WO2002049613A3 - Method for enhancing integrity of epithelium using retinoic acid - Google Patents

Method for enhancing integrity of epithelium using retinoic acid Download PDF

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Publication number
WO2002049613A3
WO2002049613A3 PCT/US2001/046499 US0146499W WO0249613A3 WO 2002049613 A3 WO2002049613 A3 WO 2002049613A3 US 0146499 W US0146499 W US 0146499W WO 0249613 A3 WO0249613 A3 WO 0249613A3
Authority
WO
WIPO (PCT)
Prior art keywords
epithelium
retinoic acid
integrity
enhancing integrity
enhancing
Prior art date
Application number
PCT/US2001/046499
Other languages
French (fr)
Other versions
WO2002049613A2 (en
Inventor
Andrea Lever
Richard V Smerbeck
Original Assignee
Bausch & Lomb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bausch & Lomb filed Critical Bausch & Lomb
Priority to AU2002232487A priority Critical patent/AU2002232487A1/en
Publication of WO2002049613A2 publication Critical patent/WO2002049613A2/en
Publication of WO2002049613A3 publication Critical patent/WO2002049613A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A method for improving the integrity of the corneal epithelium by introducing into the eye an effective amount of a ophthalmically compatible retinoid sufficient to enhance the integrity of the corneal epithelium.
PCT/US2001/046499 2000-12-19 2001-12-03 Method for enhancing integrity of epithelium using retinoic acid WO2002049613A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002232487A AU2002232487A1 (en) 2000-12-19 2001-12-03 Method for enhancing integrity of epithelium using retinoic acid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25671300P 2000-12-19 2000-12-19
US60/256,713 2000-12-19

Publications (2)

Publication Number Publication Date
WO2002049613A2 WO2002049613A2 (en) 2002-06-27
WO2002049613A3 true WO2002049613A3 (en) 2003-01-16

Family

ID=22973298

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/046499 WO2002049613A2 (en) 2000-12-19 2001-12-03 Method for enhancing integrity of epithelium using retinoic acid

Country Status (3)

Country Link
US (2) US6787131B2 (en)
AU (1) AU2002232487A1 (en)
WO (1) WO2002049613A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040122110A1 (en) * 2002-09-06 2004-06-24 Maccabee Mendy S. Effect of vitamin A gel on paranasal sinus mucosal regeneration
US20080027031A1 (en) * 2006-03-08 2008-01-31 Kinemed, Inc. Retinoids and Related Compounds for the Treatment of Neuroinflammatory Conditions, Diseases and Disorders

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826871A (en) * 1985-03-13 1989-05-02 Gressel Philip D Topical ophthalmic compositions containing one or more retinoids
US5032392A (en) * 1986-09-04 1991-07-16 Vision Pharmaceuticals Aqueous ophthalmic solutions for the treatment of dryness and/or irritation of human or animal eyes
EP0473159A1 (en) * 1990-08-30 1992-03-04 Senju Pharmaceutical Co., Ltd. Stable aqueous preparation
WO1995003784A1 (en) * 1993-07-28 1995-02-09 Insite Vision Incorporated Suspensions for delivery of medicament
WO1996010403A1 (en) * 1994-09-30 1996-04-11 Alcon Laboratories, Inc. Use of retinoid glycosides in topical pharmaceutical compositions
EP1016406A1 (en) * 1997-08-26 2000-07-05 Senju Pharmaceutical Co., Ltd. Ophthalmic compositions for soft contact lens, method of enhancing wettability of soft contact lens, and method of inhibiting terpenoid adsorption
US6136850A (en) * 1991-05-10 2000-10-24 Allergan Methods and compositions for inhibiting deposit formation on contact lenses
JP2001158734A (en) * 1999-12-02 2001-06-12 Lion Corp Composition for ophthalmology and method for inhibiting adsorption to soft contact lens

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US4740533A (en) 1987-07-28 1988-04-26 Ciba-Geigy Corporation Wettable, flexible, oxygen permeable, substantially non-swellable contact lens containing block copolymer polysiloxane-polyoxyalkylene backbone units, and use thereof
US5236969A (en) 1987-04-02 1993-08-17 Bausch & Lomb Incorporated Polymer compositions for contact lenses
US5006622A (en) 1987-04-02 1991-04-09 Bausch & Lomb Incorporated Polymer compositions for contact lenses
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US4910277A (en) 1988-02-09 1990-03-20 Bambury Ronald E Hydrophilic oxygen permeable polymers
US5070215A (en) 1989-05-02 1991-12-03 Bausch & Lomb Incorporated Novel vinyl carbonate and vinyl carbamate contact lens material monomers
US5034461A (en) 1989-06-07 1991-07-23 Bausch & Lomb Incorporated Novel prepolymers useful in biomedical devices
US5032658A (en) 1989-10-17 1991-07-16 Polymer Technology Corporation Polymeric compositions useful in oxygen permeable contact lenses
US5177168A (en) 1989-10-17 1993-01-05 Polymer Technology Corp. Polymeric compositions useful in oxygen permeable contact lenses
US5219965A (en) 1990-11-27 1993-06-15 Bausch & Lomb Incorporated Surface modification of polymer objects
US5177165A (en) 1990-11-27 1993-01-05 Bausch & Lomb Incorporated Surface-active macromonomers
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US5358995A (en) 1992-05-15 1994-10-25 Bausch & Lomb Incorporated Surface wettable silicone hydrogels
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US5336797A (en) 1992-12-30 1994-08-09 Bausch & Lomb Incorporated Siloxane macromonomers
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US5346976A (en) 1993-03-29 1994-09-13 Polymer Technology Corporation Itaconate copolymeric compositions for contact lenses
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US5451651A (en) 1993-12-17 1995-09-19 Bausch & Lomb Incorporated Urea and urethane monomers for contact lens materials
AU1373195A (en) 1993-12-21 1995-07-10 Bausch & Lomb Incorporated Method for increasing hydrophilicity of contact lenses
AU2966595A (en) 1994-07-26 1996-02-22 Bausch & Lomb Incorporated Method of polymerizing methacrylate-based compositions
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US5708094A (en) 1996-12-17 1998-01-13 Bausch & Lomb Incorporated Polybutadiene-based compositions for contact lenses
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US5969076A (en) 1998-05-15 1999-10-19 Bausch & Lomb Incorporated Thermoplastic silicone-containing hydrogels
US5981675A (en) 1998-12-07 1999-11-09 Bausch & Lomb Incorporated Silicone-containing macromonomers and low water materials

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826871A (en) * 1985-03-13 1989-05-02 Gressel Philip D Topical ophthalmic compositions containing one or more retinoids
US5032392A (en) * 1986-09-04 1991-07-16 Vision Pharmaceuticals Aqueous ophthalmic solutions for the treatment of dryness and/or irritation of human or animal eyes
EP0473159A1 (en) * 1990-08-30 1992-03-04 Senju Pharmaceutical Co., Ltd. Stable aqueous preparation
US6136850A (en) * 1991-05-10 2000-10-24 Allergan Methods and compositions for inhibiting deposit formation on contact lenses
WO1995003784A1 (en) * 1993-07-28 1995-02-09 Insite Vision Incorporated Suspensions for delivery of medicament
WO1996010403A1 (en) * 1994-09-30 1996-04-11 Alcon Laboratories, Inc. Use of retinoid glycosides in topical pharmaceutical compositions
EP1016406A1 (en) * 1997-08-26 2000-07-05 Senju Pharmaceutical Co., Ltd. Ophthalmic compositions for soft contact lens, method of enhancing wettability of soft contact lens, and method of inhibiting terpenoid adsorption
JP2001158734A (en) * 1999-12-02 2001-06-12 Lion Corp Composition for ophthalmology and method for inhibiting adsorption to soft contact lens

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ISHII, REIKO ET AL: "Ophthalmic compositions containing fat-soluble vitamins and prevention of adsorption of fat-soluble vitamins on soft contact lenses", XP002215526, retrieved from STN Database accession no. 135:37180 *
RENGSTORFF R.H. ET AL: "Topical antioxidant treatment for dry-eye disorders and contact lens-related complications.", AFRO-ASIAN JOURNAL OF OPHTHALMOLOGY, (1988) 7/3 (81-83)., XP008008991 *

Also Published As

Publication number Publication date
US6787131B2 (en) 2004-09-07
US20020115720A1 (en) 2002-08-22
US20040225110A1 (en) 2004-11-11
WO2002049613A2 (en) 2002-06-27
AU2002232487A1 (en) 2002-07-01
US7087222B2 (en) 2006-08-08

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