WO2002022172A3 - Powdered/microfibrillated cellulose - Google Patents

Powdered/microfibrillated cellulose Download PDF

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Publication number
WO2002022172A3
WO2002022172A3 PCT/US2001/024404 US0124404W WO0222172A3 WO 2002022172 A3 WO2002022172 A3 WO 2002022172A3 US 0124404 W US0124404 W US 0124404W WO 0222172 A3 WO0222172 A3 WO 0222172A3
Authority
WO
WIPO (PCT)
Prior art keywords
cellulose
excipient
topical formulations
powdered
microfibrillated cellulose
Prior art date
Application number
PCT/US2001/024404
Other languages
French (fr)
Other versions
WO2002022172A2 (en
Inventor
Vijay Kumar
Original Assignee
Univ Iowa Res Found
Vijay Kumar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Iowa Res Found, Vijay Kumar filed Critical Univ Iowa Res Found
Priority to AU2001283107A priority Critical patent/AU2001283107A1/en
Publication of WO2002022172A2 publication Critical patent/WO2002022172A2/en
Publication of WO2002022172A3 publication Critical patent/WO2002022172A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
    • C08B15/02—Oxycellulose; Hydrocellulose; Cellulosehydrate, e.g. microcrystalline cellulose

Abstract

A new cellulose excipient suitable for use as a binder, filler, and/or disintegrant in the development of solid dosage forms and as a bodying agent or a drug carrier in the preparation of topical formulations is described. The cellulose excipient is formed by soaking a source of cellulose in an aqueous alkali metal hydroxide solution. The cellulose is then regenerated, washed, and optionally hydrolyzed with a dilute mineral acid. The cellulose excipient is also useful as an aqueous dispersion in topical formulations and in the manufacture of cellulose beads.
PCT/US2001/024404 2000-09-14 2001-08-03 Powdered/microfibrillated cellulose WO2002022172A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001283107A AU2001283107A1 (en) 2000-09-14 2001-08-03 Powdered/microfibrillated cellulose

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23265700P 2000-09-14 2000-09-14
US60/232,657 2000-09-14

Publications (2)

Publication Number Publication Date
WO2002022172A2 WO2002022172A2 (en) 2002-03-21
WO2002022172A3 true WO2002022172A3 (en) 2002-06-06

Family

ID=22874014

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/024404 WO2002022172A2 (en) 2000-09-14 2001-08-03 Powdered/microfibrillated cellulose

Country Status (3)

Country Link
US (1) US6821531B2 (en)
AU (1) AU2001283107A1 (en)
WO (1) WO2002022172A2 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050287208A1 (en) * 2004-06-22 2005-12-29 University Of Iowa Research Foundation Cross-linked powered/microfibrillated cellulose II
WO2008010464A1 (en) * 2006-07-19 2008-01-24 Kyoto University Microfibrillated cellulose having cellulose type-ii crystalline structure, and molded article containing the microfibrillated cellulose
GB2445161B (en) * 2006-12-29 2011-08-10 Mologic Ltd Diagnostic test device
GB2445160B (en) * 2006-12-29 2011-08-10 Mologic Ltd Diagnostic test device
WO2008115934A1 (en) * 2007-03-19 2008-09-25 Syngenta Participations Ag Methods for generating non cellulose microfibres comprising an active ingredient
WO2009037143A1 (en) * 2007-09-17 2009-03-26 Basf Se Binder-consolidated cellulose beads
WO2009037146A1 (en) * 2007-09-17 2009-03-26 Basf Se Crosslinked cellulose beads
AT505905B1 (en) * 2007-09-21 2009-05-15 Chemiefaser Lenzing Ag CELLULOSE POWDER AND METHOD FOR THE PRODUCTION THEREOF
US8017396B2 (en) * 2008-02-22 2011-09-13 Vijay Kumar Cellulose based heart valve prosthesis
PT2274433E (en) * 2008-04-03 2012-08-16 Cellulose Sciences International Inc Highly disordered cellulose
WO2012037250A2 (en) 2010-09-14 2012-03-22 Cellulose Sciences International, Inc. Nano-deaggregated cellulose
US20090312537A1 (en) * 2008-04-30 2009-12-17 Xyleco, Inc. Carbohydrates
US8753677B2 (en) 2008-09-16 2014-06-17 The Invention Science Fund I, Llc Ex vivo modifiable multiple medicament final dosage form
CA2772172A1 (en) * 2009-09-08 2011-03-17 John Mcarthur Swazey, Jr. Methods to improve the compatibility and efficiency of powdered versions of microfibrous cellulose
US9050264B2 (en) 2009-11-07 2015-06-09 University Of Iowa Research Foundation Cellulose capsules and methods for making them
JP5622412B2 (en) * 2010-03-19 2014-11-12 国立大学法人京都大学 Molding material and manufacturing method thereof
AT509515B1 (en) * 2010-06-23 2012-10-15 Chemiefaser Lenzing Ag USE OF CELLULOSE IN TABLETS
WO2013009253A1 (en) * 2011-07-08 2013-01-17 Chalmers Tekniska Högskola Aktiebolag Microfibrillated cellulose films for controlled release of active agents
FI130619B (en) * 2011-11-15 2023-12-15 Upm Kymmene Corp Matrix for sustained delivery of bioactive agents
CO7150300A1 (en) * 2013-06-27 2014-12-29 Univ Antioquia Production of a new multipurpose agglomerated cellulosic excipient
AU2015251692B2 (en) * 2014-04-21 2019-12-19 Daicel Corporation Disintegrating particle composition including microfibrous cellulose
US10130584B2 (en) * 2014-11-24 2018-11-20 Daicel Corporation Disintegrative particle composition including pulverized lactose or granulated lactose
ITUA20161937A1 (en) * 2016-03-23 2017-09-23 S I I T S R L Servizio Int Imballaggi Termosaldanti PREPARATION FOR CHITOSAN AND CELLULOSE BASED BODY WEIGHT CONTROL
JP2017203063A (en) * 2016-05-10 2017-11-16 日本製紙株式会社 Method for producing powdery cellulose
CN108264569B (en) * 2017-01-03 2020-01-03 中国科学院金属研究所 Cellulose II type nanocrystalline particles and preparation method and application thereof
EP3626272B1 (en) * 2017-05-18 2023-10-04 Daicel Corporation Composition for disintegrating tablets containing microfibrous cellulose and active ingredient
WO2019108887A1 (en) * 2017-11-30 2019-06-06 Warner Babcok Institute For Green Chemistry, Llc Products comprising plant-based micro fibers
US20210290497A1 (en) * 2018-07-31 2021-09-23 Daicel Corporation Disintegrating solid containing disintegrant component and microfibrous cellulose
EP3632408A1 (en) 2018-10-04 2020-04-08 Jim Seido Wood particles microbeads enriched with berry (mainly: 1- bilberry: vaccinium myrtillus/2- lingonberry: vaccinium vitis-idaea / 3- american blueberry: vaccinium cyanococcus) extract
CN111116761B (en) * 2019-11-13 2022-02-18 王卫 Preparation method of modified microcrystalline cellulose

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4159345A (en) * 1977-04-13 1979-06-26 Fmc Corporation Novel excipient and pharmaceutical composition containing the same
JPS594601A (en) * 1982-06-30 1984-01-11 Unitika Ltd Crystalline cellulose of high whiteness and manufacture of the same
US4438263A (en) * 1982-08-06 1984-03-20 James River Corporation Of Virginia Cellulose granules and process for producing the same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643591A (en) * 1991-01-16 1997-07-01 Fmc Corporation Solid dosage forms

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4159345A (en) * 1977-04-13 1979-06-26 Fmc Corporation Novel excipient and pharmaceutical composition containing the same
JPS594601A (en) * 1982-06-30 1984-01-11 Unitika Ltd Crystalline cellulose of high whiteness and manufacture of the same
US4438263A (en) * 1982-08-06 1984-03-20 James River Corporation Of Virginia Cellulose granules and process for producing the same

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 78, no. 4, 29 January 1973, Columbus, Ohio, US; abstract no. 17867, ARAKI TSUNAO ET AL.: "Preparation of microcrystalline cellulose by aging alkali cellulose" XP002190276 *
DATABASE WPI Week 198408, Derwent World Patents Index; AN 1984-045022 *
KOBUNSHI KAGAKU, vol. 29, no. 9, 1972, pages 647 - 651 *
PATENT ABSTRACTS OF JAPAN vol. 8, no. 85 (C - 219) 18 April 1984 (1984-04-18) *

Also Published As

Publication number Publication date
US6821531B2 (en) 2004-11-23
US20020061335A1 (en) 2002-05-23
WO2002022172A2 (en) 2002-03-21
AU2001283107A1 (en) 2002-03-26

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