WO2002039906A2 - Method and device for the treatment of vulnerable tissue site - Google Patents
Method and device for the treatment of vulnerable tissue site Download PDFInfo
- Publication number
- WO2002039906A2 WO2002039906A2 PCT/US2001/048354 US0148354W WO0239906A2 WO 2002039906 A2 WO2002039906 A2 WO 2002039906A2 US 0148354 W US0148354 W US 0148354W WO 0239906 A2 WO0239906 A2 WO 0239906A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- containment member
- tissue site
- containment
- vulnerable
- lumen
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/88—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/064—Surgical staples, i.e. penetrating the tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12009—Implements for ligaturing other than by clamps or clips, e.g. using a loop with a slip knot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
- A61B2017/0406—Pledgets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
- A61B2017/0409—Instruments for applying suture anchors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
- A61B2017/0417—T-fasteners
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/064—Surgical staples, i.e. penetrating the tissue
- A61B2017/0649—Coils or spirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
- A61F2002/072—Encapsulated stents, e.g. wire or whole stent embedded in lining
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
- A61F2002/075—Stent-grafts the stent being loosely attached to the graft material, e.g. by stitching
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
- A61F2002/077—Stent-grafts having means to fill the space between stent-graft and aneurysm wall, e.g. a sleeve
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0008—Fixation appliances for connecting prostheses to the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0028—Shapes in the form of latin or greek characters
- A61F2230/0054—V-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
- A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
Definitions
- This invention relates to the fields of intervention, surgery, and more particularly to method and apparatus for treatment of aneurysms.
- An aneurysm is a condition in which a portion of a vessel has a weakened wall that results in the expansion of the vessel due to internal pressures.
- Aneurysm may be an aortic aneurysm occurring in the abdominal area or in other areas, including but not limited to: aneurysm in the thoracic aorta and neurovascular aneurysms.
- Aortic aneurysm results from abnormal dilation of the artery wall and is often associated with arteriosclerotic disease. Unless treated, an aneurysm can rupture, leading to severe and often fatal hemorrhaging. Treating an aortic aneurysm generally involves transplanting a prosthetic graft to bridge or bypass the affected portion of the aorta. Surgical implantation of the graft is possible but this treatment causes considerable trauma, results in high mortality and morbidity and, even when completely successful, requires a lengthy recuperation period. Due to the difficulty of the operation, surgical replacement is even less attractive when it must be performed on an emergency basis after the aneurysm has ruptured.
- a less invasive alternative involves the use of a catheter for intraluminal delivery of a graft.
- Graft delivery systems can employ a graft with expandable portions that anchor the graft in the aorta. Often, the systems use an inflatable balloon on the delivery catheter to expand the anchoring portion of the graft as disclosed in U.S. Pat. No. 5,275,622 (Lazarus et al.) which is hereby incorporated in its entirety by reference thereto.
- This latter example requires the use of a bulky capsule to store the graft and a complicated pushrod system to deploy the graft.
- the success of a percutaneous vessel repair depends in large part on getting the graft to the location of the vasculature in need of repair and deploying the graft effectively.
- a difficulty associated with graft deployment and its effectiveness is blood flow-by which occurs when blood can pass between the graft and the patient's vessel wall, bypassing the graft.
- aneurysm repair is the treatment of an aneurysm by placing radiopaque materials within an aneurysm pouch. For example, it is known to push embolic coils through an introducer catheter. However, once the embolic coils leave the introducer catheter they are no longer under control and may become repositioned away from the desired location.
- vein grafts implanted as a bypass graft in CABG procedures.
- a disadvantage of a vein graft is that it may degrade over time as a result of the vein structure not being adept to effectively handle high arterial pressure (e.g., being a weaker structure against pressure), thereby degrading and occluding over time.
- the vein graft has degraded or occluded thus making it difficult to salvage or treat.
- the present invention is directed to a method and apparatus for treating vulnerable tissue sites such as aneurysms in the abdominal or thoracic aorta.
- vulnerable tissue sites such as aneurysms in the abdominal or thoracic aorta.
- Other applications of for the method and apparatus of the present invention include neurovascular aneurysms, veins, vein grafts, and expanded or thinned tissues on various organs and body surfaces.
- the apparatus of the present invention is directed to containment members for at least partially containing a vulnerable tissue site, thus preventing or minimizing the further vulnerability or growth of the site. Additionally, or alternatively, the containment members can apply resistive force to the vulnerable tissue site. The force can be compressive against the exterior surface of the tissue site.
- the containment members of the present invention can be used alone or in combination with support members, such as stent/grafts, in treating a tissue site.
- the support member is disposed within the inner lumen of the vulnerable tissue site with the containment member disposed on the exterior surface of the lumen.
- the containment members may totally encircle the vulnerable tissue site or they may be disposed about less than the entire circumference of body lumen including the vulnerable tissue site.
- the containment members have a containment surface of sufficient dimensions to at least partially encircle a region of the vulnerable tissue.
- the containment member can be configured to provide a compressive force against the vulnerable tissue.
- the containment members may be configured for attachment to a positioning member.
- the positioning member can be configured for securing the containment member to an adjacent tissue site or body part to minimize further vulnerability of the tissue site.
- the positioning member is configured to be biased against an adjacent healthy tissue site or body part.
- the various embodiments of the containment members of the present invention can be configured to deliver agents, such as therapeutic agents, to the tissue site. Additionally, the containment members can be configured to accommodate different anatomical settings having vulnerable tissue sites.
- the embodiments include but are not limited to strands, coils, sheaths, omega shaped coils for structures that can not be looped around entirely, and inflatable containment members.
- the containment member may be formed of polymeric or metallic material to remain in place until the removal of the same, or in the alternative may be formed of bio-degradable material, degrading over a period of time.
- the containment members of the present invention may be introduced to the vulnerable tissue site in one of several ways, including: (1 ) surgical methods, such as cut-down or laparoscopically; (2) intra-endoscopically, i.e., through the same body conduit or lumen as the one including the vulnerable tissue; and (3) inter-endoscopically, i.e., through, at least in part, a body conduit or lumen adjacent the conduit which has the vulnerable tissue.
- the containment member is advanced through the first lumen of the first tubular member including the vulnerable tissue site and through an access site in a wall of the first tubular member and is disposed about an exterior surface of the tissue site.
- the access site is part of a second tubular body member having a second lumen and disposed, at least in part, substantially parallel and adjacent the tissue site.
- the containment member is advanced through the second tubular body and through the access site located in a wall of the second tubular body and disposed about an exterior surface of the tissue site.
- the containment member can be disposed about the exterior surface of the first body lumen which includes the vulnerable tissue site alone or together with the exterior surface of the second body lumen.
- vulnerable tissue site includes, without limitation, any tissue site which is or can be weakened, enlarged, thickened, or thinned, either permanently or periodically (as for example during different phases, cycles, or conditions).
- the vulnerable tissue may be present in any area of a host body, such as but not limited to: cardiovascular or neurovascular arteries or veins, vein grafts such as saphenous vein graft for a pass surgery, aorta including abdominal and thoracic, vena cava including inferior and superior, organs such as stomach or glands.
- the vulnerable tissue site may be native to the intracorporeal body or it may be a transplanted intracorporeal body such as a saphenous vein graft introduced to the body as a result of a procedure such as bypass before it becomes weakened as a result of its new environment.
- a transplanted intracorporeal body such as a saphenous vein graft introduced to the body as a result of a procedure such as bypass before it becomes weakened as a result of its new environment.
- FIG. 1 is an elevational view, partially cut away view of a containment member embodying features of the present invention.
- FIG. 2 is another embodiment of a containment member embodying features of the present invention taking the form of a coil.
- FIG. 3A is a side elevational view of a vulnerable tissue site.
- FIG. 3B is a side elevational view of the vulnerable tissue site of FIG. 3A having the containment member disposed about its exterior surface.
- FIG. 4A is a side elevational view of an embodiment of the containment member of FIG. 2 including apertures.
- FIG. 4B is a transverse cross-sectional view of the containment member of FIG. 4A taken along lines 4B-4B.
- FIG. 4C is a transverse cross-sectional view of the containment member of FIG. 4A taken along lines 4C-4C.
- FIG. 5A is another embodiment of a containment member embodying features of the present invention and having a plurality of strands and having a circular cross section.
- FIG. 5B is another embodiment of a containment member embodying features of the present invention and having a plurality of strands having a flat cross section.
- FIGS. 6A-6C are transverse cross sectional views of containment members embodying features of the present invention and having different cross-sectional shapes.
- FIG. 7 is an elevational view of another embodiment of a containment member having a double helix configuration.
- FIG. 8 is an elevational view of a an omega shaped containment member.
- FIG. 9 is an elevation view of another embodiment of a containment member including longitudinal strands with transverse connecting member.
- FIG. 10 is an elevational view of a containment member including two sheets disposed around the exterior surface of a strand.
- FIG. 10A is a cross sectional view of the containment member of FIG. 10 taken along lines 10A-10A.
- FIGS. 1 1 A and 1 1 B are side elevational views of the containment member of FIG. 10 in a disposed configuration.
- FIG. 1 1 C is a side elevational view of the containment member i of FIG. 10 disposed around the exterior surface of a body lumen with the edges of the containment member being longitudinally set apart.
- FIG. 12 is an elevational view of another embodiment of a containment member including a plurality of strands disposed substantially parallel to one another and sealed between two sheets.
- FIG. 13 is an elevational view of another embodiment of the containment member of FIG. 12 including an inflation pocket defined between the two sheets.
- FIG. 14, 15A and 15B are side elevational views of containment members including sheets disposed about longitudinal strands and further including transverse connecting member, the longitudinal strands having solid or hollow cross-sections.
- FIG. 16-18 are side elevational views of different embodiments of transverse connecting.
- FIG. 19 is a side elevational view of a containment member having a fluid pocket.
- FIG. 20 is a cross sectional view of the containment member of
- FIG. 19 taken along line 20-20 with the strand being hollow.
- FIG. 21 is a cross sectional view of the containment member of FIG. 19 taken along line 21 -21 with the strand being solid.
- FIG. 22A is a top elevational view of a containment member disposed on an exterior surface a vulnerable tissue site being secured to a body tissue mass.
- FIG. 22B is a side elevational view of the tissue site of FIG. 22A showing the reduction in size of the tissue site at different time or phase intervals.
- FIG. 22C is a front elevational view of a region of a vulnerable tissue site, with a containment member having a containment surface of sufficient dimensions to at least partially encircle the region of vulnerable tissue, the containment member being secured to adjacent healthy tissue by positioning member such as a suture.
- FIG. 22D is a front elevational view of a region of a vulnerable tissue site, with a containment member having a containment surface of sufficient dimensions to at least partially encircle the region of vulnerable tissue and being in substantial contact with the vulnerable tissue site, the containment member being secured to adjacent healthy tissue by positioning member such as a suture.
- FIG. 22E is a front elevational view of a region of a vulnerable tissue site, with a containment member having a containment surface of sufficient dimensions to at least partially encircle the region of vulnerable tissue, the containment member being secured to adjacent healthy body part by positioning member such as a strut.
- FIG. 22F is a front elevational view of a region of a vulnerable tissue site, with a containment member having a containment surface of sufficient dimensions to at least partially encircle the region of vulnerable tissue and being in substantial contact with the vulnerable tissue site, the containment member being secured to adjacent healthy body part by positioning member such as a strut.
- FIG. 23 is a side elevational view of a vulnerable tissue site showing the various access locations.
- FIGS. 24-29 are schematic side elevational views of the steps of a surgical method of the present invention disposing a containment member about the exterior surface of a first body lumen including the vulnerable tissue site.
- FIGS. 30-35 are schematic side elevational views of the steps of another surgical method disposing a containment member about the exterior surface of the first body lumen including the vulnerable tissue site and a second body lumen substantially parallel and adjacent the first body lumen.
- FIG. 36-43 are schematic side elevational views of the steps of another surgical method disposing a containment member about the exterior surface of the first body lumen which includes peripheral branches.
- FIG. 44-47 are schematic side elevational views of the steps of an intra-endoscopic method introducing a containment member through an inner lumen of the first body lumen and being disposed about the exterior surface of the first body lumen.
- FIG. 48-53 are schematic side elevational views of the steps of an inter-endoscopic method introducing a containment member through an inner lumen of the second body lumen and being disposed about the exterior surface of the first body lumen.
- FIG. 54-59 are schematic side elevational views of the steps of another intra-endoscopic method introducing a containment member through an inner lumen of the first body lumen and being disposed about the exterior surface of the first and second body lumens.
- FIGS. 60-62 are schematic side elevational views of the steps of another intra-endoscopic method introducing a containment member through an inner lumen of the first body lumen and being disposed about the exterior surface of the first and second body lumens and further including an elongate glide for securing the containment member to the tissue site.
- FIGS. 63-65 are schematic side elevational views of the containment members embodying features of the present invention and disposed about the outer surface of host body such as an organ, showing the reduction in size of the organ at the vulnerable tissue site, immediately, over time, or at phase intervals.
- FIGS. 66A-66C are side elevational views of the containment members embodying features of the present invention used in combination with a stent graft.
- FIGS. 67A-67C are side elevational views of the containment members embodying features of the present invention used in combination with a stent graft with the two ends of the containment member defining a neck and extending onto the adjacent healthy tissue site.
- FIGS. 1 and 2 illustrate containment members 10 and 10A embodying features of the invention, generally including a strand 13, preferably having atraumatic proximal and distal tips, 16 and 19.
- the containment member 10, preferably, is wound in a helical configuration as generally depicted as 10A in FIG. 2.
- the containment member 10 forms, as in containment member 10A of
- FIG. 2 can be shaped to form, a tubular body 25 having open proximal and distal ends, 28 and 31 , respectively, with a containment lumen 34 extending longitudinally therebetween, and defining an interior surface 37.
- a vulnerable tissue site 40 such as that shown in FIGS. 3A and 3B
- the interior surface 37 of the containment member 10 comes into contact, at least in part, with an exterior surface 43 of the vulnerable tissue site 40, thus containing, at least in part, the vulnerable tissue site.
- the containment member 10 in the disposed configuration, can apply resistive force to the tissue site, aiding in the minimizing the further vulnerability of the vulnerable tissue site.
- the containment member 10 can also apply a compressive force against the exterior of the vulnerable tissue.
- the strand 13 may be formed of any suitable material such as polymeric or metallic materials, including thermoplastic and thermosets; stainless steel, nickel titanium alloys such as Nitinol, and precipitation hardenable material.
- the precipitation hardenable material preferably, is formed of at least two material selected from the group consisting of nickel, cobalt, molybdenum, chromium, tungsten, and iron; and a combination thereof.
- Such precipitation hardenable material include, but are not limited to, AISI (American Iron and Steel Institute) Type 600 series precipitation hardenable stainless steel; chromium- nickel based single stage martensitic precipitation hardenable stainless steel having modified proportions of chromium and nickel and with additional elements of copper and titanium, commercially available from Carpenter Steel Company of Reading, Pa., under the designation 455PH or 17-7PH; and a precipitation hardenable steel available under the trade designation 1 RK91 from Sweden Steel.
- Other suitable precipitation hardenable stainless steel include those which are essentially "nickel free” such as those sold under the designation BioDur 108, available from Carpenter's Specialty Alloys Operations, Reading, Pa.
- the nominal composition of BioDur is chromium (21 %), manganese (23%), nitrogen (1 %), nickel (less than 0.3%), and iron (balance).
- Suitable precipitation hardenable material include cobalt based alloys such as those including nickel, cobalt, molybdenum and chromium, also commercially available under the designation MP35N (UNS (Unified Numbering System) R30035) available from Carpenter
- the strand 13 may be formed of biodegradable material, preferably degrading over a period of time, as for example few days to years, preferably within 1 to 10 months.
- the biodegradable material may be formed from any suitable bio- compatible material such as, but not limited to: enzymatically degradable polymers including polypeptices such as collagens, gelatin, poly(amino acids); polysaccharides such as amylose cellulose, dextran, chitin; polyesters such as poly(Vhydroxyalkanoates), pHB (poly Vhydroxybutyrate); and nucleic Acids; or nonenzymatically degradable polymers, including, polyesters such as aliphatic polyesters, as for example, PLA (polylactic acid), PGA (polyglycolic acid), co-polymer of PLA/PGA; poly (ester-ethers) such as PEG
- poly(ethylene glycol) poly(ethylene glycol)); poly caprolactones; and poly (amide-esters).
- vulnerable tissue site refers to any tissue site which is or can be weakened, enlarged, thickened, or thinned, either permanently or periodically (as for example during different phases, cycles, or conditions).
- the vulnerable tissue may be present in any area of a host body, such as but not limited to: cardiovascular or neurovascular arteries and veins, aorta including abdominal and thoracic, vena cava including inferior and superior, organs such as stomach or glands, and vein grafts.
- the containment member 10 and other embodiments of the same, will be further discussed in reference to the figures below, wherein like reference represent like elements.
- the containment member 10 can, optionally, include, one or more connecting bodies 46, for connecting adjacent turns 49 and 52 of the containment member.
- the containment member 10 for aortic aneurysms preferably, has a disposed inner diameter ranging from about 0.25 to about 4 inches, more preferably, from about 0.75 to about 2.5 inches; with a disposed outer diameter ranging from about 0.27 to about 5 inches, more preferably, from about 0.77 to about 2.6 inches; and a disposed length ranging from about 1 to about 30 cm (with a straight length ranging from about 1 to about 50 cm), more preferably, from about 5 to about 20 cm.
- the containment member 10 inner and outer diameters and length may vary in size from those stated above for other applications and size of the vulnerable tissue site on which the containment member 10 is to be disposed.
- the containment member in a disposed but unstrained (or relaxed) condition can have an inner diameter substantially the same or slightly larger than a first thickness (outer diameter of the tissue site) of the vulnerable tissue site; substantially larger than the thickness of the vulnerable tissue site; about 25% larger than the thickness of the vulnerable tissue site; substantially between the first thickness of the vulnerable tissue site and second thickness of a healthy tissue site adjacent the vulnerable tissue site; substantially the same as the second thickness of the adjacent tissue site; or slightly smaller, for example 10% smaller than the second thickness of the adjacent tissue site.
- Adjacent tissue site refers to a tissue site which is adjacent the vulnerable tissue site and is substantially healthy, or adjacent body part, including but not limiting to tissue sites, bones, organs, etc.
- the containment member 10A preferably, has a pitch (distance between adjacent turns), ranging from about 0.01 to about 3 inches, more preferably, from about 0.04 to about 1 inch.
- the containment member 10B is formed of a hollow strand 13B having a strand lumen 34 extending therein, and further including one or more apertures 58 extending between the lumen 34 and an strand outer surface 61.
- the strand lumen 34, and the apertures 58 when present, are configured to deliver fluids, such as therapeutic fluids, to and/or from the vulnerable tissue 40.
- the apertures 58 may be used to deliver a hardenable material, including bio-degradable and permanent materials, preferably, bio-degradable over time (such as those described above in reference to strand material) to the outer surface of the vulnerable tissue site.
- the hardenable material may be delivered to the exterior surface of the vulnerable tissue site by another delivery device, such as a catheter. It should be appreciated that the delivery of the hardenable material can occur, after, concurrently with, or prior to the placement of the containment member on the vulnerable tissue site.
- the hardenable material itself can be the containment member left in place permanently, or degradable over time.
- the containment member can take any suitable shape necessary for at least partially containing the vulnerable tissue site.
- the containment member 10 is generally shown in 10C and 10D respectively and includes a plurality of strands 13, 5 A in-phase and 5B out of phase, having varying cross sections, as for example, substantially circular as shown in FIG. 6A, substantially flat as in FIG. 6B, substantially triangular as in FIG. 6C, or other shapes as dictated by a particular application or anatomy.
- the containment member 10E includes a multiple helix configuration having two counter helix strands 13E and 13F.
- the strands 13E and 13F can have identical or differing diameters (inner and/or outer).
- the counter helix strands 13E and 13F forming the double helix containment member 10E can interlock by alternating inner and outer positions as shown in FIG. 7.
- the proximal and distal ends of the counter helix strands 13E and 13F, or portions along their length can be joined by suitable means, such as connecting member 46 as shown in FIG. 7, and means in the form of a ring 70 as shown in FIG. 8.
- the embodiment shown in FIG. 8 can be a containment member having a omega shape for containing vulnerable tissue sites, such as those attached to other tissue and or organs such as bones.
- One or more omega shaped containment members loops, at least partially, around the vulnerable tissue site, thus containing the site.
- the legs of the containment member can be affixed or secured to the vulnerable tissue site, or an adjacent structure such as a bone, with adhesive, staples suture, or strand; or when multiple containment members are used, each leg can be connected to a leg of another containment member.
- the containment member 10G includes a plurality of longitudinal strands 13 transversely set apart, with transverse connecting member 76 disposed about the inner or outer surface of the longitudinal strands 13 securing the relative position of the longitudinal strands 13.
- the transverse connecting member 76 may be only secured to the corresponding underlying longitudinal strands 13, or they may be additionally linked to one another through linking member 79.
- Transverse connecting member 76 and linking member 79 can, independently, be made of any suitable material such as those described above with reference to the strand 13.
- containment members of the present invention described above may further include one or more sheets disposed around the exterior surface of one or more strands.
- an enlarged section of a containment member 10H is shown having a strand 13 sealingly disposed between two sheets or strips of film or mesh 82.
- the exterior surface of one or more of the strips of film, or any strand or containment member can include a securing material such as a adhesion promoting material or time-release adhesive, such as fibrin or cyanoacrylate, to aid in securing the containment member
- the containment member 10H to the outer surface 43 of the vulnerable tissue 40.
- the containment member 10H forms, preferably, a helical configuration with the edges of the attached films 82 overlapping, to form a tubular structure 25A.
- the containment member 10H is, preferably, disposed about the exterior of the vulnerable tissue site 40 such that the side having the securing material comes into contact, at least in part, with the outer surface 43 of the vulnerable tissue site 40.
- edges of the containment member 10H may be longitudinally set apart by a gap 85.
- FIG. 12 an enlarged section of a containment member 10J prior to being disposed about the vulnerable tissue is shown in FIG. 12.
- a plurality of strands 13 of the containment member 10J are disposed substantially parallel to one another and are sealed between two sheets or strips of film or mesh 82, as described above in relation to FIG. 10.
- the two films 82 together define an inflation pocket 88 sealingly and fluidically connectable to a source of inflation fluid.
- the inflation pocket 88 can be used to inflate, with a fluid (liquid or gas), the containment member 10K thus exerting pressure on the vulnerable tissue site 40.
- a fluid liquid or gas
- FIGS. 15A and 15B an enlarged section of a containment member 10L is shown having longitudinal strands 13 disposed between two sheets or strips of film or mesh 82, with transverse connecting member 76 disposed on the outer or the inner sheets or therebetween.
- the longitudinal strands 13 may be solid or hollow (or have closed proximal and distal ends), as shown in FIGS. 15A and 15B, respectively.
- transverse connecting member 90 includes a generally annular body 93 with averted ends 96 which may be used to secure the transverse connecting member 90 about the longitudinal strand 13. As shown in FIG. 16, the two averted ends 96 may be secured in place on either side of the longitudinal strand 13 in rings 99 located on an outer surface of the outer sheet 82. Alternatively, and as shown in FIG. 17, ends 96 of transverse connecting member 90A may hold sutures or other means for connecting the containment member to other containment members or tissue site. Alternatively, the member shown in FIG. 17 can itself be a containment member to be disposed about the vulnerable tissue site individually or in multiples (as discussed in reference to FIG. 8).
- transverse connecting member 90B can include a substantially longitudinal portion 102 with a plurality of encircling portions 105 for encircling the longitudinal strands.
- containment member 10N includes a fluid pocket 108 defined between the outer surface of strand 13 and inner surface of sheath 82.
- the fluid pocket 108 is fluidically connectable to a source of therapeutic fluid for delivering the fluid to the vulnerable tissue and/or the surrounding tissue sites through sheath apertures 1 1 1 .
- the strand 13 may be hollow as shown in FIG. 20 or solid as shown in
- FIG 21 features of a containment member 10P are shown containing a vulnerable tissue site 40A which is located on a body site 1 15 secured to body tissue mass.
- the containment member 10P includes strands 13 and is disposed about less than the circumference of the vulnerable tissue site 40A.
- the containment member 10P is secured to the vulnerable tissue site 40A or adjacent tissue site by sutures 1 18 or other suitable securing means.
- the containment member 10P may be used to apply pressure onto the vulnerable tissue site 40A, thereby reducing its size as it is reduced from 40A to 40B to 40C.
- the containment member 10R can have a containment member surface 37A of sufficient dimensions to at least partially encircle at least a region 121 of the vulnerable tissue 40.
- the containment member 10R is configured for attachment to a positioning member, such as 125A in the form of a suture or C ring, or 125B in the form of a strut.
- the containment members may be positioned to simply act as a means to minimize future vulnerability of the site (i.e., initially there is not substantial contact between the vulnerable tissue and the containment member), as for example depicted in FIGS. 22C & E; or to apply force against the vulnerable tissue (FIGS. 22D and F).
- the containment member can be biased against adjacent healthy tissue site or body part (including bones).
- the containment members of the present invention may be introduced to the vulnerable tissue site in one of several ways, including: (1 ) surgical methods, such as cut-down or laparoscopically; (2) intra-endoscopically, i.e., through the same body conduit or lumen as the one including the vulnerable tissue; and (3) inter-endoscopically, i.e., through, at least in part, a body conduit or lumen adjacent the conduit which has the vulnerable tissue.
- (1 ) surgical methods such as cut-down or laparoscopically
- intra-endoscopically i.e., through the same body conduit or lumen as the one including the vulnerable tissue
- inter-endoscopically i.e., through, at least in part, a body conduit or lumen adjacent the conduit which has the vulnerable tissue.
- an access site for accessing the vulnerable tissue site may be above or below the vulnerable tissue site 40, as for example, directly above or below, or proximal or distal to the site, as indicated by 150, 153, 156 and 159, respectively.
- FIGS. 24-29 schematically depict a procedure whereby a containment member 10R, under imaging guidance; such as fluoroscopic techniques, ultrasound (e.g. catheter-based on external), angioscope, direct visualization, MRI, (including catheter-based and external), and CT scan; is disposed about the exterior surface of an vulnerable tissue site 40D of a patient included in a first body lumen 167.
- the containment member 10R is introduced over the surface of the aneurysm by percutaneous means through a lumen 170 of a catheter 173 through an access site 176, the containment member
- the catheter may be in the form of a hypotube or tubular member.
- a distal end of the catheter may include a curve, or may form a curve on demand.
- the catheter can be formed of any conventional material for forming such devices.
- the distal end 183 of catheter 173 is advanced to a location, distal or proximal, to the aneurysm 10R. Using a suitable mechanism such as a pusher rod, the containment member 10R is then advanced within the inner lumen 170 of the catheter 173, preferably, the catheter having a detachment mechanism 186 disposed at the catheter distal end 183 (FIG. 28).
- the detachment mechanism 186 is detachably secured to a proximal end 189 of the containment member 10R which allows proximal manipulation of the delivery system 180 to control axial advancement and retraction containment member 10R within the catheter 173 and the patient.
- the containment member 10R is then distally advanced out of a port 190 in the distal end 183 of the catheter 173 along the exterior surface of a body site which includes the vulnerable tissue 40, so as to contain at least a portion of the length of the vulnerable tissue 40.
- the containment member 10R is appropriately positioned, the containment member 10R is detached from the delivery system 180 and is left in place and the catheter 173 is withdrawn from the body.
- the catheter 173 catheter can have multiple lumens (e.g.
- the catheter can also be inserted through a guiding catheter or sleeve having a pre-set shape at it is distal end according to the anatomy to be treated.
- the catheter can be a fixed wire type, over the wire type, or rapid exchange type.
- the containment member 10R may be advanced onto the exterior surface of the aneurysm in an ascending direction, as shown in the figures, or in a descending direction, depending on the location of the introduction of the catheter; from above or below the site.
- detachment mechanisms include polymeric links susceptible to chain cleavage upon degradation of the polymer link, mechanical detachment, electrolytic detachment, shape memory metal or polymer activation via a temperature change by application of RF energy, laser energy, ultrasonic energy, heating of a hot melt adhesive joint, ultrasonic joint degradation, hydrokinetic activation of a mechanical retaining device, and the like.
- RF energy radio frequency
- laser energy laser energy
- ultrasonic energy heating of a hot melt adhesive joint
- ultrasonic joint degradation hydrokinetic activation of a mechanical retaining device, and the like.
- the containment member 10R may be disposed about both the first body lumen 168 including the vulnerable tissue 40D and a second body lumen 193 substantially parallel to or adjacent the first body lumen.
- the containment member 10R is laparoscopically introduced through the access site 176 and is advanced and disposed about, at least in part, both the esophagus as the second body lumen and the vulnerable tissue site 40D (e.g. aneurysm) located in the aorta as the first body lumen.
- the vulnerable tissue site 40D e.g. aneurysm
- the vulnerable tissue 40D may be located in a part of the body which includes peripheral branches, as for example, peripheral branches of aorta.
- FIGS. 36-43 show the steps associated with disposing the containment member 10R about the exterior surface of the first body lumen 167 which includes peripheral branches 196.
- a helical containment member 10A similar to that previously shown in FIG. 2 (or one or more omega shaped containment members such as that shown in FIG. 8 ).
- the helical configuration of the containment member allows the advancement of the containment member along the exterior surface of the length of the first body lumen without being impeded by the peripheral branches.
- the containment member may optionally be secured in place by the use of a suitable device 200 to tie or tighten the coils with suture 1 18 or other means.
- a suitable device 200 to tie or tighten the coils with suture 1 18 or other means.
- the containment member may be secured in place by the application of heat or energy, thus, transforming its size and dimensions.
- the containment member can be pre-shaped to the desired configuration
- the containment member assumes the desired disposed shape.
- the catheter 173 is introduced through an inner lumen 203 of a first body lumen 167 which includes the vulnerable tissue 40D, from a location proximal or distal (above or below) to the vulnerable tissue. Similar to the surgical method, the catheter 173 is advanced along the interior lumen 203 of the first body lumen 167 to an access point 210 being proximal or distal to the vulnerable tissue 40D, at which point the catheter 173 is advanced through wall 213 of the first body lumen 167 and unto the exterior surface of the first body lumen (or body site). The containment member is then advanced onto the vulnerable tissue similar to the surgical method described above. Now referring to FIG.
- the catheter 173 is introduced through an inner lumen 370 of the second body lumen 193 extending either or both substantially parallel, at least in part, and adjacent, at least in part, to the first body lumen 137 which includes the vulnerable tissue 4D.
- the catheter 173 is then advanced through access site 219 located in a wall of the second body lumen and unto the exterior surface of the first body lumen (or body site).
- the containment member 10R is then advanced onto the vulnerable tissue similar to the surgical method described above.
- the inter-endoscopic method is particularly useful when a relatively easily accessible second body lumen lies substantially parallel or adjacent to the first body lumen having the vulnerable tissue.
- the esophagus can be a suitable second lumen for accessing the aneurysm located in the thoracic aorta.
- the containment member 10R may be disposed, at least in part, along the exterior surface of both the first and the second body lumens, 167 and 193, once it exits the wall of the second body lumen.
- the catheter 173 may be equipped to deliver an elongate glide 221 used to secure the containment member 10R along the exterior surface of the first body lumen 167.
- the glide 221 includes loops 224 along its length. Once advanced out of the catheter 173, the glide 2210 is secured to the first body lumen at various points along its length.
- the containment member 10R as it is being advanced along the exterior surface of the length of the vulnerable tissue, is looped through the glide loops 224, thus, becoming secure in place.
- sutures can be passed through one or more of the glide loops to secure the glide to the first body lumen.
- the containment member 10R may be secured to the exterior surface of the vulnerable tissue site by other suitable means, such as adhesives.
- suitable means such as adhesives.
- containment member 10S can be advanced by way of any one of the methods described above and disposed on the exterior surface of the organ. In operation, one or more individual containment members may be disposed on the organ in the same or differing orientations, as shown in the FIGS. 63-65.
- the containment member may only act to contain the vulnerable tissue site minimizing its further growth or it may apply pressure or compressive force on the vulnerable tissue site 40 tissue thereby reducing its size, as depicted in Figures 63, 64A and 64B; and or 65A, 65B, and 65C.
- the containment members of the present invention can be used in conjunction with a stent/graft 230.
- the containment member 10T is shown enclosing longitudinally, at least in part, the vulnerable tissue 40.
- the containment member may only contain the vulnerable tissue site or it may act to reduce its size, immediately or over time, as shown in FIG. 66C.
- FIG. 66C Alternatively, as shown in FIG.
- either or both the proximal and distal ends of the containment member 10V can extend to cover healthy tissue 235 (i.e., not-vulnerable tissue) on either or both sides of the vulnerable tissue 40 or compress vulnerable tissue to define a neck, whereby, the compression of the containment member 10V onto the vulnerable tissue site aids in creation of a neck 242 thereby aiding in the securing of the of the stent/graft 230 within the body lumen of the aneurysm.
- the containment members may contain the vulnerable tissue site 40 with or without application of pressure to the site.
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01985031A EP1397088A2 (en) | 2000-11-20 | 2001-11-19 | Method and device for the treatment of vulnerable tissue sites |
CA002446472A CA2446472A1 (en) | 2000-11-20 | 2001-11-19 | Method and device for the treatment of vulnerable tissue site |
AU2002234021A AU2002234021A1 (en) | 2000-11-20 | 2001-11-19 | Method and device for the treatment of vulnerable tissue site |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/717,910 | 2000-11-20 | ||
US09/717,910 US6648911B1 (en) | 2000-11-20 | 2000-11-20 | Method and device for the treatment of vulnerable tissue site |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002039906A2 true WO2002039906A2 (en) | 2002-05-23 |
WO2002039906A3 WO2002039906A3 (en) | 2003-05-30 |
Family
ID=24883982
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/048354 WO2002039906A2 (en) | 2000-11-20 | 2001-11-19 | Method and device for the treatment of vulnerable tissue site |
Country Status (5)
Country | Link |
---|---|
US (2) | US6648911B1 (en) |
EP (1) | EP1397088A2 (en) |
AU (1) | AU2002234021A1 (en) |
CA (1) | CA2446472A1 (en) |
WO (1) | WO2002039906A2 (en) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004026178A3 (en) * | 2002-09-19 | 2004-06-24 | Exstent Ltd | External stent |
EP1617788A1 (en) * | 2003-02-28 | 2006-01-25 | Edward G. Shifrin | Extravenous corrector for repair of incompetent venous valves |
WO2006082493A2 (en) | 2005-02-04 | 2006-08-10 | Zuli Holdings, Ltd. | Device and methods for non-surgical clipping of aneurysms |
EP1713453A2 (en) * | 2004-02-13 | 2006-10-25 | Conor Medsystems, Inc. | Implantable drug delivery device including wire filaments |
WO2007061538A2 (en) * | 2005-11-22 | 2007-05-31 | Boston Scientific Limited | Shape memory hemostasis band |
WO2007109007A1 (en) * | 2006-03-17 | 2007-09-27 | Gore Enterprise Holdings, Inc. | Endoprosthesis having multiple helically wound flexible framework elements |
EP2417934A1 (en) * | 2010-08-10 | 2012-02-15 | Sangomed S.R.L. | Stent-based extra-venous support for venous valve repair |
US8246673B2 (en) | 2002-09-19 | 2012-08-21 | Exstent Limited | External support for a blood vessel |
WO2012149205A1 (en) * | 2011-04-27 | 2012-11-01 | Dolan Mark J | Nerve impingement systems including an intravascular prosthesis and an extravascular prosthesis and associated systems and methods |
EP2931140A4 (en) * | 2012-12-11 | 2016-08-10 | Dolly Jeanne Holt | Tissue repair devices and methods |
DE102015121374A1 (en) | 2015-12-08 | 2017-06-08 | Otto-Von-Guericke-Universität Magdeburg | Clip for the treatment of aneurysms and closure of tubular anatomical structures |
DE102019106488A1 (en) * | 2019-03-14 | 2020-09-17 | Advanced Angioneers UG (haftungsbeschränkt) | Endoluminally insertable exovascular (perivascular) device and device for improving the elasticity of a stiffened blood vessel |
Families Citing this family (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060178727A1 (en) * | 1998-12-03 | 2006-08-10 | Jacob Richter | Hybrid amorphous metal alloy stent |
US8382821B2 (en) | 1998-12-03 | 2013-02-26 | Medinol Ltd. | Helical hybrid stent |
US8202312B2 (en) * | 2000-03-01 | 2012-06-19 | Medinol Ltd. | Longitudinally flexible stent |
US8496699B2 (en) * | 2000-03-01 | 2013-07-30 | Medinol Ltd. | Longitudinally flexible stent |
US7621947B2 (en) * | 2000-03-01 | 2009-11-24 | Medinol, Ltd. | Longitudinally flexible stent |
US6723119B2 (en) * | 2000-03-01 | 2004-04-20 | Medinol Ltd. | Longitudinally flexible stent |
US7141062B1 (en) * | 2000-03-01 | 2006-11-28 | Medinol, Ltd. | Longitudinally flexible stent |
US7828835B2 (en) * | 2000-03-01 | 2010-11-09 | Medinol Ltd. | Longitudinally flexible stent |
US8920487B1 (en) | 2000-03-01 | 2014-12-30 | Medinol Ltd. | Longitudinally flexible stent |
US7758627B2 (en) * | 2000-03-01 | 2010-07-20 | Medinol, Ltd. | Longitudinally flexible stent |
US20040097927A1 (en) * | 2001-02-13 | 2004-05-20 | Yeung Jeffrey E. | Intervertebral disc repair |
SE519069C2 (en) * | 2001-05-21 | 2003-01-07 | Cid Cardivascular Innovation D | Surgical marker and an implant |
US6953473B2 (en) * | 2001-12-20 | 2005-10-11 | Boston Scientific Scimed, Inc. | Detachable device with electrically responsive element |
US9155639B2 (en) | 2009-04-22 | 2015-10-13 | Medinol Ltd. | Helical hybrid stent |
US9039755B2 (en) | 2003-06-27 | 2015-05-26 | Medinol Ltd. | Helical hybrid stent |
WO2005037138A2 (en) * | 2003-10-14 | 2005-04-28 | Peacock James C Iii | Aneurysm treatment system and method |
WO2005039458A2 (en) * | 2003-10-23 | 2005-05-06 | Proxy Biomedical Limited | “a gastric constriction device” |
DE10355986A1 (en) * | 2003-11-27 | 2005-06-30 | Forschungszentrum Karlsruhe Gmbh | compression sleeve |
US20080027531A1 (en) * | 2004-02-12 | 2008-01-31 | Reneker Darrell H | Stent for Use in Cardiac, Cranial, and Other Arteries |
US20050266042A1 (en) * | 2004-05-27 | 2005-12-01 | Medtronic Vascular, Inc. | Methods and apparatus for treatment of aneurysmal tissue |
US7763064B2 (en) | 2004-06-08 | 2010-07-27 | Medinol, Ltd. | Stent having struts with reverse direction curvature |
WO2006026425A2 (en) | 2004-08-25 | 2006-03-09 | Spine Wave, Inc. | Expandable interbody fusion device |
US7695506B2 (en) * | 2004-09-21 | 2010-04-13 | Boston Scientific Scimed, Inc. | Atraumatic connections for multi-component stents |
BRPI0516955A (en) * | 2004-09-24 | 2008-09-30 | Ingeneus Inc | genetic assay |
DE102004046840A1 (en) * | 2004-09-27 | 2006-04-06 | Forschungszentrum Karlsruhe Gmbh | Application device for compression sleeves |
US20060106406A1 (en) * | 2004-09-27 | 2006-05-18 | Judah Weinberger | Methods and devices for extravascular intervention |
US20060069426A1 (en) * | 2004-09-27 | 2006-03-30 | Weinberger Judah Z | Methods and devices for extravascular intervention |
WO2006072926A2 (en) * | 2005-01-09 | 2006-07-13 | Shifrin Edward G | External repair of incompetent venous valves |
US8864808B2 (en) * | 2005-09-21 | 2014-10-21 | The Cleveland Clinic Foundation | Endoluminal delivery assembly |
DE102005053958A1 (en) * | 2005-11-11 | 2007-05-16 | Occlutech Gmbh | Medical self-expanding occlusion instrument for treating heart defects in patients by closing abnormal tissues openings comprises a network of thin threads made from a shape memory polymer composition |
GB0614773D0 (en) * | 2006-07-25 | 2006-09-06 | Carton Edge Systems Ltd | A cutting strip, a carton including a cutting strip and a method of making a cutting strip |
US8187315B1 (en) | 2006-12-08 | 2012-05-29 | Cardica, Inc. | Partial stent for treatment of a vascular aneurysm |
CN101715329B (en) | 2007-03-05 | 2012-11-14 | 恩多斯潘有限公司 | Multi-component expandable supportive bifurcated endoluminal grafts and methods for using same |
US9603730B2 (en) | 2007-12-12 | 2017-03-28 | Intact Vascular, Inc. | Endoluminal device and method |
US10166127B2 (en) | 2007-12-12 | 2019-01-01 | Intact Vascular, Inc. | Endoluminal device and method |
US8128677B2 (en) | 2007-12-12 | 2012-03-06 | Intact Vascular LLC | Device and method for tacking plaque to a blood vessel wall |
US10022250B2 (en) | 2007-12-12 | 2018-07-17 | Intact Vascular, Inc. | Deployment device for placement of multiple intraluminal surgical staples |
US9375327B2 (en) | 2007-12-12 | 2016-06-28 | Intact Vascular, Inc. | Endovascular implant |
US7896911B2 (en) | 2007-12-12 | 2011-03-01 | Innovasc Llc | Device and method for tacking plaque to blood vessel wall |
US8486131B2 (en) * | 2007-12-15 | 2013-07-16 | Endospan Ltd. | Extra-vascular wrapping for treating aneurysmatic aorta in conjunction with endovascular stent-graft and methods thereof |
US8992593B2 (en) * | 2007-12-26 | 2015-03-31 | Cook Medical Technologies Llc | Apparatus and methods for deployment of a modular stent-graft system |
US8728145B2 (en) | 2008-12-11 | 2014-05-20 | Cook Medical Technologies Llc | Low profile non-symmetrical stents and stent-grafts |
US9180030B2 (en) | 2007-12-26 | 2015-11-10 | Cook Medical Technologies Llc | Low profile non-symmetrical stent |
GB2476451A (en) * | 2009-11-19 | 2011-06-29 | Cook William Europ | Stent Graft |
GB2475494B (en) * | 2009-11-18 | 2011-11-23 | Cook William Europ | Stent graft and introducer assembly |
US9226813B2 (en) | 2007-12-26 | 2016-01-05 | Cook Medical Technologies Llc | Low profile non-symmetrical stent |
US8574284B2 (en) * | 2007-12-26 | 2013-11-05 | Cook Medical Technologies Llc | Low profile non-symmetrical bare alignment stents with graft |
WO2010048671A1 (en) * | 2008-10-30 | 2010-05-06 | Macquarie University | Vessel support device and methods for supporting a vessel |
US20100121278A1 (en) * | 2008-11-13 | 2010-05-13 | David Fowler | Super elastic loop extraluminal materials delivery instrument |
WO2010150208A2 (en) | 2009-06-23 | 2010-12-29 | Endospan Ltd. | Vascular prostheses for treating aneurysms |
US9757263B2 (en) * | 2009-11-18 | 2017-09-12 | Cook Medical Technologies Llc | Stent graft and introducer assembly |
CN102740807B (en) | 2009-11-30 | 2015-11-25 | 恩多斯潘有限公司 | For implantation into the multi-part overlay film frame system had in the blood vessel of multiple branch |
WO2011070576A1 (en) | 2009-12-08 | 2011-06-16 | Endospan Ltd. | Endovascular stent-graft system with fenestrated and crossing stent-grafts |
DE102010010483B4 (en) * | 2010-02-28 | 2017-02-09 | Björn H. Koslar | Medical implant |
US8702776B2 (en) | 2010-04-26 | 2014-04-22 | Paul Heltai | Method for deploying a sleeve and tubing device for restricting and constricting aneurysms and a sleeve and tubing device and system |
WO2011139521A2 (en) * | 2010-04-26 | 2011-11-10 | Paul Andre Heltai | Sleeve and tubing device for restricting and constricting aneurysms and a system and method for using such a device |
US20110277778A1 (en) * | 2010-05-14 | 2011-11-17 | Tyco Healthcare Group Lp | System and Method for Diverticulitis Treatment |
US9855046B2 (en) | 2011-02-17 | 2018-01-02 | Endospan Ltd. | Vascular bands and delivery systems therefor |
EP2680788A4 (en) | 2011-03-02 | 2014-12-10 | Endospan Ltd | Reduced-strain extra- vascular ring for treating aortic aneurysm |
US10390977B2 (en) | 2011-06-03 | 2019-08-27 | Intact Vascular, Inc. | Endovascular implant |
US9433722B2 (en) * | 2011-08-09 | 2016-09-06 | Abbott Cardiovascular Systems Inc. | Vascular shield and delivery system |
US9839510B2 (en) | 2011-08-28 | 2017-12-12 | Endospan Ltd. | Stent-grafts with post-deployment variable radial displacement |
WO2013065040A1 (en) | 2011-10-30 | 2013-05-10 | Endospan Ltd. | Triple-collar stent-graft |
EP2785277B1 (en) | 2011-12-04 | 2017-04-05 | Endospan Ltd. | Branched stent-graft system |
CN107028691B (en) | 2012-01-25 | 2019-08-16 | 因特脉管有限公司 | Intracavitary unit and method |
US9770350B2 (en) | 2012-05-15 | 2017-09-26 | Endospan Ltd. | Stent-graft with fixation elements that are radially confined for delivery |
WO2014098811A2 (en) * | 2012-12-18 | 2014-06-26 | Empire Technology Development, Llc | Helical vascular reinforcement device |
US9283096B2 (en) * | 2012-12-18 | 2016-03-15 | Empire Technology Development Llc | Vascular reinforcement device |
US9668892B2 (en) | 2013-03-11 | 2017-06-06 | Endospan Ltd. | Multi-component stent-graft system for aortic dissections |
WO2015075708A1 (en) | 2013-11-19 | 2015-05-28 | Endospan Ltd. | Stent system with radial-expansion locking |
EP3068339B1 (en) | 2014-12-18 | 2017-11-01 | Endospan Ltd. | Endovascular stent-graft with fatigue-resistant lateral tube |
US9375336B1 (en) | 2015-01-29 | 2016-06-28 | Intact Vascular, Inc. | Delivery device and method of delivery |
US9433520B2 (en) | 2015-01-29 | 2016-09-06 | Intact Vascular, Inc. | Delivery device and method of delivery |
US10188538B2 (en) | 2015-12-30 | 2019-01-29 | Cook Medical Technologies Llc | Hybrid trigger wire for endografts |
US10993824B2 (en) | 2016-01-01 | 2021-05-04 | Intact Vascular, Inc. | Delivery device and method of delivery |
US11660218B2 (en) | 2017-07-26 | 2023-05-30 | Intact Vascular, Inc. | Delivery device and method of delivery |
KR102428946B1 (en) * | 2020-10-08 | 2022-08-03 | 연세대학교 산학협력단 | Drug delivery device and method of drug delivering using the same |
KR102428943B1 (en) * | 2020-10-08 | 2022-08-03 | 연세대학교 산학협력단 | Drug delivery stent, method of fabricating thereof and method of delivering drug using the same |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993015671A1 (en) * | 1992-02-14 | 1993-08-19 | Endomedix Corporation | Devices for enclosing, manipulating, debulking and removing tissue through minimal access incisions |
US5562685A (en) * | 1994-09-16 | 1996-10-08 | General Surgical Innovations, Inc. | Surgical instrument for placing suture or fasteners |
WO1997040755A1 (en) * | 1996-04-29 | 1997-11-06 | W.L. Gore & Associates, Inc. | Device for restoring competence to venous valves |
US5868700A (en) * | 1992-05-01 | 1999-02-09 | Voda; Jan | Preformed coronary artery guide catheter |
US5910129A (en) * | 1996-12-19 | 1999-06-08 | Ep Technologies, Inc. | Catheter distal assembly with pull wires |
WO1999033509A1 (en) * | 1997-12-30 | 1999-07-08 | Cardima, Inc. | Deflectable guiding catheter |
WO1999035979A1 (en) * | 1998-01-13 | 1999-07-22 | Lumend, Inc. | Methods and apparatus for crossing total occlusions in blood vessels |
WO2000016700A1 (en) * | 1998-09-21 | 2000-03-30 | Myocor, Inc. | External stress reduction device and method |
US6053891A (en) * | 1996-08-26 | 2000-04-25 | Decampli; William M. | Apparatus and methods for providing selectively adjustable blood flow through a vascular graft |
WO2000025717A2 (en) * | 1998-10-31 | 2000-05-11 | Kuebeler Harald | Device for covering and protecting an injury, especially a wound, of an indwelling venous cannula or the like |
WO2000043062A1 (en) * | 1999-01-22 | 2000-07-27 | Cardeon Corporation | Aortic catheter with flow divider and methods for preventing cerebral embolization |
Family Cites Families (175)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2533004A (en) | 1943-10-27 | 1950-12-05 | John D Ferry | Fibrin clots and methods for preparing the same |
US2642874A (en) | 1951-06-04 | 1953-06-23 | Wilmer B Keeling | Instrument for treating prostate glands |
US3089815A (en) | 1951-10-11 | 1963-05-14 | Lieb Hans | Injectable pharmaceutical preparation, and a method of making same |
US2854982A (en) | 1958-01-22 | 1958-10-07 | Vito V Pagano | Nasopharyngeal tube |
US3223083A (en) | 1960-09-09 | 1965-12-14 | President And Directors Of Geo | Method for adhesively securing together skin and other soft tissue and bone |
US3221745A (en) | 1962-09-12 | 1965-12-07 | Eastman Kodak Co | Method of bonding body tissue together using methylenemalonic acid esters |
US3620218A (en) | 1963-10-31 | 1971-11-16 | American Cyanamid Co | Cylindrical prosthetic devices of polyglycolic acid |
US3438374A (en) | 1966-02-28 | 1969-04-15 | Us Health Education & Welfare | Method of bonding tissue surfaces and controlling hemorrhaging thereof using a tissue adhesive and hemostatic composition |
US3523807A (en) | 1966-11-25 | 1970-08-11 | Mihaly Gerendas | Method of making a cross-linked fibrin prosthesis |
US3707146A (en) | 1967-03-07 | 1972-12-26 | Prod Res & Chem Corp | Means to inject a plastic into a cavity to produce a replica thereof |
US3552986A (en) | 1967-11-24 | 1971-01-05 | Sun Chemical Corp | Printing and coating untreated polyolefins |
US3640741A (en) | 1970-02-24 | 1972-02-08 | Hollister Inc | Composition containing gel |
US3726279A (en) | 1970-10-08 | 1973-04-10 | Carolina Medical Electronics I | Hemostatic vascular cuff |
US3723244A (en) | 1971-01-18 | 1973-03-27 | Atomic Energy Commission | Fibrous fibrin sheet and method for producing same |
US3749084A (en) | 1971-05-03 | 1973-07-31 | A Cucchiara | Sequentially dispensing syringe with multiple needle assembly |
US3868956A (en) | 1972-06-05 | 1975-03-04 | Ralph J Alfidi | Vessel implantable appliance and method of implanting it |
DE2364675C2 (en) | 1972-12-29 | 1983-06-23 | Kuraray Co., Ltd., Kurashiki, Okayama | Copolymer consisting of a polymer main chain and polymer side chains and its use for the manufacture of articles for biomedical purposes |
CA1039189A (en) | 1973-08-31 | 1978-09-26 | Beiersdorf Aktiengesellschaft | Film-forming sprayable polymer-solution for producing a wound-dressing |
AR205997A1 (en) | 1973-11-21 | 1976-06-23 | American Cyanamid Co | NORMALLY SOLID BIODEGRADABLE AND HYDROLYZABLE POLYESTER RESIN |
US3880158A (en) | 1974-04-04 | 1975-04-29 | Johnson & Johnson | Spray-spun bandage composition |
US3939049A (en) | 1974-04-10 | 1976-02-17 | The United States Of America As Represented By The United States Energy Research And Development Administration | Process for radiation grafting hydrogels onto organic polymeric substrates |
US4023559A (en) | 1975-01-28 | 1977-05-17 | Smith & Nephew (Australia) Pty. Limited | Sampling catheter device |
US4079124A (en) | 1976-04-21 | 1978-03-14 | Medi-Physics, Inc. | Method of preparing X-ray contrast media containing ores of hafnium, tantalum and tungsten |
US4040420A (en) | 1976-04-22 | 1977-08-09 | General Dynamics | Packaging and dispensing kit |
US4118470A (en) | 1976-06-01 | 1978-10-03 | American Cyanamid Company | Normally-solid, bioabsorbable, hydrolyzable, polymeric reaction product |
US4140126A (en) | 1977-02-18 | 1979-02-20 | Choudhury M Hasan | Method for performing aneurysm repair |
US4156066A (en) | 1977-06-23 | 1979-05-22 | Tyndale Plains - Hunter Ltd. | Polyurethane polymers characterized by lactone groups and hydroxyl groups in the polymer backbone |
US4200939A (en) | 1977-10-19 | 1980-05-06 | Codman & Shurtleff, Inc. | Method for fixation of prostheses to bone |
US4179304A (en) | 1978-04-03 | 1979-12-18 | Polychrome Corporation | Finger nail lacquer |
US4265233A (en) | 1978-04-12 | 1981-05-05 | Unitika Ltd. | Material for wound healing |
AU516741B2 (en) | 1978-05-23 | 1981-06-18 | Bio Nova Neo Technics Pty. Ltd. | Vascular prostheses |
JPS6037735B2 (en) | 1978-10-18 | 1985-08-28 | 住友電気工業株式会社 | Artificial blood vessel |
JPS5562012A (en) | 1978-11-06 | 1980-05-10 | Teijin Ltd | Slow-releasing preparation |
AT359652B (en) | 1979-02-15 | 1980-11-25 | Immuno Ag | METHOD FOR PRODUCING A TISSUE ADHESIVE |
AT359653B (en) | 1979-02-15 | 1980-11-25 | Immuno Ag | METHOD FOR PRODUCING A TISSUE ADHESIVE |
US4286341A (en) | 1979-04-16 | 1981-09-01 | Iowa State University Research Foundation, Inc. | Vascular prosthesis and method of making the same |
US4256094A (en) | 1979-06-18 | 1981-03-17 | Kapp John P | Arterial pressure control system |
US4272518A (en) | 1979-07-10 | 1981-06-09 | Moro Daniel G | Plastic wound bandage |
US4300244A (en) | 1979-09-19 | 1981-11-17 | Carbomedics, Inc. | Cardiovascular grafts |
DE2967060D1 (en) | 1979-12-18 | 1984-07-19 | Oscobal Ag | Bone replacement material and process for producing a bone replacement material |
AT366916B (en) | 1980-04-02 | 1982-05-25 | Immuno Ag | DEVICE FOR APPLICATING A TISSUE ADHESIVE BASED ON HUMAN OR ANIMAL PROTEINS |
US4393041A (en) | 1980-04-25 | 1983-07-12 | International Minerals & Chemical Corp. | Fibrin binder/carrier for active biochemical agents |
US4337327A (en) | 1980-07-07 | 1982-06-29 | S.K.Y. Polymers, Inc. | Novel block copolymers including acrylonitrile sequences and sequences including units derived from glutarimide units and processes for preparing same |
US4420589A (en) | 1980-07-07 | 1983-12-13 | Stoy Vladimir A | Polymer composition including polyacrylonitrile polymers and process for preparing same |
US4379874A (en) | 1980-07-07 | 1983-04-12 | Stoy Vladimir A | Polymer composition comprising polyacrylonitrile polymer and multi-block copolymer |
US4370451A (en) | 1980-07-07 | 1983-01-25 | S.K.Y. Polymers | Novel block copolymers including acrylonitrile sequences and sequences including units derived from glutarimide units and processes for preparing same |
US4423099A (en) | 1980-07-28 | 1983-12-27 | Ciba-Geigy Corporation | Membrane modified hydrogels |
US4789732A (en) | 1980-08-04 | 1988-12-06 | Regents Of The University Of California | Bone morphogenetic protein composition |
US4619989A (en) | 1981-05-05 | 1986-10-28 | The Regents Of The University Of Cal. | Bone morphogenetic protein composition |
US4761471A (en) | 1980-08-04 | 1988-08-02 | The Regents Of The University Of California | Bone morphogenetic protein composition |
US4331783A (en) | 1980-09-17 | 1982-05-25 | S.K.Y. Polymers | Novel block copolymers including acrylonitrile sequences and glutarimide units and processes for preparing same |
DE3105624A1 (en) | 1981-02-16 | 1982-09-02 | Hormon-Chemie München GmbH, 8000 München | MATERIAL FOR SEALING AND HEALING Wounds |
DE3206725A1 (en) | 1981-05-13 | 1982-12-02 | Merck Patent Gmbh, 6100 Darmstadt | PERSONALLY SOLUBLE SALTS OF AMINOGLYCOSIDANTIBIOTICS |
ATE20824T1 (en) | 1981-06-25 | 1986-08-15 | Serapharm Gmbh & Co Kg | ENRICHED PLASMA DERIVES TO SUPPORT WOUND CLOSURE AND HEALING. |
EP0068047B1 (en) | 1981-06-25 | 1986-07-23 | Serapharm GmbH & Co. KG | Enriched plasma derivative for promoting wound sealing and wound healing |
US4442655A (en) | 1981-06-25 | 1984-04-17 | Serapharm Michael Stroetmann | Fibrinogen-containing dry preparation, manufacture and use thereof |
US4373519A (en) | 1981-06-26 | 1983-02-15 | Minnesota Mining And Manufacturing Company | Composite wound dressing |
US4394370A (en) | 1981-09-21 | 1983-07-19 | Jefferies Steven R | Bone graft material for osseous defects and method of making same |
US4472840A (en) | 1981-09-21 | 1984-09-25 | Jefferies Steven R | Method of inducing osseous formation by implanting bone graft material |
IL68218A (en) | 1983-03-23 | 1985-12-31 | Univ Ramot | Compositions for cartilage repair comprising embryonal chondrocytes |
US4548736A (en) | 1983-08-29 | 1985-10-22 | Wisconsin Alumni Research Foundation | Preparation of protein films |
US4631188A (en) | 1983-08-31 | 1986-12-23 | S.K.Y. Polymers, Ltd. (Kingston Technologies) | Injectable physiologically-acceptable polymeric composition |
US4511478A (en) | 1983-11-10 | 1985-04-16 | Genetic Systems Corporation | Polymerizable compounds and methods for preparing synthetic polymers that integrally contain polypeptides |
US5693083A (en) | 1983-12-09 | 1997-12-02 | Endovascular Technologies, Inc. | Thoracic graft and delivery catheter |
US4708861A (en) | 1984-02-15 | 1987-11-24 | The Liposome Company, Inc. | Liposome-gel compositions |
US4600574A (en) | 1984-03-21 | 1986-07-15 | Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte | Method of producing a tissue adhesive |
AT379311B (en) | 1984-03-29 | 1985-12-27 | Immuno Ag | DEVICE FOR APPLICATING A TISSUE ADHESIVE |
US4617932A (en) | 1984-04-25 | 1986-10-21 | Elliot Kornberg | Device and method for performing an intraluminal abdominal aortic aneurysm repair |
US4619913A (en) | 1984-05-29 | 1986-10-28 | Matrix Pharmaceuticals, Inc. | Treatments employing drug-containing matrices for introduction into cellular lesion areas |
US4928603A (en) | 1984-09-07 | 1990-05-29 | The Trustees Of Columbia University In The City Of New York | Method of preparing a cryoprecipitated suspension and use thereof |
US4627879A (en) | 1984-09-07 | 1986-12-09 | The Trustees Of Columbia University In The City Of New York | Fibrin adhesive prepared as a concentrate from single donor fresh frozen plasma |
US4881939A (en) | 1985-02-19 | 1989-11-21 | The Johns Hopkins University | Implantable helical cuff |
GB2172937B (en) | 1985-03-26 | 1988-09-28 | Phillips Pty Ltd N J | A dual barrel injector |
US4820626A (en) | 1985-06-06 | 1989-04-11 | Thomas Jefferson University | Method of treating a synthetic or naturally occuring surface with microvascular endothelial cells, and the treated surface itself |
IL78826A (en) | 1986-05-19 | 1991-05-12 | Yissum Res Dev Co | Precursor composition for the preparation of a biodegradable implant for the sustained release of an active material and such implants prepared therefrom |
US4741872A (en) | 1986-05-16 | 1988-05-03 | The University Of Kentucky Research Foundation | Preparation of biodegradable microspheres useful as carriers for macromolecules |
US4714457A (en) | 1986-09-15 | 1987-12-22 | Robert Alterbaum | Method and apparatus for use in preparation of fibrinogen from a patient's blood |
US4717717A (en) | 1986-11-05 | 1988-01-05 | Ethicon, Inc. | Stabilized compositions containing epidermal growth factor |
US5019559A (en) | 1986-11-14 | 1991-05-28 | President And Fellows Of Harvard College | Wound healing using PDGF and IGF-II |
CA1322714C (en) | 1986-11-14 | 1993-10-05 | Harry N. Antoniades | Wound healing and bone regeneration |
CA1322314C (en) | 1987-02-10 | 1993-09-21 | Paul Mulhauser | Venous cuff applicator |
US4816339A (en) | 1987-04-28 | 1989-03-28 | Baxter International Inc. | Multi-layered poly(tetrafluoroethylene)/elastomer materials useful for in vivo implantation |
US4795741A (en) | 1987-05-06 | 1989-01-03 | Biomatrix, Inc. | Compositions for therapeutic percutaneous embolization and the use thereof |
IL82834A (en) | 1987-06-09 | 1990-11-05 | Yissum Res Dev Co | Biodegradable polymeric materials based on polyether glycols,processes for the preparation thereof and surgical artiicles made therefrom |
US4952403A (en) | 1987-06-19 | 1990-08-28 | President And Fellows Of Harvard College | Implants for the promotion of healing of meniscal tissue |
US4804691A (en) | 1987-08-28 | 1989-02-14 | Richards Medical Company | Method for making a biodegradable adhesive for soft living tissue |
US5171318A (en) | 1987-11-09 | 1992-12-15 | Chiron Ophthalmics, Inc. | Treated corneal prosthetic device |
US4874746A (en) | 1987-12-22 | 1989-10-17 | Institute Of Molecular Biology, Inc. | Wound headling composition of TGF-alpha and PDGF |
US5290552A (en) | 1988-05-02 | 1994-03-01 | Matrix Pharmaceutical, Inc./Project Hear | Surgical adhesive material |
US4983581A (en) | 1988-05-20 | 1991-01-08 | Institute Of Molecular Biology, Inc. | Wound healing composition of IGF-I and TGF-β |
AT397203B (en) | 1988-05-31 | 1994-02-25 | Immuno Ag | FABRIC ADHESIVE |
US4837379A (en) | 1988-06-02 | 1989-06-06 | Organogenesis Inc. | Fibrin-collagen tissue equivalents and methods for preparation thereof |
US5124155A (en) | 1988-06-21 | 1992-06-23 | Chiron Ophthalmics, Inc. | Fibronectin wound-healing dressings |
US5034375A (en) | 1988-08-10 | 1991-07-23 | Institute Of Molecular Biology, Inc. | Process of wound healing using PDGF and EGF |
US5634946A (en) | 1988-08-24 | 1997-06-03 | Focal, Inc. | Polymeric endoluminal paving process |
US5213580A (en) | 1988-08-24 | 1993-05-25 | Endoluminal Therapeutics, Inc. | Biodegradable polymeric endoluminal sealing process |
US4938763B1 (en) | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
US6171338B1 (en) * | 1988-11-10 | 2001-01-09 | Biocon, Oy | Biodegradable surgical implants and devices |
US4856516A (en) | 1989-01-09 | 1989-08-15 | Cordis Corporation | Endovascular stent apparatus and method |
US5186711A (en) | 1989-03-07 | 1993-02-16 | Albert Einstein College Of Medicine Of Yeshiva University | Hemostasis apparatus and method |
US4969880A (en) | 1989-04-03 | 1990-11-13 | Zamierowski David S | Wound dressing and treatment method |
US5057117A (en) | 1989-04-27 | 1991-10-15 | The Research Foundation Of State University Of New York | Method and apparatus for hemostasis and compartmentalization of a bleeding internal bodily organ |
US5207695A (en) * | 1989-06-19 | 1993-05-04 | Trout Iii Hugh H | Aortic graft, implantation device, and method for repairing aortic aneurysm |
US5226877A (en) | 1989-06-23 | 1993-07-13 | Epstein Gordon H | Method and apparatus for preparing fibrinogen adhesive from whole blood |
US5035887A (en) | 1989-09-07 | 1991-07-30 | Institute Of Moelcular Biology, Inc. | Wound healing composition of IL-1 and PDGF or IGF-1 |
US5439446A (en) * | 1994-06-30 | 1995-08-08 | Boston Scientific Corporation | Stent and therapeutic delivery system |
US5030215A (en) | 1990-01-03 | 1991-07-09 | Cryolife, Inc. | Preparation of fibrinogen/factor XIII precipitate |
US5219328A (en) | 1990-01-03 | 1993-06-15 | Cryolife, Inc. | Fibrin sealant delivery method |
JP2849937B2 (en) | 1990-04-18 | 1999-01-27 | 日東電工株式会社 | Medical patch |
US5059123A (en) | 1990-05-14 | 1991-10-22 | Jernberg Gary R | Periodontal barrier and method for aiding periodontal tissue regeneration |
US5139227A (en) | 1990-06-04 | 1992-08-18 | Mitsubishi Denki K.K. | Proportional flow control valve |
US5108407A (en) | 1990-06-08 | 1992-04-28 | Rush-Presbyterian St. Luke's Medical Center | Method and apparatus for placement of an embolic coil |
EP0461791B1 (en) | 1990-06-11 | 1997-01-02 | Hector D. Barone | Aortic graft and apparatus for repairing an abdominal aortic aneurysm |
US5360443A (en) | 1990-06-11 | 1994-11-01 | Barone Hector D | Aortic graft for repairing an abdominal aortic aneurysm |
US5578071A (en) | 1990-06-11 | 1996-11-26 | Parodi; Juan C. | Aortic graft |
US5209776A (en) | 1990-07-27 | 1993-05-11 | The Trustees Of Columbia University In The City Of New York | Tissue bonding and sealing composition and method of using the same |
US5074868A (en) | 1990-08-03 | 1991-12-24 | Inamed Development Company | Reversible stoma-adjustable gastric band |
EP0470569B1 (en) | 1990-08-08 | 1995-11-22 | Takeda Chemical Industries, Ltd. | Intravascular embolizing agent containing angiogenesis inhibiting substance |
AR246020A1 (en) | 1990-10-03 | 1994-03-30 | Hector Daniel Barone Juan Carl | A ball device for implanting an intraluminous aortic prosthesis, for repairing aneurysms. |
US5626863A (en) | 1992-02-28 | 1997-05-06 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
US5206023A (en) | 1991-01-31 | 1993-04-27 | Robert F. Shaw | Method and compositions for the treatment and repair of defects or lesions in cartilage |
US5156620A (en) | 1991-02-04 | 1992-10-20 | Pigott John P | Intraluminal graft/stent and balloon catheter for insertion thereof |
US5628783A (en) * | 1991-04-11 | 1997-05-13 | Endovascular Technologies, Inc. | Bifurcated multicapsule intraluminal grafting system and method |
US5217484A (en) | 1991-06-07 | 1993-06-08 | Marks Michael P | Retractable-wire catheter device and method |
US5792835A (en) | 1991-09-05 | 1998-08-11 | Baxter International Inc. | Method of preparing a topical fibrinogen complex |
US5171579A (en) | 1991-10-11 | 1992-12-15 | Genetics Institute, Inc. | Formulations of blood clot-polymer matrix for delivery of osteogenic proteins |
AU669338B2 (en) | 1991-10-25 | 1996-06-06 | Cook Incorporated | Expandable transluminal graft prosthesis for repair of aneurysm and method for implanting |
US5456713A (en) | 1991-10-25 | 1995-10-10 | Cook Incorporated | Expandable transluminal graft prosthesis for repairs of aneurysm and method for implanting |
US5316023A (en) | 1992-01-08 | 1994-05-31 | Expandable Grafts Partnership | Method for bilateral intra-aortic bypass |
US5573934A (en) | 1992-04-20 | 1996-11-12 | Board Of Regents, The University Of Texas System | Gels for encapsulation of biological materials |
US5342393A (en) | 1992-08-27 | 1994-08-30 | Duke University | Method and device for vascular repair |
US5443454A (en) | 1992-12-09 | 1995-08-22 | Terumo Kabushiki Kaisha | Catheter for embolectomy |
US5356424A (en) * | 1993-02-05 | 1994-10-18 | American Cyanamid Co. | Laparoscopic suturing device |
US5395923A (en) | 1993-02-23 | 1995-03-07 | Haemacure-Biotech, Inc. | Process for the obtention of a biological adhesive made of concentrated coagulation factors by "salting-out" |
US5749968A (en) | 1993-03-01 | 1998-05-12 | Focal, Inc. | Device for priming for improved adherence of gels to substrates |
US5552452A (en) | 1993-03-15 | 1996-09-03 | Arch Development Corp. | Organic tissue glue for closure of wounds |
IL106738A (en) * | 1993-08-19 | 1998-02-08 | Mind E M S G Ltd | Device for external correction of deficient valves in venous junctions |
US5423829A (en) | 1993-11-03 | 1995-06-13 | Target Therapeutics, Inc. | Electrolytically severable joint for endovascular embolic devices |
US5507769A (en) | 1994-10-18 | 1996-04-16 | Stentco, Inc. | Method and apparatus for forming an endoluminal bifurcated graft |
US6165210A (en) | 1994-04-01 | 2000-12-26 | Gore Enterprise Holdings, Inc. | Self-expandable helical intravascular stent and stent-graft |
US5527355A (en) * | 1994-09-02 | 1996-06-18 | Ahn; Sam S. | Apparatus and method for performing aneurysm repair |
US5843170A (en) | 1994-09-02 | 1998-12-01 | Ahn; Sam Seunghae | Apparatus and method for performing aneurysm repair |
US5707378A (en) | 1994-09-02 | 1998-01-13 | Sam S. Ahn | Apparatus and method for performing aneurysm repair |
US6015429A (en) | 1994-09-08 | 2000-01-18 | Gore Enterprise Holdings, Inc. | Procedures for introducing stents and stent-grafts |
JP3611578B2 (en) | 1994-11-09 | 2005-01-19 | エンドテックス インターベンショナル システムズ,インコーポレイテッド | Delivery catheter and graft for the treatment of aneurysms |
US5464471A (en) | 1994-11-10 | 1995-11-07 | Whalen Biomedical Inc. | Fibrin monomer based tissue adhesive |
US5989244A (en) | 1994-11-15 | 1999-11-23 | Gregory; Kenton W. | Method of use of a sheet of elastin or elastin-based material |
IL116561A0 (en) | 1994-12-30 | 1996-03-31 | Target Therapeutics Inc | Severable joint for detachable devices placed within the body |
US5585108A (en) | 1994-12-30 | 1996-12-17 | Nanosystems L.L.C. | Formulations of oral gastrointestinal therapeutic agents in combination with pharmaceutically acceptable clays |
US5603720A (en) * | 1995-01-27 | 1997-02-18 | Kieturakis; Maciej J. | Surgical method for use with transluminal dilation catheter |
US5755770A (en) | 1995-01-31 | 1998-05-26 | Boston Scientific Corporatiion | Endovascular aortic graft |
WO1996029937A1 (en) | 1995-03-24 | 1996-10-03 | Organ, Inc. | Vessel and duct salvage device and method |
US5722989A (en) | 1995-05-22 | 1998-03-03 | The Regents Of The University Of California | Microminiaturized minimally invasive intravascular micro-mechanical systems powered and controlled via fiber-optic cable |
NO962336L (en) * | 1995-06-06 | 1996-12-09 | Target Therapeutics Inc | Vaso-occlusive spiral |
US5785679A (en) | 1995-07-19 | 1998-07-28 | Endotex Interventional Systems, Inc. | Methods and apparatus for treating aneurysms and arterio-venous fistulas |
US5665117A (en) | 1995-11-27 | 1997-09-09 | Rhodes; Valentine J. | Endovascular prosthesis with improved sealing means for aneurysmal arterial disease and method of use |
US6042605A (en) | 1995-12-14 | 2000-03-28 | Gore Enterprose Holdings, Inc. | Kink resistant stent-graft |
US5741274A (en) | 1995-12-22 | 1998-04-21 | Cardio Vascular Concepts, Inc. | Method and apparatus for laparoscopically reinforcing vascular stent-grafts |
US5702343A (en) | 1996-10-02 | 1997-12-30 | Acorn Medical, Inc. | Cardiac reinforcement device |
US5972001A (en) * | 1996-11-25 | 1999-10-26 | Yoon; Inbae | Method of ligating anatomical tissue with a suture spring device |
US5735891A (en) * | 1996-12-02 | 1998-04-07 | Sulzer Intermedics Inc. | Self-clamping anchoring sleeve |
US6015431A (en) | 1996-12-23 | 2000-01-18 | Prograft Medical, Inc. | Endolumenal stent-graft with leak-resistant seal |
US5938669A (en) | 1997-05-07 | 1999-08-17 | Klasamed S.A. | Adjustable gastric banding device for contracting a patient's stomach |
US5944750A (en) * | 1997-06-30 | 1999-08-31 | Eva Corporation | Method and apparatus for the surgical repair of aneurysms |
US5997556A (en) | 1997-06-30 | 1999-12-07 | Eva Corporation | Surgical fastener |
US6007538A (en) | 1997-07-25 | 1999-12-28 | Duke University | Sternal closure device |
CA2300049C (en) | 1997-08-08 | 2009-03-10 | Duke University | Compositions, apparatus and methods for facilitating surgical procedures |
US6248116B1 (en) * | 1997-12-16 | 2001-06-19 | B. Braun Celsa | Medical treatment of a diseased anatomical duct |
US6051007A (en) | 1998-03-02 | 2000-04-18 | Corvascular, Inc. | Sternal closure device and instruments therefor |
US6095997A (en) | 1998-03-04 | 2000-08-01 | Corvascular, Inc. | Intraluminal shunt and methods of use |
US6110188A (en) | 1998-03-09 | 2000-08-29 | Corvascular, Inc. | Anastomosis method |
US6113588A (en) | 1998-03-13 | 2000-09-05 | Corvascular, Inc. | Transillumination catheter and method |
US6063111A (en) | 1998-03-31 | 2000-05-16 | Cordis Corporation | Stent aneurysm treatment system and method |
US6080175A (en) | 1998-07-29 | 2000-06-27 | Corvascular, Inc. | Surgical cutting instrument and method of use |
US6156064A (en) * | 1998-08-14 | 2000-12-05 | Schneider (Usa) Inc | Stent-graft-membrane and method of making the same |
-
2000
- 2000-11-20 US US09/717,910 patent/US6648911B1/en not_active Expired - Fee Related
-
2001
- 2001-11-19 EP EP01985031A patent/EP1397088A2/en not_active Withdrawn
- 2001-11-19 AU AU2002234021A patent/AU2002234021A1/en not_active Abandoned
- 2001-11-19 WO PCT/US2001/048354 patent/WO2002039906A2/en not_active Application Discontinuation
- 2001-11-19 CA CA002446472A patent/CA2446472A1/en not_active Abandoned
-
2003
- 2003-07-16 US US10/621,126 patent/US20040098104A1/en not_active Abandoned
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993015671A1 (en) * | 1992-02-14 | 1993-08-19 | Endomedix Corporation | Devices for enclosing, manipulating, debulking and removing tissue through minimal access incisions |
US5868700A (en) * | 1992-05-01 | 1999-02-09 | Voda; Jan | Preformed coronary artery guide catheter |
US5562685A (en) * | 1994-09-16 | 1996-10-08 | General Surgical Innovations, Inc. | Surgical instrument for placing suture or fasteners |
WO1997040755A1 (en) * | 1996-04-29 | 1997-11-06 | W.L. Gore & Associates, Inc. | Device for restoring competence to venous valves |
US6053891A (en) * | 1996-08-26 | 2000-04-25 | Decampli; William M. | Apparatus and methods for providing selectively adjustable blood flow through a vascular graft |
US5910129A (en) * | 1996-12-19 | 1999-06-08 | Ep Technologies, Inc. | Catheter distal assembly with pull wires |
WO1999033509A1 (en) * | 1997-12-30 | 1999-07-08 | Cardima, Inc. | Deflectable guiding catheter |
WO1999035979A1 (en) * | 1998-01-13 | 1999-07-22 | Lumend, Inc. | Methods and apparatus for crossing total occlusions in blood vessels |
WO2000016700A1 (en) * | 1998-09-21 | 2000-03-30 | Myocor, Inc. | External stress reduction device and method |
WO2000025717A2 (en) * | 1998-10-31 | 2000-05-11 | Kuebeler Harald | Device for covering and protecting an injury, especially a wound, of an indwelling venous cannula or the like |
WO2000043062A1 (en) * | 1999-01-22 | 2000-07-27 | Cardeon Corporation | Aortic catheter with flow divider and methods for preventing cerebral embolization |
Cited By (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8252039B2 (en) | 2002-09-19 | 2012-08-28 | Golesworthy Taliesin John | Aortic root dissection treatment |
WO2004026178A3 (en) * | 2002-09-19 | 2004-06-24 | Exstent Ltd | External stent |
US8246673B2 (en) | 2002-09-19 | 2012-08-21 | Exstent Limited | External support for a blood vessel |
EP1617788A4 (en) * | 2003-02-28 | 2007-05-02 | Edward G Shifrin | Extravenous corrector for repair of incompetent venous valves |
EP1617788A1 (en) * | 2003-02-28 | 2006-01-25 | Edward G. Shifrin | Extravenous corrector for repair of incompetent venous valves |
EP1713453A4 (en) * | 2004-02-13 | 2007-03-07 | Conor Medsystems Inc | Implantable drug delivery device including wire filaments |
EP1713453A2 (en) * | 2004-02-13 | 2006-10-25 | Conor Medsystems, Inc. | Implantable drug delivery device including wire filaments |
EP1855600A2 (en) * | 2005-02-04 | 2007-11-21 | Zuli Holdings, Ltd. | Device and methods for non-surgical clipping of aneurysms |
JP2008532575A (en) * | 2005-02-04 | 2008-08-21 | ズーリ ホルディングズ リミテッド | Instruments and methods for non-surgical clipping of aneurysms |
EP1855600A4 (en) * | 2005-02-04 | 2009-08-12 | Zuli Holdings Ltd | Device and methods for non-surgical clipping of aneurysms |
US7601160B2 (en) | 2005-02-04 | 2009-10-13 | Zuli Holdings, Ltd | Device and methods for non-surgical clipping of aneurysms |
WO2006082493A2 (en) | 2005-02-04 | 2006-08-10 | Zuli Holdings, Ltd. | Device and methods for non-surgical clipping of aneurysms |
US8202280B2 (en) | 2005-02-04 | 2012-06-19 | Zuli Holdings Ltd. | Device and methods for non-surgical clipping of aneurysms |
WO2007061538A2 (en) * | 2005-11-22 | 2007-05-31 | Boston Scientific Limited | Shape memory hemostasis band |
WO2007061538A3 (en) * | 2005-11-22 | 2007-09-07 | Boston Scient Scimed Inc | Shape memory hemostasis band |
US9370370B2 (en) | 2005-11-22 | 2016-06-21 | Boston Scientific Scimed, Inc. | Shape memory hemostasis band |
JP2009530025A (en) * | 2006-03-17 | 2009-08-27 | ゴア エンタープライズ ホールディングス,インコーポレイティド | Endoprosthesis with multiple spiral wound flexible framework elements |
WO2007109007A1 (en) * | 2006-03-17 | 2007-09-27 | Gore Enterprise Holdings, Inc. | Endoprosthesis having multiple helically wound flexible framework elements |
EP2417934A1 (en) * | 2010-08-10 | 2012-02-15 | Sangomed S.R.L. | Stent-based extra-venous support for venous valve repair |
WO2012149205A1 (en) * | 2011-04-27 | 2012-11-01 | Dolan Mark J | Nerve impingement systems including an intravascular prosthesis and an extravascular prosthesis and associated systems and methods |
EP2931140A4 (en) * | 2012-12-11 | 2016-08-10 | Dolly Jeanne Holt | Tissue repair devices and methods |
DE102015121374A1 (en) | 2015-12-08 | 2017-06-08 | Otto-Von-Guericke-Universität Magdeburg | Clip for the treatment of aneurysms and closure of tubular anatomical structures |
DE102015121374B4 (en) * | 2015-12-08 | 2021-03-18 | Otto-Von-Guericke-Universität Magdeburg | Implant system comprising a feed unit and a clip for closing tubular anatomical structures |
DE102019106488A1 (en) * | 2019-03-14 | 2020-09-17 | Advanced Angioneers UG (haftungsbeschränkt) | Endoluminally insertable exovascular (perivascular) device and device for improving the elasticity of a stiffened blood vessel |
Also Published As
Publication number | Publication date |
---|---|
CA2446472A1 (en) | 2002-05-23 |
US20040098104A1 (en) | 2004-05-20 |
AU2002234021A1 (en) | 2002-05-27 |
US6648911B1 (en) | 2003-11-18 |
EP1397088A2 (en) | 2004-03-17 |
WO2002039906A3 (en) | 2003-05-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6648911B1 (en) | Method and device for the treatment of vulnerable tissue site | |
US20220168091A1 (en) | Stent graft with fenestration lock and methods of use | |
JP3754125B2 (en) | Intravascular multi-anchor stent | |
US10299791B2 (en) | Endovascular aneurysm repair system | |
CA2162956C (en) | Intraluminal stent for attaching a graft | |
EP1267748B1 (en) | Stent with cover connectors | |
EP2301476B1 (en) | Stent-graft suture locks | |
US6699277B1 (en) | Stent with cover connectors | |
US8690937B2 (en) | Stent graft device | |
US5782907A (en) | Involuted spring stent and graft assembly and method of use | |
US20070219627A1 (en) | Prosthesis Fixation Apparatus and Methods | |
JPH0852165A (en) | Device and method for arrangement of transplanting piece in cavity | |
EP2679197A1 (en) | Sealing mechanism for expandable vascular graft | |
EP1263348B1 (en) | Intraluminal prosthesis | |
JP2005169072A (en) | Delivery catheter for aneurysm repair, and graft | |
JPH08322943A (en) | Sheath | |
JP3679810B2 (en) | Graft delivery system | |
AU701676B2 (en) | Intraluminal stent for attaching a graft | |
EP2781204A1 (en) | Intravascular system for introducing and fastening an autogenous vascular prosthesis |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2001985031 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2446472 Country of ref document: CA |
|
WWP | Wipo information: published in national office |
Ref document number: 2001985031 Country of ref document: EP |
|
NENP | Non-entry into the national phase |
Ref country code: JP |
|
WWW | Wipo information: withdrawn in national office |
Country of ref document: JP |