configured to conduct a time-varying voltage. The signal transmission structure also includes one or more ground elements formed on the at least a portion of the interior surface of the well structure and is configured to maintain a time-invariant voltage, the one or more ground elements spaced apart from and extending generally parallel to the signal line.
PCT/US2002/003181 2001-02-01 2002-01-30 Well-based biosensor for detecting molecular or cellular events WO2002060575A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002250009A AU2002250009A1 (en) 2001-02-01 2002-01-30 Well-based biosensor for detecting molecular or cellular events

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US77571801A 2001-02-01 2001-02-01
US09/775,718 2001-02-01
US92952001A 2001-08-13 2001-08-13
US09/929,520 2001-08-13

Publications (2)

Publication Number Publication Date
WO2002060575A2 WO2002060575A2 (en) 2002-08-08
WO2002060575A3 true WO2002060575A3 (en) 2002-09-19

Family

ID=27119084

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/003181 WO2002060575A2 (en) 2001-02-01 2002-01-30 Well-based biosensor for detecting molecular or cellular events

Country Status (2)

Country Link
AU (1) AU2002250009A1 (en)
WO (1) WO2002060575A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020177175A1 (en) * 1998-02-02 2002-11-28 Hefti John J. Coplanar waveguide biosensor for detecting molecular or cellular events
WO2003101618A1 (en) * 2002-05-31 2003-12-11 Cancer Research Technology Ltd Substrate for holding an array of experimental samples
WO2007106402A2 (en) * 2006-03-10 2007-09-20 President And Fellows Of Harvard College Methods and apparatus for near field irradiation
WO2009138939A1 (en) * 2008-05-13 2009-11-19 Nxp B.V. A sensor array and a method of manufacturing the same
JP6310327B2 (en) * 2014-05-27 2018-04-11 株式会社エンプラス Fluid handling equipment

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0519250A2 (en) * 1991-06-10 1992-12-23 Miles Inc. Microparticle-labeled binding assay analyzed by microwave spectroscopy
US5187096A (en) * 1991-08-08 1993-02-16 Rensselaer Polytechnic Institute Cell substrate electrical impedance sensor with multiple electrode array
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5989402A (en) * 1997-08-29 1999-11-23 Caliper Technologies Corp. Controller/detector interfaces for microfluidic systems
DE19916867A1 (en) * 1999-04-14 2000-10-19 Fraunhofer Ges Forschung Making a molecular array on which molecules are immobilized, using micro-compartments or microcapillary reactors on planar substrates with sensor elements employs microelectronic production techniques

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0519250A2 (en) * 1991-06-10 1992-12-23 Miles Inc. Microparticle-labeled binding assay analyzed by microwave spectroscopy
US5187096A (en) * 1991-08-08 1993-02-16 Rensselaer Polytechnic Institute Cell substrate electrical impedance sensor with multiple electrode array
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5989402A (en) * 1997-08-29 1999-11-23 Caliper Technologies Corp. Controller/detector interfaces for microfluidic systems
DE19916867A1 (en) * 1999-04-14 2000-10-19 Fraunhofer Ges Forschung Making a molecular array on which molecules are immobilized, using micro-compartments or microcapillary reactors on planar substrates with sensor elements employs microelectronic production techniques

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HEFTI J ET AL: "SENSITIVE DETECTION METHOD OF DIELECTRIC DISPERSIONS IN AQUEOUS-BASED, SURFACE-BOUND MACROMOLECULAR STRUCTURES USING MICROWAVE SPECTROSCOPY", APPLIED PHYSICS LETTERS, AMERICAN INSTITUTE OF PHYSICS. NEW YORK, US, vol. 75, no. 12, 20 September 1999 (1999-09-20), pages 1802 - 1804, XP000868333, ISSN: 0003-6951 *

Also Published As

Publication number Publication date
WO2002060575A2 (en) 2002-08-08
AU2002250009A1 (en) 2002-08-12

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