WO2002037398A3 - Systems, methods and computer program products for guiding the selection of therapeutic treatment regimens - Google Patents

Systems, methods and computer program products for guiding the selection of therapeutic treatment regimens Download PDF

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Publication number
WO2002037398A3
WO2002037398A3 PCT/EP2001/012666 EP0112666W WO0237398A3 WO 2002037398 A3 WO2002037398 A3 WO 2002037398A3 EP 0112666 W EP0112666 W EP 0112666W WO 0237398 A3 WO0237398 A3 WO 0237398A3
Authority
WO
WIPO (PCT)
Prior art keywords
therapeutic treatment
knowledge base
systems
computer program
methods
Prior art date
Application number
PCT/EP2001/012666
Other languages
French (fr)
Other versions
WO2002037398A2 (en
Inventor
Kurt Berlin
Alexander Olek
Christian Piepenbrock
Original Assignee
Epigenomics Ag
Kurt Berlin
Alexander Olek
Christian Piepenbrock
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epigenomics Ag, Kurt Berlin, Alexander Olek, Christian Piepenbrock filed Critical Epigenomics Ag
Priority to EP01992975A priority Critical patent/EP1358616A2/en
Priority to JP2002540070A priority patent/JP2004517394A/en
Priority to CA002427624A priority patent/CA2427624A1/en
Priority to AU2002221800A priority patent/AU2002221800A1/en
Publication of WO2002037398A2 publication Critical patent/WO2002037398A2/en
Publication of WO2002037398A3 publication Critical patent/WO2002037398A3/en

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Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

Systems, methods and computer program products for guiding selection of a therapeutic treatment regimen or a preventive therapeutic treatment regimen are disclosed. The method comprises (A) providing to a computing device comprising a first knowledge base comprising information about a plurality of different methylation statuses at selected sites of the DNA in cells with a known disease or medical condition and/or healthy cells, a second knowledge base comprising a plurality of expert rules for evaluating and selecting a type of disease or medical condition based on the methylation status at selected sites of the DNA of a patient, (B) generating in said computing device a ranked listing of diseases or medical conditions based on the information about the methylation status at selected sites of the DNA of the patient, the first knowledge base and the second knowledge base.
PCT/EP2001/012666 2000-11-02 2001-11-02 Systems, methods and computer program products for guiding the selection of therapeutic treatment regimens WO2002037398A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP01992975A EP1358616A2 (en) 2000-11-02 2001-11-02 Systems, methods and computer program products for guiding selection of a therapeutic treatment regimen based on the methylation status of the dna
JP2002540070A JP2004517394A (en) 2000-11-02 2001-11-02 System, method and computer program for guiding the selection of a therapy based on DNA methylation status
CA002427624A CA2427624A1 (en) 2000-11-02 2001-11-02 Systems, methods and computer program products for guiding selection of a therapeutic treatment regimen based on the methylation status of the dna
AU2002221800A AU2002221800A1 (en) 2000-11-02 2001-11-02 Systems, methods and computer program products for guiding the selection of therapeutic treatment regimens

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70530200A 2000-11-02 2000-11-02
US09/705,302 2000-11-02

Publications (2)

Publication Number Publication Date
WO2002037398A2 WO2002037398A2 (en) 2002-05-10
WO2002037398A3 true WO2002037398A3 (en) 2003-08-21

Family

ID=24832866

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/012666 WO2002037398A2 (en) 2000-11-02 2001-11-02 Systems, methods and computer program products for guiding the selection of therapeutic treatment regimens

Country Status (5)

Country Link
EP (1) EP1358616A2 (en)
JP (1) JP2004517394A (en)
AU (1) AU2002221800A1 (en)
CA (1) CA2427624A1 (en)
WO (1) WO2002037398A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7949545B1 (en) 2004-05-03 2011-05-24 The Medical RecordBank, Inc. Method and apparatus for providing a centralized medical record system
US9249456B2 (en) 2004-03-26 2016-02-02 Agena Bioscience, Inc. Base specific cleavage of methylation-specific amplification products in combination with mass analysis
US9394565B2 (en) 2003-09-05 2016-07-19 Agena Bioscience, Inc. Allele-specific sequence variation analysis

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI20012593A0 (en) 2001-12-28 2001-12-28 Pertti Laehteenmaeki A method and system for providing a nutrition information service
FI20021031A (en) 2001-12-28 2003-06-29 Pertti Laehteenmaeki Nutritional Machine
US7608394B2 (en) * 2004-03-26 2009-10-27 Sequenom, Inc. Methods and compositions for phenotype identification based on nucleic acid methylation
US7762181B2 (en) 2004-10-01 2010-07-27 Fonterra Co-Operative Group Limited Customised nutritional food and beverage dispensing system
US20100063839A1 (en) * 2006-09-20 2010-03-11 Koninklijke Philips Electronics N.V. Molecular diagnostics decision support system
US20130268290A1 (en) * 2012-04-02 2013-10-10 David Jackson Systems and methods for disease knowledge modeling
JP2016514291A (en) 2013-01-29 2016-05-19 モレキュラー ヘルス ゲーエムベーハー System and method for clinical decision support

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985559A (en) * 1997-04-30 1999-11-16 Health Hero Network System and method for preventing, diagnosing, and treating genetic and pathogen-caused disease
EP0976835A1 (en) * 1998-07-29 2000-02-02 Keygene N.V. Method for detecting nucleic acid methylation using AFLPTM
US6081786A (en) * 1998-04-03 2000-06-27 Triangle Pharmaceuticals, Inc. Systems, methods and computer program products for guiding the selection of therapeutic treatment regimens
WO2000044934A2 (en) * 1999-01-29 2000-08-03 Epigenomics Ag Method of identifying cytosine methylation patterns in genomic dna samples
EP1176539A1 (en) * 2000-07-13 2002-01-30 Virology Networks B.V. Method for effecting computer implemented decision-support in the selection of the drug therapy of patients having a viral disease

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985559A (en) * 1997-04-30 1999-11-16 Health Hero Network System and method for preventing, diagnosing, and treating genetic and pathogen-caused disease
US6081786A (en) * 1998-04-03 2000-06-27 Triangle Pharmaceuticals, Inc. Systems, methods and computer program products for guiding the selection of therapeutic treatment regimens
EP0976835A1 (en) * 1998-07-29 2000-02-02 Keygene N.V. Method for detecting nucleic acid methylation using AFLPTM
WO2000044934A2 (en) * 1999-01-29 2000-08-03 Epigenomics Ag Method of identifying cytosine methylation patterns in genomic dna samples
EP1176539A1 (en) * 2000-07-13 2002-01-30 Virology Networks B.V. Method for effecting computer implemented decision-support in the selection of the drug therapy of patients having a viral disease

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LATHORP R H ET AL: "KNOWLEDGE-BASED AVOIDANCE OF DRUG-RESISTANT HIV MUTANTS", AI MAGAZINE, LA CANADA, CA, vol. 20, no. 1, March 1999 (1999-03-01), pages 13 - 25, XP000972629, ISSN: 0738-4602 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9394565B2 (en) 2003-09-05 2016-07-19 Agena Bioscience, Inc. Allele-specific sequence variation analysis
US9249456B2 (en) 2004-03-26 2016-02-02 Agena Bioscience, Inc. Base specific cleavage of methylation-specific amplification products in combination with mass analysis
US7949545B1 (en) 2004-05-03 2011-05-24 The Medical RecordBank, Inc. Method and apparatus for providing a centralized medical record system

Also Published As

Publication number Publication date
CA2427624A1 (en) 2002-05-10
EP1358616A2 (en) 2003-11-05
JP2004517394A (en) 2004-06-10
WO2002037398A2 (en) 2002-05-10
AU2002221800A1 (en) 2002-05-15

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