WO2002046472A3 - Nanoparticles having oligonucleotides attached thereto and uses therefor - Google Patents
Nanoparticles having oligonucleotides attached thereto and uses therefor Download PDFInfo
- Publication number
- WO2002046472A3 WO2002046472A3 PCT/US2001/046418 US0146418W WO0246472A3 WO 2002046472 A3 WO2002046472 A3 WO 2002046472A3 US 0146418 W US0146418 W US 0146418W WO 0246472 A3 WO0246472 A3 WO 0246472A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nanoparticles
- methods
- nucleic acid
- provides
- conjugates
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002230593A AU2002230593A1 (en) | 2000-12-08 | 2001-12-07 | Nanoparticles having oligonucleotides attached thereto and uses therefor |
EP01990826A EP1356109A2 (en) | 2000-12-08 | 2001-12-07 | Nanoparticles having oligonucleotides attached thereto and uses therefor |
Applications Claiming Priority (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25439200P | 2000-12-08 | 2000-12-08 | |
US25441800P | 2000-12-08 | 2000-12-08 | |
US60/254,418 | 2000-12-08 | ||
US60/254,392 | 2000-12-08 | ||
US25523600P | 2000-12-11 | 2000-12-11 | |
US25523500P | 2000-12-11 | 2000-12-11 | |
US60/255,236 | 2000-12-11 | ||
US60/255,235 | 2000-12-11 | ||
US09/760,500 US6767702B2 (en) | 1996-07-29 | 2001-01-12 | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US09/760,500 | 2001-01-12 | ||
US09/820,279 | 2001-03-28 | ||
US09/820,279 US6750016B2 (en) | 1996-07-29 | 2001-03-28 | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US28264001P | 2001-04-09 | 2001-04-09 | |
US60/282,640 | 2001-04-09 | ||
US09/927,777 | 2001-08-10 | ||
US09/927,777 US20020172953A1 (en) | 1996-07-29 | 2001-08-10 | Movement of biomolecule-coated nanoparticles in an electric field |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002046472A2 WO2002046472A2 (en) | 2002-06-13 |
WO2002046472A3 true WO2002046472A3 (en) | 2003-09-04 |
Family
ID=27575286
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/046418 WO2002046472A2 (en) | 2000-12-08 | 2001-12-07 | Nanoparticles having oligonucleotides attached thereto and uses therefor |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1356109A2 (en) |
AU (1) | AU2002230593A1 (en) |
WO (1) | WO2002046472A2 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7985539B2 (en) | 2002-05-07 | 2011-07-26 | Northwestern University | Nanoparticle probes with raman spectroscopic fingerprints for analyte detection |
US8323888B2 (en) | 1996-07-29 | 2012-12-04 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US11845986B2 (en) | 2016-05-25 | 2023-12-19 | Becton, Dickinson And Company | Normalization of nucleic acid libraries |
US11970737B2 (en) | 2019-08-26 | 2024-04-30 | Becton, Dickinson And Company | Digital counting of individual molecules by stochastic attachment of diverse labels |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6506564B1 (en) | 1996-07-29 | 2003-01-14 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US7098320B1 (en) | 1996-07-29 | 2006-08-29 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US6984491B2 (en) | 1996-07-29 | 2006-01-10 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
AU4043497A (en) | 1996-07-29 | 1998-02-20 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US6750016B2 (en) | 1996-07-29 | 2004-06-15 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US6974669B2 (en) | 2000-03-28 | 2005-12-13 | Nanosphere, Inc. | Bio-barcodes based on oligonucleotide-modified nanoparticles |
AU774593C (en) | 2000-01-13 | 2005-06-23 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
AU7687001A (en) | 2000-07-11 | 2002-01-21 | Nanospherre Inc | Method of detection by enhancement of silver staining |
JP4220397B2 (en) | 2001-11-09 | 2009-02-04 | ナノスフェアー インコーポレイテッド | Bioconjugate-nanoparticle probe |
US7153687B2 (en) | 2002-08-13 | 2006-12-26 | Hong Kong Dna Chips Limited | Apparatus and methods for detecting DNA in biological samples |
EP1867990A1 (en) * | 2006-06-14 | 2007-12-19 | Koninklijke Philips Electronics N.V. | Sensitive assay through amplification of a label signal |
EP1933144B1 (en) * | 2006-12-11 | 2011-09-28 | AraGen Biotechnology Co. Ltd. | Rapid immunochromatographic detection by amplification of the colloidal gold signal |
EP1933147B1 (en) * | 2006-12-11 | 2011-08-17 | AraGen Biotechnology Co. Ltd. | Rapid immunochromatographic detection by amplification of the colloidal gold signal |
EP1933141B1 (en) * | 2006-12-11 | 2011-08-17 | AraGen Biotechnology Co. Ltd. | Antigen detection method involving an oligonucleotide enhanced collodial gold signal |
EP1933142B1 (en) | 2006-12-11 | 2011-08-17 | AraGen Biotechnology Co. Ltd. | Rapid immunochromatographic detection by amplification of the colloidal gold signal |
EP1933139B1 (en) * | 2006-12-11 | 2011-09-28 | AraGen Biotechnology Co. Ltd. | Rapid immunochromatographic detection by amplification of the colloidal gold signal |
EP1933140B1 (en) * | 2006-12-11 | 2011-08-17 | AraGen Biotechnology Co. Ltd. | Antibody detection method involving an oligonucleotide enhanced collodial gold signal |
EP1933145B1 (en) * | 2006-12-11 | 2011-09-28 | AraGen Biotechnology Co. Ltd. | Rapid immunochromatographic detection by amplification of the colloidal gold signal |
CN102227631B (en) * | 2008-11-28 | 2014-04-23 | 英佛皮亚有限公司 | Method for amplification of signal in immunochromatographic assay and immunochromatographic kit using same |
US9335292B2 (en) | 2011-10-13 | 2016-05-10 | Auburn University | Electrochemical proximity assay |
SG11201405274WA (en) | 2012-02-27 | 2014-10-30 | Cellular Res Inc | Compositions and kits for molecular counting |
SG10201806890VA (en) | 2013-08-28 | 2018-09-27 | Cellular Res Inc | Massively parallel single cell analysis |
US9727810B2 (en) | 2015-02-27 | 2017-08-08 | Cellular Research, Inc. | Spatially addressable molecular barcoding |
EP3277843A2 (en) | 2015-03-30 | 2018-02-07 | Cellular Research, Inc. | Methods and compositions for combinatorial barcoding |
CN107580632B (en) | 2015-04-23 | 2021-12-28 | 贝克顿迪金森公司 | Methods and compositions for whole transcriptome amplification |
WO2017044574A1 (en) | 2015-09-11 | 2017-03-16 | Cellular Research, Inc. | Methods and compositions for nucleic acid library normalization |
US10640763B2 (en) | 2016-05-31 | 2020-05-05 | Cellular Research, Inc. | Molecular indexing of internal sequences |
US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
WO2018058073A2 (en) | 2016-09-26 | 2018-03-29 | Cellular Research, Inc. | Measurement of protein expression using reagents with barcoded oligonucleotide sequences |
CN110382708A (en) | 2017-02-01 | 2019-10-25 | 赛卢拉研究公司 | Selective amplification is carried out using blocking property oligonucleotides |
WO2018165566A1 (en) | 2017-03-09 | 2018-09-13 | Auburn University | Differential circuit for background correction in electrochemical measurements |
CA3059559A1 (en) | 2017-06-05 | 2018-12-13 | Becton, Dickinson And Company | Sample indexing for single cells |
WO2019010341A1 (en) | 2017-07-07 | 2019-01-10 | Innamed, Inc. | Aptamers for measuring lipoprotein levels |
JP7358388B2 (en) | 2018-05-03 | 2023-10-10 | ベクトン・ディキンソン・アンド・カンパニー | Molecular barcoding at opposite transcript ends |
US11773441B2 (en) | 2018-05-03 | 2023-10-03 | Becton, Dickinson And Company | High throughput multiomics sample analysis |
US11560565B2 (en) | 2018-06-13 | 2023-01-24 | Auburn University | Electrochemical detection nanostructure, systems, and uses thereof |
US11639517B2 (en) | 2018-10-01 | 2023-05-02 | Becton, Dickinson And Company | Determining 5′ transcript sequences |
US11932849B2 (en) | 2018-11-08 | 2024-03-19 | Becton, Dickinson And Company | Whole transcriptome analysis of single cells using random priming |
EP3894552A1 (en) | 2018-12-13 | 2021-10-20 | Becton, Dickinson and Company | Selective extension in single cell whole transcriptome analysis |
EP3914728B1 (en) | 2019-01-23 | 2023-04-05 | Becton, Dickinson and Company | Oligonucleotides associated with antibodies |
US11939622B2 (en) | 2019-07-22 | 2024-03-26 | Becton, Dickinson And Company | Single cell chromatin immunoprecipitation sequencing assay |
CN114729350A (en) | 2019-11-08 | 2022-07-08 | 贝克顿迪金森公司 | Obtaining full-length V (D) J information for immunohistorian sequencing using random priming |
WO2021146207A1 (en) | 2020-01-13 | 2021-07-22 | Becton, Dickinson And Company | Methods and compositions for quantitation of proteins and rna |
WO2021231779A1 (en) | 2020-05-14 | 2021-11-18 | Becton, Dickinson And Company | Primers for immune repertoire profiling |
US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
CN112698020B (en) * | 2020-11-12 | 2022-08-26 | 中山大学 | Multimodal coupling analysis method of cross response system based on DNA-AuNP coding |
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993025709A1 (en) * | 1992-06-09 | 1993-12-23 | Medical Research Council | Preparation of nucleic acids |
WO1998004740A1 (en) * | 1996-07-29 | 1998-02-05 | Nanosphere Llc | Nanoparticles having oligonucleotides attached thereto and uses therefor |
WO1998017317A2 (en) * | 1996-10-23 | 1998-04-30 | Skw Trostberg Aktiengesellschaft | Process for producing biologically active polymer nanoparticle-nucleic acid conjugates |
US5900481A (en) * | 1996-11-06 | 1999-05-04 | Sequenom, Inc. | Bead linkers for immobilizing nucleic acids to solid supports |
WO1999060169A1 (en) * | 1998-05-20 | 1999-11-25 | Molecular Machines, Inc. | Multimolecular devices, drug delivery systems and single-molecule selection |
-
2001
- 2001-12-07 AU AU2002230593A patent/AU2002230593A1/en not_active Abandoned
- 2001-12-07 EP EP01990826A patent/EP1356109A2/en not_active Withdrawn
- 2001-12-07 WO PCT/US2001/046418 patent/WO2002046472A2/en not_active Application Discontinuation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993025709A1 (en) * | 1992-06-09 | 1993-12-23 | Medical Research Council | Preparation of nucleic acids |
WO1998004740A1 (en) * | 1996-07-29 | 1998-02-05 | Nanosphere Llc | Nanoparticles having oligonucleotides attached thereto and uses therefor |
WO1998017317A2 (en) * | 1996-10-23 | 1998-04-30 | Skw Trostberg Aktiengesellschaft | Process for producing biologically active polymer nanoparticle-nucleic acid conjugates |
US5900481A (en) * | 1996-11-06 | 1999-05-04 | Sequenom, Inc. | Bead linkers for immobilizing nucleic acids to solid supports |
WO1999060169A1 (en) * | 1998-05-20 | 1999-11-25 | Molecular Machines, Inc. | Multimolecular devices, drug delivery systems and single-molecule selection |
Non-Patent Citations (3)
Title |
---|
LETSINGER ET AL: "Chemistry of oligonucleotide -gold nanoparticle conjugates", PHOSPHORUS, SULFUR AND SILICON AND THE RELATED ELEMENTS (1999), 144-146, 359-362, XP008019085 * |
LETSINGER R L ET AL: "Use of a steroid cyclic disulfide anchor in constructing gold nanoparticle- oligonucleotide conjugates.", BIOCONJUGATE CHEMISTRY, (2000 MAR-APR) 11 (2) 289-91., XP002205939 * |
LI ZHI ET AL: "Multiple thiol-anchor capped DNA -gold nanoparticle conjugates.", NUCLEIC ACIDS RESEARCH, (2002 APR 1) 30 (7) 1558-62., XP002205940 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8323888B2 (en) | 1996-07-29 | 2012-12-04 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US7985539B2 (en) | 2002-05-07 | 2011-07-26 | Northwestern University | Nanoparticle probes with raman spectroscopic fingerprints for analyte detection |
US11845986B2 (en) | 2016-05-25 | 2023-12-19 | Becton, Dickinson And Company | Normalization of nucleic acid libraries |
US11970737B2 (en) | 2019-08-26 | 2024-04-30 | Becton, Dickinson And Company | Digital counting of individual molecules by stochastic attachment of diverse labels |
Also Published As
Publication number | Publication date |
---|---|
EP1356109A2 (en) | 2003-10-29 |
WO2002046472A2 (en) | 2002-06-13 |
AU2002230593A1 (en) | 2002-06-18 |
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