WO2002060321A3 - Analysis of raman spectrum signals from selected regions of the eye - Google Patents

Analysis of raman spectrum signals from selected regions of the eye Download PDF

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Publication number
WO2002060321A3
WO2002060321A3 PCT/US2002/000649 US0200649W WO02060321A3 WO 2002060321 A3 WO2002060321 A3 WO 2002060321A3 US 0200649 W US0200649 W US 0200649W WO 02060321 A3 WO02060321 A3 WO 02060321A3
Authority
WO
WIPO (PCT)
Prior art keywords
eye
raman spectrum
blood
level
brain
Prior art date
Application number
PCT/US2002/000649
Other languages
French (fr)
Other versions
WO2002060321A2 (en
Inventor
James L Lambert
Mark S Borchert
Original Assignee
Los Angeles Childrens Hospital
California Inst Of Techn
James L Lambert
Mark S Borchert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Los Angeles Childrens Hospital, California Inst Of Techn, James L Lambert, Mark S Borchert filed Critical Los Angeles Childrens Hospital
Priority to AU2002248331A priority Critical patent/AU2002248331A1/en
Priority to CA002438027A priority patent/CA2438027A1/en
Priority to AT02717315T priority patent/ATE450195T1/en
Priority to DE60234583T priority patent/DE60234583D1/en
Priority to EP02717315A priority patent/EP1383417B1/en
Publication of WO2002060321A2 publication Critical patent/WO2002060321A2/en
Priority to US10/396,010 priority patent/US6961599B2/en
Priority to US10/396,035 priority patent/US7398119B2/en
Publication of WO2002060321A3 publication Critical patent/WO2002060321A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4058—Detecting, measuring or recording for evaluating the nervous system for evaluating the central nervous system
    • A61B5/4064—Evaluating the brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/411—Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/027—Control of working procedures of a spectrometer; Failure detection; Bandwidth calculation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]
    • G01N2021/656—Raman microprobe

Abstract

A non-invasive method for analyzing the blood-brain barrier includes obtaining a Raman spectrum of a selected portion of the eye and monitoring the Raman spectrum to ascertain a change to the dynamics of the blood brain barrier. Also, non-invasive methods for determining the brain or blood level of an analyte of interest, such as glucose, drugs, alcohol, poisons, and the like, comprises: generating an excitation laser beam (e.g., at a wavelength of 600 to 900 nanometers); focusing the excitation laser beam into the anterior chamber of an eye of the subject so that aqueous humor, vitreous humor, or one or more conjunctiva vessels in the eye is illuminated; detecting (preferably confocally detecting) a Raman spectrum from the illuminated portion of the eye; and then determining the blood level or brain level (intracranial or cerebral spinal fluid level) of an analyte of interest for the subject from the Raman spectrum.
PCT/US2002/000649 1998-07-13 2002-01-09 Analysis of raman spectrum signals from selected regions of the eye WO2002060321A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AU2002248331A AU2002248331A1 (en) 2001-01-09 2002-01-09 Analysis of raman spectrum signals from selected regions of the eye
CA002438027A CA2438027A1 (en) 2001-01-09 2002-01-09 Assessing blood brain barrier dynamics or identifying or measuring selected substances or toxins in a subject by analyzing raman spectrum signals of selected regions in the eye
AT02717315T ATE450195T1 (en) 2001-01-09 2002-01-09 ANALYSIS OF RAMAN SPECtral SIGNALS FROM SELECTED EYE AREAS
DE60234583T DE60234583D1 (en) 2001-01-09 2002-01-09 ANALYSIS OF RAMAN SPECTRAL SIGNALS FROM SELECTED EYE RANGE
EP02717315A EP1383417B1 (en) 2001-01-09 2002-01-09 Analysis of raman spectrum signals from selected regions of the eye
US10/396,010 US6961599B2 (en) 2001-01-09 2003-03-25 Identifying or measuring selected substances or toxins in a subject using resonant raman signals
US10/396,035 US7398119B2 (en) 1998-07-13 2003-03-25 Assessing blood brain barrier dynamics or identifying or measuring selected substances, including ethanol or toxins, in a subject by analyzing Raman spectrum signals

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/756,897 US6574501B2 (en) 1998-07-13 2001-01-09 Assessing blood brain barrier dynamics or identifying or measuring selected substances or toxins in a subject by analyzing Raman spectrum signals of selected regions in the eye
US09/756,897 2001-01-09

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US09/756,897 Continuation-In-Part US6574501B2 (en) 1998-07-13 2001-01-09 Assessing blood brain barrier dynamics or identifying or measuring selected substances or toxins in a subject by analyzing Raman spectrum signals of selected regions in the eye

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10/396,010 Continuation-In-Part US6961599B2 (en) 2001-01-09 2003-03-25 Identifying or measuring selected substances or toxins in a subject using resonant raman signals
US10/396,035 Continuation-In-Part US7398119B2 (en) 1998-07-13 2003-03-25 Assessing blood brain barrier dynamics or identifying or measuring selected substances, including ethanol or toxins, in a subject by analyzing Raman spectrum signals

Publications (2)

Publication Number Publication Date
WO2002060321A2 WO2002060321A2 (en) 2002-08-08
WO2002060321A3 true WO2002060321A3 (en) 2003-11-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/000649 WO2002060321A2 (en) 1998-07-13 2002-01-09 Analysis of raman spectrum signals from selected regions of the eye

Country Status (7)

Country Link
US (1) US6574501B2 (en)
EP (1) EP1383417B1 (en)
AT (1) ATE450195T1 (en)
AU (1) AU2002248331A1 (en)
CA (1) CA2438027A1 (en)
DE (1) DE60234583D1 (en)
WO (1) WO2002060321A2 (en)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7398119B2 (en) * 1998-07-13 2008-07-08 Childrens Hospital Los Angeles Assessing blood brain barrier dynamics or identifying or measuring selected substances, including ethanol or toxins, in a subject by analyzing Raman spectrum signals
US20020115477A1 (en) * 2001-02-13 2002-08-22 Raja Singh Portable high speed internet access device with scrolling
US7068381B1 (en) * 2000-02-02 2006-06-27 Raja Tuli Portable high speed internet access device
US7023572B2 (en) * 2000-02-02 2006-04-04 Raja Singh Tuli Portable high speed internet access device
US20020030843A1 (en) * 2000-02-02 2002-03-14 Tuli Raja Singh Portable high speed internet access device
US6633314B1 (en) * 2000-02-02 2003-10-14 Raja Tuli Portable high speed internet device integrating cellular telephone and palm top computer
US7191211B2 (en) * 2000-10-03 2007-03-13 Raja Tuli Portable high speed internet access device priority protocol
CA2414616A1 (en) * 2000-12-21 2002-06-27 Bp Oil International Limited Dual use hydrocarbon fuel composition
US7711403B2 (en) 2001-04-05 2010-05-04 Rhode Island Hospital Non-invasive determination of blood components
US7616123B2 (en) * 2001-04-11 2009-11-10 Trutouch Technologies, Inc. Apparatus and method for noninvasively monitoring for the presence of alcohol or substances of abuse in controlled environments
US8581697B2 (en) * 2001-04-11 2013-11-12 Trutouch Technologies Inc. Apparatuses for noninvasive determination of in vivo alcohol concentration using raman spectroscopy
US8174394B2 (en) * 2001-04-11 2012-05-08 Trutouch Technologies, Inc. System for noninvasive determination of analytes in tissue
DE10129754A1 (en) * 2001-06-20 2003-01-02 Holger Jungmann Detection of the presence of substances in vital tissue materials by passing light of a given wavelength through the material for its intensity to be compared with a reference system
WO2003012486A2 (en) 2001-08-02 2003-02-13 Jonathan Gerlitz Non-invasive glucose-meter
US6785638B2 (en) * 2001-08-06 2004-08-31 Timbre Technologies, Inc. Method and system of dynamic learning through a regression-based library generation process
WO2006029097A2 (en) * 2001-10-22 2006-03-16 Fovioptics, Inc. Systems and methods for maintaining optical fixation and alignment
US7303578B2 (en) * 2001-11-01 2007-12-04 Photothera, Inc. Device and method for providing phototherapy to the brain
US7725144B2 (en) * 2002-04-04 2010-05-25 Veralight, Inc. Determination of disease state using raman spectroscopy of tissue
US7233817B2 (en) * 2002-11-01 2007-06-19 Brian Yen Apparatus and method for pattern delivery of radiation and biological characteristic analysis
US8176428B2 (en) * 2002-12-03 2012-05-08 Datawind Net Access Corporation Portable internet access device back page cache
US7354432B2 (en) * 2003-01-17 2008-04-08 Mcw Research Foundation, Inc. Red to near-infrared photobiomodulation treatment of the visual system in visual system disease or injury
US7326576B2 (en) * 2003-04-09 2008-02-05 Prescient Medical, Inc. Raman spectroscopic monitoring of hemodialysis
EP1634061A4 (en) * 2003-04-30 2007-11-21 Univ Mcgill Method and system for measuring lactate levels in vivo
US6958039B2 (en) * 2003-05-02 2005-10-25 Oculir, Inc. Method and instruments for non-invasive analyte measurement
US6975892B2 (en) * 2003-10-21 2005-12-13 Oculir, Inc. Methods for non-invasive analyte measurement from the conjunctiva
GB0312151D0 (en) * 2003-05-28 2003-07-02 Suisse Electronique Microtech Optical glucose detector
GB2407378B (en) 2003-10-24 2006-09-06 Lein Applied Diagnostics Ltd Ocular property measuring apparatus and method therefor
GB2409033C (en) * 2003-12-12 2006-05-24 Lein Applied Diagnostics Ltd Extended focal region measuring apparatus and method
GB0405798D0 (en) * 2004-03-15 2004-04-21 E San Ltd Medical data display
US20080032420A1 (en) * 2004-03-30 2008-02-07 Lambert James L Surface Enhanced Raman Scattering and Multiplexed Diagnostic Assays
US20060258919A1 (en) * 2004-04-14 2006-11-16 Oculir, Inc. Non-Invasive Analyte Measurement Device for Measuring Tears and Other Ocular Elements Using Electromagnetic Radiation and Method of Using the Same
WO2005106017A2 (en) * 2004-04-21 2005-11-10 University Of Virginia Patent Foundation Method, system and computer program product for evaluating the accuracy of blood glucose monitoring sensors/devices
US7251516B2 (en) * 2004-05-11 2007-07-31 Nostix Llc Noninvasive glucose sensor
US20110178420A1 (en) * 2010-01-18 2011-07-21 Trent Ridder Methods and apparatuses for improving breath alcohol testing
US8730047B2 (en) 2004-05-24 2014-05-20 Trutouch Technologies, Inc. System for noninvasive determination of analytes in tissue
US20080319286A1 (en) * 2004-05-24 2008-12-25 Trent Ridder Optical Probes for Non-Invasive Analyte Measurements
US8515506B2 (en) * 2004-05-24 2013-08-20 Trutouch Technologies, Inc. Methods for noninvasive determination of in vivo alcohol concentration using Raman spectroscopy
DE102004027443B3 (en) * 2004-06-04 2005-07-21 Dräger Safety AG & Co. KGaA Measurement system for contactless body core temperature determination has evaluation unit for evaluating infrared signal that selects maximum value in matrix, computer unit for computing core temperature from selected maximum value
US7209773B2 (en) * 2004-06-18 2007-04-24 In Technology Holdings Llc Method and apparatus for performing in-vivo blood analysis using raman spectrum
US7899636B2 (en) * 2004-12-15 2011-03-01 Koninklijke Philips Electronics N.V. Calibration of optical analysis making use of multivariate optical elements
US7279132B2 (en) 2005-01-12 2007-10-09 Delphi Technologies, Inc. Chemical vapor sensor having an active and a passive measurement mode
US7524671B2 (en) * 2005-01-27 2009-04-28 Prescient Medical, Inc. Handheld raman blood analyzer
US7688440B2 (en) 2005-01-27 2010-03-30 Prescient Medical, Inc. Raman spectroscopic test strip systems
US7651851B2 (en) * 2005-01-27 2010-01-26 Prescient Medical, Inc. Handheld Raman body fluid analyzer
US7177022B2 (en) * 2005-02-18 2007-02-13 Axsun Technologies, Inc. Method and system removing fluorescence and other slowly varying baseline in Raman spectra
WO2006116637A2 (en) * 2005-04-27 2006-11-02 Massachusetts Institute Of Technology Raman spectroscopy for non-invasive glucose measurements
US7330747B2 (en) * 2005-06-07 2008-02-12 Chemimage Corporation Invasive chemometry
US7330746B2 (en) * 2005-06-07 2008-02-12 Chem Image Corporation Non-invasive biochemical analysis
US9103793B2 (en) * 2005-07-22 2015-08-11 Massachusetts Institute Of Technology Intrinsic Raman spectroscopy
EP2157911A2 (en) * 2007-05-16 2010-03-03 Yeda Research And Development Co. Ltd. Assessment of blood-brain barrier disruption
GB2451442B (en) * 2007-07-30 2013-03-06 Lein Applied Diagnostics Ltd Optical measurement apparatus and method therefor
GB2451441B (en) * 2007-07-30 2012-07-11 Lein Applied Diagnostics Ltd Optical alignment apparatus and method thereof
GB2451443B (en) * 2007-07-30 2012-12-26 Lein Applied Diagnostics Ltd Optical measurement apparatus and method therefor
US8467842B2 (en) * 2010-02-10 2013-06-18 Tokitae Llc Systems, devices, and methods including multi-harmonic optical detection of hemozoin nanoparticles
US8385997B2 (en) * 2007-12-11 2013-02-26 Tokitae Llc Spectroscopic detection of malaria via the eye
US7802883B2 (en) 2007-12-20 2010-09-28 Johnson & Johnson Vision Care, Inc. Cosmetic contact lenses having a sparkle effect
GB2457302B (en) 2008-02-11 2013-04-10 Lein Applied Diagnostics Ltd Measurement apparatus and method therefor
US8364218B2 (en) 2008-02-11 2013-01-29 Glucovista, Inc. Apparatus and method for non-invasive measurement of the concentration of a substance in subjects blood
US8219169B2 (en) 2008-02-11 2012-07-10 Glucovista Inc. Apparatus and method using light retro-reflected from a retina to non-invasively measure the blood concentration of a substance
EP2467060A2 (en) 2009-08-18 2012-06-27 Ben Gurion University Of The Negev Research And Development Authority System and method for analyzing imaging data
US9044141B2 (en) * 2010-02-10 2015-06-02 Tokitae Llc Systems, devices, and methods including a dark-field reflected-illumination apparatus
US8781184B2 (en) 2010-02-10 2014-07-15 Tokitae Llc Systems, devices, and methods for detection of malaria
US8159665B2 (en) * 2010-07-21 2012-04-17 Bwt Property, Inc. Apparatus and methods for fluorescence subtraction in Raman spectroscopy
US8467996B2 (en) 2011-02-09 2013-06-18 Jorge E Perez Spectral analysis operating system
GB2489717B (en) * 2011-04-05 2017-10-18 Electronic Medical Solutions Ltd Device and method for the detection of blood analytes
US9255842B2 (en) * 2011-07-13 2016-02-09 Thermo Scientific Portable Analytical Instruments Inc. Heroin detection by raman spectroscopy from impure compositions comprising an interfering fluorescent contaminant
WO2013057697A1 (en) 2011-10-19 2013-04-25 Tel Hashomer Medical Research Infrastructure And Services Ltd. Magnetic resonance maps for analyzing tissue
WO2013110001A1 (en) 2012-01-19 2013-07-25 Cerebrotech Medical Systems, Inc. Diagnostic system for detection of fluid changes
US10743815B2 (en) 2012-01-19 2020-08-18 Cerebrotech Medical Systems, Inc. Detection and analysis of spatially varying fluid levels using magnetic signals
US11357417B2 (en) 2012-01-19 2022-06-14 Cerebrotech Medical Systems, Inc. Continuous autoregulation system
US11249026B2 (en) * 2013-03-15 2022-02-15 Biogen Ma Inc. Use of raman spectroscopy to monitor culture medium
EP2988668B1 (en) 2013-04-24 2019-07-24 Tel HaShomer Medical Research Infrastructure and Services Ltd. Magnetic resonance maps for analyzing tissue
ES2877351T3 (en) 2013-08-07 2021-11-16 Univ Wayne State Micro-raman-based portable detection instrument and detection method
CN104749156B (en) * 2013-12-27 2017-08-29 同方威视技术股份有限公司 Raman spectra detection process
CN104749155B (en) * 2013-12-27 2018-01-16 同方威视技术股份有限公司 For detecting the Raman spectra detection process of the sample contained in body
US10004398B2 (en) 2014-01-13 2018-06-26 Nanyang Technological University Device for determining a condition of an organ and method of operating the same
WO2015183994A1 (en) * 2014-05-28 2015-12-03 Santec Corporation Non-invasive optical measurement of blood analyte
US10563163B2 (en) 2014-07-02 2020-02-18 Biogen Ma Inc. Cross-scale modeling of bioreactor cultures using Raman spectroscopy
WO2016054079A1 (en) 2014-09-29 2016-04-07 Zyomed Corp. Systems and methods for blood glucose and other analyte detection and measurement using collision computing
US10548520B2 (en) 2015-04-01 2020-02-04 Santec Corporation Non-invasive optical measurement of blood analyte
WO2016157156A1 (en) 2015-04-02 2016-10-06 Livspek Medical Technologies Inc. Method and apparatus for a spectral detector for noninvasive detection and monitoring of a variety of biomarkers and other blood constituents in the conjunctiva
US10874333B2 (en) 2015-09-15 2020-12-29 Massachusetts Institute Of Technology Systems and methods for diagnosis of middle ear conditions and detection of analytes in the tympanic membrane
US9554738B1 (en) 2016-03-30 2017-01-31 Zyomed Corp. Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing
US10677580B2 (en) 2016-04-27 2020-06-09 Santec Corporation Optical coherence tomography system using polarization switching
KR102487059B1 (en) 2017-10-31 2023-01-09 삼성전자주식회사 Apparatus and method for processing spectrum
US10502546B2 (en) 2017-11-07 2019-12-10 Santec Corporation Systems and methods for variable-range fourier domain imaging
US11213200B2 (en) 2018-03-22 2022-01-04 Santec Corporation Topographical imaging using combined sensing inputs
US11698304B2 (en) 2019-02-15 2023-07-11 Wayne State University Apparatuses, systems, and methods for detecting materials based on Raman spectroscopy
WO2020195199A1 (en) * 2019-03-27 2020-10-01 株式会社シード Contact lens, aqueous humor raman spectroscopic measurement device, aqueous humor raman spectroscopic measurement system, and aqueous humor raman spectroscopic measurement method
CN110336952B (en) * 2019-06-06 2020-11-17 华为技术有限公司 Spectral curve acquisition method, electronic device and chip
GB202104630D0 (en) * 2021-03-31 2021-05-12 ams Sensors Germany GmbH Optical module
CN113989578B (en) * 2021-12-27 2022-04-26 季华实验室 Method, system, terminal device and medium for analyzing peak position of Raman spectrum

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0722692A1 (en) * 1995-01-20 1996-07-24 Hughes Aircraft Company Noninvasive method and apparatus for determining body chemistry
WO2000002479A1 (en) * 1998-07-13 2000-01-20 Children's Hospital Of Los Angeles Non-invasive glucose monitor

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5377681A (en) * 1989-11-13 1995-01-03 University Of Florida Method of diagnosing impaired blood flow
US5243983A (en) 1990-12-14 1993-09-14 Georgia Tech Research Corporation Non-invasive blood glucose measurement system and method using stimulated raman spectroscopy
US5433197A (en) 1992-09-04 1995-07-18 Stark; Edward W. Non-invasive glucose measurement method and apparatus
DE4243142A1 (en) * 1992-12-19 1994-06-23 Boehringer Mannheim Gmbh Device for in-vivo determination of an optical property of the aqueous humor of the eye
US5308356A (en) 1993-02-25 1994-05-03 Blackshear Jr Perry L Passive perfusion angioplasty catheter
GB9323884D0 (en) * 1993-11-19 1994-01-05 Eisai London Res Lab Ltd Physiological modulation
US5521392A (en) 1994-04-29 1996-05-28 Efos Canada Inc. Light cure system with closed loop control and work piece recording
TW275570B (en) 1994-05-05 1996-05-11 Boehringer Mannheim Gmbh
US5666956A (en) 1996-05-20 1997-09-16 Buchert; Janusz Michal Instrument and method for non-invasive monitoring of human tissue analyte by measuring the body's infrared radiation
DE19635038A1 (en) * 1996-08-29 1998-03-12 Pulsion Verwaltungs Gmbh & Co Method for the non-invasive determination of cerebral blood flow by means of near infrared spectroscopy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0722692A1 (en) * 1995-01-20 1996-07-24 Hughes Aircraft Company Noninvasive method and apparatus for determining body chemistry
WO2000002479A1 (en) * 1998-07-13 2000-01-20 Children's Hospital Of Los Angeles Non-invasive glucose monitor

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Publication number Publication date
US6574501B2 (en) 2003-06-03
ATE450195T1 (en) 2009-12-15
EP1383417A2 (en) 2004-01-28
DE60234583D1 (en) 2010-01-14
EP1383417B1 (en) 2009-12-02
AU2002248331A1 (en) 2002-08-12
CA2438027A1 (en) 2002-08-08
WO2002060321A2 (en) 2002-08-08
US20010034478A1 (en) 2001-10-25

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