WO2002042261A3 - PROCESS FOR PREPARING α-(3-ARYLTHIO)-ACETOPHENONES - Google Patents
PROCESS FOR PREPARING α-(3-ARYLTHIO)-ACETOPHENONES Download PDFInfo
- Publication number
- WO2002042261A3 WO2002042261A3 PCT/US2001/042939 US0142939W WO0242261A3 WO 2002042261 A3 WO2002042261 A3 WO 2002042261A3 US 0142939 W US0142939 W US 0142939W WO 0242261 A3 WO0242261 A3 WO 0242261A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- preparing
- acetophenones
- arylthio
- compound
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002228593A AU2002228593A8 (en) | 2000-11-27 | 2001-11-14 | Process for preparing alpha-(3-arylthio)-acetophenones |
AU2002228593A AU2002228593A1 (en) | 2000-11-27 | 2001-11-14 | Process for preparing alpha-(3-arylthio)-acetophenones |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25307300P | 2000-11-27 | 2000-11-27 | |
US60/253,073 | 2000-11-27 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2002042261A2 WO2002042261A2 (en) | 2002-05-30 |
WO2002042261A3 true WO2002042261A3 (en) | 2003-03-06 |
WO2002042261A8 WO2002042261A8 (en) | 2008-04-24 |
Family
ID=22958714
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/042939 WO2002042261A2 (en) | 2000-11-27 | 2001-11-14 | PROCESS FOR PREPARING α-(3-ARYLTHIO)-ACETOPHENONES |
Country Status (2)
Country | Link |
---|---|
AU (2) | AU2002228593A1 (en) |
WO (1) | WO2002042261A2 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6921827B2 (en) | 2000-11-27 | 2005-07-26 | Eli Lilly And Company | Process for preparing 3-aryl-benzo{b} thiophenes |
EP1826205A1 (en) | 2002-09-30 | 2007-08-29 | A/S GEA Farmaceutisk Fabrik | Novel raloxifene succinic acid addition salts and/or solvates thereof, and pharmaceutical compositions comprising these |
DE10309645A1 (en) | 2003-03-06 | 2004-09-16 | Basf Ag | Process for the preparation of a- (3-arylthio) acetophenones |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
-
2001
- 2001-11-14 WO PCT/US2001/042939 patent/WO2002042261A2/en not_active Application Discontinuation
- 2001-11-14 AU AU2002228593A patent/AU2002228593A1/en not_active Abandoned
- 2001-11-14 AU AU2002228593A patent/AU2002228593A8/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
Non-Patent Citations (3)
Title |
---|
A.D. PALKOWITZ, ET AL.: "Discovery and synthesis of [6-hydroxy-3-[4-[2-(1- piperdinyl)-ethoxy]phenoxy]-2-(4- hydroxyphenyl)]benzo[b]thiophene: a novel, highly potent, selective oestrogen receptor modulator", JOURNAL OF MEDICINAL CHEMISTRY, vol. 40, no. 10, 9 May 1997 (1997-05-09), American Chemical Society, Washington, DC, US, pages 1407 - 1416, XP002217620, ISSN: 0022-2623 * |
C.D. JONES, ET AL.: "Antioestrogens. 2. Structure-activity studies in a series of 3-aroyl-2-arylbenzo[b]thiophene derivatives leading to [6-hydroxy-2-(4- hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1- piperidinyl)ethoxy]phenyl]methanone hydrochloride (LY156758), a remarkably effective oestrogen anganonist", JOURNAL OF MEDICINAL CHEMISTRY, vol. 27, no. 8, August 1984 (1984-08-01), American Chemical Society, Washington, DC, US, pages 1057 - 1066, XP000560343, ISSN: 0022-2623 * |
S. KIM, ET AL.: "A facile synthesis of 3-aryl-substituted-benzothiophenes via a Lewis acid mediated cyclisation of 2-arylthio-acetophenones", TETRAHEDRON LETTERS, vol. 40, no. 15, 1999, Elsevier Science Publishers, Amsterdam, NL, pages 2909 - 2912, XP001068955, ISSN: 0040-4039 * |
Also Published As
Publication number | Publication date |
---|---|
WO2002042261A8 (en) | 2008-04-24 |
AU2002228593A1 (en) | 2002-06-03 |
AU2002228593A8 (en) | 2008-06-12 |
WO2002042261A2 (en) | 2002-05-30 |
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