WO2002051474A1 - Drive mechanism for an injection device - Google Patents

Drive mechanism for an injection device Download PDF

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Publication number
WO2002051474A1
WO2002051474A1 PCT/GB2001/005741 GB0105741W WO02051474A1 WO 2002051474 A1 WO2002051474 A1 WO 2002051474A1 GB 0105741 W GB0105741 W GB 0105741W WO 02051474 A1 WO02051474 A1 WO 02051474A1
Authority
WO
WIPO (PCT)
Prior art keywords
housing
shuttle
drive mechanism
movement
piston means
Prior art date
Application number
PCT/GB2001/005741
Other languages
French (fr)
Inventor
Christopher Nigel Langley
Shane Alistair Day
Robert Frederick Veasey
Robert Woolston
Original Assignee
Dca Design International Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9905751&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2002051474(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to IL15624500A priority Critical patent/IL156245A0/en
Priority to JP2002552615A priority patent/JP4308525B2/en
Priority to US10/433,650 priority patent/US7052484B2/en
Priority to EP01272106A priority patent/EP1351728B1/en
Priority to DK01272106T priority patent/DK1351728T3/en
Priority to KR1020037008405A priority patent/KR100788319B1/en
Priority to AU2002216254A priority patent/AU2002216254B2/en
Application filed by Dca Design International Limited filed Critical Dca Design International Limited
Priority to AT01272106T priority patent/ATE294002T1/en
Priority to DE60110463T priority patent/DE60110463T2/en
Priority to BRPI0116274-8A priority patent/BR0116274B1/en
Priority to MXPA03005578A priority patent/MXPA03005578A/en
Priority to CA002430938A priority patent/CA2430938C/en
Publication of WO2002051474A1 publication Critical patent/WO2002051474A1/en
Priority to IL156245A priority patent/IL156245A/en
Priority to HK04102605A priority patent/HK1059747A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14566—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir for receiving a piston rod of the pump
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M2005/31588—Constructional features or modes of drive mechanisms for piston rods electrically driven
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/21—General characteristics of the apparatus insensitive to tilting or inclination, e.g. spill-over prevention
    • A61M2205/215—Tilt detection, e.g. for warning or shut-off
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A61M2205/6018—General characteristics of the apparatus with identification means providing set-up signals for the apparatus configuration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8206—Internal energy supply devices battery-operated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31546—Electrically operated dose setting, e.g. input via touch screen or plus/minus buttons
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/01—Motorized syringe

Definitions

  • the present invention relates to improvements in an injection device, and in particular to improvements in a portable injection device for dispensing controlled quantities of a medicament.
  • injection devices are used by those suffering from diabetes to administer a dose of insulin or insulin-type medicine to themselves. It will be understood that such injection devices are suitable for the injection of other medicines.
  • pen-type injectors To overcome these difficulties a number of so-called pen-type injectors have been developed. These devices are small, being capable of being carried in a jacket pocket or the like and allow a number of doses to be obtained from a cartridge or ampoule contained within the injector. The present invention has particular application to such pen-type injectors.
  • the drive system must be accurate and reliable, and at the same time compact and efficient.
  • the drive system must be reliable and robust; being able to function for the life of the product.
  • the drive system must also be intrinsically fail-safe. It is an advantage of the present invention that it eliminates, or at least substantially reduces such problems.
  • the present invention also provides for improved ease of use and improved interaction with a user.
  • Figure 1 shows a plan view of a pen-type injector in accordance with the present invention
  • Figure 2 shows a similar view to Figure 1 with an end cap of the injector omitted
  • Figure 3 shows a cross-sectional view of the injector of Figures 1 and 2
  • Figure 4 shows in plan view a part of a drive mechanism for use with an injector in accordance with the present invention.
  • the injector 2 comprises a main housing 4 to which is releasably secured an end cap or cover 6.
  • a control panel region 8 At a first end of the main housing 4 there is provided a control panel region 8.
  • This region includes a display panel 10, typically a LCD display, and a first dose button 12 and a second dose button 14, the first and second dose buttons being operated to increase or decrease a dose of medicament to be delivered.
  • the control panel region 10 in the illustrated embodiment also includes an arm button 16.
  • a dispense button 18 At the first end of the main housing there is also provided a dispense button 18. Preferably, when not depressed, the dispense button- 18 is flush with the main housing 4.
  • a needle unit 22 is releasably secured to the main housing.
  • the second end of the main housing 4 is also provided with a shaped portion 24.
  • a cartridge 40 or ampoule of medicament is stored in the housing 4 behind the shaped portion 24.
  • the shaped portion is transparent to permit the cartridge 40 to be seen by a user.
  • a primer button 26 is also provided on the second end of the housing 4. It will be appreciated that
  • a cover detection switch 28 may also be included at the second end of the main housing 4 to detect whether the end cap or cover 6 is in place or not.
  • FIG 3 there can be seen a priming contact 30, an arm contact 32, a first dose contact 34 and a second dose contact 36 corresponding to the respective buttons.
  • a dispense contact 19 corresponding to the dispense button 18 is also shown.
  • a suitable location for a power source 38 such as a battery or batteries.
  • a suitable region in which a cartridge 40 or ampoule of medicament is to be located This region may be accessed by way of the removable shaped portion 24 of the main housing 4 to allow for replacement of the cartridge 40 or ampoule as required by the user.
  • a drive mechanism 42 which operates from the power source 38 and acts upon the cartridge 40 or ampoule of medicament.
  • the cartridge 40 or ampoule comprises a container 44 or sleeve closed at one end by a cover 46 at a head end thereof, and sealed at the other by a movable bung 48 or stopper. When in position, the needle unit 22 pierces the cover 46 and movement of the bung 48 towards the cover 46 will cause the medicament contained within the cartridge 40 or ampoule to be expelled.
  • the cartridge may be a 3ml cartridge in accordance with ISO/FDIS 11608 Part 3, or any other suitable cartridge to suit the injector.
  • Movement of the bung 48 or stopper is caused by movement of a piston or plunger 50 forming a part of the drive mechanism 42.
  • the piston or plunger 50 is movable between a first fully withdrawn position (not shown) which allows for the replacement of the cartridge 40 or ampoule and a second fully extended portion in which as much medicament as possible has been expelled from the cartridge 40 or ampoule.
  • An end stop switch 52 may be provided in the main housing 4 to detect when the piston 50 is in the fully withdrawn position. Tripping of the switch end stop 52 may release a catch or other fastening device to allow access to the main housing 4 for replacement of the cartridge 40.
  • the drive mechanism 42 is operated by a motor 54 under the control of an electronic control unit (not shown).
  • the motor 54 should be reversible in order to allow the piston 50 to be moved between the first and second positions.
  • the motor 54 can be seen to drive the piston 50 by way of a gear train 42, such that rotation of a third rotor 58 causes the piston 50 to be moved in relation to the third rotor 58.
  • the user can feel the vibration of the motor 54 and the associated drive mechanism 42 and/or hear them in operation. In this way an added degree of confidence in the fact of the operation of the injector 2 is provided to the user.
  • a mechanism In order to harness a solenoid for use in an injector, a mechanism has been developed to convert the reciprocating motion of a solenoid into an incremental linear motion to displace a cartridge bung.
  • a two piece shuttle 300 is constrained rotationally within a housing 302 for free axial movement therein.
  • a double faced gear component 304 is also located within the housing.
  • the double faced gear component 304 is free for movement rotationally, but constrained axially.
  • the double faced gear component 304 is coupled to a shaft 306 of a lead screw.
  • the lead screw will be understood to comprise piston means for the advancement of bung 48 within a medicament cartridge 40 within the context of this description.
  • the shuttle comprises two ferrite cores 308,310, each with teeth on an inner face thereof. At either end the housing 302 are disposed coils 312,314.
  • An annular permanent magnet 316 is used to latch the mechanism in one of two end positions when the cores and their associated coils are not energised.
  • the shuttle 300 In the de-energised condition, the shuttle 300 is held latched to one end of the device by the magnet 316.
  • the shuttle is held in position by a closed magnetic 'circuit' passing through one of the shuttle ferrite cores and a casing of the housing 302.
  • both coils 312,314 are energised.
  • the coil at the 'latched' end is energised to oppose the magnetic field of the permanent magnet 316; the coil at the opposite end is energised to reinforce the permanent magnetic field.
  • the shuttle 300 is thus pulled from the rest position to the opposite end of the housing 302.
  • the shuttle 300 engages with the double faced gear component 304 causing it to rotate by a fixed increment, thereby turning a shaft 320 of a lead screw.
  • the mechanism can be seen to work on both strokes of the solenoid. Also, it can be latched at either end allowing for finer control of the lead screw.

Abstract

A drive mechanism for an injection device is disclosed in wich piston means 306 are selectively driven to expel medicament from within a medicament cartridge 40. A drive mechanism for controlling the movement of the piston means is described comprising a housing 302, a shuttle 300 located for movement within the housing 302 along a longitudinal axis between a first position and a second position, and drive means to move the shuttle 300 within the housing 302. A gear component 304 is located within the housing 302 for rotation about the longitudinal axis and associated with the piston means 306, movement of the shittle 300 between each of the first and the second positions causing movement of the piston means 306.

Description

DRIVE MECHANISM FOR AN INJECTION DEVICE
The present invention relates to improvements in an injection device, and in particular to improvements in a portable injection device for dispensing controlled quantities of a medicament.
Typically such injection devices are used by those suffering from diabetes to administer a dose of insulin or insulin-type medicine to themselves. It will be understood that such injection devices are suitable for the injection of other medicines.
At one time, such doses were administered by use of a disposable syringe; the syringe first being filled from a separate phial or other container and then used to inject the dose. However, there were a number of difficulties in such an arrangement. In particular, such an arrangement was not suitable for the infirm. For others, the social stigma associated with such syringes made their public use problematic.
To overcome these difficulties a number of so-called pen-type injectors have been developed. These devices are small, being capable of being carried in a jacket pocket or the like and allow a number of doses to be obtained from a cartridge or ampoule contained within the injector. The present invention has particular application to such pen-type injectors.
While such pen-type injectors are a considerable improvement upon disposable hypodermic syringes, problems nevertheless remain.
In particular when considering the design of a drive system for a pen-type injector, there are a number of, sometimes, conflicting technical requirements. The drive system must be accurate and reliable, and at the same time compact and efficient. The drive system must be reliable and robust; being able to function for the life of the product. The drive system must also be intrinsically fail-safe. It is an advantage of the present invention that it eliminates, or at least substantially reduces such problems. The present invention also provides for improved ease of use and improved interaction with a user.
The invention will now be described, by way of example only, with reference to the accompanying drawings; in wl ich:-
Figure 1 shows a plan view of a pen-type injector in accordance with the present invention; Figure 2 shows a similar view to Figure 1 with an end cap of the injector omitted; Figure 3 shows a cross-sectional view of the injector of Figures 1 and 2; and Figure 4 shows in plan view a part of a drive mechanism for use with an injector in accordance with the present invention.
Referring first to Figures 1 to 3, there can be seen a pen-type injector 2 in accordance with the present invention. The injector 2 comprises a main housing 4 to which is releasably secured an end cap or cover 6.
At a first end of the main housing 4 there is provided a control panel region 8. This region includes a display panel 10, typically a LCD display, and a first dose button 12 and a second dose button 14, the first and second dose buttons being operated to increase or decrease a dose of medicament to be delivered. The control panel region 10 in the illustrated embodiment also includes an arm button 16.
At the first end of the main housing there is also provided a dispense button 18. Preferably, when not depressed, the dispense button- 18 is flush with the main housing 4.
Along a longitudinal axis of the injector 2, to each side of the control panel region 10 are provided a number of grooves or recesses 20. These aid in the gripping of the injector 2 by a user. At a second end of the main housing 4 a needle unit 22 is releasably secured to the main housing. The second end of the main housing 4 is also provided with a shaped portion 24.
In use a cartridge 40 or ampoule of medicament is stored in the housing 4 behind the shaped portion 24. For preference, the shaped portion is transparent to permit the cartridge 40 to be seen by a user.
A primer button 26 is also provided on the second end of the housing 4. It will be
> understood that when the end cap 6 is in place over the second end of the housing, it will not be possible inadvertently to depress the primer button 26 or to be pricked by the needle unit 22. A cover detection switch 28 may also be included at the second end of the main housing 4 to detect whether the end cap or cover 6 is in place or not.
In Figure 3, there can be seen a priming contact 30, an arm contact 32, a first dose contact 34 and a second dose contact 36 corresponding to the respective buttons. A dispense contact 19 corresponding to the dispense button 18 is also shown.
With reference to Figure 3 it may be seen that there is provided a suitable location for a power source 38 such as a battery or batteries. There is also a suitable region in which a cartridge 40 or ampoule of medicament is to be located. This region may be accessed by way of the removable shaped portion 24 of the main housing 4 to allow for replacement of the cartridge 40 or ampoule as required by the user.
In a third region of the main housing 4 there is provided a drive mechanism 42 which operates from the power source 38 and acts upon the cartridge 40 or ampoule of medicament. The cartridge 40 or ampoule comprises a container 44 or sleeve closed at one end by a cover 46 at a head end thereof, and sealed at the other by a movable bung 48 or stopper. When in position, the needle unit 22 pierces the cover 46 and movement of the bung 48 towards the cover 46 will cause the medicament contained within the cartridge 40 or ampoule to be expelled. The cartridge may be a 3ml cartridge in accordance with ISO/FDIS 11608 Part 3, or any other suitable cartridge to suit the injector.
Movement of the bung 48 or stopper is caused by movement of a piston or plunger 50 forming a part of the drive mechanism 42. The piston or plunger 50 is movable between a first fully withdrawn position (not shown) which allows for the replacement of the cartridge 40 or ampoule and a second fully extended portion in which as much medicament as possible has been expelled from the cartridge 40 or ampoule. An end stop switch 52 may be provided in the main housing 4 to detect when the piston 50 is in the fully withdrawn position. Tripping of the switch end stop 52 may release a catch or other fastening device to allow access to the main housing 4 for replacement of the cartridge 40.
The drive mechanism 42 is operated by a motor 54 under the control of an electronic control unit (not shown). The motor 54 should be reversible in order to allow the piston 50 to be moved between the first and second positions. In Figure 3, the motor 54 can be seen to drive the piston 50 by way of a gear train 42, such that rotation of a third rotor 58 causes the piston 50 to be moved in relation to the third rotor 58.
Preferably, the user can feel the vibration of the motor 54 and the associated drive mechanism 42 and/or hear them in operation. In this way an added degree of confidence in the fact of the operation of the injector 2 is provided to the user.
In order to harness a solenoid for use in an injector, a mechanism has been developed to convert the reciprocating motion of a solenoid into an incremental linear motion to displace a cartridge bung. Referring to Figure 4, a two piece shuttle 300 is constrained rotationally within a housing 302 for free axial movement therein. A double faced gear component 304 is also located within the housing. The double faced gear component 304 is free for movement rotationally, but constrained axially. The double faced gear component 304 is coupled to a shaft 306 of a lead screw. The lead screw will be understood to comprise piston means for the advancement of bung 48 within a medicament cartridge 40 within the context of this description. The shuttle comprises two ferrite cores 308,310, each with teeth on an inner face thereof. At either end the housing 302 are disposed coils 312,314. An annular permanent magnet 316 is used to latch the mechanism in one of two end positions when the cores and their associated coils are not energised.
In the de-energised condition, the shuttle 300 is held latched to one end of the device by the magnet 316. The shuttle is held in position by a closed magnetic 'circuit' passing through one of the shuttle ferrite cores and a casing of the housing 302.
In order to move the shuttle 300 to the opposite end of the housing both coils 312,314 are energised. The coil at the 'latched' end is energised to oppose the magnetic field of the permanent magnet 316; the coil at the opposite end is energised to reinforce the permanent magnetic field. The shuttle 300 is thus pulled from the rest position to the opposite end of the housing 302. In moving from one end of the housing 302 to the other, the shuttle 300 engages with the double faced gear component 304 causing it to rotate by a fixed increment, thereby turning a shaft 320 of a lead screw.
When the shuttle 300 comes to rest at the opposite end of the housing 302, it is again latched in position by the permanent magnet 316.
The mechanism can be seen to work on both strokes of the solenoid. Also, it can be latched at either end allowing for finer control of the lead screw.

Claims

1 A drive mechanism for an injection device in which piston means 306 are selectively driven to expel medicament from within a medicament cartridge 40 and a drive mechanism for controlling the movement of the piston means, the drive mechanism comprising a housing 302, a shuttle 300 located for movement within the housing 302 along a longitudinal axis between a first position and a second position, drive means to move the shuttle 300 within the housing 302, a gear component 304 located within the housing 302 for rotation about the longitudinal axis and associated with the piston means 306, movement of the shuttle 300 between each of the first and the second positions causing movement of the piston means 306.
2 A drive mechanism according to claim 1, characterised in that the drive means comprises separately energisable coils 312,314 located at each end of the housing 302 and an annular permanent magnet 316 located between the coils 312,314 acting upon the shuttle 300, the shuttle 300 comprising at least one ferrite core 308,310.
3 A drive mechanism according to claim 1 or claim 2, characterised in that the shuttle 300 and the gear component 304 are each provided with teeth upon an annular surface thereof, engagement of the shuttle 300 with the gear component 304 causing the gear component 304 to be rotated by a fixed increment.
PCT/GB2001/005741 2000-12-22 2001-12-21 Drive mechanism for an injection device WO2002051474A1 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
IL15624500A IL156245A0 (en) 2000-12-22 2000-12-21 Drive mechanism for an injection device
CA002430938A CA2430938C (en) 2000-12-22 2001-12-21 Drive mechanism for an injection device
AT01272106T ATE294002T1 (en) 2000-12-22 2001-12-21 DRIVE MECHANISM FOR AN INJECTION DEVICE
EP01272106A EP1351728B1 (en) 2000-12-22 2001-12-21 Drive mechanism for an injection device
DK01272106T DK1351728T3 (en) 2000-12-22 2001-12-21 Injection device drive mechanism
KR1020037008405A KR100788319B1 (en) 2000-12-22 2001-12-21 Drive mechanism for an injection device
AU2002216254A AU2002216254B2 (en) 2000-12-22 2001-12-21 Drive mechanism for an injection device
JP2002552615A JP4308525B2 (en) 2000-12-22 2001-12-21 Drive mechanism for injection device
US10/433,650 US7052484B2 (en) 2000-12-22 2001-12-21 Drive mechanism for an injection device
DE60110463T DE60110463T2 (en) 2000-12-22 2001-12-21 Drive mechanism for an injection device
BRPI0116274-8A BR0116274B1 (en) 2000-12-22 2001-12-21 drive mechanism for an injection device.
MXPA03005578A MXPA03005578A (en) 2000-12-22 2001-12-21 Drive mechanism for an injection device.
IL156245A IL156245A (en) 2000-12-22 2003-06-01 Drive mechanism for an injection device
HK04102605A HK1059747A1 (en) 2000-12-22 2004-04-14 Drive mechanism for an injection device.

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GBGB0031466.6A GB0031466D0 (en) 2000-12-22 2000-12-22 Improvements in and relating to an injection device

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PCT/GB2001/005693 WO2002058766A1 (en) 2000-12-22 2001-12-21 Pen-type injector having an electronic control unit
PCT/GB2001/005710 WO2002051478A1 (en) 2000-12-22 2001-12-21 Pen-type injector having an electronic control unit
PCT/GB2001/005705 WO2002051472A1 (en) 2000-12-22 2001-12-21 Drive mechanism for an injection device
PCT/GB2001/005709 WO2002051477A1 (en) 2000-12-22 2001-12-21 Pen-type injector having an electronic control unit
PCT/GB2001/005726 WO2002051481A1 (en) 2000-12-22 2001-12-21 Pen-type injector having holding mechanism for medicament cartridge
PCT/GB2001/005712 WO2002051480A1 (en) 2000-12-22 2001-12-21 Pen-type injector having an electronic control unit
PCT/GB2001/005707 WO2002051476A1 (en) 2000-12-22 2001-12-21 Pen-type injector having an electronic control unit
PCT/GB2001/005704 WO2002051471A1 (en) 2000-12-22 2001-12-21 Drive mechanism for an injection device
PCT/GB2001/005711 WO2002051479A1 (en) 2000-12-22 2001-12-21 Pen-type injector having an electronic control unit
PCT/GB2001/005743 WO2002051475A1 (en) 2000-12-22 2001-12-21 Injection device with replaceable cartridge
PCT/GB2001/005741 WO2002051474A1 (en) 2000-12-22 2001-12-21 Drive mechanism for an injection device
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PCT/GB2001/005693 WO2002058766A1 (en) 2000-12-22 2001-12-21 Pen-type injector having an electronic control unit
PCT/GB2001/005710 WO2002051478A1 (en) 2000-12-22 2001-12-21 Pen-type injector having an electronic control unit
PCT/GB2001/005705 WO2002051472A1 (en) 2000-12-22 2001-12-21 Drive mechanism for an injection device
PCT/GB2001/005709 WO2002051477A1 (en) 2000-12-22 2001-12-21 Pen-type injector having an electronic control unit
PCT/GB2001/005726 WO2002051481A1 (en) 2000-12-22 2001-12-21 Pen-type injector having holding mechanism for medicament cartridge
PCT/GB2001/005712 WO2002051480A1 (en) 2000-12-22 2001-12-21 Pen-type injector having an electronic control unit
PCT/GB2001/005707 WO2002051476A1 (en) 2000-12-22 2001-12-21 Pen-type injector having an electronic control unit
PCT/GB2001/005704 WO2002051471A1 (en) 2000-12-22 2001-12-21 Drive mechanism for an injection device
PCT/GB2001/005711 WO2002051479A1 (en) 2000-12-22 2001-12-21 Pen-type injector having an electronic control unit
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005059508A1 (en) * 2005-12-13 2007-06-14 Tecpharma Licensing Ag Electricity generating pen
EP1911479A1 (en) * 2006-10-09 2008-04-16 F.Hoffmann-La Roche Ag Drug delivery device with magnetic connection between piston and piston rod

Families Citing this family (311)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8346337B2 (en) 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6949816B2 (en) 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US20010041869A1 (en) * 2000-03-23 2001-11-15 Causey James D. Control tabs for infusion devices and methods of using the same
IL156245A0 (en) * 2000-12-22 2004-01-04 Dca Design Int Ltd Drive mechanism for an injection device
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
JP3993169B2 (en) 2002-02-11 2007-10-17 アンタレス・ファーマ・インコーポレーテッド Intradermal syringe
US8260393B2 (en) 2003-07-25 2012-09-04 Dexcom, Inc. Systems and methods for replacing signal data artifacts in a glucose sensor data stream
US9282925B2 (en) 2002-02-12 2016-03-15 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US8010174B2 (en) 2003-08-22 2011-08-30 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US9247901B2 (en) 2003-08-22 2016-02-02 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
EP1391794A1 (en) * 2002-07-23 2004-02-25 Novo Nordisk A/S Device with time indicating means
JP4198435B2 (en) * 2002-10-15 2008-12-17 富士電機エフテック株式会社 Electric syringe for dental anesthesia
FR2846453B1 (en) * 2002-10-28 2005-01-28 Valois Sas ELECTRONIC DISPLAY DEVICE AND FLUID PRODUCT DELIVERY DEVICE HAVING SUCH A DISPLAY DEVICE
FR2846308B1 (en) * 2002-10-28 2006-02-10 Valois Sas FLUID PRODUCT DISPENSING DEVICE WITH DOSE INDICATOR
AU2002953483A0 (en) 2002-12-20 2003-01-09 Acrux Dds Pty. Ltd. Usage indicator
US6814265B2 (en) * 2003-03-06 2004-11-09 Alcon, Inc. Device for dispensing fluid medicine
GB0311461D0 (en) 2003-05-19 2003-06-25 Glaxo Group Ltd Display system
JP2007524816A (en) * 2003-06-20 2007-08-30 エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト Method for producing thin uniform reagent strip and its reagent
US8282549B2 (en) 2003-12-09 2012-10-09 Dexcom, Inc. Signal processing for continuous analyte sensor
US8423113B2 (en) 2003-07-25 2013-04-16 Dexcom, Inc. Systems and methods for processing sensor data
US20100168657A1 (en) 2003-08-01 2010-07-01 Dexcom, Inc. System and methods for processing analyte sensor data
US7519408B2 (en) 2003-11-19 2009-04-14 Dexcom, Inc. Integrated receiver for continuous analyte sensor
US8845536B2 (en) 2003-08-01 2014-09-30 Dexcom, Inc. Transcutaneous analyte sensor
US7276029B2 (en) 2003-08-01 2007-10-02 Dexcom, Inc. System and methods for processing analyte sensor data
US20190357827A1 (en) 2003-08-01 2019-11-28 Dexcom, Inc. Analyte sensor
US7774145B2 (en) 2003-08-01 2010-08-10 Dexcom, Inc. Transcutaneous analyte sensor
US8761856B2 (en) 2003-08-01 2014-06-24 Dexcom, Inc. System and methods for processing analyte sensor data
US20070208245A1 (en) * 2003-08-01 2007-09-06 Brauker James H Transcutaneous analyte sensor
US7591801B2 (en) * 2004-02-26 2009-09-22 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US9135402B2 (en) 2007-12-17 2015-09-15 Dexcom, Inc. Systems and methods for processing sensor data
US8369919B2 (en) 2003-08-01 2013-02-05 Dexcom, Inc. Systems and methods for processing sensor data
US8160669B2 (en) * 2003-08-01 2012-04-17 Dexcom, Inc. Transcutaneous analyte sensor
US7494465B2 (en) 2004-07-13 2009-02-24 Dexcom, Inc. Transcutaneous analyte sensor
US7933639B2 (en) 2003-08-01 2011-04-26 Dexcom, Inc. System and methods for processing analyte sensor data
US8275437B2 (en) 2003-08-01 2012-09-25 Dexcom, Inc. Transcutaneous analyte sensor
US8886273B2 (en) 2003-08-01 2014-11-11 Dexcom, Inc. Analyte sensor
US20140121989A1 (en) 2003-08-22 2014-05-01 Dexcom, Inc. Systems and methods for processing analyte sensor data
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
SG179411A1 (en) * 2003-11-06 2012-04-27 Lifescan Inc Drug delivery pen with event notification means
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
EP2239567B1 (en) * 2003-12-05 2015-09-02 DexCom, Inc. Calibration techniques for a continuous analyte sensor
US8364231B2 (en) 2006-10-04 2013-01-29 Dexcom, Inc. Analyte sensor
US8423114B2 (en) 2006-10-04 2013-04-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8774886B2 (en) 2006-10-04 2014-07-08 Dexcom, Inc. Analyte sensor
US11633133B2 (en) 2003-12-05 2023-04-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8287453B2 (en) 2003-12-05 2012-10-16 Dexcom, Inc. Analyte sensor
EP1543854A1 (en) * 2003-12-16 2005-06-22 Novo Nordisk A/S Vibrating injection needle and method for detecting the presence of medicament therein
ATE551086T1 (en) * 2004-02-18 2012-04-15 Ares Trading Sa PORTABLE ELECTRONIC INJECTION DEVICE FOR INJECTING LIQUID MEDICATIONS
US8808228B2 (en) 2004-02-26 2014-08-19 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
CN105641776B (en) 2004-03-03 2021-03-30 株式会社根本杏林堂 Chemical solution injection system, chemical solution injection device, and chemical solution heat-insulating device
JP4549079B2 (en) 2004-03-05 2010-09-22 パナソニック株式会社 Medical dosing device
DE102004013415B4 (en) 2004-03-18 2011-12-08 Disetronic Licensing Ag Rotatable display of a medical, pharmaceutical or cosmetic device
AU2005253993B2 (en) * 2004-06-09 2010-05-27 Mark Anderson And Associates, Incorporated Hypodermic injection system
US8187535B2 (en) * 2004-06-14 2012-05-29 Parker-Hannifin Corporation Robotic handling system and method with independently operable detachable tools
US7783333B2 (en) 2004-07-13 2010-08-24 Dexcom, Inc. Transcutaneous medical device with variable stiffness
US8565848B2 (en) 2004-07-13 2013-10-22 Dexcom, Inc. Transcutaneous analyte sensor
US20060020192A1 (en) 2004-07-13 2006-01-26 Dexcom, Inc. Transcutaneous analyte sensor
US7640048B2 (en) 2004-07-13 2009-12-29 Dexcom, Inc. Analyte sensor
US8452368B2 (en) 2004-07-13 2013-05-28 Dexcom, Inc. Transcutaneous analyte sensor
US7255684B2 (en) * 2004-08-09 2007-08-14 Boris Zubry Medical injection system
KR100620517B1 (en) * 2004-08-27 2006-09-12 (주)옥토메티칼어플라이언스 Insulin Auto Feeder
EP1640029A1 (en) * 2004-09-24 2006-03-29 Novo Nordisk A/S Injection device with cap
EP1804864B2 (en) * 2004-10-21 2012-03-14 Novo Nordisk A/S An injection device with means for signalling the time since the last injection
US10737028B2 (en) 2004-11-22 2020-08-11 Kaleo, Inc. Devices, systems and methods for medicament delivery
CN101087625B (en) 2004-11-22 2012-02-22 因特利杰克特有限公司 Devices and systems for medicament delivery
US11590286B2 (en) 2004-11-22 2023-02-28 Kaleo, Inc. Devices, systems and methods for medicament delivery
US7648483B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems and methods for medicament delivery
US7648482B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems, and methods for medicament delivery
WO2006083876A2 (en) 2005-02-01 2006-08-10 Intelliject, Llc Devices, systems, and methods for medicament delivery
US7947017B2 (en) 2004-11-22 2011-05-24 Intelliject, Inc. Devices, systems and methods for medicament delivery
CN101132820B (en) 2005-01-24 2010-05-19 安塔雷斯制药公司 Prefilled needle assisted jet injector
EP1849012A2 (en) * 2005-01-28 2007-10-31 Parker-Hannifin Corporation Sampling probe, gripper and interface for laboratory sample management systems
US8231573B2 (en) 2005-02-01 2012-07-31 Intelliject, Inc. Medicament delivery device having an electronic circuit system
US7731686B2 (en) 2005-02-01 2010-06-08 Intelliject, Inc. Devices, systems and methods for medicament delivery
US8361026B2 (en) * 2005-02-01 2013-01-29 Intelliject, Inc. Apparatus and methods for self-administration of vaccines and other medicaments
US9022980B2 (en) * 2005-02-01 2015-05-05 Kaleo, Inc. Medical injector simulation device
US8206360B2 (en) 2005-02-01 2012-06-26 Intelliject, Inc. Devices, systems and methods for medicament delivery
US7833189B2 (en) 2005-02-11 2010-11-16 Massachusetts Institute Of Technology Controlled needle-free transport
EP1690559A1 (en) * 2005-02-14 2006-08-16 Ares Trading S.A. Medication delivery device
EP1690560A1 (en) * 2005-02-14 2006-08-16 Ares Trading S.A. Medication delivery device
US7993300B2 (en) * 2005-02-21 2011-08-09 Novo Nordisk As Method for ensuring constant speed of a motor in an injection device
DE202005010389U1 (en) * 2005-07-01 2005-09-08 Tecpharma Licensing Ag Injection unit capable of accommodating an ampule incorporates a fixed magnet and a counter-magnet on the movable piston rod of the unit
US20070060887A1 (en) * 2005-08-22 2007-03-15 Marsh David A Ophthalmic injector
EP1759727A1 (en) * 2005-09-02 2007-03-07 F.Hoffmann-La Roche Ag Infusion device having a control unit
WO2007038060A2 (en) * 2005-09-26 2007-04-05 M2 Medical A/S Modular infusion pump having two different energy sources
WO2007067540A1 (en) * 2005-12-05 2007-06-14 Parker-Hannifin Self-cleaning injection port for analytical applications
JP2009518655A (en) * 2005-12-08 2009-05-07 パーカー・ハニフィン・コーポレーション Syringe wash station for analytical applications
GB2433032A (en) † 2005-12-08 2007-06-13 Owen Mumford Ltd Syringe with dose adjustment means
US8192698B2 (en) * 2006-01-27 2012-06-05 Parker-Hannifin Corporation Sampling probe, gripper and interface for laboratory sample management systems
US8147460B2 (en) * 2006-01-31 2012-04-03 Roche Diagnostics International Ag Administering device with a multi-component injection-moulded housing
US7931620B2 (en) * 2006-02-01 2011-04-26 Roche Diagnostics International Ag Self-sealing connection for housing shells of an administering device
KR100737441B1 (en) * 2006-02-09 2007-07-09 단국대학교 산학협력단 Electro-motion syringe
AU2006338189B2 (en) * 2006-02-14 2012-01-19 Battelle Memorial Institute Accurate metering system
WO2007099044A1 (en) 2006-03-03 2007-09-07 Shl Medical Ab Medical device with orientation sensitive priming mechanism
EP1991110B1 (en) 2006-03-09 2018-11-07 DexCom, Inc. Systems and methods for processing analyte sensor data
WO2007107559A1 (en) * 2006-03-20 2007-09-27 Novo Nordisk A/S Flat assembly for medication delivery device
GB2477046B (en) * 2006-03-29 2011-08-24 Intelliject Inc Devices,systems and methods for medicament delivery
US9144648B2 (en) 2006-05-03 2015-09-29 Antares Pharma, Inc. Injector with adjustable dosing
WO2007131013A1 (en) 2006-05-03 2007-11-15 Antares Pharma, Inc. Two-stage reconstituting injector
US7811252B2 (en) * 2006-05-17 2010-10-12 Alcon Research, Ltd. Dosage control device
US7887521B2 (en) * 2006-05-17 2011-02-15 Alcon Research, Ltd. Ophthalmic injection system
US20070270744A1 (en) * 2006-05-17 2007-11-22 Bruno Dacquay Limited Reuse Assembly For Ophthalmic Injection Device
US7920907B2 (en) 2006-06-07 2011-04-05 Abbott Diabetes Care Inc. Analyte monitoring system and method
CN101484199B (en) * 2006-06-30 2014-06-25 艾伯维生物技术有限公司 Automatic injection device
DE102006047613A1 (en) * 2006-10-07 2008-04-10 Sanofi-Aventis Deutschland Gmbh Peristaltic micropump with exchangeable pump head
DE102006048180A1 (en) * 2006-10-10 2008-04-17 Tecpharma Licensing Ag Injection device with a trigger lock with not inserted product container
ES2355960T3 (en) * 2006-10-16 2011-04-01 Alcon Research, Ltd. UNIVAERSAL RECHARGEABLE LIMITED REUSABLE SET FOR OPHTHALMIC HAND PIECE.
EP2063933A2 (en) * 2006-10-16 2009-06-03 Alcon Research, Ltd. Method of operating ophthalmic hand piece with disposable end
US20080281292A1 (en) * 2006-10-16 2008-11-13 Hickingbotham Dyson W Retractable Injection Port
AU2007347669A1 (en) * 2006-10-16 2008-09-04 Alcon Research, Ltd. Ceramic chamber with integrated temperature control device for ophthalmic medical device
US9022970B2 (en) * 2006-10-16 2015-05-05 Alcon Research, Ltd. Ophthalmic injection device including dosage control device
WO2008083875A1 (en) * 2007-01-09 2008-07-17 Shl Medical Ab Information device
WO2008091838A2 (en) 2007-01-22 2008-07-31 Intelliject, Inc. Medical injector with compliance tracking and monitoring
US7910392B2 (en) * 2007-04-02 2011-03-22 Solaria Corporation Method and system for assembling a solar cell package
US7817498B1 (en) * 2007-05-11 2010-10-19 Michael R. Schramm Medical apparatus having elapsed time indicated and method of use
EP2152350A4 (en) * 2007-06-08 2013-03-27 Dexcom Inc Integrated medicament delivery device for use with continuous analyte sensor
US9205193B2 (en) * 2007-06-12 2015-12-08 Peter V. Boesen Self-contained medication injection system and method
EP4098177A1 (en) 2007-10-09 2022-12-07 DexCom, Inc. Integrated insulin delivery system with continuous glucose sensor
US8417312B2 (en) 2007-10-25 2013-04-09 Dexcom, Inc. Systems and methods for processing sensor data
WO2009062509A1 (en) 2007-11-12 2009-05-22 Bang & Olufsen Medicom A/S Auto injector with changing anchor locations for a mechanical driver
US9839395B2 (en) 2007-12-17 2017-12-12 Dexcom, Inc. Systems and methods for processing sensor data
ES2679674T3 (en) 2008-01-11 2018-08-30 Ucb Biopharma Sprl Systems for administering medication for patients with rheumatoid arthritis
CA2715624A1 (en) * 2008-02-20 2009-08-27 Dexcom, Inc. Continuous medicament sensor system for in vivo use
CA2715628A1 (en) 2008-02-21 2009-08-27 Dexcom, Inc. Systems and methods for processing, transmitting and displaying sensor data
ES2548447T3 (en) 2008-03-10 2015-10-16 Antares Pharma, Inc. Injector safety device
US8396528B2 (en) 2008-03-25 2013-03-12 Dexcom, Inc. Analyte sensor
CN103041478B (en) 2008-04-10 2015-01-21 松下健康医疗控股株式会社 Medication administering device
US8021344B2 (en) 2008-07-28 2011-09-20 Intelliject, Inc. Medicament delivery device configured to produce an audible output
USD994111S1 (en) 2008-05-12 2023-08-01 Kaleo, Inc. Medicament delivery device cover
CN102076332B (en) * 2008-05-12 2015-01-14 Kaleo公司 Medicament delivery device having an electronic circuit system
US9597053B2 (en) * 2008-06-11 2017-03-21 Bracco Diagnostics Inc. Infusion systems including computer-facilitated maintenance and/or operation and methods of use
US8317674B2 (en) 2008-06-11 2012-11-27 Bracco Diagnostics Inc. Shielding assemblies for infusion systems
RU2512939C2 (en) 2008-06-11 2014-04-10 Бракко Дайэгностикс Инк. Computer-maintained and/or operated infusion systems
US8708352B2 (en) 2008-06-11 2014-04-29 Bracco Diagnostics Inc. Cabinet structure configurations for infusion systems
US7862534B2 (en) * 2008-06-11 2011-01-04 Bracco Diagnostics Inc. Infusion circuit subassemblies
CA2730968C (en) * 2008-07-18 2017-01-31 James S. Bates Dual chamber and gear pump assembly for a high pressure delivery system
US8376993B2 (en) 2008-08-05 2013-02-19 Antares Pharma, Inc. Multiple dosage injector
CA2734963A1 (en) 2008-08-29 2010-03-04 Andre Larsen Medical injection device with time delay indicator
DK2337596T3 (en) 2008-09-18 2020-02-10 Becton Dickinson Co Medical injector with garbage stamp
EP2196233A1 (en) 2008-12-12 2010-06-16 Sanofi-Aventis Deutschland GmbH Resettable drive mechanism for a medication delivery device and medication delivery device
US8840591B2 (en) 2008-12-12 2014-09-23 Sanofi-Aventis Deutschland Gmbh Drive mechanism for a medication delivery device and medication delivery device
CN102256642B (en) * 2008-12-16 2014-09-17 松下健康医疗器械株式会社 Medication administering device
ES2398486T3 (en) † 2008-12-18 2013-03-19 Sanofi-Aventis Deutschland Gmbh Medication administration device and method for manufacturing a medication administration device
US9155835B2 (en) 2008-12-22 2015-10-13 Panasonic Healthcare Holdings Co., Ltd. Medicament dispensing device
EP2208503A1 (en) 2009-01-20 2010-07-21 Sanofi-Aventis Deutschland GmbH Drive assembly and medication delivery device
TWI519331B (en) * 2009-02-05 2016-02-01 賽諾菲阿凡提斯德意志有限公司 Medicament delivery devices
US8663538B2 (en) 2009-02-12 2014-03-04 Picolife Technologies, Llc Method of making a membrane for use with a flow control system for a micropump
JP5711156B2 (en) 2009-02-27 2015-04-30 ライフスキャン・インコーポレイテッドＬｉｆｅｓｃａｎ，Ｉｎｃ． Drug delivery system
DE202009003009U1 (en) * 2009-03-03 2009-06-25 Dieter Hölzle Technik-Projekte GmbH Injection device with injection volume adjustment
US8784381B2 (en) 2009-03-04 2014-07-22 Panasonic Healthcare Co., Ltd. Drug injection device with acceleration sensor for detecting abnormal operation
AU2010226442A1 (en) 2009-03-20 2011-10-13 Antares Pharma, Inc. Hazardous agent injection system
EP2410910A4 (en) 2009-03-27 2014-10-15 Dexcom Inc Methods and systems for promoting glucose management
WO2010125153A1 (en) * 2009-04-30 2010-11-04 Sanofi-Aventis Deutschland Gmbh Pen-type injector with ergonomic button arrangement
CA2760376A1 (en) * 2009-04-30 2010-11-04 Sanofi-Aventis Deutschland Gmbh Pen-type injector with ergonomic button arrangement
US20100286612A1 (en) * 2009-05-06 2010-11-11 William Cirillo Medication injection supervisor device
US8632511B2 (en) * 2009-05-06 2014-01-21 Alcon Research, Ltd. Multiple thermal sensors in a multiple processor environment for temperature control in a drug delivery device
JP2012527272A (en) * 2009-05-20 2012-11-08 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Drug delivery device
KR101036543B1 (en) * 2009-05-28 2011-05-24 린나이코리아 주식회사 Over floe cover of dish washer
US9623187B2 (en) 2009-06-01 2017-04-18 Sanofi-Aventis Deutschland Gmbh Resettable drug delivery device
WO2010142598A2 (en) * 2009-06-03 2010-12-16 Novo Nordisk A/S Electronically monitored injection device
EP2445552B1 (en) * 2009-06-24 2015-10-14 Tecpharma Licensing AG Administering device having a priming function
CN101987220B (en) * 2009-07-30 2013-11-13 德昌电机(深圳)有限公司 Needle driving assembly for medical instrument
WO2011028719A2 (en) 2009-09-01 2011-03-10 Massachusetts Institute Of Technology Nonlinear system identification techniques and devices for discovering dynamic and static tissue properties
US8642088B2 (en) 2009-09-04 2014-02-04 Wisconsin Alumni Research Foundation Tannin-chitosan composites
CA2772282A1 (en) * 2009-09-18 2011-03-24 Sanofi-Aventis Deutschland Gmbh Latching and control unit for integration in a medical device
JP4873061B2 (en) * 2009-10-09 2012-02-08 パナソニック株式会社 Medical dosing device
DE102009053154A1 (en) 2009-11-06 2011-05-12 Tecpharma Licensing Ag Administration device e.g. autoinjector for administrating insulin, has actuating element releasing blocking element, and driven element movable around priming stroke to discharge condition by storage unit when block element is released
EP2335755A1 (en) 2009-12-17 2011-06-22 Sanofi-Aventis Deutschland GmbH Device and method for delivery of two or more drug agents
US8177747B2 (en) * 2009-12-22 2012-05-15 Alcon Research, Ltd. Method and apparatus for drug delivery
JP5598903B2 (en) 2010-01-29 2014-10-01 富士電機エフテック株式会社 Electric syringe for chemicals
JP5818874B2 (en) 2010-04-09 2015-11-18 ノボ・ノルデイスク・エー／エス Reminder programming device and reminder programming method
EP2915552A1 (en) * 2010-10-07 2015-09-09 Massachusetts Institute of Technology Injection methods using a servo-controlled needle-free injector
ES2637979T3 (en) * 2011-01-24 2017-10-18 Abbvie Biotechnology Ltd Automatic injection devices with overmolded grip surfaces
US8627816B2 (en) 2011-02-28 2014-01-14 Intelliject, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US9084849B2 (en) 2011-01-26 2015-07-21 Kaleo, Inc. Medicament delivery devices for administration of a medicament within a prefilled syringe
US8939943B2 (en) 2011-01-26 2015-01-27 Kaleo, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US20120239020A1 (en) * 2011-03-15 2012-09-20 Tyco Healthcare Group Lp Geo-Location Addition to Electrosurgical Generator
CN105498049B (en) * 2011-03-17 2018-09-21 贝克顿·迪金森公司 Medical injector with ratchet-type plunger
EP3799907A1 (en) 2011-03-24 2021-04-07 Sanofi-Aventis Deutschland GmbH Device and method for detecting an actuation action performable with a medical device
WO2012142502A2 (en) 2011-04-15 2012-10-18 Dexcom Inc. Advanced analyte sensor calibration and error detection
CN103702697B (en) * 2011-05-10 2017-06-30 茵苏莱恩医药有限公司 Promote the devices, systems and methods of medicine delivery and its management based on syringe
CA2836042C (en) 2011-05-12 2019-04-02 Medrad, Inc. Fluid injection system having various systems for controlling an injection procedure
WO2012160156A2 (en) 2011-05-25 2012-11-29 Sanofi-Aventis Deutschland Gmbh Medicament delivery device and method of controlling the device
US9492618B2 (en) * 2011-05-25 2016-11-15 Sanofi-Aventis Deutschland Gmbh Medicament injection device and priming operation
CN103688332A (en) * 2011-05-25 2014-03-26 赛诺菲-安万特德国有限公司 Handheld medicament delivery device with dose button
WO2012164390A2 (en) 2011-06-02 2012-12-06 Ucb Pharma S.A. Auto-injector
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
US8496619B2 (en) 2011-07-15 2013-07-30 Antares Pharma, Inc. Injection device with cammed ram assembly
CN106267472B (en) 2011-07-15 2019-08-30 赛诺菲-安万特德国有限公司 Drug delivery device with electromechanical driving mechanism
JP5770296B2 (en) * 2011-09-12 2015-08-26 パナソニックヘルスケアホールディングス株式会社 Drug injection device
US9526831B2 (en) 2011-09-12 2016-12-27 Panasonic Healthcare Co., Ltd. Pharmaceutical injection device
ES2444783T3 (en) * 2011-09-28 2014-02-26 Q-Med Ab Electronic injector
CN103813820B (en) * 2011-11-10 2015-10-21 松下健康医疗控股株式会社 Drug infusion device
US8771229B2 (en) 2011-12-01 2014-07-08 Picolife Technologies, Llc Cartridge system for delivery of medicament
US8790307B2 (en) 2011-12-01 2014-07-29 Picolife Technologies, Llc Drug delivery device and methods therefor
US9751056B2 (en) 2012-01-23 2017-09-05 Merit Medical Systems, Inc. Mixing syringe
US8834449B2 (en) 2012-01-23 2014-09-16 Ikomed Technologies, Inc. Mixing syringe
JP2013150672A (en) * 2012-01-24 2013-08-08 Terumo Corp Sterile joining device
EP2814542B1 (en) * 2012-02-13 2020-12-30 Sanofi-Aventis Deutschland GmbH Supplemental device for attachment to an injection device
EP2822618B1 (en) 2012-03-06 2024-01-10 Antares Pharma, Inc. Prefilled syringe with breakaway force feature
US10130759B2 (en) 2012-03-09 2018-11-20 Picolife Technologies, Llc Multi-ported drug delivery device having multi-reservoir cartridge system
US10748449B2 (en) 2012-04-04 2020-08-18 Noble International, Inc. Medicament delivery training device
US10283014B2 (en) * 2012-04-04 2019-05-07 Jbcb Holdings, Llc Smart packaging and display system
EP2833944A4 (en) 2012-04-06 2016-05-25 Antares Pharma Inc Needle assisted jet injection administration of testosterone compositions
US9883834B2 (en) 2012-04-16 2018-02-06 Farid Amirouche Medication delivery device with multi-reservoir cartridge system and related methods of use
US9364610B2 (en) 2012-05-07 2016-06-14 Antares Pharma, Inc. Injection device with cammed ram assembly
US9522235B2 (en) 2012-05-22 2016-12-20 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
US8784372B1 (en) 2012-06-12 2014-07-22 Johnathan D. Hoggatt First aid pen having separate compartments
US10245420B2 (en) 2012-06-26 2019-04-02 PicoLife Technologies Medicament distribution systems and related methods of use
US9757524B2 (en) 2012-07-30 2017-09-12 Ucb Biopharma Sprl Auto-injector
WO2014019997A1 (en) 2012-07-30 2014-02-06 Ucb Pharma S.A. Auto-injector
EP2879736B1 (en) 2012-07-30 2018-11-14 UCB Biopharma SPRL Auto-injector
US9757513B2 (en) 2012-07-30 2017-09-12 Ucb Biopharma Sprl Auto-injector
USD726901S1 (en) 2012-07-30 2015-04-14 Ucb Pharma S.A. Drive device for administering medication
EP2885031B1 (en) * 2012-08-20 2017-10-04 Sanofi-Aventis Deutschland GmbH Drug delivery device and method for electrically detecting contact between piston rod and cartridge bung
WO2014037946A1 (en) 2012-09-05 2014-03-13 Elcam Medical Agricultural Cooperative Association Ltd. Electronic auto-injection device
CN103656782B (en) * 2012-09-21 2016-04-13 上海微创生命科技有限公司 For monitoring the method and apparatus of the infusion of novopen
EP2716317A1 (en) * 2012-10-04 2014-04-09 Sanofi-Aventis Deutschland GmbH Medicament delivery device with trigger button
GB2508588A (en) * 2012-11-30 2014-06-11 Owen Mumford Ltd Medical delivery device comprising mechanical-electrical transducer
EP3178505B1 (en) 2012-12-13 2018-05-02 Panasonic Healthcare Holdings Co., Ltd. Medicament injection device
CN103007391B (en) * 2012-12-19 2014-12-03 四川大学 Predictive adaptive control system for liquid medicament push-injecting
EP2938376A4 (en) 2012-12-27 2017-01-25 Kaleo, Inc. Devices, systems and methods for locating and interacting with medicament delivery systems
DK2945668T3 (en) 2013-01-15 2018-09-03 Sanofi Aventis Deutschland ASSEMBLY ASSEMBLY FOR A MEDICAL INJECTION DEVICE FOR GENERATION OF USE REPORTS ON THE USE OF THE DIGITAL IMAGE INJECTION DEVICE
WO2014118108A1 (en) * 2013-01-29 2014-08-07 Sanofi-Aventis Deutschland Gmbh Electronically controlled drug delivery device with touch screen
US10159795B2 (en) * 2013-01-29 2018-12-25 Sanofi-Aventis Deutschland Gmbh Drug delivery device
EP2953667B1 (en) 2013-02-11 2019-10-23 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
WO2014164786A1 (en) 2013-03-11 2014-10-09 Madsen Patrick Dosage injector with pinion system
WO2014165136A1 (en) 2013-03-12 2014-10-09 Antares Pharma, Inc. Constant volume prefilled syringes and kits thereof
US20140276413A1 (en) 2013-03-15 2014-09-18 Jeff Baker Medicament delivery and simulation system with a removable disposable container for medicament and a rotatable actuation component
DK2981312T3 (en) * 2013-04-05 2018-03-26 Novo Nordisk As Logging device adapted to combine doses
JP6756806B2 (en) * 2013-04-05 2020-09-16 ノボ・ノルデイスク・エー／エス Logging device that combines multiple doses
CN103285490A (en) * 2013-05-29 2013-09-11 毕良佳 Syringe for painless oral local anesthesia
CN105377337A (en) 2013-07-17 2016-03-02 赛诺菲 Drive mechanism for delivery device
JP6525991B2 (en) 2013-07-17 2019-06-05 サノフイＳａｎｏｆｉ Assembly for a drug delivery device and method of operation thereof
DK3021902T3 (en) * 2013-07-17 2018-12-17 Sanofi Sa MEDICATION DELIVERY DEVICE
US9849221B2 (en) * 2013-10-04 2017-12-26 Flex Fluidics, Llc Inline pump with rear attachable syringe
USD755372S1 (en) * 2013-12-12 2016-05-03 Daicel Corporation Needleless syringe
WO2015110529A1 (en) 2014-01-27 2015-07-30 Ucb Biopharma Sprl Auto-injector
WO2015110532A1 (en) 2014-01-27 2015-07-30 Ucb Biopharma Sprl Auto-injector
US10342925B2 (en) 2014-01-27 2019-07-09 Ucb Biopharma Sprl Auto-injector
CN105979983A (en) 2014-02-11 2016-09-28 史密斯医疗Asd公司 Pump startup algorithms and related systems and methods
EP3117240A1 (en) 2014-03-13 2017-01-18 Bracco Diagnostics Inc. Real time nuclear isotope detection
CN106456884A (en) * 2014-03-14 2017-02-22 卡贝欧洲有限公司 A monitoring device
WO2015163009A1 (en) * 2014-04-25 2015-10-29 パナソニックヘルスケアホールディングス株式会社 Medicament injection device
US9517307B2 (en) 2014-07-18 2016-12-13 Kaleo, Inc. Devices and methods for delivering opioid antagonists including formulations for naloxone
US10971260B2 (en) 2014-09-14 2021-04-06 Becton, Dickinson And Company System and method for capturing dose information
US10704944B2 (en) 2014-09-14 2020-07-07 Becton, Dickinson And Company System and method for capturing dose information
EP3058970A1 (en) 2015-02-19 2016-08-24 Sanofi-Aventis Deutschland GmbH Data collection device for attachment to an injection device
AU2016235054B2 (en) 2015-03-24 2020-07-16 Kaleo, Inc. Devices and methods for delivering a lyophilized medicament
CN104888315A (en) * 2015-04-29 2015-09-09 安徽养和医疗器械设备有限公司 Automatic injection syringe pusher
HUE050055T2 (en) 2015-06-09 2020-11-30 Sanofi Aventis Deutschland Data collection apparatus for attachment to an injection device
GB2556479B (en) 2015-06-30 2022-09-07 Kaleo Inc Auto-injectors for administration of a medicament within a prefilled syringe
JP6584172B2 (en) * 2015-07-03 2019-10-02 株式会社アイカムス・ラボ Discharge device
US20170043139A1 (en) * 2015-08-11 2017-02-16 Vascular Solutions, Inc. Fluid delivery or removal system
US10279123B2 (en) 2015-10-01 2019-05-07 Noble International, Inc. Microcartridge
US11065381B2 (en) 2015-10-05 2021-07-20 E3D A.C.A.L. Infusion pump device and method for use thereof
JP2016035597A (en) * 2015-12-01 2016-03-17 イーエイチエス レンズ フィリピン インク Method for manufacturing polarizing plastic lens for spectacle
WO2017114907A1 (en) 2015-12-30 2017-07-06 Ascendis Pharma A/S Auto injector with cartridge retention system
US11406760B2 (en) 2015-12-30 2022-08-09 Ascendis Pharma A/S Auto injector with charger safety
JP7335072B2 (en) 2015-12-30 2023-08-29 アセンディス ファーマ エー／エス Auto-injector with spent cartridge detection and related methods
HUE060792T2 (en) 2015-12-30 2023-04-28 Ascendis Pharma As Auto injector with temperature control
NZ742538A (en) 2015-12-30 2023-06-30 Ascendis Pharma As Auto injector with adaptable air-shot mechanism
US20180092770A1 (en) * 2016-03-14 2018-04-05 Virchow Biotech Pvt. Ltd. Sterile protective cover comprising a device for opthalmic delivery
US20170258633A1 (en) * 2016-03-14 2017-09-14 Virchow Biotech Pvt. Ltd. Novel device for ophthalmic delivery
CN106080739A (en) * 2016-06-20 2016-11-09 山东理工大学 The controller that a kind of diabetes patient of auxiliary drives
CN106004976A (en) * 2016-06-30 2016-10-12 青岛大学附属医院 Control device assisting in driving of diabetic patient
US10709845B2 (en) 2016-07-21 2020-07-14 Amgen Inc. Drug delivery device with a rotatable drive mechanism
BR112019005432B1 (en) 2016-09-20 2023-04-04 Bracco Diagnostics Inc PROTECTION ASSEMBLY FOR A RADIOISOTOPE DISTRIBUTION SYSTEM THAT HAS MULTIPLE RADIATION DETECTORS
JP6764319B2 (en) * 2016-11-16 2020-09-30 Ｐｈｃホールディングス株式会社 Drug injection device
JP7014797B2 (en) 2016-12-23 2022-02-01 カレオ，インコーポレイテッド Drug delivery devices and methods for delivering drugs to babies and children
KR101958067B1 (en) 2016-12-27 2019-07-04 최규동 Monotoring and Magement System for Pen Type Injection Appartus
AU2018210313A1 (en) 2017-01-17 2019-06-20 Kaleo, Inc. Medicament delivery devices with wireless connectivity and event detection
EP3348293A1 (en) * 2017-01-17 2018-07-18 Carebay Europe Ltd. Medicament delivery device
KR102539193B1 (en) 2017-02-28 2023-06-02 일라이 릴리 앤드 캄파니 Dose detection and drug identification for a medication delivery device
EP3595752A1 (en) * 2017-03-16 2020-01-22 Novartis AG Piercing mechanism and cartridge piercing system
JP6990234B2 (en) * 2017-03-30 2022-01-12 テルモ株式会社 Chemical administration device and its operation method
MX2019013691A (en) 2017-05-23 2020-07-14 Ascendis Pharma As Auto injector with variable plunger force.
US9789260B1 (en) * 2017-05-25 2017-10-17 Innovative Precision Instruments Limited Device and system for drug information detection
CN107412910A (en) * 2017-06-26 2017-12-01 江苏德尔福医疗器械有限公司 Syringe pump
KR20190005572A (en) 2017-07-07 2019-01-16 최규동 Monotoring and Magement System for Pen Type Injection Appartus
KR20190042830A (en) 2017-10-17 2019-04-25 최규동 Monotoring and Magement System for Pen Type Injection Appartus
US11331022B2 (en) 2017-10-24 2022-05-17 Dexcom, Inc. Pre-connected analyte sensors
US11382540B2 (en) 2017-10-24 2022-07-12 Dexcom, Inc. Pre-connected analyte sensors
JP2021506430A (en) 2017-12-18 2021-02-22 サノフイＳａｎｏｆｉ Injection device including remote controller
HUE063591T2 (en) 2018-02-22 2024-01-28 Lilly Co Eli Dose detection system module for medication delivery device
EP3776599B1 (en) 2018-03-28 2023-09-13 Bracco Diagnostics Inc. Early detection of radioisotope generator end life
US11850395B2 (en) * 2018-05-17 2023-12-26 Carefusion 303, Inc. Syringe driver for infusion
CN108969840A (en) * 2018-06-11 2018-12-11 杭州光启医疗科技发展有限公司 With the drug delivery system for weakening medicinal liquid flow fluctuation and pressure oscillation function
CN108888826A (en) * 2018-06-11 2018-11-27 杭州光启医疗科技发展有限公司 Administration pump with successive administration function
WO2020018433A1 (en) 2018-07-16 2020-01-23 Kaleo, Inc. Medicament delivery devices with wireless connectivity and compliance detection
TR201815876A2 (en) * 2018-10-24 2018-11-21 Hasan Kalyoncu Ueniversitesi SPEAKING DIGITAL INSULIN PEN
US20220062555A1 (en) * 2018-12-27 2022-03-03 Daicel Corporation Needleless injector
KR102194269B1 (en) * 2018-12-31 2020-12-22 권기만 Portable refrigerated storage case for Pen Type Injection Appartus
EP3912658A4 (en) * 2019-01-16 2022-10-19 Daicel Corporation Needleless syringe
CN111514412A (en) * 2019-02-03 2020-08-11 杜建涛 Painless anesthesia multifunctional automatic injection gun
JP2022543523A (en) 2019-08-09 2022-10-13 カレオ，インコーポレイテッド Device and method for delivery of substances in pre-filled syringes
CN110507881B (en) * 2019-09-04 2021-07-16 四川大学华西医院 Multifunctional insulin injection pen
JP2022553786A (en) * 2019-10-28 2022-12-26 サノフイ Haptic feedback in electronic medical devices
KR102251405B1 (en) * 2020-04-09 2021-05-12 (주)풍림파마텍 Automatic injector
WO2021251965A1 (en) * 2020-06-11 2021-12-16 Bioworld Technology, Inc Automated injection device for administering antigens to animals
CN115397502A (en) * 2020-07-02 2022-11-25 雅萌股份有限公司 Liquid injection device, system thereof and cartridge unit
WO2022076424A1 (en) * 2020-10-05 2022-04-14 Noble International, Llc Medicament training device and system
CA3192520A1 (en) * 2020-11-05 2022-05-12 Dexcom, Inc. Medicament injection pen for distinguishing between priming pen events and therapeutic pen events
DE102021100818A1 (en) 2021-01-15 2022-07-21 B. Braun Melsungen Aktiengesellschaft Devices for administering medicinal liquids and corresponding methods
KR102600940B1 (en) * 2022-01-13 2023-11-09 인제대학교 산학협력단 Chamber unit for subcutaneous injection with drug storage and discharge function

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4619646A (en) * 1984-01-25 1986-10-28 Fernandez Tresguerres Hernande Device for the delivery-dosing of injectable products
US4749109A (en) * 1983-11-15 1988-06-07 Kamen Dean L Volumetric pump with replaceable reservoir assembly
US4921487A (en) * 1988-09-21 1990-05-01 Compagnie Financiere Saint. Nicolas External device for injecting medicine
EP0514816A1 (en) * 1991-05-23 1992-11-25 Ivac Corporation Dynamic lead screw engagement and indicator
US5747350A (en) * 1993-04-02 1998-05-05 Boehringer Mannheim Gmbh System for dosing liquids
US6042571A (en) * 1996-07-01 2000-03-28 Pharmacia & Upjohn Aktiebolag Injection device

Family Cites Families (147)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US604257A (en) * 1898-05-17 Carl hermann
US435173A (en) * 1890-08-26 Attachment for shelves
AT65129B (en) 1911-08-21 1914-06-10 Wirth Beck & Knauss Electrical device for starting and stopping a number of machines or other facilities from a remote point.
AT115417B (en) 1927-10-18 1929-12-27 Aeg X-ray tube, especially for very low voltages.
US2866910A (en) * 1954-11-09 1958-12-30 Northrop Aircraft Inc Pawl type incremental motor
US3858581A (en) * 1973-07-02 1975-01-07 Dean Kamen Medication injection device
NL172403C (en) 1974-04-08 1983-09-01 Duphar Int Res SYRINGE WITH A CARTRIDGE AND A CARTRIDGE, WITH THE CARTRIDGE CONTAINING PATTERN LOCKERS, AND THE CARTRIDGE CONTAINER FOR AN INJECTION SYRINGE.
US3964139A (en) * 1975-06-16 1976-06-22 Harvard Apparatus Company, Inc. Syringe holder
GB1601471A (en) * 1975-12-10 1981-10-28 Nat Res Dev Dispensing apparatus
DE2937066A1 (en) † 1979-09-13 1981-03-26 Clinicon International Gmbh, 6800 Mannheim DOSING DEVICE
GB2094628A (en) * 1981-03-10 1982-09-22 Ealing The Corp Infusion apparatus
US4529401A (en) * 1982-01-11 1985-07-16 Cardiac Pacemakers, Inc. Ambulatory infusion pump having programmable parameters
US4435173A (en) 1982-03-05 1984-03-06 Delta Medical Industries Variable rate syringe pump for insulin delivery
DE8213933U1 (en) 1982-05-13 1982-10-14 Berlemann, Klaus, 4440 Rheine SLIDING GATE
SE432054B (en) 1982-09-10 1984-03-19 Anders Tamsen PROGRAMMABLE INJECTION AND INFUSION DEVICE
JPS59126608A (en) * 1983-01-07 1984-07-21 Aisin Seiki Co Ltd Solenoid apparatus
EP0398394B1 (en) 1983-11-15 1993-10-06 KAMEN, Dean L. Reservoir assembly for removable engagement with a motor drive
ATE65129T1 (en) 1983-11-15 1991-07-15 Dean L Kamen VOLUMETRIC PUMP WITH REPLACEABLE TANK.
US4648872A (en) 1983-11-15 1987-03-10 Kamen Dean L Volumetric pump with replaceable reservoir assembly
US4563175A (en) * 1983-12-19 1986-01-07 Lafond Margaret Multiple syringe pump
US4613327A (en) * 1984-01-26 1986-09-23 Tegrarian Haig V Apparatus for infusing blood and other related fluids into a patient's body
DK159526C (en) 1984-11-01 1991-04-08 Novo Nordisk As DRIVE MECHANISM FOR AXIAL PROMOTION OF A Piston Rod, Especially For An Injection Spray
US4812724A (en) † 1984-11-13 1989-03-14 Liebel-Flarsheim Corporation Injector control
US4681566A (en) * 1984-11-30 1987-07-21 Strato Medical Corporation Infusion device
US4652260A (en) † 1985-03-11 1987-03-24 Strato Medical Corporation Infusion device
US4627835A (en) 1985-03-11 1986-12-09 Strato Medical Corporation Tubing assembly for infusion device
JPH0645295B2 (en) 1985-09-18 1994-06-15 日本電装株式会社 Operating device for automobile air conditioner
CH665955A5 (en) * 1985-11-19 1988-06-30 Universo Sa Manually programmable injector - has interchangeable drug cartridge, and data input setting the valves which can be manually selected
US5180371A (en) † 1986-05-30 1993-01-19 Spintech, Inc. Hypodermic anesthetic injection apparatus and method
NL8701091A (en) 1987-05-08 1988-12-01 Spruyt Hillen Bv INJECTION PEN.
GB2205460B (en) * 1987-06-02 1991-09-04 Multitone Electronics Plc Local oscillators for radio receivers
US5034004A (en) 1987-06-19 1991-07-23 The University Of Melbourne Infusion pump and drive systems therefor
US5207642A (en) 1987-08-07 1993-05-04 Baxter International Inc. Closed multi-fluid delivery system and method
US4925444A (en) 1987-08-07 1990-05-15 Baxter Travenol Laboratories, Inc. Closed multi-fluid delivery system and method
US4976696A (en) 1987-08-10 1990-12-11 Becton, Dickinson And Company Syringe pump and the like for delivering medication
NZ226230A (en) * 1987-09-18 1991-01-29 Schering Agrochemicals Ltd Implant gun for use with cartridge of strip form
US5041086A (en) * 1987-12-04 1991-08-20 Pacesetter Infusion, Ltd. Clinical configuration of multimode medication infusion system
US5060658A (en) * 1988-02-23 1991-10-29 Vance Products Incorporated Fine-needle aspiration cell sampling apparatus
GB8809410D0 (en) 1988-04-21 1988-05-25 Welmed Ltd Syringe pump
DE3833821A1 (en) 1988-10-05 1990-04-12 Braun Melsungen Ag INJECTION DEVICE
JPH0649069Y2 (en) 1988-11-25 1994-12-12 株式会社竹中工務店 Floor duct
US4955868A (en) 1988-11-28 1990-09-11 Edward Klein Disposable safety medical syringe
DK68789A (en) 1989-02-14 1990-08-15 Novo Nordisk As injector
GB2229497B (en) 1989-03-10 1992-06-03 Graseby Medical Ltd Infusion pump
JP2739233B2 (en) * 1989-04-19 1998-04-15 東レ・ダウコーニング・シリコーン株式会社 Silicone granules containing mineral oil
AU635262B2 (en) * 1989-05-11 1993-03-18 Bespak Plc Pump apparatus for biomedical use
US5085643A (en) * 1989-06-02 1992-02-04 Abbott Laboratories Syringe, adaptor, and check valve combination for parenteral infuser
US5060058A (en) 1989-06-07 1991-10-22 U.S. Philips Corporation Modulation system for projection display
CN2065888U (en) 1989-07-18 1990-11-21 刘吉勇 Safety monitor for induced abortion
CN2065461U (en) 1989-07-19 1990-11-14 朱苏豫 Detecting and treating instrument for boilogy electric information
CN2066747U (en) * 1989-12-14 1990-12-05 张克针 Intravenous injection automatic propelling device
US5003239A (en) 1990-01-11 1991-03-26 Baxter International Inc. Peristaltic pump monitoring device
US5176502A (en) * 1990-04-25 1993-01-05 Becton, Dickinson And Company Syringe pump and the like for delivering medication
CN2085668U (en) * 1990-09-05 1991-10-02 中国人民解放军271医院 Pulse controllable syringe system for insuline
US5709668A (en) 1991-01-16 1998-01-20 Senetek Plc Automatic medicament injector employing non-coring needle
US5360410A (en) 1991-01-16 1994-11-01 Senetek Plc Safety syringe for mixing two-component medicaments
US5078698A (en) 1991-02-19 1992-01-07 Sterling Drug Inc. Axial eject hypodermic syringe holder
US5176646A (en) * 1991-02-19 1993-01-05 Takayuki Kuroda Motorized syringe pump
US5425716A (en) * 1991-08-09 1995-06-20 Atom Kabushiki Kaisha Infusion apparatus
US5219099A (en) 1991-09-06 1993-06-15 California Institute Of Technology Coaxial lead screw drive syringe pump
US5321392A (en) * 1991-10-18 1994-06-14 Baxter International Inc. Infusion pump with battery back-up
DK175491D0 (en) 1991-10-18 1991-10-18 Novo Nordisk As APPARATUS
US5271527A (en) 1992-04-02 1993-12-21 Habley Medical Technology Corporation Reusable pharmaceutical dispenser with full stroke indicator
US5423752A (en) 1992-07-31 1995-06-13 Habley Medical Technology Corporation Variable proportion dispenser with cartridge replacement assembly
JPH05277181A (en) 1992-04-03 1993-10-26 Sharp Corp Infusion device
JPH067445A (en) * 1992-06-25 1994-01-18 Matsushita Electric Works Ltd Pen type injection device
IL107038A (en) 1992-10-05 1997-04-15 Senetek Plc Medicament injectors and methods for injection using same
DE69329774T2 (en) * 1992-10-15 2001-06-21 Gen Hospital Corp INFUSION PUMP WITH ELECTRONICALLY LOADABLE MEDICINE LIBRARY
US5448117A (en) * 1993-02-25 1995-09-05 Consulier Engineering, Inc. Stepper motor
CA2129284C (en) * 1993-11-24 1999-03-09 Kenneth J. Niehoff Controlling plunger drives for fluid injection in animals
US5442669A (en) * 1993-12-27 1995-08-15 Medin; David L. Perishable good integrity indicator
US5514097A (en) 1994-02-14 1996-05-07 Genentech, Inc. Self administered injection pen apparatus and method
CA2181802C (en) 1994-02-14 2006-10-10 Peter Michael Knauer Self administered injection pen apparatus and method
US5536249A (en) 1994-03-09 1996-07-16 Visionary Medical Products, Inc. Pen-type injector with a microprocessor and blood characteristic monitor
US5482446A (en) † 1994-03-09 1996-01-09 Baxter International Inc. Ambulatory infusion pump
US5460490A (en) 1994-05-19 1995-10-24 Linvatec Corporation Multi-purpose irrigation/aspiration pump system
CA2186869A1 (en) * 1994-08-24 1996-02-29 Hideto Yamagata Injection apparatus
US6397098B1 (en) 1994-09-21 2002-05-28 Medrad, Inc. Data communication and control for medical imaging systems
US5533981A (en) 1994-10-06 1996-07-09 Baxter International Inc. Syringe infusion pump having a syringe plunger sensor
SE510420C2 (en) 1994-11-14 1999-05-25 Cma Microdialysis Ab Infusion and microdialysis pump
CN2209532Y (en) 1994-12-31 1995-10-11 纪文龙 Electric-driving fluid expeller for intravenous injection
US5637093A (en) * 1995-03-06 1997-06-10 Sabratek Corporation Infusion pump with selective backlight
US5843014A (en) * 1995-03-24 1998-12-01 Alza Corporation Display for an electrotransport delivery device
US6099502A (en) 1995-04-20 2000-08-08 Acist Medical Systems, Inc. Dual port syringe
US5722956A (en) * 1995-08-24 1998-03-03 The General Hospital Corporation Multi-dose syringe driver
AU1860697A (en) 1995-09-08 1997-07-28 Visionary Medical Products Corporation Pen-type injector drive mechanism
SE9503685D0 (en) * 1995-10-20 1995-10-20 Pharmacia Ab Arrangement in electronically controlled injection devices
KR100469207B1 (en) * 1995-10-20 2005-03-16 화이자 헬스 에이비 Arrangement in electronically controlled injection devices
US6159161A (en) † 1995-10-20 2000-12-12 Hodosh; Milton Microprocessor-controlled fluid dispensing apparatus
AUPN707195A0 (en) 1995-12-12 1996-01-11 University Of Melbourne, The Field programmable intravenous infusion system
US5671285A (en) * 1995-12-13 1997-09-23 Newman; Bruce D. Secure communication system
EP0959770A1 (en) * 1995-12-28 1999-12-01 Bio-Plexus, Inc. Needle holder for fluid collection and/or injection system
US5966671A (en) * 1996-01-03 1999-10-12 Motorola, Inc. Radiotelephone having an auxiliary actuator and method for operating said radiotelephone
JP3892095B2 (en) 1996-01-23 2007-03-14 テルモ株式会社 Syringe
DE69720570T2 (en) 1996-01-23 2003-11-27 Terumo Corp injector
JP4472026B2 (en) 1996-02-23 2010-06-02 ノボ ノルディスク アクティーゼルスカブ Syringe with electronic representation of parameters
BR9707986A (en) * 1996-03-12 1999-07-27 Novo Nordisk Injection device
GB9606829D0 (en) 1996-03-30 1996-06-05 Jeffrey Peter Supplying materials etc
CN2273583Y (en) * 1996-04-29 1998-02-04 刘世棣 Full automatic and magnetic actuated piston machine for syringe
CN1225023A (en) 1996-07-05 1999-08-04 诺沃挪第克公司 Dose setting device
DE69729300T2 (en) 1996-07-05 2005-08-04 Novo Nordisk A/S DOSING
US6110149A (en) 1996-09-13 2000-08-29 Novo Nordisk A/S Syringe
US5868710A (en) 1996-11-22 1999-02-09 Liebel Flarsheim Company Medical fluid injector
JP3288943B2 (en) 1996-12-06 2002-06-04 スーガン株式会社 Medical injector head
US6558351B1 (en) * 1999-06-03 2003-05-06 Medtronic Minimed, Inc. Closed loop system for controlling insulin infusion
SE9702872D0 (en) 1997-08-06 1997-08-06 Pharmacia & Upjohn Ab Automated delivery device and method for its operation
US5957896A (en) 1997-08-11 1999-09-28 Becton, Dickinson And Company Medication delivery pen
WO1999010029A1 (en) * 1997-08-22 1999-03-04 Deka Products Limited Partnership System and method for intelligent admixture and delivery of medications
US6636732B1 (en) * 1998-03-19 2003-10-21 Securealert, Inc. Emergency phone with single-button activation
US6200289B1 (en) † 1998-04-10 2001-03-13 Milestone Scientific, Inc. Pressure/force computer controlled drug delivery system and the like
CZ290250B6 (en) 1998-04-17 2002-06-12 Josef Bure© Force converter for internal combustion engines
US6302855B1 (en) 1998-05-20 2001-10-16 Novo Nordisk A/S Medical apparatus for use by a patient for medical self treatment of diabetes
KR100301657B1 (en) * 1998-08-14 2001-10-27 최수봉 Control method of insulin syringe with pseudo mode
US6554798B1 (en) 1998-08-18 2003-04-29 Medtronic Minimed, Inc. External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities
US6248093B1 (en) 1998-10-29 2001-06-19 Minimed Inc. Compact pump drive system
CA2533850C (en) 1998-10-29 2009-09-01 Medtronic Minimed, Inc. Reservoir connector
US6379337B1 (en) * 1998-12-22 2002-04-30 Owais Mohammad M. B. B. S. Retractable safety needles for medical applications
US6645177B1 (en) * 1999-02-09 2003-11-11 Alaris Medical Systems, Inc. Directly engaged syringe driver system
US20040158193A1 (en) 1999-02-10 2004-08-12 Baxter International Inc. Medical apparatus using selective graphical interface
SE9901736D0 (en) 1999-05-12 1999-05-12 Pharmacia & Upjohn Ab Injectino device and method for ITS operation
DE19925904C1 (en) * 1999-06-07 2001-02-01 Disetronic Licensing Ag Unit for subcutaneous application of an injectable product comprises a system which indicates whether the protection sleeve of the injection needle is in its fully retracted position
US6752787B1 (en) 1999-06-08 2004-06-22 Medtronic Minimed, Inc., Cost-sensitive application infusion device
US6423035B1 (en) * 1999-06-18 2002-07-23 Animas Corporation Infusion pump with a sealed drive mechanism and improved method of occlusion detection
US6277099B1 (en) 1999-08-06 2001-08-21 Becton, Dickinson And Company Medication delivery pen
TW453884B (en) * 1999-09-16 2001-09-11 Novo Nordisk As Dose setting limiter
AU7839900A (en) 1999-09-29 2001-04-30 Sterling Medivations, Inc. Reusable medication delivery device
IL148956A0 (en) 1999-10-12 2002-11-10 Novo Nordisk As Air shot mechanism for electronic injection devices
DE29918149U1 (en) * 1999-10-15 1999-12-30 Volmer Wolfgang Insulin delivery device
US6585698B1 (en) 1999-11-01 2003-07-01 Becton, Dickinson & Company Electronic medical delivery pen having a multifunction actuator
AU1792401A (en) 1999-11-24 2001-06-04 Medrad, Inc. Injectors, injector systems and injector control
US6958053B1 (en) 1999-11-24 2005-10-25 Medrad, Inc. Injector providing drive member advancement and engagement with syringe plunger, and method of connecting a syringe to an injector
US6427088B1 (en) * 2000-01-21 2002-07-30 Medtronic Minimed, Inc. Ambulatory medical apparatus and method using telemetry system with predefined reception listening periods
US6485465B2 (en) 2000-03-29 2002-11-26 Medtronic Minimed, Inc. Methods, apparatuses, and uses for infusion pump fluid pressure and force detection
US6544229B1 (en) 2000-05-01 2003-04-08 Baxter International Inc Linearly motile infusion pump
US6623459B1 (en) * 2000-05-05 2003-09-23 Safety Syringes, Inc. Passive needle guard for syringes
US6716198B2 (en) * 2000-05-18 2004-04-06 Novo Nordisk A/S Injection device
DE10046279A1 (en) * 2000-09-19 2002-04-04 Disetronic Licensing Ag Device for the dosed administration of an injectable product
DE60119354T2 (en) 2000-10-10 2007-04-19 Dentsply International Inc. Syringe for dental anesthesia
JP2002121404A (en) * 2000-10-19 2002-04-23 Polymatech Co Ltd Heat-conductive polymer sheet
IL156245A0 (en) 2000-12-22 2004-01-04 Dca Design Int Ltd Drive mechanism for an injection device
US6613280B2 (en) * 2001-03-20 2003-09-02 Therox, Inc. Disposable cartridge for producing gas-enriched fluids
US6723072B2 (en) 2002-06-06 2004-04-20 Insulet Corporation Plunger assembly for patient infusion device
CN1301184C (en) 2003-12-16 2007-02-21 汪开庆 Optical grinding machine and method for processing sapphire crystal substrate for semiconductor use
DE102004058408B4 (en) 2004-12-03 2013-10-31 Byk Gardner Gmbh Device for determining surface properties
US7660628B2 (en) 2005-03-23 2010-02-09 Cardiac Pacemakers, Inc. System to provide myocardial and neural stimulation
US8778375B2 (en) 2005-04-29 2014-07-15 Advanced Cardiovascular Systems, Inc. Amorphous poly(D,L-lactide) coating
DE102005021371A1 (en) 2005-05-04 2006-11-23 Autoliv Development Ab airbag

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4749109A (en) * 1983-11-15 1988-06-07 Kamen Dean L Volumetric pump with replaceable reservoir assembly
US4619646A (en) * 1984-01-25 1986-10-28 Fernandez Tresguerres Hernande Device for the delivery-dosing of injectable products
US4921487A (en) * 1988-09-21 1990-05-01 Compagnie Financiere Saint. Nicolas External device for injecting medicine
EP0514816A1 (en) * 1991-05-23 1992-11-25 Ivac Corporation Dynamic lead screw engagement and indicator
US5747350A (en) * 1993-04-02 1998-05-05 Boehringer Mannheim Gmbh System for dosing liquids
US6042571A (en) * 1996-07-01 2000-03-28 Pharmacia & Upjohn Aktiebolag Injection device

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005059508A1 (en) * 2005-12-13 2007-06-14 Tecpharma Licensing Ag Electricity generating pen
EP1911479A1 (en) * 2006-10-09 2008-04-16 F.Hoffmann-La Roche Ag Drug delivery device with magnetic connection between piston and piston rod

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CA2430914A1 (en) 2002-08-01
KR100788319B1 (en) 2007-12-27
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US20040122355A1 (en) 2004-06-24
ES2272411T3 (en) 2007-05-01
HK1059585A1 (en) 2004-07-09
IL156270A (en) 2009-02-11
CN1325127C (en) 2007-07-11
JP2010005414A (en) 2010-01-14
MXPA03005591A (en) 2004-05-14
KR20030066729A (en) 2003-08-09
US6969370B2 (en) 2005-11-29
BR0116297A (en) 2004-08-17
EP1349596A1 (en) 2003-10-08
IL156248A0 (en) 2004-01-04
ATE295749T1 (en) 2005-06-15
BR0116273A (en) 2003-12-30
IL156238A (en) 2009-02-11
ES2241745T3 (en) 2005-11-01
HK1059582A1 (en) 2004-07-09
HK1059586A1 (en) 2004-07-09
BR0116296B1 (en) 2009-12-01
JP2004516106A (en) 2004-06-03
ATE300324T1 (en) 2005-08-15
CA2430917A1 (en) 2002-07-04
DK1351728T3 (en) 2005-08-22
CN1482929A (en) 2004-03-17
DE60110463D1 (en) 2005-06-02
BR0116279A (en) 2003-12-30
HK1059581A1 (en) 2004-07-09
PT1353712E (en) 2007-01-31
KR100788317B1 (en) 2007-12-27
KR100788314B1 (en) 2007-12-27
EP1349593B2 (en) 2018-04-04
KR20030066739A (en) 2003-08-09
IL156238A0 (en) 2004-01-04
IL156243A (en) 2008-11-03
US6949082B2 (en) 2005-09-27
KR100788318B1 (en) 2007-12-27
ES2263550T3 (en) 2006-12-16
EP1349592A1 (en) 2003-10-08
DE60110637T2 (en) 2006-01-19
GB0031466D0 (en) 2001-02-07
DE60110638T2 (en) 2006-01-19
CN1284609C (en) 2006-11-15
DK1349588T3 (en) 2005-09-05
CN1261171C (en) 2006-06-28
IL156244A0 (en) 2004-01-04
MXPA03005589A (en) 2004-05-14
IL156243A0 (en) 2004-01-04
EP1353715B1 (en) 2005-05-04
EP1349591B8 (en) 2005-12-28
CA2430942C (en) 2010-02-02
CY1106128T1 (en) 2011-06-08
CN1267161C (en) 2006-08-02
JP2004516107A (en) 2004-06-03
CN1290589C (en) 2006-12-20
EP1349595A1 (en) 2003-10-08
DE60110929T2 (en) 2006-04-27
HK1059903A1 (en) 2004-07-23
PT1351728E (en) 2005-08-31
US20040049156A1 (en) 2004-03-11
IL156251A (en) 2009-02-11
MXPA03005595A (en) 2004-05-17
CA2430942A1 (en) 2002-08-01
DE60110639D1 (en) 2005-06-09
BR0116276A (en) 2003-12-30
JP2004516111A (en) 2004-06-03
EP1353712A1 (en) 2003-10-22
JP4150589B2 (en) 2008-09-17
BR0116277A (en) 2003-12-30
MXPA03005590A (en) 2004-05-14
JP5054739B2 (en) 2012-10-24
JP2004521681A (en) 2004-07-22
BR0116280B1 (en) 2009-12-01
DE60110636T2 (en) 2006-01-19
IL156239A0 (en) 2004-01-04
ATE294601T1 (en) 2005-05-15
DE60112326D1 (en) 2005-09-01
BR0116296A (en) 2004-08-17
US20040024364A1 (en) 2004-02-05
DE60112472T2 (en) 2006-08-17

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