WO2002044276A3 - Polyalkylene glycol viscosity-enhancing polymeric formulations - Google Patents

Polyalkylene glycol viscosity-enhancing polymeric formulations Download PDF

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Publication number
WO2002044276A3
WO2002044276A3 PCT/US2001/044769 US0144769W WO0244276A3 WO 2002044276 A3 WO2002044276 A3 WO 2002044276A3 US 0144769 W US0144769 W US 0144769W WO 0244276 A3 WO0244276 A3 WO 0244276A3
Authority
WO
WIPO (PCT)
Prior art keywords
viscosity
tissue
polyalkylene glycol
mixture
hyaluronic acid
Prior art date
Application number
PCT/US2001/044769
Other languages
French (fr)
Other versions
WO2002044276A2 (en
Inventor
Luis Z Avila
Peter K Jarrett
Hildegard Kramer
Michael C Philbrook
Original Assignee
Focal Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22960435&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2002044276(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Focal Inc filed Critical Focal Inc
Priority to DE60135784T priority Critical patent/DE60135784D1/en
Priority to JP2002546630A priority patent/JP2004514778A/en
Priority to EP01998596A priority patent/EP1370610B1/en
Priority to AU2002219935A priority patent/AU2002219935A1/en
Priority to CA002430130A priority patent/CA2430130A1/en
Publication of WO2002044276A2 publication Critical patent/WO2002044276A2/en
Publication of WO2002044276A3 publication Critical patent/WO2002044276A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/041—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/043—Mixtures of macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides

Abstract

Hyaluronic acid and polyalkylene glycol (PAG) based materials have been found to exhibit a synergistic interaction, in which the viscosity of the mixture is more than twice as high as the viscosity expected from the viscosity of the individual components. The mixture otherwise has similar properties to those of its constituents, and in particular will crosslink to form covalently crosslinked gels if the PEG carries crosslinkable groups. The viscous formulation adheres well to tissue, and has applications as a tissue sealant and in tissue coating, prevention of adhesions, cell immobilization, regeneration of cartilage, bone and other tissue, as well as in controlled delivery of hyaluronic acid to sites in the body. Related materials exhibit similar effects.
PCT/US2001/044769 2000-11-28 2001-11-28 Polyalkylene glycol viscosity-enhancing polymeric formulations WO2002044276A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE60135784T DE60135784D1 (en) 2000-11-28 2001-11-28 THE VISCOSITY OF POLYALKYLENE GLYCOL INCREASING POLYMERS FORMULATIONS
JP2002546630A JP2004514778A (en) 2000-11-28 2001-11-28 Polyalkylene glycol viscosity enhancing polymer formulation
EP01998596A EP1370610B1 (en) 2000-11-28 2001-11-28 Polyalkylene glycol viscosity-enhancing polymeric formulations
AU2002219935A AU2002219935A1 (en) 2000-11-28 2001-11-28 Polyalkylene glycol viscosity-enhancing polymeric formulations
CA002430130A CA2430130A1 (en) 2000-11-28 2001-11-28 Polyalkylene glycol viscosity-enhancing polymeric formulations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25347700P 2000-11-28 2000-11-28
US60/253,477 2000-11-28

Publications (2)

Publication Number Publication Date
WO2002044276A2 WO2002044276A2 (en) 2002-06-06
WO2002044276A3 true WO2002044276A3 (en) 2003-03-20

Family

ID=22960435

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/044769 WO2002044276A2 (en) 2000-11-28 2001-11-28 Polyalkylene glycol viscosity-enhancing polymeric formulations

Country Status (8)

Country Link
US (1) US7074424B2 (en)
EP (1) EP1370610B1 (en)
JP (1) JP2004514778A (en)
AT (1) ATE407975T1 (en)
AU (1) AU2002219935A1 (en)
CA (1) CA2430130A1 (en)
DE (1) DE60135784D1 (en)
WO (1) WO2002044276A2 (en)

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AR039744A1 (en) * 2002-06-26 2005-03-09 Alza Corp METHODS AND DOSAGE FORMS TO INCREASE THE SOLUBILITY OF PHARMACOS COMPOSITIONS FOR CONTROLLED ADMINISTRATION
US20050232995A1 (en) 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
US6992127B2 (en) * 2002-11-25 2006-01-31 Ast Products, Inc. Polymeric coatings containing a pH buffer agent
WO2005010080A1 (en) * 2003-07-28 2005-02-03 Teijin Limited Temperature-responsive hydrogel
US20050058707A1 (en) * 2003-08-06 2005-03-17 Iran Reyes Uniform delivery of topiramate over prolonged period of time with enhanced dispersion formulation
EP1658048A2 (en) * 2003-08-22 2006-05-24 ALZA Corporation Stepwise delivery of topiramate over prolonged period of time
CA2551815A1 (en) * 2003-12-29 2005-07-21 Alza Corporation Novel drug compositions and dosage forms
US20050175696A1 (en) * 2003-12-29 2005-08-11 David Edgren Drug granule coatings that impart smear resistance during mechanical compression
US7544671B2 (en) * 2004-05-07 2009-06-09 S.K. Pharmaceuticals, Inc. Stabilized hyaluronan preparations and related methods
US8288362B2 (en) 2004-05-07 2012-10-16 S.K. Pharmaceuticals, Inc. Stabilized glycosaminoglycan preparations and related methods
US20050281866A1 (en) * 2004-05-24 2005-12-22 Genzyme Corporation Adherent polymeric compositions
US20060140988A1 (en) * 2004-12-23 2006-06-29 Guohua Chen Visco-supplement composition and methods
US8414907B2 (en) * 2005-04-28 2013-04-09 Warsaw Orthopedic, Inc. Coatings on medical implants to guide soft tissue healing
US9119901B2 (en) 2005-04-28 2015-09-01 Warsaw Orthopedic, Inc. Surface treatments for promoting selective tissue attachment to medical impants
CA2621604A1 (en) * 2005-09-07 2007-03-15 Amo Regional Holdings Bi-modal hyaluronate solution
ES2285910B1 (en) * 2005-09-08 2008-12-16 Vicente Tormo Maicas PROCEDURE FOR THE ELABORATION OF THE FORMULA OF SODIUM HYALURONATE FOR THE HEALING AND CICATRIZATION OF WOUNDS.
AU2006321912B2 (en) * 2005-12-06 2012-07-12 Covidien Lp Carbodiimide crosslinking of functionalized polethylene glycols
GB0608359D0 (en) * 2006-04-28 2006-06-07 Johnson Matthey Plc Catalyst additives
CA2658646A1 (en) * 2006-07-25 2008-01-31 Osmotica Corp. Ophthalmic solutions
US20090105561A1 (en) * 2007-10-17 2009-04-23 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Medical or veterinary digestive tract utilization systems and methods
KR101406743B1 (en) 2009-01-13 2014-06-20 페르가뭄 아베 Hylauronic acid containing compositions for treatment of wounds, scars, post-surgical adhesion formation
MX2012012001A (en) * 2010-04-16 2013-05-01 Apatech Ltd Biomaterial.
KR102493613B1 (en) * 2010-05-07 2023-01-31 유니버시티 오브 노스캐롤라이나 앳 채플 힐 Method of engrafting cells from solid tissues
CN102988274B (en) * 2010-09-08 2015-01-28 上海市肿瘤研究所 Sustained-release blood vessel embolic gel used for treating tumor, and preparation method thereof
TWI413535B (en) * 2010-12-09 2013-11-01 Yung Kai Lin Thremosensitivity hydrogel for tissue engineering and use thereof
TWI544922B (en) 2011-05-19 2016-08-11 愛爾康研究有限公司 High concentration olopatadine ophthalmic composition
US10279079B2 (en) 2011-07-05 2019-05-07 The Research Foundation For The State University Of New York Compositions and methods for spinal disc repair and other surgical and non-surgical indications
KR101269423B1 (en) * 2011-12-22 2013-05-30 오스템임플란트 주식회사 Hydrogel with controllable biodegradation behavior and the manufacturing method thereof
WO2014028209A1 (en) * 2012-08-14 2014-02-20 The Trustees Of The University Of Pennsylvania Stabilizing shear-thinning hydrogels
CN112203828B (en) * 2018-04-19 2023-06-09 聚合-医药有限公司 Macromers and compositions for use in a photocuring process
US20220249700A1 (en) * 2019-05-13 2022-08-11 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Polymer-based implant for retinal therapy and methods of making and using the same
US20210094226A1 (en) * 2019-09-26 2021-04-01 The Curators Of The University Of Missouri Oxidation polymerization additive manufacturing
CN116077731A (en) * 2021-11-05 2023-05-09 重庆医科大学附属口腔医院 Tissue repair material based on giant salamander skin secretion and application thereof

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US3325472A (en) * 1964-06-18 1967-06-13 Mortimer D Sackler Polycyclohexose-polyoxyethyleneglycol suppository bases
EP0138572A2 (en) * 1983-10-11 1985-04-24 FIDIA S.p.A. Hyaluronic acid fractions having pharmaceutical activity, methods for preparation thereof, and pharmaceutical compositions containing the same
US4629623A (en) * 1984-06-11 1986-12-16 Biomatrix, Inc. Hyaluronate-poly (ethylene oxide) compositions and cosmetic formulations thereof
US5068225A (en) * 1987-05-04 1991-11-26 Mdr Group, Inc. Viscoelastic fluid for use in surgery and other therapies and method of using same
EP0466300A2 (en) * 1990-07-09 1992-01-15 Biomatrix, Inc. Biocompatible viscoelastic gel slurries, their preparation and use
US6133325A (en) * 1997-06-17 2000-10-17 Fziomed, Inc. Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions

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Patent Citations (6)

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Publication number Priority date Publication date Assignee Title
US3325472A (en) * 1964-06-18 1967-06-13 Mortimer D Sackler Polycyclohexose-polyoxyethyleneglycol suppository bases
EP0138572A2 (en) * 1983-10-11 1985-04-24 FIDIA S.p.A. Hyaluronic acid fractions having pharmaceutical activity, methods for preparation thereof, and pharmaceutical compositions containing the same
US4629623A (en) * 1984-06-11 1986-12-16 Biomatrix, Inc. Hyaluronate-poly (ethylene oxide) compositions and cosmetic formulations thereof
US5068225A (en) * 1987-05-04 1991-11-26 Mdr Group, Inc. Viscoelastic fluid for use in surgery and other therapies and method of using same
EP0466300A2 (en) * 1990-07-09 1992-01-15 Biomatrix, Inc. Biocompatible viscoelastic gel slurries, their preparation and use
US6133325A (en) * 1997-06-17 2000-10-17 Fziomed, Inc. Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions

Also Published As

Publication number Publication date
EP1370610B1 (en) 2008-09-10
JP2004514778A (en) 2004-05-20
EP1370610A2 (en) 2003-12-17
US7074424B2 (en) 2006-07-11
AU2002219935A1 (en) 2002-06-11
ATE407975T1 (en) 2008-09-15
WO2002044276A2 (en) 2002-06-06
DE60135784D1 (en) 2008-10-23
US20020127196A1 (en) 2002-09-12
CA2430130A1 (en) 2002-06-06

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