WO2002044713A3 - Flow through device for two dimensional incubation and/or hybridization on solid supports - Google Patents

Flow through device for two dimensional incubation and/or hybridization on solid supports Download PDF

Info

Publication number
WO2002044713A3
WO2002044713A3 PCT/EP2001/014222 EP0114222W WO0244713A3 WO 2002044713 A3 WO2002044713 A3 WO 2002044713A3 EP 0114222 W EP0114222 W EP 0114222W WO 0244713 A3 WO0244713 A3 WO 0244713A3
Authority
WO
WIPO (PCT)
Prior art keywords
incubation
solid support
test fluid
disc
reservoir
Prior art date
Application number
PCT/EP2001/014222
Other languages
French (fr)
Other versions
WO2002044713A2 (en
Inventor
Fredericus Bernardu Thunnissen
F Nijpels
Original Assignee
Dot Diagnostics B V
Fredericus Bernardu Thunnissen
F Nijpels
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dot Diagnostics B V, Fredericus Bernardu Thunnissen, F Nijpels filed Critical Dot Diagnostics B V
Priority to AU2002220747A priority Critical patent/AU2002220747A1/en
Publication of WO2002044713A2 publication Critical patent/WO2002044713A2/en
Publication of WO2002044713A3 publication Critical patent/WO2002044713A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/29—Mixing by periodically deforming flexible tubular members through which the material is flowing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/65—Mixers with shaking, oscillating, or vibrating mechanisms the materials to be mixed being directly submitted to a pulsating movement, e.g. by means of an oscillating piston or air column
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics

Abstract

The present invention provides flow through devices for incubation and/or hybridisation on two-dimensional solid supports. In a first device the following parts are provided: a. a solid support comprising a target for binding; b. a support holder i) comprising the solid support as one of the walls including an incubation space, ii) two reservoirs on one each side of the incubation space where the first one allows test fluid to be entered into the incubation space, and the second one allowing collection of the test fluid; c. means for providing pressure, allowing transport of the test fluid from one reservoir to the other; d. a control system for moving the fluid from one reservoir along the incubation chamber to the other reservoir and back, allowing repeated exposure of test fluid components to the component present on the solid support. In a second device the following parts are provided: a. a solid support comprising a target for binding, b. a wall of the support holder opposite to the solid support, part of which consisting of one or more roatable disc(s), c. a mechanical system for controlled rotating of the disc(s), d. means for controlling the inflow of test fluid, and rotating the disc(s). The invention also comprises assemblies in which two or more of the above devices are combined.
PCT/EP2001/014222 2000-11-30 2001-11-30 Flow through device for two dimensional incubation and/or hybridization on solid supports WO2002044713A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002220747A AU2002220747A1 (en) 2000-11-30 2001-11-30 Flow through device for two dimensional incubation and/or hybridization on solid supports

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00204277 2000-11-30
NL00204277.8 2000-11-30

Publications (2)

Publication Number Publication Date
WO2002044713A2 WO2002044713A2 (en) 2002-06-06
WO2002044713A3 true WO2002044713A3 (en) 2002-09-19

Family

ID=8172365

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/014222 WO2002044713A2 (en) 2000-11-30 2001-11-30 Flow through device for two dimensional incubation and/or hybridization on solid supports

Country Status (2)

Country Link
AU (1) AU2002220747A1 (en)
WO (1) WO2002044713A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6913931B2 (en) 2002-10-03 2005-07-05 3M Innovative Properties Company Devices, methods and systems for low volume microarray processing

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4726889A (en) * 1986-02-04 1988-02-23 Oncor, Inc. Process and apparatus for conducting electrophoresis and transfer
US5188963A (en) * 1989-11-17 1993-02-23 Gene Tec Corporation Device for processing biological specimens for analysis of nucleic acids
US5382511A (en) * 1988-08-02 1995-01-17 Gene Tec Corporation Method for studying nucleic acids within immobilized specimens
WO2001054814A2 (en) * 2000-01-26 2001-08-02 Motorola, Inc. Compositions and methods for performing biological reactions

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4726889A (en) * 1986-02-04 1988-02-23 Oncor, Inc. Process and apparatus for conducting electrophoresis and transfer
US5382511A (en) * 1988-08-02 1995-01-17 Gene Tec Corporation Method for studying nucleic acids within immobilized specimens
US5188963A (en) * 1989-11-17 1993-02-23 Gene Tec Corporation Device for processing biological specimens for analysis of nucleic acids
WO2001054814A2 (en) * 2000-01-26 2001-08-02 Motorola, Inc. Compositions and methods for performing biological reactions

Also Published As

Publication number Publication date
AU2002220747A1 (en) 2002-06-11
WO2002044713A2 (en) 2002-06-06

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