WO2002034307A3 - Transmural concentric multilayer ingrowth matrix within well-defined porosity - Google Patents

Transmural concentric multilayer ingrowth matrix within well-defined porosity Download PDF

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Publication number
WO2002034307A3
WO2002034307A3 PCT/US1999/027567 US9927567W WO0234307A3 WO 2002034307 A3 WO2002034307 A3 WO 2002034307A3 US 9927567 W US9927567 W US 9927567W WO 0234307 A3 WO0234307 A3 WO 0234307A3
Authority
WO
WIPO (PCT)
Prior art keywords
ingrowth
well
matrix
defined porosity
transmural
Prior art date
Application number
PCT/US1999/027567
Other languages
French (fr)
Other versions
WO2002034307A2 (en
Inventor
Peter Paul Zilla
Deon Bezuidenhout
Theresa Yvonne Dower
Original Assignee
Medtronic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic Inc filed Critical Medtronic Inc
Priority to DE69918189T priority Critical patent/DE69918189T2/en
Priority to EP99974270A priority patent/EP1251890B1/en
Priority to AU35115/02A priority patent/AU3511502A/en
Publication of WO2002034307A2 publication Critical patent/WO2002034307A2/en
Publication of WO2002034307A3 publication Critical patent/WO2002034307A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/146—Porous materials, e.g. foams or sponges

Abstract

A multilayer ingrowth matrix is constructed within well-defined porosity of a prosthetic material. The matrix consists of either proteinaceous or synthetic layers or gradients, or a combination of proteinaceous and synthetic layers or gradients. Each layer within the matrix is designed to achieve a specific function, such as facilitation of ingrowth of a particular cell type or release of a particular growth factor. The well-defined porosity is in the form of either helically oriented, interconnected transmural ingrowth channels, or a porous wall structure containing uniformly shaped pores (i.e. voids) in a very narrow size range, or a combination of channels and pores. This invention allows for uninterrupted ingrowth of connective tissue into walls of a synthetic graft prosthesis made from the prosthetic material. Furthermore, this invention can produce small diameter prostheses having an internal diameter of 6 mm or less.
PCT/US1999/027567 1999-07-20 1999-11-19 Transmural concentric multilayer ingrowth matrix within well-defined porosity WO2002034307A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE69918189T DE69918189T2 (en) 1999-07-20 1999-11-19 TRANSMURAL MULTILAYER IMMERSION MATRIX WITH EXACTLY DEFINED POROUSITY
EP99974270A EP1251890B1 (en) 1999-07-20 1999-11-19 Transmural concentric multilayer ingrowth matrix within well-defined porosity
AU35115/02A AU3511502A (en) 1999-07-20 1999-11-19 Transmural concentric multilayer ingrowth matrix within well-defined porosity

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US14470399P 1999-07-20 1999-07-20
US60/144,703 1999-07-20
US09/434,069 US6554857B1 (en) 1999-07-20 1999-11-05 Transmural concentric multilayer ingrowth matrix within well-defined porosity
US09/434,069 1999-11-05

Publications (2)

Publication Number Publication Date
WO2002034307A2 WO2002034307A2 (en) 2002-05-02
WO2002034307A3 true WO2002034307A3 (en) 2002-08-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/027567 WO2002034307A2 (en) 1999-07-20 1999-11-19 Transmural concentric multilayer ingrowth matrix within well-defined porosity

Country Status (5)

Country Link
US (2) US6554857B1 (en)
EP (1) EP1251890B1 (en)
AU (1) AU3511502A (en)
DE (1) DE69918189T2 (en)
WO (1) WO2002034307A2 (en)

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Also Published As

Publication number Publication date
AU3511502A (en) 2002-05-06
US6554857B1 (en) 2003-04-29
US6673108B2 (en) 2004-01-06
US20020151968A1 (en) 2002-10-17
DE69918189D1 (en) 2004-07-22
EP1251890B1 (en) 2004-06-16
EP1251890A2 (en) 2002-10-30
DE69918189T2 (en) 2005-07-07
WO2002034307A2 (en) 2002-05-02

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