WO2002053173A3 - Design and use of advanced zinc chelating peptides to regulate matrix metalloproteinases - Google Patents

Design and use of advanced zinc chelating peptides to regulate matrix metalloproteinases Download PDF

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Publication number
WO2002053173A3
WO2002053173A3 PCT/US2001/049276 US0149276W WO02053173A3 WO 2002053173 A3 WO2002053173 A3 WO 2002053173A3 US 0149276 W US0149276 W US 0149276W WO 02053173 A3 WO02053173 A3 WO 02053173A3
Authority
WO
WIPO (PCT)
Prior art keywords
design
matrix metalloproteinases
chelating peptides
mmp
zinc chelating
Prior art date
Application number
PCT/US2001/049276
Other languages
French (fr)
Other versions
WO2002053173A2 (en
Inventor
Stephen Quirk
David John Tyrrell
Original Assignee
Kimberly Clark Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kimberly Clark Co filed Critical Kimberly Clark Co
Priority to KR1020037008713A priority Critical patent/KR100818874B1/en
Priority to CA002431853A priority patent/CA2431853A1/en
Priority to AU2002231087A priority patent/AU2002231087A1/en
Priority to EP01991359A priority patent/EP1348024B1/en
Priority to DE60123833T priority patent/DE60123833T2/en
Priority to MXPA03005903A priority patent/MXPA03005903A/en
Publication of WO2002053173A2 publication Critical patent/WO2002053173A2/en
Publication of WO2002053173A3 publication Critical patent/WO2002053173A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

Abstract

The present invention relates to MMP regulators that comprise new synthetic peptides, that comprise amino acid sequences structurally similar to those of MMP binding region of TIMPs, coupled to zinc chelators. The invention also relates to methods for making these MMP regulators and their use for the treatment of chronic and acute wounds and for the treatment of angiogenesis-associated diseases.
PCT/US2001/049276 2000-12-29 2001-12-21 Design and use of advanced zinc chelating peptides to regulate matrix metalloproteinases WO2002053173A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
KR1020037008713A KR100818874B1 (en) 2000-12-29 2001-12-21 Design and Use of Advanced Zinc Chelating Peptides to Regulate Matrix Metalloproteinases
CA002431853A CA2431853A1 (en) 2000-12-29 2001-12-21 Design and use of advanced zinc chelating peptides to regulate matrix metalloproteinases
AU2002231087A AU2002231087A1 (en) 2000-12-29 2001-12-21 Design and use of advanced zinc chelating peptides to regulate matrix metalloproteinases
EP01991359A EP1348024B1 (en) 2000-12-29 2001-12-21 Design and use of advanced zinc chelating peptides to regulate matrix metalloproteinases
DE60123833T DE60123833T2 (en) 2000-12-29 2001-12-21 DESIGN AND USE OF IMPROVED ZINC CHELAT-MAKING PEPTIDES FOR REGULATING MATRIX METAL PROTEINASES
MXPA03005903A MXPA03005903A (en) 2000-12-29 2001-12-21 Design and use of advanced zinc chelating peptides to regulate matrix metalloproteinases.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/753,139 US7041787B2 (en) 2000-12-29 2000-12-29 Design and use of advanced zinc chelating peptides to regulate matrix metalloproteinases
US09/753,139 2000-12-29

Publications (2)

Publication Number Publication Date
WO2002053173A2 WO2002053173A2 (en) 2002-07-11
WO2002053173A3 true WO2002053173A3 (en) 2003-04-10

Family

ID=25029322

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/049276 WO2002053173A2 (en) 2000-12-29 2001-12-21 Design and use of advanced zinc chelating peptides to regulate matrix metalloproteinases

Country Status (9)

Country Link
US (1) US7041787B2 (en)
EP (1) EP1348024B1 (en)
KR (1) KR100818874B1 (en)
AT (1) ATE342352T1 (en)
AU (1) AU2002231087A1 (en)
CA (1) CA2431853A1 (en)
DE (1) DE60123833T2 (en)
MX (1) MXPA03005903A (en)
WO (1) WO2002053173A2 (en)

Families Citing this family (9)

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US6989139B2 (en) * 2000-02-15 2006-01-24 Bristol-Myers Squibb Pharma Company Matrix metalloproteinase inhibitors
AU2003251906B2 (en) * 2002-07-12 2008-12-04 Medarex, Inc. Methods and compositions for preventing oxidative degradation of proteins
US20100131051A1 (en) * 2008-11-24 2010-05-27 Medtronic Vascular, Inc. Systems and Methods for Treatment of Aneurysms Using Zinc Chelator(s)
US20100131001A1 (en) * 2008-11-24 2010-05-27 Medtronic Vascular, Inc. Targeted Drug Delivery for Aneurysm Treatment
WO2010070076A1 (en) 2008-12-19 2010-06-24 Crystax Pharmaceuticals, S.L. Alkanoic acid derivatives and their therapeutic use as hdac inhibitors
KR101363455B1 (en) * 2011-09-09 2014-02-21 (주)케어젠 Peptides Inhibiting the Activity of Matrix Metalloproteases and Use Thereof
US9782457B2 (en) * 2011-10-07 2017-10-10 Tissue Repair Company Flowable formulations for tissue repair and regeneration
WO2015073538A2 (en) * 2013-11-12 2015-05-21 Echogen, Inc. Interaction with metalloenzymes
CN104710525B (en) * 2015-03-18 2020-08-04 浙江海洋学院 Tuna bone collagen source zinc chelated collagen peptide and preparation method and application thereof

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Also Published As

Publication number Publication date
MXPA03005903A (en) 2003-09-10
AU2002231087A1 (en) 2002-07-16
US20030073808A1 (en) 2003-04-17
ATE342352T1 (en) 2006-11-15
EP1348024B1 (en) 2006-10-11
EP1348024A2 (en) 2003-10-01
KR20030064885A (en) 2003-08-02
US7041787B2 (en) 2006-05-09
WO2002053173A2 (en) 2002-07-11
DE60123833D1 (en) 2006-11-23
DE60123833T2 (en) 2007-11-29
CA2431853A1 (en) 2002-07-11
KR100818874B1 (en) 2008-04-01

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