WO2002055740A3 - Method for detecting disease associated mutations by means of primer extension - Google Patents
Method for detecting disease associated mutations by means of primer extension Download PDFInfo
- Publication number
- WO2002055740A3 WO2002055740A3 PCT/US2002/000935 US0200935W WO02055740A3 WO 2002055740 A3 WO2002055740 A3 WO 2002055740A3 US 0200935 W US0200935 W US 0200935W WO 02055740 A3 WO02055740 A3 WO 02055740A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- primer extension
- disease associated
- associated mutations
- detecting disease
- assays
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/702—Specific hybridization probes for retroviruses
- C12Q1/703—Viruses associated with AIDS
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002243527A AU2002243527A1 (en) | 2001-01-10 | 2002-01-10 | Method for detecting disease associated mutations by means of primer extension |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/757,949 US6503718B2 (en) | 1999-01-10 | 2001-01-10 | Methods for detecting mutations using primer extension for detecting disease |
US09/757,949 | 2001-01-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002055740A2 WO2002055740A2 (en) | 2002-07-18 |
WO2002055740A3 true WO2002055740A3 (en) | 2003-11-06 |
Family
ID=25049848
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/000935 WO2002055740A2 (en) | 2001-01-10 | 2002-01-10 | Method for detecting disease associated mutations by means of primer extension |
Country Status (3)
Country | Link |
---|---|
US (3) | US6503718B2 (en) |
AU (1) | AU2002243527A1 (en) |
WO (1) | WO2002055740A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9109256B2 (en) | 2004-10-27 | 2015-08-18 | Esoterix Genetic Laboratories, Llc | Method for monitoring disease progression or recurrence |
Families Citing this family (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6406857B1 (en) | 1997-06-16 | 2002-06-18 | Exact Sciences Corporation | Methods for stool sample preparation |
US6818404B2 (en) * | 1997-10-23 | 2004-11-16 | Exact Sciences Corporation | Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples |
US6503718B2 (en) * | 1999-01-10 | 2003-01-07 | Exact Sciences Corporation | Methods for detecting mutations using primer extension for detecting disease |
JP2002537777A (en) | 1999-02-25 | 2002-11-12 | エグザクト サイエンシーズ コーポレイション | Methods for preserving DNA integrity |
JP4794052B2 (en) * | 1999-04-09 | 2011-10-12 | ジェンザイム・コーポレーション | Method for detecting a nucleic acid that is an indicator of cancer |
US6586177B1 (en) | 1999-09-08 | 2003-07-01 | Exact Sciences Corporation | Methods for disease detection |
US6919174B1 (en) * | 1999-12-07 | 2005-07-19 | Exact Sciences Corporation | Methods for disease detection |
CA2394921A1 (en) * | 1999-12-07 | 2001-06-14 | Anthony P. Shuber | Supracolonic aerodigestive neoplasm detection |
US6911308B2 (en) | 2001-01-05 | 2005-06-28 | Exact Sciences Corporation | Methods for detecting, grading or monitoring an H. pylori infection |
US7226739B2 (en) | 2001-03-02 | 2007-06-05 | Isis Pharmaceuticals, Inc | Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations |
US20040121313A1 (en) | 2002-12-06 | 2004-06-24 | Ecker David J. | Methods for rapid detection and identification of bioagents in organs for transplantation |
US20030027135A1 (en) | 2001-03-02 | 2003-02-06 | Ecker David J. | Method for rapid detection and identification of bioagents |
WO2004060278A2 (en) | 2002-12-06 | 2004-07-22 | Isis Pharmaceuticals, Inc. | Methods for rapid identification of pathogens in humans and animals |
US7666588B2 (en) | 2001-03-02 | 2010-02-23 | Ibis Biosciences, Inc. | Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy |
US6428964B1 (en) | 2001-03-15 | 2002-08-06 | Exact Sciences Corporation | Method for alteration detection |
US8073627B2 (en) | 2001-06-26 | 2011-12-06 | Ibis Biosciences, Inc. | System for indentification of pathogens |
US7217510B2 (en) | 2001-06-26 | 2007-05-15 | Isis Pharmaceuticals, Inc. | Methods for providing bacterial bioagent characterizing information |
US7776524B2 (en) | 2002-02-15 | 2010-08-17 | Genzyme Corporation | Methods for analysis of molecular events |
WO2004003173A2 (en) * | 2002-07-01 | 2004-01-08 | Cleveland State University | Method for detecting mutated polynucleotides within a large population of wild-type polynucleotides |
JP4395133B2 (en) | 2002-12-20 | 2010-01-06 | カリパー・ライフ・サイエンシズ・インク. | Single molecule amplification and detection of DNA |
US8275554B2 (en) * | 2002-12-20 | 2012-09-25 | Caliper Life Sciences, Inc. | System for differentiating the lengths of nucleic acids of interest in a sample |
US20050042639A1 (en) * | 2002-12-20 | 2005-02-24 | Caliper Life Sciences, Inc. | Single molecule amplification and detection of DNA length |
US8046171B2 (en) | 2003-04-18 | 2011-10-25 | Ibis Biosciences, Inc. | Methods and apparatus for genetic evaluation |
US8057993B2 (en) | 2003-04-26 | 2011-11-15 | Ibis Biosciences, Inc. | Methods for identification of coronaviruses |
US7964343B2 (en) | 2003-05-13 | 2011-06-21 | Ibis Biosciences, Inc. | Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture |
US8158354B2 (en) | 2003-05-13 | 2012-04-17 | Ibis Biosciences, Inc. | Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture |
US20040259101A1 (en) * | 2003-06-20 | 2004-12-23 | Shuber Anthony P. | Methods for disease screening |
US20120122096A1 (en) | 2003-09-11 | 2012-05-17 | Rangarajan Sampath | Compositions for use in identification of bacteria |
US8546082B2 (en) | 2003-09-11 | 2013-10-01 | Ibis Biosciences, Inc. | Methods for identification of sepsis-causing bacteria |
US8097416B2 (en) | 2003-09-11 | 2012-01-17 | Ibis Biosciences, Inc. | Methods for identification of sepsis-causing bacteria |
WO2005047881A2 (en) * | 2003-11-05 | 2005-05-26 | Exact Sciences Corporation | Repetitive reversed-field affinity electrophoresis and uses therefor |
US8163895B2 (en) | 2003-12-05 | 2012-04-24 | Ibis Biosciences, Inc. | Compositions for use in identification of orthopoxviruses |
US7666592B2 (en) | 2004-02-18 | 2010-02-23 | Ibis Biosciences, Inc. | Methods for concurrent identification and quantification of an unknown bioagent |
US8119336B2 (en) | 2004-03-03 | 2012-02-21 | Ibis Biosciences, Inc. | Compositions for use in identification of alphaviruses |
US20080241827A1 (en) * | 2004-05-10 | 2008-10-02 | Exact Sciences Corporation | Methods For Detecting A Mutant Nucleic Acid |
US20080124714A1 (en) * | 2004-05-14 | 2008-05-29 | Exact Sciences Corporation | Method for Stabilizing Biological Samples for Nucleic Acid Analysis |
EP2458619B1 (en) | 2004-05-24 | 2017-08-02 | Ibis Biosciences, Inc. | Mass spectrometry with selective ion filtration by digital thresholding |
US20050266411A1 (en) | 2004-05-25 | 2005-12-01 | Hofstadler Steven A | Methods for rapid forensic analysis of mitochondrial DNA |
US7811753B2 (en) | 2004-07-14 | 2010-10-12 | Ibis Biosciences, Inc. | Methods for repairing degraded DNA |
WO2006026654A2 (en) | 2004-08-27 | 2006-03-09 | Exact Sciences Corporation | Method for detecting a recombinant event |
WO2006094149A2 (en) * | 2005-03-01 | 2006-09-08 | Exact Sciences Corporation | Methods and compositions for detecting adenoma |
WO2006094238A2 (en) | 2005-03-03 | 2006-09-08 | Isis Pharmaceuticals, Inc. | Compositions for use in identification of adventitious viruses |
US8084207B2 (en) | 2005-03-03 | 2011-12-27 | Ibis Bioscience, Inc. | Compositions for use in identification of papillomavirus |
EP1891244B1 (en) * | 2005-04-13 | 2010-10-06 | Ibis Biosciences, Inc. | Compositions for use in identification of adenoviruses |
US9777314B2 (en) | 2005-04-21 | 2017-10-03 | Esoterix Genetic Laboratories, Llc | Analysis of heterogeneous nucleic acid samples |
CA2616281C (en) | 2005-07-21 | 2014-04-22 | Isis Pharmaceuticals, Inc. | Methods for rapid identification and quantitation of mitochondrial dna variants |
US20070248546A1 (en) * | 2005-11-09 | 2007-10-25 | Exact Sciences Corporation | Clinical algorithm for excluding patients identified in virtual imaging |
AU2007353877B2 (en) | 2006-09-14 | 2012-07-19 | Ibis Biosciences, Inc. | Targeted whole genome amplification method for identification of pathogens |
US8871471B2 (en) | 2007-02-23 | 2014-10-28 | Ibis Biosciences, Inc. | Methods for rapid forensic DNA analysis |
US9598724B2 (en) | 2007-06-01 | 2017-03-21 | Ibis Biosciences, Inc. | Methods and compositions for multiple displacement amplification of nucleic acids |
GB2450356A (en) * | 2007-06-20 | 2008-12-24 | Secretary Trade Ind Brit | Method of Determining the Genotype of a Polymorphism using labelled nucleotides |
US8148163B2 (en) | 2008-09-16 | 2012-04-03 | Ibis Biosciences, Inc. | Sample processing units, systems, and related methods |
WO2010033599A2 (en) | 2008-09-16 | 2010-03-25 | Ibis Biosciences, Inc. | Mixing cartridges, mixing stations, and related kits, systems, and methods |
EP2344893B1 (en) | 2008-09-16 | 2014-10-15 | Ibis Biosciences, Inc. | Microplate handling systems and methods |
EP2396803A4 (en) | 2009-02-12 | 2016-10-26 | Ibis Biosciences Inc | Ionization probe assemblies |
WO2011008971A1 (en) | 2009-07-17 | 2011-01-20 | Ibis Biosciences, Inc. | Lift and mount apparatus |
US9194877B2 (en) | 2009-07-17 | 2015-11-24 | Ibis Biosciences, Inc. | Systems for bioagent indentification |
WO2011031861A1 (en) * | 2009-09-09 | 2011-03-17 | Quintiles Transnational Corp. | Methods for predicting responsiveness of a disease or disorder to a receptor tyrosine kinase inhibitor by analysis of mutations in pik3ca |
EP2957641B1 (en) | 2009-10-15 | 2017-05-17 | Ibis Biosciences, Inc. | Multiple displacement amplification |
WO2011119531A1 (en) | 2010-03-22 | 2011-09-29 | Esoterix Genetic Laboratories, Llc | Mutations associated with cystic fibrosis |
WO2012129363A2 (en) | 2011-03-24 | 2012-09-27 | President And Fellows Of Harvard College | Single cell nucleic acid detection and analysis |
GB201107466D0 (en) | 2011-05-05 | 2011-06-15 | Loktionov Alexandre | Device and method for non-invasive collection of colorectal mucocellular layer and disease detection |
US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
US11913065B2 (en) | 2012-09-04 | 2024-02-27 | Guardent Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
KR102210852B1 (en) | 2012-09-04 | 2021-02-01 | 가던트 헬쓰, 인크. | Systems and methods to detect rare mutations and copy number variation |
US10253358B2 (en) | 2013-11-04 | 2019-04-09 | Exact Sciences Development Company, Llc | Multiple-control calibrators for DNA quantitation |
US10138524B2 (en) | 2013-12-19 | 2018-11-27 | Exact Sciences Development Company, Llc | Synthetic nucleic acid control molecules |
US10909551B2 (en) | 2013-12-23 | 2021-02-02 | The Nielsen Company (Us), Llc | Methods and apparatus to identify users associated with device application usage |
SG11201604923XA (en) | 2013-12-28 | 2016-07-28 | Guardant Health Inc | Methods and systems for detecting genetic variants |
WO2015167972A1 (en) * | 2014-04-28 | 2015-11-05 | Tsavachidou Dimitra | Methods for nucleic acid base determination |
CN108603228B (en) | 2015-12-17 | 2023-09-01 | 夸登特健康公司 | Method for determining tumor gene copy number by analyzing cell-free DNA |
ES2963227T3 (en) | 2016-07-19 | 2024-03-26 | Exact Sciences Corp | Nucleic acid control molecules of non-human organisms |
EP3978624A1 (en) | 2016-07-19 | 2022-04-06 | Exact Sciences Corporation | Methylated control dna |
JP7169993B2 (en) | 2017-05-12 | 2022-11-11 | ラボラトリー コーポレイション オブ アメリカ ホールディングス | Compositions and methods for detecting non-celiac-gluten sensitivity |
WO2018209165A1 (en) | 2017-05-12 | 2018-11-15 | Laboratory Corporation Of America Holdings | Systems and methods for biomarker identificaton |
WO2019126249A1 (en) | 2017-12-20 | 2019-06-27 | Laboratory Corporation Of America Holdings | Compositions and methods to detect head and neck cancer |
WO2019217899A2 (en) | 2018-05-11 | 2019-11-14 | Laboratory Corporation Of America Holdings | Compositions and methods to detect kidney fibrosis |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6013431A (en) * | 1990-02-16 | 2000-01-11 | Molecular Tool, Inc. | Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators |
WO2000070096A2 (en) * | 1999-01-10 | 2000-11-23 | Exact Laboratories, Inc. | Methods of detecting colorectal disease by conduction an assay to detect a mutation in a bat-26 locus |
WO2001011083A2 (en) * | 1999-08-11 | 2001-02-15 | Exact Laboratories, Inc. | Methods for detecting mutations using primer extension |
US20010018180A1 (en) * | 1999-01-10 | 2001-08-30 | Shuber Anthony P. | Methods for detecting mutations using primer extension for detecting disease |
Family Cites Families (89)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4101279A (en) | 1977-04-06 | 1978-07-18 | Muhammed Javed Aslam | Device for the collection and processing of stool specimens |
US4333734A (en) | 1980-01-18 | 1982-06-08 | Sloan-Kettering Institute For Cancer Research | Diagnostic device for fecal occult blood and method of use |
US4535058A (en) | 1982-10-01 | 1985-08-13 | Massachusetts Institute Of Technology | Characterization of oncogenes and assays based thereon |
US4309782A (en) | 1980-09-11 | 1982-01-12 | Esteban Paulin | Device for collecting fecal specimens |
US4445235A (en) | 1982-09-13 | 1984-05-01 | Pearl Slover | Stool specimen collector |
US4883750A (en) | 1984-12-13 | 1989-11-28 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4871838A (en) | 1985-07-23 | 1989-10-03 | The Board Of Rijks Universiteit Leiden | Probes and methods for detecting activated ras oncogenes |
US4705050A (en) | 1985-10-02 | 1987-11-10 | Markham Charles W | Moisture-activated floatation device |
US5348855A (en) | 1986-03-05 | 1994-09-20 | Miles Inc. | Assay for nucleic acid sequences in an unpurified sample |
CA1284931C (en) | 1986-03-13 | 1991-06-18 | Henry A. Erlich | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
US4981783A (en) | 1986-04-16 | 1991-01-01 | Montefiore Medical Center | Method for detecting pathological conditions |
US5635347A (en) | 1986-04-30 | 1997-06-03 | Igen, Inc. | Rapid assays for amplification products |
CA1341576C (en) | 1986-08-11 | 2008-07-08 | Thaddeus P. Dryja | Diagnosis of retinoblastoma |
US4735905A (en) | 1986-08-15 | 1988-04-05 | V-Tech, Inc. | Specimen-gathering apparatus and method |
AU625169B2 (en) | 1987-03-23 | 1992-07-02 | Imperial Chemical Industries Plc | Molecular markers |
US5202231A (en) | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
US4857300A (en) | 1987-07-27 | 1989-08-15 | Cytocorp, Inc. | Cytological and histological fixative formulation and methods for using same |
IE61148B1 (en) | 1988-03-10 | 1994-10-05 | Ici Plc | Method of detecting nucleotide sequences |
EP0333465B1 (en) | 1988-03-18 | 1994-07-13 | Baylor College Of Medicine | Mutation detection by competitive oligonucleotide priming |
IL89964A0 (en) | 1988-04-15 | 1989-12-15 | Montefiore Med Center | Method for determining malignant progression,cdna,polypeptides encoded thereby and pharmaceutical compositions containing the same |
FR2630000A1 (en) | 1988-04-18 | 1989-10-20 | Sultan Bernard | BOTTLE FOR COLLECTING AN URINARY BIOLOGICAL SAMPLE FOR CYTOBACTERIOLOGICAL EXAMINATION |
EP0377015B1 (en) | 1988-05-24 | 1994-11-30 | Gesellschaft für Biotechnologische Forschung mbH (GBF) | Oligonucleotide bank and process for dna sequencing |
US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
CA2044591C (en) | 1989-02-13 | 2002-08-13 | James Langham Dale | Detection of a nucleic acid sequence or a change therein |
US5248671A (en) | 1989-02-15 | 1993-09-28 | Board Of Regents, The University Of Texas System | Methods and compositions for treatment of cancer using oligonucleotides |
US5087617A (en) | 1989-02-15 | 1992-02-11 | Board Of Regents, The University Of Texas System | Methods and compositions for treatment of cancer using oligonucleotides |
US5380645A (en) | 1989-03-16 | 1995-01-10 | The Johns Hopkins University | Generalized method for assessment of colorectal carcinoma |
EP0390323B2 (en) | 1989-03-29 | 2012-08-08 | Johns Hopkins University | Detection of loss of the wild-type p53 gene |
US5362623A (en) | 1991-06-14 | 1994-11-08 | The John Hopkins University | Sequence specific DNA binding by p53 |
US5527676A (en) | 1989-03-29 | 1996-06-18 | The Johns Hopkins University | Detection of loss of the wild-type P53 gene and kits therefor |
US5196167A (en) | 1989-04-04 | 1993-03-23 | Helena Laboratories Corporation | Fecal occult blood test product with positive and negative controls |
US5589335A (en) | 1989-04-05 | 1996-12-31 | Amoco Corporation | Hybridization promotion reagents |
JP2802125B2 (en) | 1989-06-23 | 1998-09-24 | キヤノン株式会社 | Nucleic acid detection method |
ES2059895T3 (en) | 1989-06-23 | 1994-11-16 | Canon Kk | METHOD FOR THE DETECTION OF NUCLEIC ACID. |
US5302509A (en) | 1989-08-14 | 1994-04-12 | Beckman Instruments, Inc. | Method for sequencing polynucleotides |
US5137806A (en) | 1989-12-11 | 1992-08-11 | Board Of Regents, The University Of Texas System | Methods and compositions for the detection of sequences in selected DNA molecules |
EP0507852B1 (en) | 1990-01-04 | 1998-04-01 | The Johns Hopkins University | Gene deleted in colorectal cancer of humans |
IL97222A (en) | 1990-02-16 | 1995-08-31 | Orion Yhtymae Oy | Method and reagent for determining specific nucleotide variations |
US5126239A (en) | 1990-03-14 | 1992-06-30 | E. I. Du Pont De Nemours And Company | Process for detecting polymorphisms on the basis of nucleotide differences |
DE69133528T2 (en) | 1990-06-27 | 2006-09-07 | Princeton University | Protein complex p53 / p90 |
WO1992008133A1 (en) | 1990-10-29 | 1992-05-14 | Dekalb Plant Genetics | Isolation of biological materials using magnetic particles |
US5846710A (en) | 1990-11-02 | 1998-12-08 | St. Louis University | Method for the detection of genetic diseases and gene sequence variations by single nucleotide primer extension |
US5627032A (en) | 1990-12-24 | 1997-05-06 | Ulanovsky; Levy | Composite primers for nucleic acids |
US5352775A (en) | 1991-01-16 | 1994-10-04 | The Johns Hopkins Univ. | APC gene and nucleic acid probes derived therefrom |
AU1366992A (en) | 1991-01-16 | 1992-08-27 | Cancer Institute, The | Inherited and somatic mutations of apc gene in colorectal cancer of humans |
IE66125B1 (en) | 1991-01-31 | 1995-12-13 | Zeneca Ltd | Detection method for variant nucleotides |
CA2101943A1 (en) | 1991-02-05 | 1992-08-06 | Kamal Bahar | Simple test for detecting carcinoembryonic antigen |
EP0570497B1 (en) | 1991-02-05 | 1996-05-08 | Lifecodes Corporation | Molecular genetic identification using probes that recognize polymorphic loci |
US5888819A (en) | 1991-03-05 | 1999-03-30 | Molecular Tool, Inc. | Method for determining nucleotide identity through primer extension |
US6004744A (en) | 1991-03-05 | 1999-12-21 | Molecular Tool, Inc. | Method for determining nucleotide identity through extension of immobilized primer |
WO1992016657A1 (en) | 1991-03-13 | 1992-10-01 | E.I. Du Pont De Nemours And Company | Method of identifying a nucleotide present at a defined position in a nucleic acid |
US5330892A (en) | 1991-03-13 | 1994-07-19 | The Johns Hopkins University | MCC gene (mutated in colorectal cancer) used for diagnosis of cancer in humans |
US5468610A (en) | 1991-05-29 | 1995-11-21 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Three highly informative microsatellite repeat polymorphic DNA markers |
US5378602A (en) | 1991-05-29 | 1995-01-03 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Highly informative microsatellite repeat polymorphic DNA markers twenty-[seven]six |
US5149506A (en) | 1991-08-09 | 1992-09-22 | Sage Products, Inc. | Stool collection and transport device |
DE69219627T2 (en) | 1991-09-13 | 1997-09-04 | Cytocell Ltd | Method for determining a nucleic acid sequence |
WO1993018186A1 (en) | 1992-03-04 | 1993-09-16 | The Regents Of The University Of California | Comparative genomic hybridization (cgh) |
GB9206667D0 (en) | 1992-03-27 | 1992-05-13 | Ici Plc | Purification process |
ATE253645T1 (en) | 1992-04-01 | 2003-11-15 | Univ Johns Hopkins Med | METHOD FOR DETERMINING MAMMAL NUCLEIC ACIDS FROM Stool SAMPLES AND REAGENTS REQUIRED THEREFOR |
US5489508A (en) | 1992-05-13 | 1996-02-06 | University Of Texas System Board Of Regents | Therapy and diagnosis of conditions related to telomere length and/or telomerase activity |
EP0654092B1 (en) | 1992-06-26 | 2003-09-10 | The Trustees Of Princeton University | Method for detecting pre-cancerous or cancerous cells using p90 and p53 antibodies or probes |
US5650277A (en) | 1992-07-02 | 1997-07-22 | Diagenetics Ltd. | Method of determining the presence and quantifying the number of di- and trinucleotide repeats |
US5409586A (en) | 1992-08-26 | 1995-04-25 | Hitachi, Ltd. | Method for analyzing nucleic acid or protein and apparatus therefor |
US5858679A (en) | 1992-11-12 | 1999-01-12 | Fornace, Jr.; Albert J. | Method for determining the presence of functional p53 by measuring GADD45 protein expression |
US5331973A (en) | 1993-03-15 | 1994-07-26 | Fiedler Paul N | Method for obtaining stool samples for gastrointestinal cancer testing |
US5492808A (en) | 1993-05-05 | 1996-02-20 | The Johns Hopkins University | Means for detecting familial colon cancer (FCC) |
US6153379A (en) | 1993-06-22 | 2000-11-28 | Baylor College Of Medicine | Parallel primer extension approach to nucleic acid sequence analysis |
US5466576A (en) | 1993-07-02 | 1995-11-14 | Fred Hutchinson Cancer Research Center | Modulation of PIF-1-type helicases |
WO1995002068A1 (en) | 1993-07-09 | 1995-01-19 | Wakunaga Seiyaku Kabushiki Kaisha | Method of discriminating nucleic acid and testing set for discriminating nucleic acid |
US5610287A (en) | 1993-12-06 | 1997-03-11 | Molecular Tool, Inc. | Method for immobilizing nucleic acid molecules |
US5709998A (en) | 1993-12-15 | 1998-01-20 | The Johns Hopkins University | Molecular diagnosis of familial adenomatous polyposis |
US5496470A (en) | 1994-05-27 | 1996-03-05 | Barnes International, Inc. | Magnetic separator |
US5545527A (en) | 1994-07-08 | 1996-08-13 | Visible Genetics Inc. | Method for testing for mutations in DNA from a patient sample |
GB2293238A (en) | 1994-09-13 | 1996-03-20 | Inceltec Ltd | Primers for replication and/or amplification reactions |
US5702886A (en) | 1994-10-05 | 1997-12-30 | The Johns Hopkins University | Chromosome I8Q loss and prognosis in colorectal cancer |
US5512441A (en) | 1994-11-15 | 1996-04-30 | American Health Foundation | Quantative method for early detection of mutant alleles and diagnostic kits for carrying out the method |
US5463782A (en) | 1994-11-21 | 1995-11-07 | Eric V. Carlson | Foldable stool sample collection device |
WO1996030545A1 (en) * | 1995-03-24 | 1996-10-03 | Mitokor | Mutation detection by differential primer extension of mutant and wildtype target sequences |
US5741677A (en) | 1995-06-07 | 1998-04-21 | Geron Corporation | Methods for measuring telomere length |
US5571676A (en) | 1995-06-07 | 1996-11-05 | Ig Laboratories, Inc. | Method for mismatch-directed in vitro DNA sequencing |
WO1997022719A1 (en) | 1995-12-18 | 1997-06-26 | Washington University | Method for nucleic acid analysis using fluorescence resonance energy transfer |
US5670325A (en) | 1996-08-14 | 1997-09-23 | Exact Laboratories, Inc. | Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample |
US5741650A (en) | 1996-01-30 | 1998-04-21 | Exact Laboratories, Inc. | Methods for detecting colon cancer from stool samples |
US5928870A (en) | 1997-06-16 | 1999-07-27 | Exact Laboratories, Inc. | Methods for the detection of loss of heterozygosity |
US5885775A (en) | 1996-10-04 | 1999-03-23 | Perseptive Biosystems, Inc. | Methods for determining sequences information in polynucleotides using mass spectrometry |
US5830665A (en) | 1997-03-03 | 1998-11-03 | Exact Laboratories, Inc. | Contiguous genomic sequence scanning |
US5945284A (en) | 1997-05-27 | 1999-08-31 | The Perkin-Elmer Corporation | Length determination of nucleic acid repeat sequences by discontinuous primer extension |
US5888778A (en) | 1997-06-16 | 1999-03-30 | Exact Laboratories, Inc. | High-throughput screening method for identification of genetic mutations or disease-causing microorganisms using segmented primers |
-
2001
- 2001-01-10 US US09/757,949 patent/US6503718B2/en not_active Expired - Fee Related
- 2001-06-18 US US09/883,717 patent/US6498012B2/en not_active Expired - Fee Related
- 2001-06-18 US US09/883,548 patent/US6475738B2/en not_active Expired - Lifetime
-
2002
- 2002-01-10 AU AU2002243527A patent/AU2002243527A1/en not_active Abandoned
- 2002-01-10 WO PCT/US2002/000935 patent/WO2002055740A2/en not_active Application Discontinuation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6013431A (en) * | 1990-02-16 | 2000-01-11 | Molecular Tool, Inc. | Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators |
WO2000070096A2 (en) * | 1999-01-10 | 2000-11-23 | Exact Laboratories, Inc. | Methods of detecting colorectal disease by conduction an assay to detect a mutation in a bat-26 locus |
US20010018180A1 (en) * | 1999-01-10 | 2001-08-30 | Shuber Anthony P. | Methods for detecting mutations using primer extension for detecting disease |
WO2001011083A2 (en) * | 1999-08-11 | 2001-02-15 | Exact Laboratories, Inc. | Methods for detecting mutations using primer extension |
Non-Patent Citations (5)
Title |
---|
AHLQUIST DAVID A ET AL: "Colorectal cancer screening by detection of altered human DNA in stool: Feasibility of a multitarget assay panel.", GASTROENTEROLOGY, vol. 119, no. 5, November 2000 (2000-11-01), pages 1219 - 1227, XP001118414, ISSN: 0016-5085 * |
GISMONDI VIVIANA ET AL: "Characterization of 19 novel and six recurring APC mutations in Italian adenomatous polyposis patients, using two different mutation detection techniques", HUMAN MUTATION, WILEY-LISS, NEW YORK, NY, US, vol. 9, no. 4, 1997, pages 370 - 373, XP002162567, ISSN: 1059-7794 * |
HOANG JEAN-MARC ET AL: "BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 57, no. 2, 1997, pages 300 - 303, XP002162454, ISSN: 0008-5472 * |
PICKETTS D J ET AL: "DIFFERENTIAL TERMINATION OF PRIMER EXTENSION: A NOVEL, QUANTIFIABLE METHOD FOR DETECTION OF POINT MUTATIONS", HUMAN GENETICS, BERLIN, DE, vol. 89, 1992, pages 155 - 157, XP002910526 * |
SHUBER ANTHONY P ET AL: "Improved detection of BAT-26 microsatellite deletions by a modified primer extension assay.", GASTROENTEROLOGY, vol. 120, no. 5 Supplement 1, April 2001 (2001-04-01), 102nd Annual Meeting of the American Gastroenterological Association and Digestive Disease Week;Atlanta, Georgia, USA; May 20-23, 2001, April, 2001, pages A.290, XP009012670, ISSN: 0016-5085 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9109256B2 (en) | 2004-10-27 | 2015-08-18 | Esoterix Genetic Laboratories, Llc | Method for monitoring disease progression or recurrence |
Also Published As
Publication number | Publication date |
---|---|
US20020064787A1 (en) | 2002-05-30 |
US6498012B2 (en) | 2002-12-24 |
AU2002243527A1 (en) | 2002-07-24 |
US6503718B2 (en) | 2003-01-07 |
US20020123052A1 (en) | 2002-09-05 |
US6475738B2 (en) | 2002-11-05 |
WO2002055740A2 (en) | 2002-07-18 |
US20010018180A1 (en) | 2001-08-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2002055740A3 (en) | Method for detecting disease associated mutations by means of primer extension | |
WO2000070096A3 (en) | Methods of detecting colorectal disease by conduction an assay to detect a mutation in a bat-26 locus | |
WO2004071517A3 (en) | Uses of il-23 related reagents | |
WO2006060513A3 (en) | Toll like receptor 3 antagonists, methods and uses | |
EP1496360A4 (en) | Method of judging leukemia, pre-leukemia or aleukemic malignant blood disease and diagnostic therefor | |
WO2004060302A3 (en) | Methods and compositions for the diagnosis, prognosis, and treatment of cancer | |
MXPA03006086A (en) | Detection of analytes. | |
WO2003024308A3 (en) | Methods of assaying connective tissue growth factor | |
WO2002063005A3 (en) | Lipid-associated molecules | |
WO2004045376A3 (en) | Screening methods to identify treatments for autoimmune disease | |
WO2002092858A3 (en) | Methods of screening for disease | |
WO2001096598A3 (en) | cDNA FOR HUMAN METHYLENETETRAHYDROFOLATE REDUCTASE AND USES THEREOF | |
WO2005017187A3 (en) | Methods for screening and identifying compounds | |
WO2004039321A8 (en) | Combinative nicotinic/d1 agonism therapy for the treatment of alzheimer’s disease | |
WO2004045545A3 (en) | Compositions and methods for the treatment of cancer, screening of putative anti-cancer compounds, and assessing cancer progression | |
WO2003055980A3 (en) | Il-17 like molecules and uses thereof | |
WO2004078142A3 (en) | Compositions and methods for preventing and treating endotoxin-related diseases and conditions | |
WO2001083524A3 (en) | Rna metabolism proteins | |
WO2002064795A3 (en) | Putative human enzymes | |
MXPA01011721A (en) | Methods for predicting and/or diagnosing the risk of gastric cancer. | |
WO2004005534A3 (en) | Screening for alzheimer's disease | |
WO2004045364A3 (en) | Methods of detecting ovarian neoplasia | |
WO2005072159A8 (en) | Biotherapeutics, diagnostics and research reagents | |
AU2002365104A8 (en) | Method for the diagnosis of breast cancer diseases, associated peptides and the uses thereof | |
EP1234835A3 (en) | Assays for assessing ABeta-Tau Aggregation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
122 | Ep: pct application non-entry in european phase | ||
NENP | Non-entry into the national phase |
Ref country code: JP |
|
WWW | Wipo information: withdrawn in national office |
Country of ref document: JP |