WO2002047638A1 - Oral bleaching composition - Google Patents

Oral bleaching composition Download PDF

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Publication number
WO2002047638A1
WO2002047638A1 PCT/EP2001/013829 EP0113829W WO0247638A1 WO 2002047638 A1 WO2002047638 A1 WO 2002047638A1 EP 0113829 W EP0113829 W EP 0113829W WO 0247638 A1 WO0247638 A1 WO 0247638A1
Authority
WO
WIPO (PCT)
Prior art keywords
tooth cleaning
oral
peracid
cleaning composition
composition
Prior art date
Application number
PCT/EP2001/013829
Other languages
French (fr)
Inventor
Andrew Joiner
Philip Christopher Waterfield
Original Assignee
Unilever N.V.
Unilever Plc
Hindustan Lever Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever N.V., Unilever Plc, Hindustan Lever Ltd filed Critical Unilever N.V.
Priority to PL362435A priority Critical patent/PL203249B1/en
Priority to EP01270310A priority patent/EP1341513B1/en
Priority to AU2002216059A priority patent/AU2002216059A1/en
Priority to DE60119973T priority patent/DE60119973T2/en
Priority to BR0116674-3A priority patent/BR0116674A/en
Priority to HU0303048A priority patent/HUP0303048A2/en
Publication of WO2002047638A1 publication Critical patent/WO2002047638A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/38—Percompounds, e.g. peracids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/738—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A61Q11/02—Preparations for deodorising, bleaching or disinfecting dentures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms

Definitions

  • the present invention relates to an oral composition with an improved teeth whitening effect . More particularly, it relates to an oral composition with an improved teeth whitening effect comprising a safe and effective amount of certain organic peroxyacids.
  • WO 96/05802 teaches an oral care composition for whitening teeth.
  • the activity is achieved by inclusion in the oral care compositions of certain organic peroxy acids as teeth whitening/bleaching agents, particularly peroxyamidophthalamides and cationic peroxycarboxylic acids such as N-phthalimido per hexanoic acid and quaternary benzylperoxyacid.
  • peracids in a whitening/bleaching agent for use on teeth would be an advantage .
  • the present invention provides an oral tooth cleaning composition according to claim 1.
  • the peracid as used obviously need be acceptable to the subject being treated and to regulatory authorities. Such acceptability will be evident to one skilled in the art.
  • the rigours of any regulatory authority will depend upon the jurisdiction and the mammal being treated. Obviously, a higher standard is set for human treatment.
  • the term "acceptable for physical contact” need be construed within the spirit of the teachings as found herein.
  • the peracid for use in the composion is a peroxy amido phthalamide having the following formula:
  • a most preferred peracid is N,N- phthaloylaminoperoxycaproic acid (PAP) .
  • the peracid is present in the composition at an amount ranging from 0.01 to 5% by weight, more preferably from 0.05 to 4%, especially from 0.1 to 2% and most preferably from 0.5 to 1.5% by weight of the composition.
  • Certain oral bleaching formulations used under medical supervision may contain up to 35% of hydrogen peroxide. It is within the scope of the present invention for the composition as defined to contain such a high level of hydrogen peroxide in conjunction with a peracid. Preferably, the peroxide source is present in an amount ranging from 0.05 to 4%, more preferably from 0.1 to 2% by weight of the composition.
  • the peroxide source is preferably hydrogen peroxide but may also be another source suitable for use in oral care compositions e.g. Carbonide peroxide.
  • the present invention extends to the use of the composition for the whitening/bleaching/cleaning of teeth.
  • the present invention also extends to a commercial package comprising a cleaning composition of the present invention, together with instructions for its use.
  • the present invention may also be extended to the cleaning of dentures .
  • the oral composition according to the invention may also comprise further ingredients which are common in the art, such as:
  • antimicrobial agents e.g. Triclosan, chlorhexidine, copper-, zinc- and stannous salts such as zinc citrate, zinc sulphate, zinc glycinate, sodium zinc citrate and stannous pyrophosphate , sanguinarine extract, metronidazole, quaternary ammonium compounds, such as cetylpyridinium chloride; bis-guanides, such as chlorhexidine digluconate, hexetidine, octenidine, alexidine; and halogenated bisphenolic compounds, such as 2,2' methylenebis- (4-chloro- 6-bromophenol) ; anti-inflammatory agents such as ibuprofen, flurbiprofen, aspirin, indomethacin etc . ,-
  • anti-caries agents such as sodium- and stannous fluoride, aminefluorides, sodium monofluorophosphate, sodium trimeta phosphate and casein;
  • plaque buffers such as urea, calcium lactate, calcium glycerophosphate and strontium polyacrylates
  • vitamins such as Vitamins A, C and E;
  • desensitising agents e.g. potassium citrate, potassium chloride, potassium tartrate, potassium bicarbonate, potassium oxalate, potassium nitrate and strontium salts;
  • anti-calculus agents e.g. alkali-metal pyrophosphates , hypophosphite-containing polymers, organic phosphonates and phosphocitrates etc . ;
  • biomolecules e.g. bacteriocins , antibodies, enzymes, etc.;
  • flavours e.g. peppermint and spearmint oils
  • proteinaceous materials such as collagen; Keratin;
  • opacifying agents opacifying agents; colouring agents;
  • pharmaceutically acceptable carriers e.g. starch, sucrose, water or water/alcohol systems etc.;
  • surfactants such as anionic, nonionic, cationic and zwitterionic or amphoteric surfactants
  • particulate abrasive materials such as silicas, aluminas, calcium carbonates, dicalciumphosphates,. calcium pyrophosphates, hydroxyapatites, trimetaphosphates, insoluble hexametaphosphates and so on, including agglomerated particulate abrasive materials, usually in amounts between 3 and 60% by weight of the oral care composition.
  • humectants such as glycerol , sorbitol, propyleneglycol, xylitol, lactitol etc.;
  • binders and thickeners such as sodium carboxymethyl- cellulose, xanthan gum, gum arabic etc. as well as synthetic polymers such as polyacrylates and carboxyvinyl polymers such as Carbopol ® ;
  • polymeric compounds which can enhance the delivery of active ingredients such as antimicrobial agents can also be included.
  • examples of such polymers are copolymers of polyvinylmethylether with maleic anhydride and other similar delivery enhancing polymers, e.g. those described in DE-A-3,942,643 (Colgate);
  • bleaching agents such as peroxy compounds e.g. potassium peroxydiphosphate, effervescing systems such as sodium bicarbonate/citric acid systems, colour change systems, and so on.
  • Liposomes may also be used to improve delivery or stability of active ingredients.
  • the oral compositions may be in any form common in the art, e.g. toothpaste, gel, mousse, bioadhesive patch/strip, aerosol, gum, lozenge, tooth lacquers, mouthwash, powder, cream, etc. and may also be formulated into systems for use in dual-compartment type dispensers.
  • the bleaching agents were evaluated as follows:
  • Synthetic hydroxyapatite discs were polished and placed in sterile saliva at 37°C overnight to form a pellicle.
  • Table 1 shows the use of PAP alone in an aqueous 0.5 M NaHC03 solution together with 0.1 % H202.
  • Table 1 shows that the addition of a hydrogen peroxide to the peracid provides a more effective bleaching composition over PAP alone.
  • Table 2 shows data from a PAP bleaching experiment in which commercial products were used to make formulations.
  • Eureco HCP-11 is a commercial formulation containing a PAP/cyclodextrin complex material .
  • Eureco HCL-17 is a commercial formulation containing an aqueous dispersion of PAP.
  • the aformentioned commercial formulations are available from available from Ausimont : Via S. Pietro, 50/A 1-20021 Bollate, Milano, Italy.

Abstract

The present invention relates to oral care compositions with an improved teeth whitening effect. This effect is achieved by inclusion in the oral care compositions of certain peroxyamido-phthalamides as teeth whitening/bleaching agents, together with hydrogen peroxide.

Description

ORAL BLEACHING COMPOSITION
The present invention relates to an oral composition with an improved teeth whitening effect . More particularly, it relates to an oral composition with an improved teeth whitening effect comprising a safe and effective amount of certain organic peroxyacids.
WO 96/05802 teaches an oral care composition for whitening teeth. The activity is achieved by inclusion in the oral care compositions of certain organic peroxy acids as teeth whitening/bleaching agents, particularly peroxyamidophthalamides and cationic peroxycarboxylic acids such as N-phthalimido per hexanoic acid and quaternary benzylperoxyacid. A more effective use of peracids in a whitening/bleaching agent for use on teeth would be an advantage .
It is an object of the present invention to provide a more effective bleaching composition than4 that taught in WO 96/05802.
We have surprisingly found the use of hydrogen peroxide in conjunction with a peracid provides a more effective oral whitening/bleaching agent over the prior art teachings of WO 96/05802.
The present invention provides an oral tooth cleaning composition according to claim 1. The peracid as used obviously need be acceptable to the subject being treated and to regulatory authorities. Such acceptability will be evident to one skilled in the art. The rigours of any regulatory authority will depend upon the jurisdiction and the mammal being treated. Obviously, a higher standard is set for human treatment. The term "acceptable for physical contact" need be construed within the spirit of the teachings as found herein.
The peracid for use in the composion is a peroxy amido phthalamide having the following formula:
Figure imgf000003_0001
wherein R = hydrogen or Cα-C alkyl; n = 1 to 8; and X = C=0 or S02. A most preferred peracid is N,N- phthaloylaminoperoxycaproic acid (PAP) .
Preferably, the peracid is present in the composition at an amount ranging from 0.01 to 5% by weight, more preferably from 0.05 to 4%, especially from 0.1 to 2% and most preferably from 0.5 to 1.5% by weight of the composition.
Certain oral bleaching formulations used under medical supervision may contain up to 35% of hydrogen peroxide. It is within the scope of the present invention for the composition as defined to contain such a high level of hydrogen peroxide in conjunction with a peracid. Preferably, the peroxide source is present in an amount ranging from 0.05 to 4%, more preferably from 0.1 to 2% by weight of the composition.
The peroxide source is preferably hydrogen peroxide but may also be another source suitable for use in oral care compositions e.g. Carbonide peroxide. The present invention extends to the use of the composition for the whitening/bleaching/cleaning of teeth.
In addition, the present invention also extends to a commercial package comprising a cleaning composition of the present invention, together with instructions for its use.
In contrast to oral use the present invention may also be extended to the cleaning of dentures .
The oral composition according to the invention may also comprise further ingredients which are common in the art, such as:
antimicrobial agents, e.g. Triclosan, chlorhexidine, copper-, zinc- and stannous salts such as zinc citrate, zinc sulphate, zinc glycinate, sodium zinc citrate and stannous pyrophosphate , sanguinarine extract, metronidazole, quaternary ammonium compounds, such as cetylpyridinium chloride; bis-guanides, such as chlorhexidine digluconate, hexetidine, octenidine, alexidine; and halogenated bisphenolic compounds, such as 2,2' methylenebis- (4-chloro- 6-bromophenol) ; anti-inflammatory agents such as ibuprofen, flurbiprofen, aspirin, indomethacin etc . ,-
anti-caries agents such as sodium- and stannous fluoride, aminefluorides, sodium monofluorophosphate, sodium trimeta phosphate and casein;
plaque buffers such as urea, calcium lactate, calcium glycerophosphate and strontium polyacrylates;
vitamins such as Vitamins A, C and E;
plant extracts;
desensitising agents, e.g. potassium citrate, potassium chloride, potassium tartrate, potassium bicarbonate, potassium oxalate, potassium nitrate and strontium salts;
anti-calculus agents, e.g. alkali-metal pyrophosphates , hypophosphite-containing polymers, organic phosphonates and phosphocitrates etc . ;
biomolecules, e.g. bacteriocins , antibodies, enzymes, etc.;
flavours, e.g. peppermint and spearmint oils;
proteinaceous materials such as collagen; Keratin;
preservatives ;
opacifying agents; colouring agents;
pH- djusting agents;
sweetening agents;
pharmaceutically acceptable carriers, e.g. starch, sucrose, water or water/alcohol systems etc.;
surfactants, such as anionic, nonionic, cationic and zwitterionic or amphoteric surfactants;
particulate abrasive materials such as silicas, aluminas, calcium carbonates, dicalciumphosphates,. calcium pyrophosphates, hydroxyapatites, trimetaphosphates, insoluble hexametaphosphates and so on, including agglomerated particulate abrasive materials, usually in amounts between 3 and 60% by weight of the oral care composition.
humectants such as glycerol , sorbitol, propyleneglycol, xylitol, lactitol etc.;
binders and thickeners such as sodium carboxymethyl- cellulose, xanthan gum, gum arabic etc. as well as synthetic polymers such as polyacrylates and carboxyvinyl polymers such as Carbopol®;
polymeric compounds which can enhance the delivery of active ingredients such as antimicrobial agents can also be included. Examples of such polymers are copolymers of polyvinylmethylether with maleic anhydride and other similar delivery enhancing polymers, e.g. those described in DE-A-3,942,643 (Colgate);
buffers and salts to buffer the pH and ionic strength of the oral care composition; and
other optional ingredients that may be included are e.g. bleaching agents such as peroxy compounds e.g. potassium peroxydiphosphate, effervescing systems such as sodium bicarbonate/citric acid systems, colour change systems, and so on.
Liposomes may also be used to improve delivery or stability of active ingredients.
The oral compositions may be in any form common in the art, e.g. toothpaste, gel, mousse, bioadhesive patch/strip, aerosol, gum, lozenge, tooth lacquers, mouthwash, powder, cream, etc. and may also be formulated into systems for use in dual-compartment type dispensers.
Experimental
The bleaching agents were evaluated as follows:
(1) Synthetic hydroxyapatite discs were polished and placed in sterile saliva at 37°C overnight to form a pellicle.
(2) Discs were stained with tea solution for seven days at
37°C. (3) Stained discs were immersed in bleaching solutions for desired time.
(4) The change in colour of the discs was measured using a Minolta chromameter CR-300 in L*a*b* mode. Using L* (initial) , L* (soiled) , and L* (cleaned) , the percentage of stain removed was calculated. A negative value indicates a darkening and a positive value indicates a bleaching (whitening) effect .
All formulations used were made up in 0.5 M NaHC03. A negative value indicates a darkening and
Table 1 below shows the use of PAP alone in an aqueous 0.5 M NaHC03 solution together with 0.1 % H202.
Figure imgf000008_0001
The results show in Table 1, show that the addition of a hydrogen peroxide to the peracid provides a more effective bleaching composition over PAP alone. Table 2 shows data from a PAP bleaching experiment in which commercial products were used to make formulations.
Figure imgf000009_0001
Eureco HCP-11 is a commercial formulation containing a PAP/cyclodextrin complex material .
Eureco HCL-17 is a commercial formulation containing an aqueous dispersion of PAP. The aformentioned commercial formulations are available from available from Ausimont : Via S. Pietro, 50/A 1-20021 Bollate, Milano, Italy.
The results shown in Table 2 above show: That the HCL-17 is much more active at bleaching than HCP-11 on an equal w/w basis of PAP. That the presence of 0.1% H202 to HCL-17 gives a surprising increase in bleaching effect.

Claims

1. An oral tooth cleaning composition comprising:
a peracid that is acceptable for physical contact with the inside of a mammalian mouth, characterised in that the composition comprises hydrogen peroxide in the range from 0.01 to 5.0 % w/w of the composition or source thereof, wherein said source generates hydrogen peroxide in the range from 0.01 to 5.0 % w/w of the composition, characterised in that the peracid is a peroxy a ido phthalamide having the following formula:
Figure imgf000010_0001
wherein R = hydrogen or Cx-C4 alkyl ; n = 1 to 8 ; and X = C=0 or S02.
An oral tooth cleaning composition according to claim 1, wherein the hydrogen peroxide is present in the form of carbamide peroxide .
3. An oral tooth cleaning composition according to claim 1, wherein the peracid is present in the range from 0.01% to 5 % w/w of the composition.
4. An oral tooth cleaning composition according to any preceding claim, wherein the peracid is N,N- phthaloylaminoperoxycaproic acid (PAP) .
5. An oral tooth cleaning composition according to any preceding claim, wherein the peracid is in the form of a cyclodextrin complex.
6. An oral tooth cleaning composition according to any preceding claim, wherein the composition in provided in a format selected from the group consisting of a gel bioadhesive patch/strip, tooth lacquer and a toothpaste .
7. Use of an oral tooth cleaning composition as defined in any preceding claim, for the cleaning of teeth.
8. A commercial package comprising an oral tooth cleaning composition as defined in any preceding claim, together with instructions for its use in whitening teeth.
PCT/EP2001/013829 2000-12-15 2001-11-26 Oral bleaching composition WO2002047638A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
PL362435A PL203249B1 (en) 2000-12-15 2001-11-26 Oral bleaching composition
EP01270310A EP1341513B1 (en) 2000-12-15 2001-11-26 Oral bleaching composition
AU2002216059A AU2002216059A1 (en) 2000-12-15 2001-11-26 Oral bleaching composition
DE60119973T DE60119973T2 (en) 2000-12-15 2001-11-26 COMPOSITION FOR BLEACHING TEETH
BR0116674-3A BR0116674A (en) 2000-12-15 2001-11-26 Oral tooth cleaning composition, use of oral tooth cleaning composition and commercial packaging
HU0303048A HUP0303048A2 (en) 2000-12-15 2001-11-26 Oral bleaching composition, its use and packaged product containing such composition

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00311230 2000-12-15
EP00311230.7 2000-12-15

Publications (1)

Publication Number Publication Date
WO2002047638A1 true WO2002047638A1 (en) 2002-06-20

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ID=8173449

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/013829 WO2002047638A1 (en) 2000-12-15 2001-11-26 Oral bleaching composition

Country Status (13)

Country Link
US (1) US6475472B2 (en)
EP (1) EP1341513B1 (en)
CN (1) CN1262265C (en)
AR (1) AR031813A1 (en)
AT (1) ATE326944T1 (en)
AU (1) AU2002216059A1 (en)
BR (1) BR0116674A (en)
DE (1) DE60119973T2 (en)
ES (1) ES2263547T3 (en)
HU (1) HUP0303048A2 (en)
PL (1) PL203249B1 (en)
WO (1) WO2002047638A1 (en)
ZA (1) ZA200303682B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1656031A2 (en) * 2003-07-11 2006-05-17 Cadbury Adams USA LLC Chewing gum and confectionery compositions containing a strain removing complex, and methods of making and using the same
FR2940121A1 (en) * 2008-12-23 2010-06-25 Oreal Composition for the care of greasy skin, especially for eliminating bacteria responsible for acne, contains a combination of phthalamidoperhexanoic acid and zinc salicylate

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6689344B2 (en) 2000-03-17 2004-02-10 Lg Household & Healthcare Ltd. Patches for teeth whitening
US8652446B2 (en) 2000-03-17 2014-02-18 Lg Household & Healthcare Ltd. Apparatus and method for whitening teeth
US7785572B2 (en) 2000-03-17 2010-08-31 Lg Household And Health Care Ltd. Method and device for teeth whitening using a dry type adhesive
ATE421894T1 (en) 2000-03-17 2009-02-15 Lg Household & Health Care Ltd PLASTER FOR WHITENING TEETH
US6916463B2 (en) * 2002-09-24 2005-07-12 The Procter & Gamble Company Oral products having an aesthetic layer
US20070098648A1 (en) * 2002-11-05 2007-05-03 Haley Jeffrey T Treating mouth sores caused by dental braces with blobs of hydrophilic gums
US8734421B2 (en) 2003-06-30 2014-05-27 Johnson & Johnson Consumer Companies, Inc. Methods of treating pores on the skin with electricity
PL1664935T3 (en) * 2003-08-19 2008-01-31 Avantor Performance Mat Inc Stripping and cleaning compositions for microelectronics
US20060045854A1 (en) 2004-08-27 2006-03-02 Lynette Zaidel Oral care composition with cross-linked polymer peroxide
WO2006089028A2 (en) * 2005-02-15 2006-08-24 Lab39, Llc Foaming compositions and methods
US20070243238A1 (en) * 2006-04-13 2007-10-18 Haley Jeffrey T Treating mouth sores with patches adhered to teeth
US20080187563A1 (en) * 2006-11-07 2008-08-07 Ehud Levy Oxygen delivery compositon
JP5467996B2 (en) * 2007-04-04 2014-04-09 ヘンケル・アクチェンゲゼルシャフト・ウント・コムパニー・コマンディットゲゼルシャフト・アウフ・アクチェン Detergent or detergent containing bleach
US20120089232A1 (en) 2009-03-27 2012-04-12 Jennifer Hagyoung Kang Choi Medical devices with galvanic particulates
CN101843563B (en) * 2010-05-11 2012-06-27 李少君 Whitening toothpaste composite
CN106726702A (en) * 2017-03-13 2017-05-31 广州欧诺洁个人护理用品有限公司 A kind of tooth whitening products without hydrogen peroxide
BR112019025631A2 (en) 2017-06-06 2020-06-16 Unilever Nv COMPOSITION OF Aqueous GEL FOR WHITE TOOTH, PARTS KIT, DEVICE FOR WHITE TOOTH, METHOD FOR WHITE TOOTH, USE OF A COMPOSITION OF WATER GEL AND PACKAGED PRODUCT
US11110047B2 (en) 2017-08-07 2021-09-07 Colgate-Palmolive Company Oral care compositions including cyclic anhydrides
BR112020023733A2 (en) 2018-06-26 2021-02-09 Unilever Nv polymer, oral care composition, process for preparing a polymer, kit of parts, teeth whitening device, teeth whitening method and use of a composition
WO2021094156A1 (en) 2019-11-11 2021-05-20 Unilever Ip Holdings B.V. A film and a kit for whitening teeth
CN113476333A (en) * 2020-08-19 2021-10-08 唯艺科学研究(深圳)有限公司 PAP-containing gel

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0545594A1 (en) * 1991-11-22 1993-06-09 Colgate-Palmolive Company Oral composition having improved tooth whitening effect
GB2290234A (en) * 1994-06-07 1995-12-20 Janina International Oral care compositions
WO1996005802A2 (en) * 1994-08-22 1996-02-29 Unilever N.V. Teeth whitening composition containing organic peroxyacids
US5616335A (en) * 1993-05-05 1997-04-01 Chemoxal S.A. Stable thickened disinfecting aqueous composition containing an organic peroxy acid intended for human or animal use
US5785957A (en) * 1995-12-12 1998-07-28 Losee; Paul Inclusion of tooth whitening oxidation chemistries into a tooth-paste composition
EP0895777A2 (en) * 1997-08-05 1999-02-10 Ausimont S.p.A. Compositions based on peroxyacids
WO2000059461A1 (en) * 1999-04-01 2000-10-12 Unilever N.V. Oral composition with an improved teeth whitening effect
US6136297A (en) * 1997-06-06 2000-10-24 The Procter & Gamble Company Delivery system for an oral care substance using a strip of material having low flexural stiffness

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5188821A (en) 1987-01-30 1993-02-23 Colgate-Palmolive Company Antibacterial antiplaque oral composition mouthwash or liquid dentifrice
SE507731C2 (en) 1988-12-29 1998-07-06 Colgate Palmolive Co Antibacterial oral antiplaque composition
US5360569A (en) * 1993-11-12 1994-11-01 Lever Brothers Company, Division Of Conopco, Inc. Activation of bleach precursors with catalytic imine quaternary salts
US5370826A (en) * 1993-11-12 1994-12-06 Lever Brothers Company, Division Of Conopco, Inc. Quaternay oxaziridinium salts as bleaching compounds
US5360568A (en) * 1993-11-12 1994-11-01 Lever Brothers Company, Division Of Conopco, Inc. Imine quaternary salts as bleach catalysts
US5693603A (en) * 1996-04-30 1997-12-02 Lever Brothers Company, Division Of Conopco, Inc. Sulfanimines as bleach catalysts
US5652207A (en) * 1996-08-12 1997-07-29 Lever Brothers Company, Division Of Conopco, Inc. Phosphinoyl imines for use as oxygen transfer agents
US5858949A (en) * 1996-08-23 1999-01-12 Lever Brothers Company, Division Of Conopco, Inc. N-acylimines as bleach catalysts
US5753599A (en) * 1996-12-03 1998-05-19 Lever Brothers Company, Division Of Conopco, Inc. Thiadiazole dioxides as bleach enhancers
US5760222A (en) * 1996-12-03 1998-06-02 Lever Brothers Company, Division Of Conopco, Inc. Thiadiazole dioxide derived oxaziridines as bleaching compounds
US5955415A (en) * 1997-08-04 1999-09-21 Lever Brothers Company, Division Of Conopco, Inc. Detergent compositions containing polyethyleneimines for enhanced peroxygen bleach stability
US6185448B1 (en) * 1998-09-29 2001-02-06 Simcha Borovsky Apparatus and method for locating and mapping a catheter in intracardiac operations
IT1311889B1 (en) * 1999-03-12 2002-03-20 Farmaceutici Dott Ciccarelli S TOOTHPASTE PASTE.

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0545594A1 (en) * 1991-11-22 1993-06-09 Colgate-Palmolive Company Oral composition having improved tooth whitening effect
US5616335A (en) * 1993-05-05 1997-04-01 Chemoxal S.A. Stable thickened disinfecting aqueous composition containing an organic peroxy acid intended for human or animal use
GB2290234A (en) * 1994-06-07 1995-12-20 Janina International Oral care compositions
WO1996005802A2 (en) * 1994-08-22 1996-02-29 Unilever N.V. Teeth whitening composition containing organic peroxyacids
US5785957A (en) * 1995-12-12 1998-07-28 Losee; Paul Inclusion of tooth whitening oxidation chemistries into a tooth-paste composition
US6136297A (en) * 1997-06-06 2000-10-24 The Procter & Gamble Company Delivery system for an oral care substance using a strip of material having low flexural stiffness
EP0895777A2 (en) * 1997-08-05 1999-02-10 Ausimont S.p.A. Compositions based on peroxyacids
WO2000059461A1 (en) * 1999-04-01 2000-10-12 Unilever N.V. Oral composition with an improved teeth whitening effect

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1656031A2 (en) * 2003-07-11 2006-05-17 Cadbury Adams USA LLC Chewing gum and confectionery compositions containing a strain removing complex, and methods of making and using the same
EP1656031A4 (en) * 2003-07-11 2011-02-09 Cadbury Adams Usa Llc Chewing gum and confectionery compositions containing a strain removing complex, and methods of making and using the same
FR2940121A1 (en) * 2008-12-23 2010-06-25 Oreal Composition for the care of greasy skin, especially for eliminating bacteria responsible for acne, contains a combination of phthalamidoperhexanoic acid and zinc salicylate

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EP1341513B1 (en) 2006-05-24
ES2263547T3 (en) 2006-12-16
DE60119973T2 (en) 2006-09-28
ATE326944T1 (en) 2006-06-15
CN1262265C (en) 2006-07-05
HUP0303048A2 (en) 2003-12-29
CN1481232A (en) 2004-03-10
DE60119973D1 (en) 2006-06-29
EP1341513A1 (en) 2003-09-10
PL362435A1 (en) 2004-11-02
AR031813A1 (en) 2003-10-01
ZA200303682B (en) 2006-06-28
BR0116674A (en) 2003-11-04
AU2002216059A1 (en) 2002-06-24
PL203249B1 (en) 2009-09-30
US6475472B2 (en) 2002-11-05
US20020122776A1 (en) 2002-09-05

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