WO2002018945A3 - Analysis chip - Google Patents

Analysis chip Download PDF

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Publication number
WO2002018945A3
WO2002018945A3 PCT/EP2001/009286 EP0109286W WO0218945A3 WO 2002018945 A3 WO2002018945 A3 WO 2002018945A3 EP 0109286 W EP0109286 W EP 0109286W WO 0218945 A3 WO0218945 A3 WO 0218945A3
Authority
WO
WIPO (PCT)
Prior art keywords
molecules
code
immobilised
chip
area
Prior art date
Application number
PCT/EP2001/009286
Other languages
German (de)
French (fr)
Other versions
WO2002018945A2 (en
Inventor
Ralph Mueller
Original Assignee
Basf Lynx Bioscience Ag
Ralph Mueller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Lynx Bioscience Ag, Ralph Mueller filed Critical Basf Lynx Bioscience Ag
Priority to AU2002212136A priority Critical patent/AU2002212136A1/en
Publication of WO2002018945A2 publication Critical patent/WO2002018945A2/en
Publication of WO2002018945A3 publication Critical patent/WO2002018945A3/en

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00529—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00542—Alphanumeric characters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00547—Bar codes
    • B01J2219/00549—2-dimensional
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00608—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes

Abstract

The invention relates to an analysis chip (10), e.g. a DNA array, on which a number of different types of molecules are immobilised in allocated spatial areas (14), respectively. A corresponding code is allocated to each type of molecule in a corresponding spatial area (24) on the chip. The code indicates which type of molecule is immobilised in the respective area. The code can be formulated according to the arrangement of the molecules, for example, if in an area of 5x5 spots, only certain spots are occupied, a binary code is formed. Alternatively, the code (24) can be formed on the chip independently of the immobilised molecules, e.g. as a two-dimensional binary code. The degree of certainty in the use of DNA arrays is increased since when the chips are read out with the help of the respective codes, it is even possible to determine which target molecules have been bound to and so which molecules were in the sample, without having recourse to external information.
PCT/EP2001/009286 2000-08-30 2001-08-10 Analysis chip WO2002018945A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002212136A AU2002212136A1 (en) 2000-08-30 2001-08-10 Analysis chip

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10042797.9 2000-08-30
DE2000142797 DE10042797C2 (en) 2000-08-30 2000-08-30 Analysis chip

Publications (2)

Publication Number Publication Date
WO2002018945A2 WO2002018945A2 (en) 2002-03-07
WO2002018945A3 true WO2002018945A3 (en) 2002-06-27

Family

ID=7654438

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/009286 WO2002018945A2 (en) 2000-08-30 2001-08-10 Analysis chip

Country Status (3)

Country Link
AU (1) AU2002212136A1 (en)
DE (1) DE10042797C2 (en)
WO (1) WO2002018945A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030017455A1 (en) * 2001-01-29 2003-01-23 Webb Peter G. Chemical array fabrication with identity map
US20020142318A1 (en) * 2001-03-30 2002-10-03 Cattell Herbert F. Chemical array reading
US20050135964A1 (en) * 2003-12-22 2005-06-23 Ulrich Sieben Carrier medium for analyzing a substance
US20050049796A1 (en) * 2003-09-03 2005-03-03 Webb Peter G. Methods for encoding non-biological information on microarrays
KR100624420B1 (en) * 2004-04-10 2006-09-19 삼성전자주식회사 A microarray having microarray identification information stored in the form of a spot, method of producing the microarray and method of using the microarray
WO2008096318A2 (en) * 2007-02-09 2008-08-14 Koninklijke Philips Electronics N.V. Identification system
JP4914503B2 (en) 2008-01-16 2012-04-11 日本電信電話株式会社 Surface plasmon resonance measuring apparatus, sample cell, and measuring method
DE102009019476A1 (en) 2009-05-04 2010-11-11 Biametrics Marken Und Rechte Gmbh Recognizable carrier for optical measuring methods
WO2013013832A1 (en) * 2011-07-27 2013-01-31 Scienion Ag Labeled device
EP2933017A1 (en) * 2014-04-17 2015-10-21 AyoxxA Biosystems GmbH Encoded device and method for encoding and decoding reference areas on a substrate
US11896944B2 (en) 2017-02-01 2024-02-13 Illumina, Inc. System and method with fiducials responding to multiple excitation frequencies
GB201701689D0 (en) 2017-02-01 2017-03-15 Illumia Inc System and method with fiducials of non-closed shapes
GB201701688D0 (en) 2017-02-01 2017-03-15 Illumia Inc System and method with fiducials in non-recliner layouts
GB201701686D0 (en) 2017-02-01 2017-03-15 Illunina Inc System & method with fiducials having offset layouts
GB201701691D0 (en) 2017-02-01 2017-03-15 Illumina Inc System and method with reflective fiducials

Citations (6)

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Publication number Priority date Publication date Assignee Title
EP0799897A1 (en) * 1996-04-04 1997-10-08 Affymetrix, Inc. (a California Corporation) Methods and compositions for selecting tag nucleic acids and probe arrays
US5935785A (en) * 1997-04-30 1999-08-10 Motorola, Inc. Binding assay methods
WO2000014197A1 (en) * 1998-09-09 2000-03-16 Hitachi Software Engineering Co., Ltd. Biochip and method of using biochip
WO2000023803A1 (en) * 1998-10-16 2000-04-27 Millstein Larry S Methods of making patterned arrays of analyte-binding molecules
WO2000051058A1 (en) * 1999-02-26 2000-08-31 General Scanning, Inc. Automatic imaging and analysis of microarray biochips
WO2000073504A2 (en) * 1999-06-01 2000-12-07 Hitachi Software Engineering Co., Ltd. Microarray chip and method for indexing the same

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Publication number Priority date Publication date Assignee Title
AU669489B2 (en) * 1991-09-18 1996-06-13 Affymax Technologies N.V. Method of synthesizing diverse collections of oligomers
US5736332A (en) * 1995-11-30 1998-04-07 Mandecki; Wlodek Method of determining the sequence of nucleic acids employing solid-phase particles carrying transponders

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0799897A1 (en) * 1996-04-04 1997-10-08 Affymetrix, Inc. (a California Corporation) Methods and compositions for selecting tag nucleic acids and probe arrays
US5935785A (en) * 1997-04-30 1999-08-10 Motorola, Inc. Binding assay methods
WO2000014197A1 (en) * 1998-09-09 2000-03-16 Hitachi Software Engineering Co., Ltd. Biochip and method of using biochip
EP1048723A1 (en) * 1998-09-09 2000-11-02 Hitachi Software Engineering Co., Ltd. Biochip and method of using biochip
WO2000023803A1 (en) * 1998-10-16 2000-04-27 Millstein Larry S Methods of making patterned arrays of analyte-binding molecules
WO2000051058A1 (en) * 1999-02-26 2000-08-31 General Scanning, Inc. Automatic imaging and analysis of microarray biochips
WO2000073504A2 (en) * 1999-06-01 2000-12-07 Hitachi Software Engineering Co., Ltd. Microarray chip and method for indexing the same

Also Published As

Publication number Publication date
DE10042797C2 (en) 2003-12-04
DE10042797A1 (en) 2002-03-28
AU2002212136A1 (en) 2002-03-13
WO2002018945A2 (en) 2002-03-07

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