WO2002047266A3 - Transient electrical signal based methods and devices for characterizing molecular interaction and/or motion in a sample - Google Patents

Transient electrical signal based methods and devices for characterizing molecular interaction and/or motion in a sample Download PDF

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Publication number
WO2002047266A3
WO2002047266A3 PCT/US2001/051398 US0151398W WO0247266A3 WO 2002047266 A3 WO2002047266 A3 WO 2002047266A3 US 0151398 W US0151398 W US 0151398W WO 0247266 A3 WO0247266 A3 WO 0247266A3
Authority
WO
WIPO (PCT)
Prior art keywords
sample
devices
electrical signal
motion
signal based
Prior art date
Application number
PCT/US2001/051398
Other languages
French (fr)
Other versions
WO2002047266A2 (en
Inventor
Nader Pourmand
Arjang Hassibi
Original Assignee
Univ Leland Stanford Junior
Nader Pourmand
Arjang Hassibi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior, Nader Pourmand, Arjang Hassibi filed Critical Univ Leland Stanford Junior
Priority to AU2002241803A priority Critical patent/AU2002241803A1/en
Priority to EP01988504A priority patent/EP1341933A4/en
Publication of WO2002047266A2 publication Critical patent/WO2002047266A2/en
Publication of WO2002047266A3 publication Critical patent/WO2002047266A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes

Abstract

Devices for detecting a transient electrical signal in a sample are provided. Also provided are systems that include the subject devices. The subject devices and systems find use in a variety of applications, particularly in the characterization of a sample, and more particularly in the characterization of molecular entities in the sample.
PCT/US2001/051398 2000-10-20 2001-10-19 Transient electrical signal based methods and devices for characterizing molecular interaction and/or motion in a sample WO2002047266A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002241803A AU2002241803A1 (en) 2000-10-20 2001-10-19 Transient electrical signal based methods and devices for characterizing molecular interaction and/or motion in a sample
EP01988504A EP1341933A4 (en) 2000-10-20 2001-10-19 Transient electrical signal based methods and devices for characterizing molecular interaction and/or motion in a sample

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24204700P 2000-10-20 2000-10-20
US60/242,047 2000-10-20
US28557801P 2001-04-20 2001-04-20
US60/285,578 2001-04-20

Publications (2)

Publication Number Publication Date
WO2002047266A2 WO2002047266A2 (en) 2002-06-13
WO2002047266A3 true WO2002047266A3 (en) 2002-08-15

Family

ID=26934788

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/051398 WO2002047266A2 (en) 2000-10-20 2001-10-19 Transient electrical signal based methods and devices for characterizing molecular interaction and/or motion in a sample

Country Status (5)

Country Link
US (2) US20020155476A1 (en)
EP (1) EP1341933A4 (en)
CN (1) CN1481441A (en)
AU (1) AU2002241803A1 (en)
WO (1) WO2002047266A2 (en)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0129012D0 (en) 2001-12-04 2002-01-23 Solexa Ltd Labelled nucleotides
US20040072208A1 (en) * 2002-05-23 2004-04-15 Peter Warthoe Surface acoustic wave sensors and method for detecting target analytes
US7414116B2 (en) 2002-08-23 2008-08-19 Illumina Cambridge Limited Labelled nucleotides
US11008359B2 (en) 2002-08-23 2021-05-18 Illumina Cambridge Limited Labelled nucleotides
SI3587433T1 (en) 2002-08-23 2020-08-31 Illumina Cambridge Limited Modified nucleotides
US7041401B2 (en) * 2002-10-18 2006-05-09 University Of Iowa Research Foundation Magnetically modified electrodes containing at least one catalyst component that mediates a subatomic particle transfer process
US20050003396A1 (en) * 2003-04-11 2005-01-06 Mihrimah Ozkan Biosensors having single reactant components immobilized over single electrodes and methods of making and using thereof
US7723099B2 (en) * 2003-09-10 2010-05-25 Abbott Point Of Care Inc. Immunoassay device with immuno-reference electrode
JP4342890B2 (en) * 2003-09-30 2009-10-14 富士フイルム株式会社 Method for removing mismatch binding polynucleotides
EP2549659A1 (en) * 2004-02-20 2013-01-23 Nuance Communications, Inc. Call Intercept Method for Customer Self-Support on a Mobile Device
KR100631213B1 (en) * 2004-05-31 2006-10-04 삼성전자주식회사 Apparatus and method of detecting bio bonding using circuit of inductor
US7692219B1 (en) 2004-06-25 2010-04-06 University Of Hawaii Ultrasensitive biosensors
US7785785B2 (en) * 2004-11-12 2010-08-31 The Board Of Trustees Of The Leland Stanford Junior University Charge perturbation detection system for DNA and other molecules
US9695472B2 (en) * 2005-03-04 2017-07-04 Intel Corporation Sensor arrays and nucleic acid sequencing applications
US9040237B2 (en) * 2005-03-04 2015-05-26 Intel Corporation Sensor arrays and nucleic acid sequencing applications
US8301123B2 (en) * 2005-06-24 2012-10-30 Nuance Communications, Inc. Local intercept methods, such as applications for providing customer assistance for training, information calls and diagnostics
US20070292855A1 (en) * 2005-08-19 2007-12-20 Intel Corporation Method and CMOS-based device to analyze molecules and nanomaterials based on the electrical readout of specific binding events on functionalized electrodes
US8682298B2 (en) * 2005-10-12 2014-03-25 Nuance Communications, Inc. Message intercept methods, such as for customer self-support on a mobile device
EP1969886B1 (en) 2005-12-13 2017-09-20 Nuance Communications, Inc. Method for performing interactive services on a mobile device, such as time or location initiated interactive services
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
US8048626B2 (en) 2006-07-28 2011-11-01 California Institute Of Technology Multiplex Q-PCR arrays
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
EP2653861B1 (en) 2006-12-14 2014-08-13 Life Technologies Corporation Method for sequencing a nucleic acid using large-scale FET arrays
US8262900B2 (en) * 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
US11339430B2 (en) 2007-07-10 2022-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US7932034B2 (en) 2006-12-20 2011-04-26 The Board Of Trustees Of The Leland Stanford Junior University Heat and pH measurement for sequencing of DNA
WO2008086320A1 (en) * 2007-01-05 2008-07-17 Snapin Software Inc. Methods of interacting between mobile devices and voice response systems
WO2008128119A1 (en) 2007-04-12 2008-10-23 Snapin Software Inc. System and method for detecting mutually supported capabilities between mobile devices
JP5667049B2 (en) 2008-06-25 2015-02-12 ライフ テクノロジーズ コーポレーション Method and apparatus for measuring analytes using large-scale FET arrays
US8589149B2 (en) 2008-08-05 2013-11-19 Nuance Communications, Inc. Probability-based approach to recognition of user-entered data
US20100069253A1 (en) * 2008-09-12 2010-03-18 Gindilis Andrei L Impedance Spectroscopy Measurement of DNA
US9186128B2 (en) 2008-10-01 2015-11-17 Covidien Lp Needle biopsy device
US9782565B2 (en) 2008-10-01 2017-10-10 Covidien Lp Endoscopic ultrasound-guided biliary access system
US11298113B2 (en) 2008-10-01 2022-04-12 Covidien Lp Device for needle biopsy with integrated needle protection
US9332973B2 (en) 2008-10-01 2016-05-10 Covidien Lp Needle biopsy device with exchangeable needle and integrated needle protection
US8968210B2 (en) 2008-10-01 2015-03-03 Covidien LLP Device for needle biopsy with integrated needle protection
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US8673627B2 (en) 2009-05-29 2014-03-18 Life Technologies Corporation Apparatus and methods for performing electrochemical reactions
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
US8574835B2 (en) 2009-05-29 2013-11-05 Life Technologies Corporation Scaffolded nucleic acid polymer particles and methods of making and using
US20120261274A1 (en) 2009-05-29 2012-10-18 Life Technologies Corporation Methods and apparatus for measuring analytes
WO2012003363A1 (en) 2010-06-30 2012-01-05 Life Technologies Corporation Ion-sensing charge-accumulation circuits and methods
EP2598804B1 (en) 2010-06-30 2021-10-20 Life Technologies Corporation Method to generate an output signal in an isfet-array
TWI569025B (en) 2010-06-30 2017-02-01 生命技術公司 Methods and apparatus for testing isfet arrays
US11307166B2 (en) 2010-07-01 2022-04-19 Life Technologies Corporation Column ADC
US8653567B2 (en) 2010-07-03 2014-02-18 Life Technologies Corporation Chemically sensitive sensor with lightly doped drains
US8715932B2 (en) 2010-08-20 2014-05-06 Intel Corporation Nucleic acid sequencing
US9618475B2 (en) 2010-09-15 2017-04-11 Life Technologies Corporation Methods and apparatus for measuring analytes
EP2619564B1 (en) 2010-09-24 2016-03-16 Life Technologies Corporation Matched pair transistor circuits
US9184099B2 (en) 2010-10-04 2015-11-10 The Board Of Trustees Of The Leland Stanford Junior University Biosensor devices, systems and methods therefor
US9399217B2 (en) 2010-10-04 2016-07-26 Genapsys, Inc. Chamber free nanoreactor system
JP6114694B2 (en) 2010-10-04 2017-04-12 ジナプシス インコーポレイテッド Systems and methods for automated reusable parallel biological reactions
US9353411B2 (en) 2011-03-30 2016-05-31 Parallel Synthesis Technologies Nucleic acid sequencing technique using a pH-sensing agent
US9926596B2 (en) 2011-05-27 2018-03-27 Genapsys, Inc. Systems and methods for genetic and biological analysis
US8893033B2 (en) * 2011-05-27 2014-11-18 Microsoft Corporation Application notifications
US8585973B2 (en) 2011-05-27 2013-11-19 The Board Of Trustees Of The Leland Stanford Junior University Nano-sensor array
US9970984B2 (en) 2011-12-01 2018-05-15 Life Technologies Corporation Method and apparatus for identifying defects in a chemical sensor array
CN104105797B (en) 2011-12-01 2016-08-31 吉纳普赛斯股份有限公司 System and method for efficent electronic order-checking with detection
KR101813907B1 (en) 2011-12-15 2018-01-02 인텔 코포레이션 Diamond electrode nanogap transducers
JP5985654B2 (en) 2011-12-28 2016-09-06 インテル コーポレイション Nanogap transducer with selective surface immobilization sites
US8821798B2 (en) 2012-01-19 2014-09-02 Life Technologies Corporation Titanium nitride as sensing layer for microwell structure
US8747748B2 (en) 2012-01-19 2014-06-10 Life Technologies Corporation Chemical sensor with conductive cup-shaped sensor surface
US8786331B2 (en) 2012-05-29 2014-07-22 Life Technologies Corporation System for reducing noise in a chemical sensor array
US9080968B2 (en) 2013-01-04 2015-07-14 Life Technologies Corporation Methods and systems for point of use removal of sacrificial material
US9841398B2 (en) 2013-01-08 2017-12-12 Life Technologies Corporation Methods for manufacturing well structures for low-noise chemical sensors
US8962366B2 (en) 2013-01-28 2015-02-24 Life Technologies Corporation Self-aligned well structures for low-noise chemical sensors
US8841217B1 (en) 2013-03-13 2014-09-23 Life Technologies Corporation Chemical sensor with protruded sensor surface
US8963216B2 (en) 2013-03-13 2015-02-24 Life Technologies Corporation Chemical sensor with sidewall spacer sensor surface
WO2014152625A1 (en) 2013-03-15 2014-09-25 Genapsys, Inc. Systems and methods for biological analysis
US9835585B2 (en) 2013-03-15 2017-12-05 Life Technologies Corporation Chemical sensor with protruded sensor surface
WO2014149779A1 (en) 2013-03-15 2014-09-25 Life Technologies Corporation Chemical device with thin conductive element
WO2014149780A1 (en) 2013-03-15 2014-09-25 Life Technologies Corporation Chemical sensor with consistent sensor surface areas
JP6581074B2 (en) 2013-03-15 2019-09-25 ライフ テクノロジーズ コーポレーション Chemical sensor with consistent sensor surface area
US9116117B2 (en) 2013-03-15 2015-08-25 Life Technologies Corporation Chemical sensor with sidewall sensor surface
WO2014139596A1 (en) 2013-03-15 2014-09-18 Illumina Cambridge Limited Modified nucleosides or nucleotides
US20140336063A1 (en) 2013-05-09 2014-11-13 Life Technologies Corporation Windowed Sequencing
US10458942B2 (en) 2013-06-10 2019-10-29 Life Technologies Corporation Chemical sensor array having multiple sensors per well
US9683958B2 (en) 2013-09-11 2017-06-20 Agilent Technologies, Inc. Nanofluidic device for charge analysis of straightened molecules
US10125393B2 (en) 2013-12-11 2018-11-13 Genapsys, Inc. Systems and methods for biological analysis and computation
EP3132060B1 (en) 2014-04-18 2019-03-13 Genapsys Inc. Methods and systems for nucleic acid amplification
KR102593647B1 (en) 2014-12-18 2023-10-26 라이프 테크놀로지스 코포레이션 High data rate integrated circuit with transmitter configuration
US10077472B2 (en) 2014-12-18 2018-09-18 Life Technologies Corporation High data rate integrated circuit with power management
EP3234575B1 (en) 2014-12-18 2023-01-25 Life Technologies Corporation Apparatus for measuring analytes using large scale fet arrays
US10077470B2 (en) 2015-07-21 2018-09-18 Omniome, Inc. Nucleic acid sequencing methods and systems
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
EP3427037A4 (en) * 2016-03-09 2019-11-27 The Regents of the University of California Transient induced molecular electronic spectroscopy method for study of molecule interactions
EP3449012B1 (en) 2016-04-29 2020-12-23 Omniome, Inc. Sequencing method employing ternary complex destabilization to identify cognate nucleotides
CN109790575A (en) 2016-07-20 2019-05-21 吉纳普赛斯股份有限公司 System and method for nucleic acid sequencing
WO2018034780A1 (en) 2016-08-15 2018-02-22 Omniome, Inc. Sequencing method for rapid identification and processing of cognate nucleotide pairs
EP4039824A1 (en) 2016-08-15 2022-08-10 Pacific Biosciences of California, Inc. Method and system for sequencing nucleic acids
CA3048415C (en) 2016-12-30 2023-02-28 Omniome, Inc. Method and system employing distinguishable polymerases for detecting ternary complexes and identifying cognate nucleotides
CA3050695C (en) 2017-01-20 2024-02-20 Omniome, Inc. Process for cognate nucleotide detection in a nucleic acid sequencing workflow
US9951385B1 (en) 2017-04-25 2018-04-24 Omniome, Inc. Methods and apparatus that increase sequencing-by-binding efficiency
US10161003B2 (en) 2017-04-25 2018-12-25 Omniome, Inc. Methods and apparatus that increase sequencing-by-binding efficiency
CN111566224A (en) 2017-09-21 2020-08-21 吉纳普赛斯股份有限公司 Systems and methods for nucleic acid sequencing
US11193166B2 (en) 2017-10-19 2021-12-07 Omniome, Inc. Simultaneous background reduction and complex stabilization in binding assay workflows
EP3937780A4 (en) 2019-03-14 2022-12-07 InSilixa, Inc. Methods and systems for time-gated fluorescent-based detection
CN110133047A (en) * 2019-05-30 2019-08-16 京东方科技集团股份有限公司 The detection method of detection unit, detection device and memebrane protein diffusion rate

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5958701A (en) * 1999-01-27 1999-09-28 The United States Of America As Represented By The Secretary Of The Navy Method for measuring intramolecular forces by atomic force
US6100045A (en) * 1997-02-10 2000-08-08 Dsm N.V. Detection of analytes using electrochemistry

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863849A (en) * 1985-07-18 1989-09-05 New York Medical College Automatable process for sequencing nucleotide
US5192507A (en) * 1987-06-05 1993-03-09 Arthur D. Little, Inc. Receptor-based biosensors
US5540828A (en) * 1987-06-08 1996-07-30 Yacynych; Alexander Method for making electrochemical sensors and biosensors having a polymer modified surface
SE8801070D0 (en) * 1988-03-23 1988-03-23 Pharmacia Ab METHOD FOR IMMOBILIZING A DNA SEQUENCE ON A SOLID SUPPORT
US5200051A (en) * 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5262305A (en) * 1991-03-04 1993-11-16 E. Heller & Company Interferant eliminating biosensors
EP0525723B1 (en) * 1991-07-29 1997-05-14 Mochida Pharmaceutical Co., Ltd. Process and device for specific binding assay
WO1993008464A1 (en) * 1991-10-21 1993-04-29 Holm Kennedy James W Method and device for biochemical sensing
DE69233391D1 (en) * 1991-11-07 2004-09-02 Nanotronics Inc Hybridization of polynucleotides conjugated with chromophores and fluorophores to create a donor-donor energy transfer system
US5632957A (en) * 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
GB9218376D0 (en) * 1992-08-28 1992-10-14 Cranfield Inst Of Tech Media for biocatalytic electrochemical reactions in the gaseous phase
EP0682671A4 (en) * 1993-02-01 1998-01-14 Seq Ltd Methods and apparatus for dna sequencing.
US6225059B1 (en) * 1993-11-01 2001-05-01 Nanogen, Inc. Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics
US5965452A (en) * 1996-07-09 1999-10-12 Nanogen, Inc. Multiplexed active biologic array
US5591578A (en) * 1993-12-10 1997-01-07 California Institute Of Technology Nucleic acid mediated electron transfer
US6071699A (en) * 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
US5643721A (en) * 1994-02-09 1997-07-01 Abbott Laboratories Bioreagent immobilization medium
US5871918A (en) * 1996-06-20 1999-02-16 The University Of North Carolina At Chapel Hill Electrochemical detection of nucleic acid hybridization
US6132971A (en) * 1995-06-27 2000-10-17 The University Of North Carolina At Chapel Hill Microelectronic device
US6127127A (en) * 1995-06-27 2000-10-03 The University Of North Carolina At Chapel Hill Monolayer and electrode for detecting a label-bearing target and method of use thereof
US6180346B1 (en) * 1995-06-27 2001-01-30 The Universtiy Of North Carolina At Chapel Hill Electropolymerizable film, and method of making and use thereof
US5968745A (en) * 1995-06-27 1999-10-19 The University Of North Carolina At Chapel Hill Polymer-electrodes for detecting nucleic acid hybridization and method of use thereof
US5955379A (en) * 1996-04-25 1999-09-21 Mcgill University Biosensor device and method
US7014992B1 (en) * 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US6096273A (en) * 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
EP0958495B1 (en) * 1997-02-06 2002-11-13 Therasense, Inc. Small volume in vitro analyte sensor
US6391558B1 (en) * 1997-03-18 2002-05-21 Andcare, Inc. Electrochemical detection of nucleic acid sequences
US6210880B1 (en) * 1997-09-19 2001-04-03 Third Wave Technologies, Inc. Polymorphism analysis by nucleic acid structure probing with structure-bridging oligonucleotides
US6194149B1 (en) * 1998-03-03 2001-02-27 Third Wave Technologies, Inc. Target-dependent reactions using structure-bridging oligonucleotides
US5882904A (en) * 1997-08-04 1999-03-16 Amersham Pharmacia Biotech Inc. Thermococcus barossii DNA polymerase mutants
SE9703314D0 (en) * 1997-09-15 1997-09-15 Sangtec Medical Ab Capacity affinity sensor
JP2000033712A (en) * 1997-09-30 2000-02-02 Seiko Epson Corp Method for forming micro-sensor device and method for evaluating liquid function using the same
US6093302A (en) * 1998-01-05 2000-07-25 Combimatrix Corporation Electrochemical solid phase synthesis
US6063573A (en) * 1998-01-27 2000-05-16 Clinical Micro Sensors, Inc. Cycling probe technology using electron transfer detection
US6287776B1 (en) * 1998-02-02 2001-09-11 Signature Bioscience, Inc. Method for detecting and classifying nucleic acid hybridization
US6287874B1 (en) * 1998-02-02 2001-09-11 Signature Bioscience, Inc. Methods for analyzing protein binding events
JP2002501760A (en) * 1998-02-02 2002-01-22 アマーシャム・ファルマシア・バイオテック・アクチボラグ Nucleic acid analysis method
US6134461A (en) * 1998-03-04 2000-10-17 E. Heller & Company Electrochemical analyte
US6322963B1 (en) * 1998-06-15 2001-11-27 Biosensor Systems Design., Inc. Sensor for analyte detection
US6290839B1 (en) * 1998-06-23 2001-09-18 Clinical Micro Sensors, Inc. Systems for electrophoretic transport and detection of analytes
JP2002518998A (en) * 1998-06-24 2002-07-02 セラセンス、インク． Multi-sensor array and method for electrochemical recognition of nucleotide sequences
US6251260B1 (en) * 1998-08-24 2001-06-26 Therasense, Inc. Potentiometric sensors for analytic determination
US6281006B1 (en) * 1998-08-24 2001-08-28 Therasense, Inc. Electrochemical affinity assay
US6468785B1 (en) * 1999-02-19 2002-10-22 New Mexico State University Technology Transfer Corporation Doped conducting polymers applications and methods
AU778438B2 (en) * 1999-04-06 2004-12-02 Yale University Fixed address analysis of sequence tags
US6274320B1 (en) * 1999-09-16 2001-08-14 Curagen Corporation Method of sequencing a nucleic acid
US6518024B2 (en) * 1999-12-13 2003-02-11 Motorola, Inc. Electrochemical detection of single base extension
AU2001261145B2 (en) 2000-05-03 2005-08-11 The United States Government, As Represented By The Department Of The Navy Biological identification system with integrated sensor chip
SE0001669D0 (en) * 2000-05-04 2000-05-04 Forskarpatent I Syd Ab Monitoring of analytes at submicromolar with extremely high sensitivity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6100045A (en) * 1997-02-10 2000-08-08 Dsm N.V. Detection of analytes using electrochemistry
US5958701A (en) * 1999-01-27 1999-09-28 The United States Of America As Represented By The Secretary Of The Navy Method for measuring intramolecular forces by atomic force

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1341933A4 *

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AU2002241803A1 (en) 2002-06-18
US7223540B2 (en) 2007-05-29
CN1481441A (en) 2004-03-10
US20020155476A1 (en) 2002-10-24
WO2002047266A2 (en) 2002-06-13
EP1341933A4 (en) 2005-02-16
US20030152985A1 (en) 2003-08-14
EP1341933A2 (en) 2003-09-10

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