WO2002060524A3 - Enhanced ultrasound detection with temperature dependent contrast agents - Google Patents

Enhanced ultrasound detection with temperature dependent contrast agents Download PDF

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Publication number
WO2002060524A3
WO2002060524A3 PCT/US2002/002631 US0202631W WO02060524A3 WO 2002060524 A3 WO2002060524 A3 WO 2002060524A3 US 0202631 W US0202631 W US 0202631W WO 02060524 A3 WO02060524 A3 WO 02060524A3
Authority
WO
WIPO (PCT)
Prior art keywords
contrast agents
ultrasound detection
temperature dependent
dependent contrast
enhanced ultrasound
Prior art date
Application number
PCT/US2002/002631
Other languages
French (fr)
Other versions
WO2002060524A2 (en
WO2002060524A9 (en
Inventor
Gregory M Lanza
Samuel A Wickline
Christopher S Hall
Original Assignee
Barnes Jewish Hospital
Gregory M Lanza
Samuel A Wickline
Christopher S Hall
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Barnes Jewish Hospital, Gregory M Lanza, Samuel A Wickline, Christopher S Hall filed Critical Barnes Jewish Hospital
Priority to JP2002560714A priority Critical patent/JP4202139B2/en
Priority to AU2002240177A priority patent/AU2002240177B2/en
Priority to CA002435395A priority patent/CA2435395A1/en
Priority to EP02706070A priority patent/EP1363538A4/en
Priority to IL15708502A priority patent/IL157085A0/en
Publication of WO2002060524A2 publication Critical patent/WO2002060524A2/en
Publication of WO2002060524A3 publication Critical patent/WO2002060524A3/en
Publication of WO2002060524A9 publication Critical patent/WO2002060524A9/en
Priority to AU2007201577A priority patent/AU2007201577B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels

Abstract

Methods and devices for enhanced ultrasound detection based upon changing temperature and ultrasound reflectivity of a temperature-dependent contrast agent bound to an ultrasound target are disclosed. The methods and devices can be used for enhanced imaging alone or in conjunction with drug delivery, with therapeutic approaches such as hyperthermia or cryotherapy or with other imaging modalities.
PCT/US2002/002631 2001-01-30 2002-01-30 Enhanced ultrasound detection with temperature dependent contrast agents WO2002060524A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2002560714A JP4202139B2 (en) 2001-01-30 2002-01-30 Enhanced ultrasound detection with temperature-dependent contrast agent
AU2002240177A AU2002240177B2 (en) 2001-01-30 2002-01-30 Enhanced ultrasound detection with temperature dependent contrast agents
CA002435395A CA2435395A1 (en) 2001-01-30 2002-01-30 Enhanced ultrasound detection with temperature dependent contrast agents
EP02706070A EP1363538A4 (en) 2001-01-30 2002-01-30 Enhanced ultrasound detection with temperature dependent contrast agents
IL15708502A IL157085A0 (en) 2001-01-30 2002-01-30 Enhanced ultrasound detection with temperature dependent contrast agents
AU2007201577A AU2007201577B2 (en) 2001-01-30 2007-04-11 Enhanced ultrasound detection with temperature-dependent contrast agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/774,278 2001-01-30
US09/774,278 US7179449B2 (en) 2001-01-30 2001-01-30 Enhanced ultrasound detection with temperature-dependent contrast agents

Publications (3)

Publication Number Publication Date
WO2002060524A2 WO2002060524A2 (en) 2002-08-08
WO2002060524A3 true WO2002060524A3 (en) 2003-04-03
WO2002060524A9 WO2002060524A9 (en) 2004-01-08

Family

ID=25100766

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/002631 WO2002060524A2 (en) 2001-01-30 2002-01-30 Enhanced ultrasound detection with temperature dependent contrast agents

Country Status (7)

Country Link
US (2) US7179449B2 (en)
EP (1) EP1363538A4 (en)
JP (1) JP4202139B2 (en)
AU (1) AU2002240177B2 (en)
CA (1) CA2435395A1 (en)
IL (1) IL157085A0 (en)
WO (1) WO2002060524A2 (en)

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Also Published As

Publication number Publication date
EP1363538A2 (en) 2003-11-26
JP2005503836A (en) 2005-02-10
CA2435395A1 (en) 2002-08-08
JP4202139B2 (en) 2008-12-24
EP1363538A4 (en) 2009-05-13
US20070255117A1 (en) 2007-11-01
IL157085A0 (en) 2004-02-08
WO2002060524A2 (en) 2002-08-08
US7179449B2 (en) 2007-02-20
AU2002240177B2 (en) 2007-01-11
US20020102216A1 (en) 2002-08-01
WO2002060524A9 (en) 2004-01-08

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