WO2002058551A9 - Wireless mems capacitive sensor for physiologic parameter measurement - Google Patents
Wireless mems capacitive sensor for physiologic parameter measurementInfo
- Publication number
- WO2002058551A9 WO2002058551A9 PCT/US2002/001870 US0201870W WO02058551A9 WO 2002058551 A9 WO2002058551 A9 WO 2002058551A9 US 0201870 W US0201870 W US 0201870W WO 02058551 A9 WO02058551 A9 WO 02058551A9
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- Prior art keywords
- sensor
- sensor device
- substrate
- sensing
- sensing device
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6852—Catheters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0031—Implanted circuitry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/02028—Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0295—Measuring blood flow using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14539—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring pH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
- A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
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- A—HUMAN NECESSITIES
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6862—Stents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
- A61B5/6876—Blood vessel
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6879—Means for maintaining contact with the body
- A61B5/6882—Anchoring means
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/028—Microscale sensors, e.g. electromechanical sensors [MEMS]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0265—Measuring blood flow using electromagnetic means, e.g. electromagnetic flowmeter
- A61B5/027—Measuring blood flow using electromagnetic means, e.g. electromagnetic flowmeter using catheters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
Definitions
- the present invention generally relates to the field of MEMS (micro- electromechanical systems) sensors and more specifically to a wireless MEMS capacitive sensor for implantation into the body of a patient to measure one or more physiologic parameters.
- MEMS micro- electromechanical systems
- a number of different biologic parameters are strong candidates for continuous monitoring. These parameters include, but are not limited to blood pressure, blood flow, intracranial pressure, intraocular pressure, glucose levels, etc.
- Wired sensors if used have certain inherent limitations because of the passage of wires (or other communication "tethers") through the cutaneous layer. Some limitations include the risks of physical injury and infection to the patient. Another risk is damage to the device if the wires (the communication link) experience excessive pulling forces and separate from the device itself. Wireless sensors are therefore highly desirable for biologic applications.
- a number of proposed schemes for wireless communication rely on magnetic coupling between an inductor coil associated with the implanted device and a separate, external "readout" coil.
- one method of wireless communication is that of the LC (inductor-capacitor) tank resonator. In such a device, a series-parallel connection of
- a capacitor and inductor has a specific resonant frequency, expressed as l/VZc ,
- the inductor-capacitor pair varies with some physical parameter (e.g. pressure), while the other element remains at a known value, the physical parameter may be determined from the resonant frequency.
- the capacitance corresponds to a capacitive pressure sensor, the capacitance may be back- calculated from the resonant frequency and the sensed pressure may then be deduced from the capacitance by means of a calibrated pressure-capacitance transfer function.
- the impedance of an LC tank resonator may be measured directly or it may also be determined indirectly from the impedance of a separate readout coil that is magnetically coupled to the internal coil.
- a separate readout coil that is magnetically coupled to the internal coil.
- the latter case is most useful for biologic applications since the sensing device may be subcutaneously implanted, while the readout coil may be located external to the patient, but in a location that allows magnetic coupling between the implanted sensing device and readout coil. It is possible for the readout coil (or coils) to simultaneously excite the resonator of the implanted device and sense the reflected back impedance. Consequently, this architecture has the substantial advantage of requiring no internal power source, which greatly improves its prospects for long-term implantation (e.g. decades to a human lifetime).
- CHF CHF Failure
- Porat U.S. Pat. No. 6,277,078
- Eigler U.S. Pat. No. 6,328,699
- Carney U.S. Pat. No. 5,368,040
- What is described is a general scheme of monitoring the heart. The existence of a method to construct a sensor with sufficient size, long-term fidelity, stability, telemetry range, and biocompatibility is noticeably absent in each case, being instead simply assumed.
- an object of the present invention is to provide a wireless MEMS sensor system in which the sensing device is adapted for implantation within the body of patient.
- a further object of this invention is to provide a wireless MEMS sensor system in which the separation distance between the sensing device and the readout device is greater than 2 cm, thereby allowing for deeper implantation of the sensing device within the body of a patient.
- Still another object of the present invention is to provide a wireless
- MEMS sensor system in which the sensing device utilizes an integrated inductor, an inductor microfabricated with the sensor itself.
- a further object of the present invention is to provide a wireless MEMS sensor system.
- the present invention provides for a wireless MEMS sensor for implantation into the body of a patient and which permits implantation at depths greater than 2 cm while still readily allowing for reading of the signals from the implanted portion by an external readout device.
- the present invention provides a MEMS sensor system having an implantable unit and a non-implantable unit.
- the implantable unit is microfabricated utilizing common microfabricating techniques to provide a monolithic device, a device where all components are located on the same chip.
- the implanted device includes a substrate on which is formed a capacitive sensor.
- the fixed electrode of the capacitive sensor may formed on the substrate itself, while the moveable electrode of the capacitive sensor is formed as part of a highly doped silicon layer on top of the substrate. Being highly doped, the silicon layer itself operates as the conductive path for the moveable electrode. A separate conductive path is provided on the substrate for the fixed electrode.
- the implanted sensing device includes an integrally formed inductor.
- the integral inductor includes a magnetic core having at least one plate and a coil defining a plurality of turns about the core. One end of the coil is coupled to the conductive lead connected with the fixed electrode while the other end of the coil is electrically coupled to the highly doped silicon layer, thereby utilizing the silicon layer as the conductive path to the moveable electrode.
- the optimized magnetic core utilizes a pair of plates formed on opposing sides of the substrate and interconnected by a post extending through the substrate. The windings of the coil, in this instance, are provided about the post.
- the external readout device of the present system also includes a coil and various suitable associated components, as well known in the field, to enable a determination of the pressure or other physiologic parameter being sensed by the implanted sensing device.
- the external readout device may similarly be utilized to power the implanted sensing device and as such the implanted sensing device is wireless.
- Integrally formed on the implanted device and microfabricated therewith, may be additionally be active circuitry for use in conjunction with capacitive sensor. Locating this circuitry as near as possible to the capacitive sensor minimizes noise and other factors which could lead to a degradation in the received signal and the sensed measured physiologic parameter.
- the active circuitry may be integrally microfabricated in the highly doped silicon layer mentioned above.
- Figure 1 is a schematic illustration of a wireless MEMS sensor system according the principles of the present invention.
- Figure 2 is a graphical illustration of impedance magnitude and phase angle near resonance, as sensed through a readout coil
- Figure 3 is a cross-sectional representation of a sensing device embodying the principles of the present invention.
- Figures 4A and 4B are schematic illustrations of the magnetic field distribution with Figure 4A illustrating the magnetic field distribution of prior art devices and with Figure 4B illustrating the magnetic field distribution for a sensing device having a magnetic core embodying the principles of the present invention
- Figure 5 is an enlarged cross-sectional view of the diaphragm portion of Figure 3 operating in what is herein referred to as a "proximity" mode;
- Figure 6 is a cross-sectional view similar to that seen in Figure 5 illustrating, however, the diaphragm operating in what is herein referred to as a
- Figure 7 is a capacitance versus pressure curve in the proximity and touch modes of operation;
- Figure 8 is a top plane view of a second embodiment of the main electrode in the capacitive sensor portion of the implanted sensing device according to the principles of the present invention;
- Figure 9 is a diagrammatic illustration of one scheme for providing electrically isolated paths for the connections and electrodes of the capacitive sensor portion;
- Figure 10 is a diagrammatic illustration of another scheme for electrically isolating the conductive paths for the connections and contacts of the capacitive sensor portion;
- Figure 11 is a cross-sectional view, generally similar to that seen in
- Figure 12 is a block diagram illustrating one possible circuit implementation of the active circuitry when incorporated into the sensing device of the present wireless MEMS sensing system
- Figure 13 illustrates one method of mounting, within the body of a patient, a sensing device embodying the principles of the presents invention
- Figure 14 illustrates a second embodiment by which a sensing device embodying the principles of the present invention may be secured to tissues within the body of a patient
- Figures 15 and 16 are diagrammatic illustrations of different embodiments for locating a sensing device according to the principles of the present invention, within a vessel in the body of a patient;
- Figure 17 illustrates a sensing device, according to the principles of the present invention, encapsulated in a material yielding a pellet-like profile for implantation into the tissues in the body of a patient;
- Figure 18 illustrates a sensing device according to the principles of the present invention being located within the electrode tip of an implantable stimulation lead, such as that used for cardiac pacing;
- Figure 19 illustrates a plurality of sensing devices according to the present invention located within a catheter and utilized to calculate various physiologic parameters within a vessel within the body of a patient;
- Figure 20 is a schematic illustration of multiple sensors being used to measure performance of a component in the body or a device mounted within the body of a patient;
- Figure 21 illustrates a sensing device according to the principles of the present invention being utilized to measure pressure externally through a vessel wall
- Figure 22 illustrates a portion of a further embodiment of the present invention in which the pressure sensing features of the sensing device have been augmented over or replaced with a structure allowing a parameter other than pressure to be sensed;
- Figure 23 is schematic perspective view, with portions enlarged, illustrating an alternative embodiment for sensing according to the principles of the present invention.
- Figure 24 is an embodiment generally similar to that seen in Figure 23 for sensing according to the principles of the present invention.
- DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS [0048]
- the present invention provides a wireless MEMS sensing system, generally designated at 10 and seen schematically in Figure 1.
- the system 10 includes a microfabricated implantable sensing device 12, optimized for coupling with an external readout device 14.
- the sensing device 12 is provided with an integrated inductor 16 that is conductive to the integration of transducers and/or other components necessary to construct the wireless sensing system 10.
- the preferred embodiment integrates a capacitive pressure sensor 18 into a common substrate 20 with the integrated inductor 16.
- a second inductor 24, in the readout device 14, couples magnetically 26 with the integrated inductor 16 of the sensing device 12.
- the readout device 14 is constructed according to techniques well known in the industry and in the sensing field in general. As such, the readout device 14 is not illustrated or described in great detail. It is noted, however, that the readout device 14 may be included, in addition to its inductor 24, signal conditioning, control and analysis circuitry and software, display and other hardware and may be a stand alone unit or may be connected to a personal computer (PC) or other computer controlled device.
- PC personal computer
- the magnetic coupling 26 seen in Figure 1 allows the impedance of the LC tank circuit 22 to be sensed by the readout device 14.
- the typical impedance magnitude 28 and phase angle 30 near resonance 32, as sensed through the readout coil 14, is seen in Figure 2. Real-time measurement and analysis of this impedance and changes therein allows the sensed pressure to be determined as previously mentioned.
- the sensing device 12 includes a main substrate 34 (preferably 7740 Pyrex glass) formed and located within recessed regions of the substrate 34 are those structures forming the integrated inductor 16.
- the integrated inductor 16 is seen to include a magnetic core 33 defined by a top plate 36, a bottom plate 38 and a post 40 connecting the top plate 36 to the bottom plate 38 and being continuous through the substrate 34.
- the plates 36 and 38 and the post 40 are preferably constructed of the same material, a ferromagnetic material and are monolithic.
- the integrated conductor 16 additionally includes a coil 42, preferably composed of copper or other high-conductivity material, successive turns of which surround the post 40 of the magnetic core 33.
- the coil 42 may additionally be planar or layered and preferably wraps as tightly as possible about the post 40. If the material of the coil 42 has a high electrical resistance relative to the material of the core 33, (as in a copper coil and NiZn ferrite core system) the core 33, and specifically the top plate 36 may be directly deposited on top of the coil 42 without need for a intermediate insulating layer. If the electrical resistance of the coil material relative to the coil material is not high, an intermediate insulating layer must be included between the successive turns of the coil 42 and the core 33.
- Top and bottom cap layers 44 and 46 are provided over upper and lower faces 48 and 50 of the substrate 20 and over the top and bottom plates 36 and 38 of the magnetic core 33.
- the cap layers 44 and "46 may be provided with recesses 52 and 54, respectively.
- the cap layers 44 and 46 are of monocrystalline silicon.
- Other preferred materials include polycrystalline silicon, epitaxially deposited silicon, ceramics, glass, plastics, or other materials that can be bonded to lower substrate and/or are suitable for fabrication of the sensor diaphragm.
- several sub-pieces may be fabricated at separate process steps, together forming a complete cap layer after processing is finished.
- FIG. 4A shows schematically the magnetic field distribution 56 in a known inductor structure having a single core layer 58 and associated windings 60.
- Figure 4b Schematically shown in Figure 4b is the magnetic field distribution 62 for an inductor structure 16' having upper and lower plates 36' and 38', connected by a post 40' about which windings of a coil 42' are located, as generally seen in the present invention.
- the design of the present invention optimizes the inductor geometry for maximum field coupling.
- the materials used to form the integrated inductor 16 should be chosen and/or processed to maximize the above mentioned effect and to minimize drift in the inductance value across time, temperature, package stress, and other potentially uncontrolled parameters.
- a high-permeability material such as NiZn ferrite is used to maximize this effect on the magnetic field and to minimize drift.
- Other preferred materials include nickel, ferrite, permalloy, or similar ferrite composites.
- the capacitive pressure sensor 18 may be constructed in many forms commonly know to those familiar with the art.
- the upper cap layer 44 is formed to define a diaphragm 64.
- the diaphragm 64 constitutes and may also be referred to as the moveable electrode of the pressure sensor 18.
- the fixed electrode 66 of the pressure sensor 18 is defined by a conductive layer formed on the upper face 48 of the substrate 20, in a position immediately below the moveable electrode or diaphragm 64. If desired, a conductive layer may additionally be located on the underside of the moveable electrode 64.
- one or both of the electrodes 64 and 66 may be provided with a thin dielectric layer (preferably less than 1000A) deposited thereon.
- a thin dielectric layer preferably less than 1000A
- one or more secondary electrodes designated at 70 may be located about the fixed electrode 66 near the projected edge of the diaphragm 64 where pressure induced deflection of the diaphragm 64 is minimal. The secondary electrodes 70 experience all of the capacitance-effecting phenomena seen by the main electrode 66, with the exception of any pressure-induced phenomena.
- the secondary electrodes 70 operate as reference electrodes and by subtracting the secondary electrodes' capacitive measurement from the capacitive measurement of the main electrode 66, most or all non-pressure-induced capacitance changes (signal drift) may be filtered out.
- sources of signal drift include thermally induced physical changes and parasitics resulting from an environment with changing dielectric constant, such as insertion of the sensor into tissue.
- the secondary (or reference) electrodes 70 would require an additional coil, similar to construction of the previously mentioned coil 42 to form a separate LC tank circuit. It is noted, that both coils may, however, share the same core post 40.
- the capacitance pressure sensor 18 may be operated in either of two modes.
- a first mode hereinafter referred to as the "proximity" mode, is generally seen in Figure 5.
- the starting gap between the fixed electrode 66 and the moveable electrode 64, as ' well as the material and physical parameters for the diaphragm 64 itself, are chosen such that the fixed electrode 66 and the moveable electrode 64will be spaced apart from one another over the entire operating pressure range of the sensor 18.
- C the standard equation of parallel plate capacitance
- the plate separation d will vary with the applied pressure, while the plate area A and the permittivity ⁇ remain constant.
- the geometry e.g., initial gap spacing between the fixed electrode 66 and the moveable electrode 64
- the material and physical parameters of the diaphragm 64 itself are chosen such that the fixed electrode 66 and the moveable electrode 64 will progressively touch each other over the operating pressure range of the sensor 18. Accordingly, the area 72 of the fixed electrode 66 and the moveable electrode 64 in contact with each other will vary with the applied pressure.
- the dominant capacitance is the capacitance of the regions of the fixed electrode 66 and the moveable electrode 64 in contact with one another (if the dielectric coating 74 is thin compared to the total gap thickness, thereby yielding a relatively small effective plate separation distance d).
- plate separation d and permittivity ⁇ will remain constant (at approximately that of the dielectric thickness) while the plate contact area A varies with the applied pressure.
- the trace 82 begins at the innermost turn of the coil 42 and proceeds to a point where the trace 82 makes electrical contact with the upper cap layer 44.
- the upper cap layer 44 serves as the electrical connection between the trace 82 and moveable electrode 64. If the upper cap layer 44 is not conductive, an additional conductive trace along the upper cap layer 44 to the moveable electrode 64 will be utilized.
- the outermost turn of the coil 42 is connected by an electrical trace 84. Where the upper cap layer 44 is conductive, a dielectric layer 86 insulates the trace 84 from the upper cap layer 44. Alternatively, a p-n junction structure (as further described below) could be used.
- the inner and outer turns of the coil 42 may be alternatively connected respectively to the fixed electrode 66 and the moveable electrode 64, thereby reversing the polarity of the LC tank circuit 22 if desired.
- the particular paths between the coil 42 and the electrodes 66 and 64 may also be varied (e.g., such that both are included on the substrate 20) as best suited by the fabrication process. In all cases, the resistance of the electrical path through the traces 82, 84 and the upper cap layer 44 (if used) should be minimized.
- the upper and lower cap layers 44 and 46 are bonded to the substrate
- a post-bond coating of the entire sensing device 12 may be used to establish hermeticity. In either situation, steps are taken to minimize the residual gas pressure within the sensing device 12 after a hermetic seal is established. Once the initial hermetic seal is achieved, gas may be trapped in the interior of the sensing device 12 due to continued outgassing of the interior surfaces and/or the bonded regions. Gas pressure of the residual gas will increase within the interior chamber 90 of the pressure sensor 18 as the diaphragm 64 deflects during normal operation. This residual gas may effect the overall sensitivity of the pressure sensor 18 by effectively increasing the spring constant of the diaphragm 64. Additionally, the residual gas will expand and/or contract with changes in the temperature of the sensing device 12 itself, causing signal drift.
- the pressure sensor 18 is provided with a displacement cavity 88.
- This displacement cavity 88 is generally seen in Figure 3 and is in communication either directly or through a small connecting channel with the interior chamber 90 of the pressure sensor 18, defined between the diaphragm 64 and the fixed electrode 66.
- the displacement cavity 88 is sized such that the total internal sensor volume, the combined volume of the displacement cavity 88 and the interior chamber 90, varies minimally with deflection of the diaphragm 64 over its operational range of displacement.
- the volume of the displacement cavity 88 is approximately ten times greater than the volume of the chamber 90.
- lower pressures within the internal volume 90 should be used.
- the diaphragm 64 may be located within, above, or below the turns of the coil 42, as well as off to one end or side of the device 12 as seen in Figure 3.
- the post 40 and/or one of the plates 36 or 38 of the magnetic core 33 may be omitted to simplify fabricating. However, this would be to the detriment of performance.
- Alternate lead transfer schemes may be used instead of the disclosed traces 82 and 84 that connect the coil 42 to the sensor 18. More or fewer wafer layers may be used to adapt manufacturing processing to available technologies. For example, the entire magnetic core 33 could be formed on the top side of the substrate 20, thereby eliminating the need for lower cap layer 46. Multiple coil layers could also be implemented to increase the coil turn count. Finally, the overall shape of the device 10 may be square, round, oval, or another shape. [0067] To isolate the internal volume of the pressure sensor 18 from the internal volume of the integrated inductor 16, a hermetic lead transfer can be provided as a substitute for the dielectric layer 86.
- a hermetic lead transfer would eliminate outgassing from the inductor coil 42 and magnetic core 33 as a source of drift for the pressure sensor 18, thereby improving long-term stability.
- the hermetic lead transfer may be accomplished by any of several means that provide a sealed and electrically isolated conductive path.
- One example, of a mechanism for achieving a sealed and electrically isolated conductive path is through the use of a p-n junction structure 92 in the sensor 18'. This is illustrated in Figure 9.
- the p-n junction structure 92 (with p-material forming the diaphragm) forms an electrically isolated path in a silicon layer and provides for electrical contact between a fixed electrode 66' and a lead trace 94 but not from the fixed electrode 66' to the diaphragm 66'.
- a separate polysilicon layer 96 forms a conductive path to a fixed electrode 66".
- the conductive layer 96 is insulated, by a separate insulating layer 98, from the doped silicon rim 100 of the sensor 18".
- An alternative embodiment of the present sensing device includes active circuitry for immediate processing of the data including logging, error correction, encoding, analysis, multiplexing of multiple sensor inputs, etc. Since the sensing device 12" of this embodiment, seen in Figure 11 , includes numerous structures which are the same or identical to the structures seen in the embodiment illustrated in Figure 3, like structures are accordingly provided with like designations and are not repetitively discussed. Reference should therefore be accordingly made to the preceding sections of this description where those structures are discussed in connection with Figure 3.
- FIG. 12 The block diagram of Figure 12 illustrates one possible circuit implementation for the active circuitry 102 seen in Figure 11.
- the integrated inductor 16 serves as an antenna for RF telemetry with the external readout device 14.
- the RF magnetic field 26 transmitted from the device 14 provides both data communication and necessary power to the circuitry 102.
- the received energy across inductor 16 is rectified and stored temporarily in an onboard capacitor or power supply designated at block 104.
- the input decoder 103 may receive digital data pertaining to short or long term memory or real time clock signals, and may transfer this information to the control logic 107.
- the front end conditioning circuitry 109 converts an analog sensor signal into a form that is encoded and amplified by the output driver 105.
- the integrated inductor 16 then serves to transmit the RF signal back to the external readout device 14, where the information can be processed, stored, or displayed.
- the many variations for circuit implementations of the rectifier of 104, modulation and coding schemes encompassing blocks 103 and 105, analog circuitry 109 and needed control logic 103 will be appreciated.
- a key issue for sensing physiologic parameters in medical applications is that the sensor must be biocompatible. Biocompatibility involves two issues: the effect of the sensor on the body (toxicity), and the effect of the body on the sensor (corrosion rate).
- the device 12 may be improved is through coating of the device 12 with titanium, iridium, Parylene (a biocompatible polymer), or various other common and/or proprietary thick and thin films.
- a coated device provides two levels of corrosion resistance: and underlying stable surface and a separate, stable coating (which may also be selectively bioactive or bioinert). Provided with these two levels of corrosion resistance, even if the outer coating contains pinholes, cracks, or other discontinuities, the device 12 retains a level of protection.
- a screw (or stud) 104 is attached to the lower cap layer 46 of the sensing device 12.
- the screw 104 is attached to the lower cap layer 46 with biocompatible epoxy or a similar method.
- the screw 104 is then embedded into tissue 106 of the patient and the device 12 retained in place.
- Preferred materials for the screw 104 include stainless steel and titanium.
- Another scheme for securing the sensing device 12 within a patient is seen in Figure 14. As seen therein, the sensing device 12 has secured to the lower cap layer 46 a sheet of mesh 108.
- the mesh 108 becomes encapsulated by tissue of the patient over time, thus anchoring the sensing device 12.
- Sutures 110 may be used to hold the sensing device 12 in place until encapsulation occurs.
- Preferred materials for the mesh 108 include loosely woven, biocompatible cloth and the mesh 108 may range in size from 1 to 20 mm.
- sensing device 12 is attached to stent-like spring cage 112.
- the sensing device 12 may be non-surgically injected into a blood vessel 1 14 or other body cavity containing fluid flow.
- the spring cage 112 expands and lodges the sensing device 12 at the sensing location, while allowing blood (or other fluid) to continue flowing past the sensing device12.
- the spring cage 12 is formed so that the arms 115 thereof are resiliently biased outward.
- Preferred materials for the arms 115 include stainless steel or titanium.
- the arms 1 15 may also be in wire or other forms.
- FIG. 16 Another endoluminal attachment scheme is shown in Figure 16.
- the sensing device 12 is anchored in place within vessel 1 14 by a set of radially outwardly expandable spring arms 1 16.
- the spring arms 116 may be provided with depth-limited anchoring tips 1 18 on their ends to further secure the sensing device 12.
- the arms 116 may be in wire, ribbon or other form and are biased outwardly to cause engagement of the anchoring tips 118 with the wall of the vessel 1 14.
- Preferred materials for the arms 116 and for the anchoring tips 118 include stainless steel or titanium.
- the sensing device 12 is encapsulated in a biocompatible material such as poly(methyl methacrylate), yielding a pellet-like profile designated at 120.
- a recess 122 formed in the pellet 120 allows access to the movable element 64.
- such an embodiment may better allow the sensing device 12 to be incorporated into the body of a medical device, such as an extrusion, injection-molded part, soft rubber, or other material, that otherwise would poorly anchor to a rectangular or other geometrically shaped sensing device 12.
- encapsulation could be used to give the sensing device other profiles or form factors as well.
- One application of the described technology locates the sensing device 12 in an electrode tip 126 of an implantable stimulation lead 128, such as a stimulation lead used for cardiac pacing.
- the sensing device 12 could be used with the read-out device 14 for monitoring arterial, atrial, ventricular, and/or other blood pressures.
- three sensing devices 12 are being used to calculate a diameter 130 of a flow path 132 defined by walls 134. In addition to the diameter 130, mass and/or volumetric blood or other fluid flow rates through the flow path 132 may be calculated.
- the sensing devices 12 are located in a variable diameter catheter 136 or similar geometric construction ' conductive to taking such measurements.
- CFD Computational fluid dynamics
- ⁇ P pressure changes
- ⁇ P 2 pressure changes
- ⁇ P 2 Pressure changes
- Cardiac monitoring applications can particularly benefit from the present system 10 in its various embodiments.
- One possibility is to locate the sensing devices 12 (either by means of a multiple-sensor catheter or individually placed sensor devices 12 (or placed as a tethered pair)) at appropriate locations around a natural or artificial heart valve or other biologic valve, to monitor the pressure on either side of, and/or the flow through, the valve.
- the same setup may also be used to monitor pressure along a vascular stent 137, as shown in Figure 20.
- Sensing devices 12 may be placed at one or more locations 138-142 along the length of the stent.
- a sensing device 12 is located such that pressure is measured externally through a vessel wall 144, such as the wall of a blood vessel.
- the sensing device 12 is placed in intimate contact with the wall 144 through use of a variety of means, including adhesive clips 146 (of a biocompatible material), tissue growth or other methods.
- the sensing device 12 is oriented so that the moveable element 64 is adjacent the vessel wall 144 and measures pressure transduced through the vessel wall 144.
- a calibration factor in active circuitry may be used to adjust the measured value to an actual value so as to account for the effects of sensing the pressure through the vessel wall 144.
- the pressure sensor As an alternative to the foregoing embodiments, the pressure sensor
- a chemical-sensitive substance 148 is placed in a confinement cavity 149 and contact with and exterior surface of sensor diaphragm 150. Osmotic expansion of the substance 148, in response to the concentration of a target chemical, generates a pressure on the diaphragm 150 and allowing the concentration of the cherhical to be monitored.
- the substrate 20 is illustrated, the fixed electrode and associated structures be omitted.
- This sensor 18' may optionally include cap structure 152 to restrict the expansion of the chemical sensitive substance 148 to the center of the diaphragm 150 to maximize deflection of the diaphragm 150.
- a micromachined mesh, grid, or semipermeable membrane 154 also optional and either integral to the cap or attached separately thereto, may be included to prevent the chemical sensitive substance 148 from escaping (or bulging out of) the confinement cavity 149, and/or to prevent foreign materials from entering the cavity 149.
- the mesh 154 could also exist on the molecular level, being formed of a material such as a cross- linked polymer.
- a material with high thermal coefficient of expansion is placed between moveable and fixed electrodes in a structure otherwise constructed similar to a capacitive sensor structure, thereby forming a temperature sensor.
- Figure 23 illustrates an alternative capacitive sensor 156 on the substrate 20, additional structures are omitted for clarity.
- this sensor 156 the capacitance changes due to a varying dielectric constant within the capacitive gap defined between electrodes 158 and 160.
- the gap is filled with sensing substance 162 chosen such that its dielectric constant changes in response to the particular physiologic stimulus being evaluated.
- Figure 24 depicts an alternate implementation of the above embodiment, with the electrodes 158' and 160' and the sensing substance 162 being stacked vertically on the substrate 20, as opposed to the lateral orientation in Figure 23.
- the pressure, temperature or other data Sensing technology in its various forms, may be incorporated into an open or closed-loop therapeutic system for the treatment of medical conditions which require or benefit from regular, subcutaneous monitoring of pressures or other parameters.
- the system may be used, for example, to control the administration of drugs.
- One particular application of this would be to control hyper- or hypotension.
- pressure data from the sensor alone or in conjunction with other real-time or preexisting data, is used to adjust drug or other therapy for hypo- or hypertensive patient. Therapy is provided by means of a control module worn by, or implanted within, the patient (similar to e.g., an insulin pump for diabetics).
- the module may alert the user to take action, directly administer a drug intravenously, and/or initiate other invasive or non-invasive responses.
- relevant information including, but not limited to, measure physiologic parameters, treatment regimens, data histories, drug reservoir levels
- Implantable wireless sensing device of this invention includes, without limitation, the following: 1) Monitoring congestive heart failure patients such as left ventricle pressure monitoring, left atrium pressure monitoring and pulmonary artery pressure monitoring; 2) other hemodynamics parameters including blood pressure, blood flow velocity, blood flow volume and blood temperature; 3) diabetic applications including glucose level monitoring; 4) urinary applications such as bladder pressure and urinary tract pressure measuring; and 5) other blood parameters including O 2 saturation, pH, CO 2 saturation, temperature, bicarbonate, glucose, creatine, hematocirt, potassium, sodium, chloride; and 6) cardiac parameters including (previously discussed) valve pressure gradients and stent pressure gradients.
- congestive heart failure patients such as left ventricle pressure monitoring, left atrium pressure monitoring and pulmonary artery pressure monitoring
- other hemodynamics parameters including blood pressure, blood flow velocity, blood flow volume and blood temperature
- diabetic applications including glucose level monitoring
- urinary applications such as bladder pressure and urinary tract pressure measuring
- other blood parameters including O 2 saturation, pH, CO 2 saturation, temperature, bicarbon
- an array of different sensors may be fabricated or assembled on one sensing device to enhance artifact removal and/or selectivity/differentiation between signals.
- a discussion of such a construction best details this construction.
- Local pressure or pH variations can add spurious signals to a pressure- or pH-based glucose sensor.
- adjacent pH or pressure reference sensors may be implemented to measure these environmental parameters.
- External sensors may also be used to compensate for factors such as atmospheric pressure.
- a combination of sensor arrays, fuzzy logic, look-up tables, and/or other signal-processing technologies could all be used to effect such compensation.
Abstract
Description
Claims
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- 2002-01-22 WO PCT/US2002/001738 patent/WO2002056763A2/en not_active Application Discontinuation
- 2002-01-22 WO PCT/US2002/001870 patent/WO2002058551A2/en not_active Application Discontinuation
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AU2002245291A1 (en) | 2002-07-30 |
WO2002058551A2 (en) | 2002-08-01 |
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WO2002058551A3 (en) | 2002-10-24 |
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WO2002056763A2 (en) | 2002-07-25 |
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US6968743B2 (en) | 2005-11-29 |
US20020151816A1 (en) | 2002-10-17 |
US20020115920A1 (en) | 2002-08-22 |
US6926670B2 (en) | 2005-08-09 |
WO2002056763A3 (en) | 2002-11-14 |
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