WO2002034322A2 - Sealed back pressure breathing device - Google Patents
Sealed back pressure breathing device Download PDFInfo
- Publication number
- WO2002034322A2 WO2002034322A2 PCT/US2001/045478 US0145478W WO0234322A2 WO 2002034322 A2 WO2002034322 A2 WO 2002034322A2 US 0145478 W US0145478 W US 0145478W WO 0234322 A2 WO0234322 A2 WO 0234322A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hollow body
- patient
- exhalation
- valve
- compression spring
- Prior art date
Links
- 230000029058 respiratory gaseous exchange Effects 0.000 title abstract description 13
- 230000006835 compression Effects 0.000 claims abstract description 25
- 238000007906 compression Methods 0.000 claims abstract description 25
- 239000003814 drug Substances 0.000 claims abstract description 22
- 239000006199 nebulizer Substances 0.000 claims abstract description 22
- 229940079593 drug Drugs 0.000 claims abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 229920001971 elastomer Polymers 0.000 claims description 4
- 230000001105 regulatory effect Effects 0.000 claims description 4
- 230000004202 respiratory function Effects 0.000 claims 3
- 239000012530 fluid Substances 0.000 claims 2
- 210000004072 lung Anatomy 0.000 abstract description 20
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract description 12
- 244000144985 peep Species 0.000 abstract description 11
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract description 6
- 239000001569 carbon dioxide Substances 0.000 abstract description 6
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 239000007789 gas Substances 0.000 description 10
- 210000003205 muscle Anatomy 0.000 description 7
- 206010014561 Emphysema Diseases 0.000 description 5
- 208000006673 asthma Diseases 0.000 description 5
- 230000003434 inspiratory effect Effects 0.000 description 5
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 210000003123 bronchiole Anatomy 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000003595 mist Substances 0.000 description 3
- 208000019901 Anxiety disease Diseases 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 230000036506 anxiety Effects 0.000 description 2
- 208000030303 breathing problems Diseases 0.000 description 2
- 229940071648 metered dose inhaler Drugs 0.000 description 2
- 125000006850 spacer group Chemical group 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 210000003437 trachea Anatomy 0.000 description 2
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 206010003504 Aspiration Diseases 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 229940124630 bronchodilator Drugs 0.000 description 1
- 239000000168 bronchodilator agent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000010339 dilation Effects 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 210000003456 pulmonary alveoli Anatomy 0.000 description 1
- 230000009325 pulmonary function Effects 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0086—Inhalation chambers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0013—Details of inhalators; Constructional features thereof with inhalation check valves
- A61M15/0015—Details of inhalators; Constructional features thereof with inhalation check valves located upstream of the dispenser, i.e. not traversed by the product
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0018—Details of inhalators; Constructional features thereof with exhalation check valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/08—Bellows; Connecting tubes ; Water traps; Patient circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/08—Bellows; Connecting tubes ; Water traps; Patient circuits
- A61M16/0816—Joints or connectors
- A61M16/0833—T- or Y-type connectors, e.g. Y-piece
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/20—Valves specially adapted to medical respiratory devices
- A61M16/208—Non-controlled one-way valves, e.g. exhalation, check, pop-off non-rebreathing valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/20—Valves specially adapted to medical respiratory devices
- A61M16/208—Non-controlled one-way valves, e.g. exhalation, check, pop-off non-rebreathing valves
- A61M16/209—Relief valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/06—Respiratory or anaesthetic masks
Definitions
- the present invention relates to a device for assisting pulmonary functions of a patient; it can be used alone for exercising muscles involved in breathing or in combination with a nebulizer for delivery of medication to the airways of a patient. More particularly, the present invention relates to a breathing device for generating positive backpressure in the airways of the user so as to keep the airways open and restore normal breathing.
- Nebulizers are some of the most widely used devices for assisting patients with breathing problems; they help deliver medication during asthma attacks, emphysema attacks and similar occasions. Nebulizers are conventionally used in emergency rooms, by patients, and medical professionals when conventional method metered dose inhalers (MDIs) fail to reverse a constriction in the airways.
- MDIs metered dose inhalers
- nebulizers break down the liquid medicine into tiny droplets that resemble mist and then deliver the medication into the lungs and airways of the patient.
- nebulizers dispense airway dilators.
- the nebulizer helps deliver the much-needed dilators to the lungs and help expel the gas from the lungs.
- the dilators contain a chemical that reacts with the receptors in the bronchioles of the patient to open the airways.
- the medications may include steroids, magnesium sulfate, and bronchodilators.
- the positive pressure is much greater than when nebulizer with an ambu bag are used.
- excessive air is forced into the patient's lungs.
- Prolonged use of the ventilator tends to cause atrophy of inspiratory muscles, which may become irreversible.
- This invention contemplates elimination of drawbacks associated with the prior art and provision of hand-held devices that can be equally used by the patient and by a medical professional for exercising inspiratory muscles and for delivery of medication with the help of a nebulizer.
- SUMMARY OF THE INVENTION It is, therefore, an object of the present invention to provide a sealed calibrated back pressure device that would allow creation of positive pressure on the constricted airways of a patient suffering from asthma, emphysema or other respiratory diseases.
- a hand-held lightweight device that has a means for adjusting the amount of positive pressure created in the airways of the patient.
- the device has a hollow body with a peep valve mounted on a bracket inside the hollow body.
- the hollow body is provided with two through openings: an intake port and an exhalation port.
- An intake valve which can be as simple as a rubber gasket, is mounted in the hollow body between the exhalation valve and an open end.
- the open end may carry a mouthpiece or be suitably sized and shaped to be connected, via a manifold, to a nebulizer.
- the opposite closed end of the hollow body carries a means for adjusting the positive pressure.
- the adjustment means is a cap that threadably engages the hollow body; in the second embodiment - it is an adjustable cam lever.
- a compression spring is mounted between the exhalation valve and the adjustment means.
- the calibration may be set to a desired pressure, preferably between 5cm and 20cm of water.
- Figure 1 is a perspective view of the attachment device in accordance with the first embodiment of the present invention.
- Figure 2 is a longitudinal sectional view of the device shown in Figure 1 showing the adjustable cap threadably engaged with the main body.
- Figure 3 is a longitudinal sectional view of the device of the first embodiment, with the adjustable cap being separated from the main body.
- Figure 4 is a perspective view of the second embodiment of the device in accordance with the present invention mounted on a manifold that connects the device to a nebulizer.
- Figure 5 is a longitudinal sectional view showing the embodiment of Figure 4 with an adjustable cam lever.
- Figure 6 is a longitudinal sectional view of the second embodiment showing air movement on inspiration and expiration.
- Figure 7 is a detail view showing a support bracket on the expiration valve.
- Figure 8 is a detail front view showing the intake open on the exhalation valve.
- Figure 9 is a detail view showing an intake valve.
- the device 10 designates the device in accordance with the first embodiment of the present invention.
- the device 10 comprises an elongated main hollow body 12 having a first cylindrical portion 14, a unitary connected middle conical portion 16, and a mouthpiece 18, which is unitary connected to the middle portion 16.
- a central opening 20 is formed in the body 12, extending from the mouthpiece opening 22, through the mouthpiece 18, conical portion 16, and the main body 14.
- An adjustable screw cap 24 closes the normally closed end 26 of the main body portion 14.
- the cap 24 is provided with threads 28 on the inner wall of the cap.
- the threads 28 matingly engage with threads 30 on the exterior wall of the end
- a central plug 32 is formed in the cap 24, the plug 32 extending outwardly from an inner end 34 of the cap 24.
- the end 34 forms an annular shoulder that provides a first abutting surface, against which a compression spring 40 abuts, as will be described in more detail below.
- An intake port 42 is cut through the wall of the hollow body 12, and an exhalation port 44 is formed in the main body portion 14, at a location spaced apart from the intake port 42.
- an exhalation peep valve 50 Positioned between the ports 42 and 44 is an exhalation peep valve 50, which is shown in an open intake position in more detail in Figure 7.
- the valve 50 is the same valve that is used in the first and second embodiments of the present invention; therefore, its description will be omitted when the second embodiment is described hereinafter.
- the exhalation valve 50 is mounted on a support bracket, or frame 52 that is fitted inside the main body portion 14.
- the support bracket 52 is provided with an annular flange 54 that frictionally engages the inner wall of the main portion 14.
- the inner corner of the flange 54 provides a second abutting surface for the compression spring 40.
- An inwardly extending shoulder 56 is formed on the inner wall of the main portion 14 adjacent to the area of connection between the main portion 14 and the conical portion 16. The shoulder forms a stop when the bracket 52, along with the peep valve 50 is forced against the shoulder 56.
- An intake valve 60 ( Figure 9) is mounted in the main portion 14 between an open end 22 and the bracket 52.
- the intake valve 60 can be as simple as a flexible rubber gasket that forms a one-way valve that opens during inhalation.
- the diameter of the circular intake valve 60 is smaller than the inner diameter of the opening 20 in the main portion 14, allowing some air to move around the intake valve 60.
- the intake valve, or flap 60 is made from a flexible material, for example latex. The flap lays over the ports of the piston/bracket 50 when pressure is against the piston and against the spring 40, but flaps open through the openings in the bracket allowing intake of fresh air.
- the spring 40 When the device 10 is assembled, the spring 40 abuts, at one of its ends, against the shoulder 34, around the plug 32. The second end of the spring 40 abuts against the valve 50 mounted in the bracket 52, normally forcing the peep valve in a closed position shown in Figure 2.
- the valve opens on intake of air, as shown in Figure 8, but offers the pre-set resistance to a gas flow during exhalation.
- the device 70 comprises an elongated, generally cylindrical body 72 that has a normally open end 74 and a normally closed end 76.
- An adjustable cam lever 78 is secured to a shaft connected to a piston 94 mounted in the end 76 to allow adjustment of the pressure required for opening and closing of the peep valve mounted inside the body 72.
- the pressure may be adjusted to a desired value, for example in the range of 5cm to 10 cm of water, depending on the user's condition.
- the adjustment may be accomplished by regulating position of the lever.
- a first position would indicate pressure of 10 cm of water.
- the user may regulate compression of the spring to create pressure of about 5 cm of water.
- the body 72 is provided with a directional intake port 80 and a directional exhalation port 82.
- the open end 74 is adapted for frictional engagement with a manifold 84 that carries a mouthpiece 86 and a conventional nebulizer 88.
- the manifold 84, mouthpiece 86, and nebulizer 88 are not part of this invention; they are shown in phantom lines in Figure 4. Referring now to Figures 5 and 6, the interior of the device 70 is shown in more detail.
- the body 72 is provided with a central opening 90 that extends from the open end 74 to the closing wall 92 of the closed end 76.
- the cam lever 78 is rotatably mounted on a shaft 77 ( Figure 6) that is fixedly attached to the wall 92 of the closed end 76.
- the piston 94 moves a small distance within the central opening 90 only to adjust compression of a spring 96.
- the compression spring 96 is mounted between the member 94 and the exhalation peep valve 98.
- the valve 98 is similar is all respects to the valve 50 and, therefore its detail description is omitted here.
- the exhalation peep valve 98 allows creation of positive back pressure by forcing the patient to exhale against the force of the compressed spring 96.
- An intake valve, similar to the valve 60 is in the body 72 between the open end 74 and the valve 98.
- the air travels through the port 80, through the valve 98 and intake valve 60 in the direction of arrow 100.
- the air moves against the rubber gasket, or flap valve 60 that normally closes the ports of the piston/bracket.
- the patient is able to move the bracket, against resistance of the compression spring 96, away from the exit port 82, allowing the gas to move through the exhalation peep valve 98 and through the exhalation port 82, in the direction of arrow 102, as shown in Figure 6.
- a quantity of medication 104 deposited in the nebulizer 88 mixes with the air passing through the manifold 84 to the mouthpiece 86 and is delivered to the airways of the patient.
- the tiny droplets of medication dispersed by the aerosol-forming member 106 intercept the airflow passing through the conduit 72.
- the formed mist mixes with the intake airflow and is delivered into the airways of the user, extending the airways and reducing the asthma attack or other breathing problems of the patient. It is preferred that during exhalation or inhalation, the patients keep their mouths firmly closed around mouthpieces 18 and 86, so as to seal the open ends of the devices 10 and 70 and to allow effective delivery of medication and exhalation of gases.
- the peep valve tends to distend airways of the patient and prevent collapsing of the alveoli by creating a positive back pressure.
- the air is forced to exit only through the exhalation valve that has been pre-set to offer resistance by a cap 24 or by the cam 78, the exhaust airflow cannot exit through the intake port and has to move through the exhalation ports 44 or 82.
- the airways of the patients are kept open restoring the normal breathing. Once the pressure inside the inflamed sac is equalized with the pressure in a trachea, the medication has a much better chance to penetrating deep into the airways and cause dilation.
- the devices 10 and 70 allow trapped carbon dioxide to escape through the exhalation ports 44 or 82, thereby reducing the toxic levels of carbon dioxide into the blood stream of the user. When the trapped gases are removed from the lungs, the lungs can then generate a greater inspiratory pressure with less effort of the patient.
- the pyramid effect establishes itself thus increasing the flow of much needed oxygenated air.
- the user allowing pressure equalization and increase of volume in all lung areas, experiences a long expiratory phase.
- the air movement into and out of the lungs is considerably improved.
- the lungs are not hyper-inflated; fresh air enters the lungs with more ease.
- the medicine 104 is pulled in from the nebulizer 88 more effectively to reach the affected areas of the lungs and further dilate the airways. Consequently, the patient's collapsed or obstructed airways remain open and more precise medication delivery may be achieved. The treatment then becomes more effective with less medication.
- the present invention can be used for patients suffering from asthma or emphysema.
- Many patients suffering from asthma have unexpected attacks and difficulty of getting to their medication.
- the attack may be enhanced by anxiety that the patient would suffocate before getting the medication.
- the patient can at least restore some breathing and reduce the anxiety factor.
- the terminal bronchioles are weakened and are in a permanently enlarged condition.
- the alveolar walls are often times damaged. Because of the loss of alveolar space, the amount of surface area for gas exchange is reduced, and the elastic recoil of the lung tissue is diminished.
- the sealed back pressure devices 10 or 70 that emphysema sufferers can increase delivery of air into the lungs and exhaust the carbon dioxide from the blood stream.
- the backpressure created by the devices 10 and 70 prevents the bronchioles, alveoli from collapsing.
- the reduction of resultant hyperinflation allows the patient to inspire and exhale more fully, thereby delivering medication to a greater surface of the damaged tissue.
- the sealed back pressure helps to keep the alveoli and airways open, allowing the release of the carbon dioxide from the lungs into the atmosphere.
- the effective removal of gas from the lungs and the blood stream improves the physiological function of the patient and allows more oxygen to be delivered into the lungs.
- valve 10 and 70 can be preset to greater values than indicated above, particularly with patients having considerable problems with collapsed airways, although the preferred settings would range from about 5cm to
- the devices of the present invention may be used for exercising the patients and restoring their ability to normally breathe. This is particularly true with a device 10 of the first embodiment. It is also envisioned that a nose clip and/or a molded cushioned mouthpiece may be used in combination with the mouthpieces to ensure a better seal of the patients' lips around the mouthpiece.
- the device of the present invention can be inexpensively manufactured from readily available materials, such as plastic and lightweight metal.
- the springs 40 and 96 will naturally be manufactured from a material that is strong enough to withstand multiple compressions and expansions during use of the device.
- the mouthpiece 18 may be manufactured to detachably engage the main body portion 14, if desired. In such a case, the device 10 with separated mouthpiece 18 may be carried in a compact space, such as the user's pocket, and engaged with the rest of the device, when needed.
- the device 70 may be attached to a metered dose inhaler (MDI), instead of a nebulizer, if necessary.
- MDI metered dose inhaler
- a mini spacer would be used instead of the manifold 84.
- the mini spacer conventionally has a port for delivery of medication, for example anti-inflammatory drugs, in the form of a fine mist.
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2006802A AU2006802A (en) | 2000-10-26 | 2001-10-24 | Sealed back pressure breathing device |
CA002425291A CA2425291A1 (en) | 2000-10-26 | 2001-10-24 | Sealed back pressure breathing device |
EP01988604A EP1328311A2 (en) | 2000-10-26 | 2001-10-24 | Sealed back pressure breathing device |
AU2002220068A AU2002220068B2 (en) | 2000-10-26 | 2001-10-24 | Sealed back pressure breathing device |
MXPA03003553A MXPA03003553A (en) | 2000-10-26 | 2001-10-24 | Sealed back pressure breathing device. |
EA200300511A EA005171B1 (en) | 2000-10-26 | 2001-10-24 | Sealed back pressure breathing device |
NZ525239A NZ525239A (en) | 2000-10-26 | 2001-10-24 | Sealed back pressure breathing device |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/699,226 | 2000-10-26 | ||
US09/699,226 US6510846B1 (en) | 1999-12-23 | 2000-10-26 | Sealed back pressure breathing device |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2002034322A2 true WO2002034322A2 (en) | 2002-05-02 |
WO2002034322A3 WO2002034322A3 (en) | 2003-01-03 |
WO2002034322B1 WO2002034322B1 (en) | 2003-04-24 |
Family
ID=24808428
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/045478 WO2002034322A2 (en) | 2000-10-26 | 2001-10-24 | Sealed back pressure breathing device |
Country Status (9)
Country | Link |
---|---|
US (1) | US6510846B1 (en) |
EP (1) | EP1328311A2 (en) |
CN (1) | CN1309429C (en) |
AU (2) | AU2002220068B2 (en) |
CA (1) | CA2425291A1 (en) |
EA (1) | EA005171B1 (en) |
MX (1) | MXPA03003553A (en) |
NZ (1) | NZ525239A (en) |
WO (1) | WO2002034322A2 (en) |
Cited By (10)
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---|---|---|---|---|
EP1466635A1 (en) * | 2003-04-08 | 2004-10-13 | Ministero dell'Istruzione, dell'Universita e della Ricerca | Ventricular assist device and accessory therefor |
US7896887B2 (en) | 2001-10-25 | 2011-03-01 | Spiration, Inc. | Apparatus and method for deployment of a bronchial obstruction device |
WO2012058208A1 (en) * | 2010-10-26 | 2012-05-03 | Dawson Medical Technologies Llc | Adjustable tracheostomy valve |
US8251067B2 (en) | 2001-03-02 | 2012-08-28 | Pulmonx Corporation | Bronchial flow control devices with membrane seal |
US8388682B2 (en) | 2004-11-19 | 2013-03-05 | Pulmonx Corporation | Bronchial flow control devices and methods of use |
US8474460B2 (en) | 2000-03-04 | 2013-07-02 | Pulmonx Corporation | Implanted bronchial isolation devices and methods |
US9211181B2 (en) | 2004-11-19 | 2015-12-15 | Pulmonx Corporation | Implant loading device and system |
US9216266B2 (en) | 2008-12-30 | 2015-12-22 | Koninklijke Philips N.V. | System and respiration appliance for supporting the airway of a subject |
US9326873B2 (en) | 2007-10-12 | 2016-05-03 | Spiration, Inc. | Valve loader method, system, and apparatus |
US9622752B2 (en) | 2003-08-08 | 2017-04-18 | Spiration, Inc. | Bronchoscopic repair of air leaks in a lung |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5954766A (en) * | 1997-09-16 | 1999-09-21 | Zadno-Azizi; Gholam-Reza | Body fluid flow control device |
US6786216B2 (en) * | 1999-12-23 | 2004-09-07 | O'rourke Sam | Sealed back pressure breathing device |
US6369725B1 (en) * | 2000-09-26 | 2002-04-09 | International Business Machines Corporation | Method for binary to decimal conversion |
US6679264B1 (en) | 2000-03-04 | 2004-01-20 | Emphasys Medical, Inc. | Methods and devices for use in performing pulmonary procedures |
US6901927B2 (en) * | 2000-03-04 | 2005-06-07 | Emphasys Medical, Inc. | Methods and devices for use in performing pulmonary procedures |
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US10456541B2 (en) | 2008-12-30 | 2019-10-29 | Koninklijke Philips N.V. | System and respiration appliance for supporting the airway of a subject |
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Also Published As
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EA200300511A1 (en) | 2004-04-29 |
EP1328311A2 (en) | 2003-07-23 |
NZ525239A (en) | 2004-05-28 |
AU2002220068B2 (en) | 2006-12-14 |
US6510846B1 (en) | 2003-01-28 |
EA005171B1 (en) | 2004-12-30 |
CN1482934A (en) | 2004-03-17 |
WO2002034322A3 (en) | 2003-01-03 |
AU2006802A (en) | 2002-05-06 |
CA2425291A1 (en) | 2002-05-02 |
WO2002034322B1 (en) | 2003-04-24 |
MXPA03003553A (en) | 2004-09-10 |
CN1309429C (en) | 2007-04-11 |
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