WO2002029400A3 - Apparatuses and methods for field flow fractionation of particles using acoustic and other forces - Google Patents

Apparatuses and methods for field flow fractionation of particles using acoustic and other forces Download PDF

Info

Publication number
WO2002029400A3
WO2002029400A3 PCT/US2001/042280 US0142280W WO0229400A3 WO 2002029400 A3 WO2002029400 A3 WO 2002029400A3 US 0142280 W US0142280 W US 0142280W WO 0229400 A3 WO0229400 A3 WO 0229400A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
apparatuses
acoustic
forces
particles
Prior art date
Application number
PCT/US2001/042280
Other languages
French (fr)
Other versions
WO2002029400A2 (en
Inventor
Xiao-Bo Wang
Jing Cheng
Lei Wu
Junquan Xu
Original Assignee
Aviva Biosciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN 00130562 external-priority patent/CN1221309C/en
Priority claimed from US09/679,023 external-priority patent/US6881314B1/en
Application filed by Aviva Biosciences Corp filed Critical Aviva Biosciences Corp
Priority to CA 2422837 priority Critical patent/CA2422837A1/en
Priority to AU2002213426A priority patent/AU2002213426A1/en
Priority to EP01981809A priority patent/EP1322953A2/en
Publication of WO2002029400A2 publication Critical patent/WO2002029400A2/en
Publication of WO2002029400A3 publication Critical patent/WO2002029400A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/0005—Field flow fractionation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3678—Separation of cells using wave pressure; Manipulation of individual corpuscles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/0005—Field flow fractionation
    • G01N2030/004—Field flow fractionation characterised by opposing force
    • G01N2030/0055—Field flow fractionation characterised by opposing force hyperlayer, i.e. different particle populations in hyperlayers elevated above wall
    • G01N2030/006—Field flow fractionation characterised by opposing force hyperlayer, i.e. different particle populations in hyperlayers elevated above wall lift hyperlayer, i.e. hydrodynamic lift forces dominate steric effect
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/0005—Field flow fractionation
    • G01N2030/004—Field flow fractionation characterised by opposing force
    • G01N2030/0065—Dielectric FFF, i.e. opposing forces dominate hydrodynamic lift forces and steric effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography

Abstract

This invention relates generally to the field of field-flow-fractionation. In particular, the invention provides apparatuses and methods for the discrimination of mattes utilizing acoustic force, or utilizing acoustic force with electrophoretic or dielectrophoretic force, in field flow fractionation.
PCT/US2001/042280 2000-09-30 2001-09-20 Apparatuses and methods for field flow fractionation of particles using acoustic and other forces WO2002029400A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA 2422837 CA2422837A1 (en) 2000-09-30 2001-09-20 Apparatuses and methods for field flow fractionation of particles using acoustic and other forces
AU2002213426A AU2002213426A1 (en) 2000-09-30 2001-09-20 Apparatuses and methods for field flow fractionation of particles using acoustic and other forces
EP01981809A EP1322953A2 (en) 2000-09-30 2001-09-20 Apparatuses and methods for field flow fractionation of particles using acoustic and other forces

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN 00130562 CN1221309C (en) 2000-09-30 2000-09-30 Apparatus for corpuscle field and flow separation by sound field force and other active force
CN00130562.X 2000-09-30
US09/679,023 2000-10-04
US09/679,023 US6881314B1 (en) 2000-09-30 2000-10-04 Apparatuses and methods for field flow fractionation of particles using acoustic and other forces

Publications (2)

Publication Number Publication Date
WO2002029400A2 WO2002029400A2 (en) 2002-04-11
WO2002029400A3 true WO2002029400A3 (en) 2003-04-17

Family

ID=25739617

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/042280 WO2002029400A2 (en) 2000-09-30 2001-09-20 Apparatuses and methods for field flow fractionation of particles using acoustic and other forces

Country Status (4)

Country Link
EP (1) EP1322953A2 (en)
AU (1) AU2002213426A1 (en)
CA (1) CA2422837A1 (en)
WO (1) WO2002029400A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8969021B2 (en) 2001-10-11 2015-03-03 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US8986945B2 (en) 2006-07-14 2015-03-24 Aviva Biosciences Corporation Methods and compositions for detecting rare cells from a biological sample
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
US9146221B2 (en) 2001-03-24 2015-09-29 Aviva Biosciences Corporation High-density ion transport measurement biochip devices and methods

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100494360C (en) 2001-03-22 2009-06-03 博奥生物有限公司 Process for separating cells and its application
EP1627675A4 (en) * 2003-12-17 2012-12-12 Panasonic Corp Component separating device, method of producing the device, and method of separating component by using the device
SE528313C2 (en) * 2004-09-24 2006-10-17 Spectronic Ab Method and apparatus for separating particles using ultrasonic waves
JP4835047B2 (en) 2005-06-24 2011-12-14 富士ゼロックス株式会社 Method for producing fine particle dispersion
WO2007006322A1 (en) * 2005-07-07 2007-01-18 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method and device for acoustic manipulation of particles, cells and viruses
KR101165162B1 (en) * 2008-04-25 2012-07-11 신닛뽄세이테쯔 카부시키카이샤 Method of determining particle size distribution of fine particles contained in metallic material
WO2011129723A1 (en) * 2010-04-15 2011-10-20 G&M Norden Ab Method for detecting gas and a gas detector therefor
GB201010724D0 (en) * 2010-06-25 2010-08-11 Isis Innovation Acoustic separators
WO2013033232A1 (en) 2011-08-29 2013-03-07 The Charles Stark Draper Laboratory, Inc. System and method for blood separation by microfluidic acoustic focusing
FR2979256B1 (en) * 2011-08-30 2014-09-26 Centre Nat Rech Scient DEVICE FOR HANDLING OBJECTS BY ACOUSTIC FORCE FIELDS
US9504780B2 (en) 2013-01-30 2016-11-29 The Charles Stark Draper Laboratory, Inc. Extracorporeal clearance of organophosphates from blood on an acoustic separation device
WO2014138739A1 (en) 2013-03-08 2014-09-12 The Charles Stark Draper Laboratory, Inc. System and method for blood separation by microfluidic acoustic focusing
US10099002B2 (en) 2014-07-31 2018-10-16 The Charles Stark Draper Laboratory, Inc. Systems and methods for parallel channel microfluidic separation
US10946133B2 (en) 2014-07-31 2021-03-16 The Charles Stark Draper Laboratory, Inc. Systems and methods for parallel channel microfluidic separation

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3449938A (en) * 1967-08-03 1969-06-17 Univ Utah Method for separating and detecting fluid materials
GB2166659A (en) * 1984-10-31 1986-05-14 Unilever Plc Processing particulate material
US4743361A (en) * 1983-10-31 1988-05-10 Internationale Octrooi Maatschappij "Octropa" Bv Manipulation of particles
EP0292470A1 (en) * 1987-05-19 1988-11-23 Wolfgang Dipl.-Ing. Stuckart Process for separating substances from liquids and apparatus for carrying out the process
EP0302724A2 (en) * 1987-08-07 1989-02-08 National Research Development Corporation Supporting means
US4877516A (en) * 1986-05-27 1989-10-31 National Research Development Corporation Manipulating particulate matter
US5192450A (en) * 1990-12-17 1993-03-09 The United States Of America As Represented By The Administrator Of The United States National Aeronautics And Space Administration Acoustophoresis separation method
US5811658A (en) * 1997-04-29 1998-09-22 Medtronic, Inc. Ultrasonic diversion of microair in blood
US5993630A (en) * 1996-01-31 1999-11-30 Board Of Regents The University Of Texas System Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3449938A (en) * 1967-08-03 1969-06-17 Univ Utah Method for separating and detecting fluid materials
US4743361A (en) * 1983-10-31 1988-05-10 Internationale Octrooi Maatschappij "Octropa" Bv Manipulation of particles
GB2166659A (en) * 1984-10-31 1986-05-14 Unilever Plc Processing particulate material
US4877516A (en) * 1986-05-27 1989-10-31 National Research Development Corporation Manipulating particulate matter
EP0292470A1 (en) * 1987-05-19 1988-11-23 Wolfgang Dipl.-Ing. Stuckart Process for separating substances from liquids and apparatus for carrying out the process
EP0302724A2 (en) * 1987-08-07 1989-02-08 National Research Development Corporation Supporting means
US5192450A (en) * 1990-12-17 1993-03-09 The United States Of America As Represented By The Administrator Of The United States National Aeronautics And Space Administration Acoustophoresis separation method
US5993630A (en) * 1996-01-31 1999-11-30 Board Of Regents The University Of Texas System Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation
US5811658A (en) * 1997-04-29 1998-09-22 Medtronic, Inc. Ultrasonic diversion of microair in blood

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CURTIS H W ET AL: "ULTRASONIC CONTINUOUS FLOW PLASMAPHERESIS SEPARATOR", IBM TECHNICAL DISCLOSURE BULLETIN, IBM CORP. NEW YORK, US, vol. 25, no. 1, 1 June 1982 (1982-06-01), pages 192 - 193, XP002029063, ISSN: 0018-8689 *
GREEN N G ET AL: "SEPARATION OF SUBMICROMETRE PARTICLES USING A COMBINATION OF DIELECTROPHORETIC AND ELECTROHYDRODYNAMIC FORCES", JOURNAL OF PHYSICS D. APPLIED PHYSICS, IOP PUBLISHING, BRISTOL, GB, vol. 31, no. 7, 7 April 1998 (1998-04-07), pages L25 - L30, XP000780543, ISSN: 0022-3727 *
YASUDA K ET AL: "PARTICLE SEPARATION USING ACOUSTIC RADIATION FORCE AND ELECROSTATICFORCE", JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, AMERICAN INSTITUTE OF PHYSICS. NEW YORK, US, vol. 99, no. 4, PART 1, 1 April 1996 (1996-04-01), pages 1965 - 1970, XP000599271, ISSN: 0001-4966 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9146221B2 (en) 2001-03-24 2015-09-29 Aviva Biosciences Corporation High-density ion transport measurement biochip devices and methods
US8969021B2 (en) 2001-10-11 2015-03-03 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
US9290812B2 (en) 2001-10-11 2016-03-22 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
US9556485B2 (en) 2001-10-11 2017-01-31 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US8986945B2 (en) 2006-07-14 2015-03-24 Aviva Biosciences Corporation Methods and compositions for detecting rare cells from a biological sample

Also Published As

Publication number Publication date
CA2422837A1 (en) 2002-04-11
AU2002213426A1 (en) 2002-04-15
EP1322953A2 (en) 2003-07-02
WO2002029400A2 (en) 2002-04-11

Similar Documents

Publication Publication Date Title
WO2002029400A3 (en) Apparatuses and methods for field flow fractionation of particles using acoustic and other forces
AU2003202943A1 (en) Flow sorting system and methods regarding same
AU2003260679A1 (en) Lateral flow assay device and method
WO2006017274A3 (en) Systems and methods for sample modification using fluidic chambers
AU7964701A (en) Particle trap for separating particles from the flow of a liquid, method for separating particles from the flow of liquid and use of said particle trap
AU2001285003A1 (en) Filter assembly, filter element, and method of utilizing the same
EG24493A (en) Multistage fluid separation assembly and method
WO2002028275A8 (en) Systems and methods for investigating blood flow
WO2004087868A3 (en) Dna polymerase fusions and uses thereof
AU2003251778A1 (en) Microfluidic closed-end metering systems and methods
WO2004099352A3 (en) Additives and methods for reducing odor
AU2002340790A1 (en) Multi-rail asynchronous flow with completion detection and system and method for designing the same
AU2003287568A1 (en) Systems and methods of sorting samples
WO2005081694A3 (en) Dielectrophoresis device and method having insulating ridges for manipulating particles
WO2005041896A3 (en) Methods of identifying individuals at risk of perioperative bleeding, renal dysfunction or stroke
NO20005198L (en) Process for separation of magnetic particles mixed in fluid, as well as separation system and separator
WO2006032048A3 (en) Separation of particle types using a non-uniform acoustic field
WO2003057715A8 (en) Novel ligand involved in the transmigration of leukocytes .
WO2003000888A3 (en) Method for separating bacterial cells and cell components
AU2002231961A1 (en) Detectable compositions, methods of forming the same and detection techniques
AU2002250018A1 (en) Coalescing and separating arrangements, systems, and methods for liquid mixtures
AU2003279017A1 (en) Methods of cleaning, clearing and separation in conduits
DE60124836D1 (en) Element, device, method and kit for the separation of particles
AU2002227338A1 (en) Piezoelectric polymer flow sensor and methods
WO2001061329A3 (en) Method for isolating a proportion of a fluid mixture

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2422837

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2001981809

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2001981809

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Ref document number: 2001981809

Country of ref document: EP